dictyNews
Electronic Edition
Volume 43, number 22
September 22, 2017

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=========
Abstracts
=========

Isolation, Synthesis and Biological Activity of Chlorinated 
Alkylresorcinols from Dictyostelium Cellular Slime Molds

Haruhisa Kikuchi1, Ikuko Ito1, Katsunori Takahashi2, Hirotaka 
Ishigaki2, Kyoichi Iizumi2, Yuzuru Kubohara2, Yoshiteru Oshima1

1Graduate School of Pharmaceutical Sciences, Tohoku University, 
6-3, Aza-Aoba, Aramaki, Aoba-ku, Sendai 980-8578, Japan.
2Department of Medical Technology, Faculty of Health Science, 
Gunma Paz University, 1-7-1, Tonyamachi, Takasaki 370-0006, Japan
3Graduate School of Health and Sports Science, Juntendo University, 
1-1 Hiraga-gakuendai, Inzai, Chiba 270-1695, Japan


J. Nat. Prod., in press.

Eight chlorinated alkylresorcinols, monochasiol A–H (1–8), were 
isolated from the fruiting bodies of Dictyostelium monochasioides. 
Compounds 1–8 were synthesized to confirm their structures and 
to obtain sufficient material for performing biological tests. 
Monochasiol A (1) selectively inhibited the concanavalin A-induced 
interleukin-2 production in Jurkat cells, a human T lymphocyte cell 
line. Monochasiols were biogenetically synthesized by the combination 
of biosynthetic enzymes relating to the principal polyketides, MPBD 
and DIF-1, produced by Dictyostelium discoideum.


submitted by: Haruhisa Kikuchi [fhal@mail.pharm.tohoku.ac.jp]
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[End dictyNews, volume 43, number 22]