interests = ingle-cell dynamics of host-pathogen interactions

In the lab, we study the host and pathogen factors involved in mycobacterial infection by using the macrophage surrogate D. discoideum as a host. Intrinsic cellular defences play an important role during infection, and I am particularly interested by their roles in the establishment of the replication niche, its breakdown and the restriction of cytosolic bacteria. Furthermore, to get a deeper understanding of the mechanisms of mycobacterial infection, we need to characterize the infection process at the single cell level. This is why I am also studying the dynamics of the host-pathogen relation using a microfluidics system allowing the capture and observation of infected cell and a long-term integration and quantification of infection parameters.