Development
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Chemotaxis of large field of cells
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Aggregation of D. discoideum amoebae towards a point source of the chemoattractant cAMP.
The numbers on the upper left corner are minutes and seconds. From G. Gerisch, Max-Planck-Institut
fur Biochemie, Martinsried, Germany. |
Aggregation towards cAMP
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Aggregation of D. discoideum
ameobae towards cAMP, lower magnification. From R. Firtel,
University of California, San Diego |
Details of Chemotaxis
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Chemotaxis of single cells towards a point source of the chemoattractant cAMP.
The numbers on the upper left corner are minutes and seconds. From G. Gerisch, Max-Planck-Institut fur Biochemie, Martinsried, Germany. |
Dynamic Reorganization of Actin
in chemotaxing cells
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Actin shows dynamic
reorganization in the leading edge of cells migrating under the influence
of cAMP. Actin is visualized by an actin binding domain-GFP fusion
made in David Knecht's laboratory (Univ. Conn.). From R. Firtel,
UCSD. |
Steps cell movement in aggregation
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Time-lapse video of small group of aggregating
cells. Interval between movement steps is 6 minute. From P.
Devreotes, Johns Hopkins Medical Institutions.
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Dark-field waves of cell shape change in aggregation
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Time-lapse video of monolayer of aggregating cells filmed through a dark-field macroscope. White bands represent chemotactically oriented cells. Period of wave initiation is 6 minutes.
From P. Devreotes, Johns Hopkins Medical Institutions.
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Movement of Cells Into an
Aggregate
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Under the influence of cAMP,
cells form streams which participate in the formation of a multicellular
tissue by chemotaxis.
From R. Firtel, UCSD. |
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