interests = Our research involves using both Dictyostelium (as a basic biomedical model) and mammalian systems in basic medical research. We focus on a range of medical conditions including epilepsy, bipolar disorder, and Alzheimer's disease. We also employ a pharmacogenetic approach relating to a range of established and new medicines, and a variety of natural products. In addition, we promote novel 3Rs methodologies to reduce animal experimentation, and have several drug discovery and pharmacology projects, both in Dictyostelium and other models. Many of these projects are based in Dictyostelium and translate discoveries to accepted (mammalian) models to provide significant advances in medical research.