Comments = I believe that Dictyostelium Discoideum - or some other slime mold (?s) - is the great undiscovered human pathogen.  DictyBase members - easily proved by YOU!  Take biopsy sample of Fordyce Spots, or skin "flakes", or mouth or nasal swab.  Do PCR with the right primers - you guys know how NOT to get a false negative.  IMO it will come up +ve for Dicty.  And IMO we are massively colonized via biofilm. This has been sitting under our noses. 
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\nIMO dicty forms the basis of our skin, "fat cells" characteristic of metabolic syndrome (dicty filled with phagocytosed fat/nutrients from human host); and at least all the conditions listed above and more.  The master cell signaler.  
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\nIf I'm wrong, no big deal. But I think I'm right, and rather colossally so LOL.
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\nDICTYBASE:  YOU GUYS CAN PROVE IT.  I have hunk of a book written, and dictaphone but am simply too ill to proceed aggressively right now.  Need to focus on Rx.  But you are the best team potentially to prove this - and quickly.  if I'm right, this is too important to not be shared widely.
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\nAgain, scoff away, but please do PCR on human skin, oily contents of pores, samples of crepe-paper skin.  faeces, tears, saliva, atherosclerotic plaques, etc.  A great place IMO to get samples of sclerota are from the lips in pts with angular chelitis.  In fact, I'd go so far as to say that dicty overgrowth IS accelerated aging.
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\nGobsmacked.  One of a zillion examples of what this means is that by obtaining sloughing-off sclerotic plasmodia, one could test the amoeba with antigens, and thus, say, do allergic testing In Vitro.  And reduce the pathogenic load enough, and one might eradicate allergy.
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\nIMO the telltale characteristic of Dicty is its ability to suddenly absorb or expel fluid, fats, etc.  This IMO could form the basis of Orthostatic Intolerance, anaphylaxis, allergy, etc.
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\nSo vitally, if I'm right, treatment is not going to be a cakewalk, because trying to eliminate the Dicty could elicit an allergic response, even anaphylaxis.  More importantly, I believe everyone likely has dicty, and this is part of our microbiome, performing vital role in skin barrier.  So total removal IMO is the last thing you want to do....  finding that sweet spot will be challenging. IMO it's a question of restoring the optimal balance, overcoming deleterious quorum sensing.  We know bacteria do quorum sensing - I wouldn't be surprised if dicty does too.
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\nThink about it:  ever wondered why you can get fat immediately from a meal?  IMO Dicty acts like a zillion little sponges in the body.  Sure, go ahead and diet, but unless you reduce the dicty count, the MINUTE you transgress with your diet, the available dicty will mop up the nutrients, and importantly fat.  So IMO dicty might also be a state of profound malnutrition, because the dicty eats what your cells should get.  One disease, Myalgic Encephalomyelitis, is characterized by "Post-Exertional Relapse".   Pathological accumulation of lactic acid.  Flu symptoms.  Cytokine cascade likely.  Worst AFTER any activity.  If dicty is involved in this disease, it would make such sense.  When exercising, say, the dicty is in flowing plasmodial state.  Then hardens after exercise, trapping exertional metabolites.  
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\nOf course all of these statements should be ignored unless PCR and BLAST can prove I'm right.  Which I think I am.
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\nDictyBase members:  go forth and conquer.
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\nAnd FYI should you need to reach me, please know that my health rather profoundly limits this.  I really think you have enough to go on with the above.
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\nFinally, I suspect that water supply specialists might be able to move this research further.  Dicty in biofilm form - highly difficult to eradicate.  Happy to contribute more in future once my health better managed.