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McLaren, MD Meagan D, Mathavarajah, Sabateeshan, Huber, RJ Robert J, (2019) ' Recent Insights into NCL Protein Function Using the Model Organism Dictyostelium discoideum. ' Cells 8
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Abstract:The neuronal ceroid lipofuscinoses (NCLs) are a group of devastating neurological disorders that have a global distribution and affect people of all ages. Commonly known as Batten disease, this form of neurodegeneration is linked to mutations in 13 genetically distinct genes. The precise mechanisms underlying the disease are unknown, in large part due to our poor understanding of the functions of NCL proteins. The social amoeba Dictyostelium discoideum has proven to be an exceptional model organism for studying a wide range of neurological disorders, including the NCLs. The Dictyostelium genome contains homologs of 11 of the 13 NCL genes. Its life cycle, comprised of both single-cell and multicellular phases, provides an excellent system for studying the effects of NCL gene deficiency on conserved cellular and developmental processes. In this review, we highlight recent advances in NCL research using Dictyostelium as a biomedical model.
Status: epublish Type: Journal article Source: PUBMED PubMed ID: 30717401

 
Genes addressed in this paper
aprA cadA cfaD cln3 cln5 ctsD gpr89 stpA
Topics in this paper
Adhesion



X


Mitosis


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Protein Physical Properties


X X


Disease Related


X X


Mammalian Gene Related


X X


Non-mammalian Gene Related







Post-Translational Modifications



X


Chemotaxis/Motility



X


Development/Morphogenesis


X



Endocytosis







Protein-Protein Interactions



X
X
Regulatory Role


X X

X
Regulated By X X X

X

Sporulation/Germination







Reviews X X X X X X X X


Genes addressed in this paper
tpp1 tpp1B tpp1C tpp1D tpp1E tpp1F
Topics in this paper
Adhesion





Mitosis





Protein Physical Properties





Disease Related X X X X X X
Mammalian Gene Related X X X X X X
Non-mammalian Gene Related X X X X X X
Post-Translational Modifications





Chemotaxis/Motility





Development/Morphogenesis X




Endocytosis X X X X X X
Protein-Protein Interactions
X


X
Regulatory Role





Regulated By





Sporulation/Germination X




Reviews X X X X X X