dictyNews
Electronic Edition
Volume 41, number 13
June 26, 2015

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=========
Abstracts
=========


Development of novel DIF-1 derivatives that selectively suppress 
innate immune responses

Van Hai Nguyen,1 Haruhisa Kikuchi,1 Yuzuru Kubohara,2,3 Katsunori 
Takahashi,4 Yasuhiro Katou,1 Yoshiteru Oshima,1

1 Graduate School of Pharmaceutical Sciences, Tohoku University
2 Department of Molecular and Cellular Biology, Institute for 
Molecular and Cellular Regulation (IMCR), Gunma University
3 Graduate School of Health and Sports Science, Juntendo University
4 Department of Medical Technology, Faculty of Health Science, 
Gunma Paz College


Bioorg. Med. Chem. , in press.

The multiple pharmacological activities of differentiation-inducing 
factor-1 (DIF-1) of the cellular slime mold Dictyostelium discoideum 
led us to examine the use of DIF-1 as a Òdrug templateÓ to develop 
promising seed compounds for drug discovery. DIF-1 and its derivatives 
were synthesized and evaluated for their regulatory activities in 
innate immune responses. We found two new derivatives (4d and 5e) 
with highly selective inhibitory activities against production of 
the antimicrobial peptide attacin in Drosophila S2 cells and against 
production of interleukin-2 in Jurkat cells.


Submitted by Haruhisa Kikuchi [hal@mail.pharm.tohoku.ac.jp] 
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[End dictyNews, volume 41, number 13]