Dictyostelium Mutants

Phenotypes for Dictyostelium mutants

View other mutant types: All mutant strains - Null - Overexpression - Multiple - Other - Developmental

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Systematic Name Strain Descriptor Associated gene(s) Phenotypes
DBS0350195 [act15]: acbA(Y72A)acbAdecreased lipid binding
DBS0350657 [csaA]: csaAcsaAaberrant aggregation | increased calcium-independent cell-cell adhesion
DBS0350059 mcln-mclnaberrant cellular response to fluid shear stress | aberrant post-lysosome organization and biogenesis | increased growth rate
DBS0350826 pinA-pinAdecreased growth rate | decreased aggregate size | decreased sporulation
DBS02354121C7gp130decreased cell-substrate adhesion | delayed development | increased growth rate
DBS02354142F5gp130decreased cell-substrate adhesion | delayed development | increased growth rate
DBS02386015NT-5NTmultiple tips in culminant | delayed tip formation | multiple tips in mound
DBS0235584CF45-1-cf45-1increased aggregate size | decreased cell motility | increased cell-cell adhesion | decreased aggregate size | increased intracellular glucose level
DBS0235585CF50-cf50-1increased aggregate size | increased gene expression | increased cell-cell adhesion | decreased extracellular counting factor component(s) level | increased protein level
DBS0235594CHE10cbpCdecreased slug migration | precocious aggregation | decreased aggregate size | decreased fruiting body size | delayed culmination
DBS0235595CHI2cbpCincreased slug migration
DBS0235612CMFR1-cmfBdecreased gene expression | abolished aggregation
DBS0235596ChLim-ChLimincreased growth rate | increased phagocytosis
DBS0235659DD3-3-DD3-3decreased gene expression | precocious aggregation
DBS0236049DDB_G0268012-DDB_G0268012wild type
DBS0236046DDB_G0268158-DDB_G0268158wild type
DBS0236039DDB_G0268678-DDB_G0268678wild type
DG1007DDB_G0269232-DDB_G0269232abolished culmination
DBS0236025DDB_G0270366-DDB_G0270366wild type
DBS0236026DDB_G0270368-DDB_G0270368wild type
DBS0236036DDB_G0270744-DDB_G0270744wild type
LAS29DDB_G0273201-DDB_G0273201decreased socially cooperative development
LAS8DDB_G0273809-DDB_G0273091 | DDB_G0273809decreased socially cooperative development
LAS43DDB_G0274429-DDB_G0274429decreased socially cooperative development
DBS0236043DDB_G0276221-fam21wild type
DBS0236042DDB_G0276689-DDB_G0276689wild type
DBS0236041DDB_G0277179-DDB_G0277179wild type
LAS26DDB_G0277239-DDB_G0277239decreased socially cooperative development
DBS0236045DDB_G0277575-DDB_G0277575wild type
DBS0236044DDB_G0278315-DDB_G0278315wild type
LAS34DDB_G0278585-DDB_G0278585decreased socially cooperative development
DBS0236038DDB_G0279005-DDB_G0279005wild type
DBS0236032DDB_G0279163-DDB_G0279163wild type
DBS0236033DDB_G0279163-DDB_G0279163wild type
LAS70DDB_G0279405-DDB_G0279405decreased socially cooperative development
DBS0236028DDB_G0279609-DDB_G0279609wild type
DBS0236029DDB_G0279609-DDB_G0279609wild type
LAS103DDB_G0280089-DDB_G0280089decreased socially cooperative development
LAS54DDB_G0280299-DDB_G0280299decreased socially cooperative development
DBS0236035DDB_G0280481-DDB_G0280481wild type
DBS0350107DDB_G0280527-DDB_G0280527decreased phagocytosis
DBS0236019DDB_G0281735-DDB_G0281735wild type
DBS0236020DDB_G0281735-DDB_G0281735wild type
LAS92DDB_G0283373-DDB_G0283373decreased socially cooperative development
LAS106DDB_G0283595-DDB_G0283595decreased socially cooperative development
LAS3DDB_G0287153-DDB_G0287153decreased socially cooperative development
LAS10DDB_G0288547-DDB_G0288547decreased socially cooperative development
DBS0350239DDB_G0288569-DDB_G0288569abolished exocytosis | decreased growth rate | abolished F-actin polymerization | abolished phagosome re-neutralization
LAS9DDB_G0289789-DDB_G0289789decreased socially cooperative development
DBS0236027DDB_G0290225-DDB_G0290225wild type
LAS7DDB_G0290685-DDB_G0290685decreased socially cooperative development
DG1003DDB_G0291992-DDB_G0291992aberrant culminant morphology
LAS39DDB_G0292148-DDB_G0292148decreased socially cooperative development
DBS0236037DDB_G0292186-DDB_G0292186wild type
DBS0350073DDB_G0293074-DDB_G0293074decreased spore viability | delayed aggregation
DBS0236023DDB_G0293116-DDB_G0293116wild type
DBS0236024DDB_G0293116-DDB_G0293116wild type
DBS0350516DDB_G0293356-DDB_G0293356increased infection rate by Legionella pneumophila
DBS0236030DDB_G0293762-DDB_G0293762wild type
DG1039DG1039-DDB_G0284037aberrant fruiting body morphology
DG1040DG1040-DDB_G0276029aberrant fruiting body morphology
DG1041DG1041-DDB_G0269126aberrant fruiting body morphology
DG1054DG1054-DDB_G0277719aberrant fruiting body morphology
DG1060DG1060-DDB_G0281953aberrant fruiting body morphology
DG1062DG1062-DDB_G0286351aberrant fruiting body morphology
DG1074DG1074-DDB_G0272108aberrant fruiting body morphology
DG1080DG1080-DDB_G0281559aberrant fruiting body morphology
DG1091DG1091-DG1091decreased fruiting body size
DG1098DG1098-DG1098decreased fruiting body size
DG1104DG1104-DDB_G0283535abolished aggregation
DG1106DG1106-keaAabolished aggregation
DG1110DG1110-DDB_G0269128aberrant fruiting body morphology
DG1112DG1112-DG1112decreased stalk width
DG1113DG1113-DG1113increased stalk length
DG1122DG1122-DG1122aberrant fruiting body morphology
DG1124DG1124-DG1124development arrests at loose mound stage
DG2033DG2033-DG2033development arrests at mound stage
DG2044DG2044-DG2044development arrests at loose mound stage
DBS0266700Dd5P1-Dd5P1wild type
DBS0266705Dd5P1-/ Dd5P2-Dd5P1 | Dd5P2wild type
DBS0266704Dd5P1-/ Dd5P3-Dd5P1 | Dd5P3wild type
DBS0235660Dd5P2-Dd5P2wild type | increased basal F-actin level
DBS0266703Dd5P2-/ Dd5P3-Dd5P2 | Dd5P3wild type
DBS0266702Dd5P3-Dd5P3wild type
DBS0266692Dd5P4-Dd5P4decreased growth rate | decreased phagocytosis | decreased engulfment during phagocytosis | multiple tips in mound
DBS0266693Dd5P4-/ [act15]: Dd5P4Dd5P4wild type
DBS0266719Dd5P4-/ [act15]: Dd5P4: GFPDd5P4wild type
DBS0266695Dd5P4-/ [act15]: GAP5P4Dd5P4decreased growth rate | multiple tips in mound
DBS0266720Dd5P4-/ [act15]: Hs-OCRLDd5P4decreased phagocytosis
DBS0266721Dd5P4-/ [act15]: Hs-OCRL(D422A)Dd5P4decreased phagocytosis
DBS0266694Dd5P4-/ [act15]: cat5P4Dd5P4decreased growth rate | multiple tips in mound
DBS0235940EB1-eb1aberrant mitosis | aberrant cytokinesis | aberrant protein localization
CW0391FLAG-VwkAvwkAincreased myosin II assembly | aberrant response to hypo-osmotic stress | decreased growth rate | aberrant cytokinesis | development arrests at mound stage | increased protein level
DBS0236015GEG04K11 (tmcB- in KAX3)tmcBsmall macrocysts | increased number of peripheral cells during sexual reproduction | aberrant aggregation during macrocyst formation
DBS0236016GEG04V12 (tmcB- in V12)tmcBsmall macrocysts | increased number of peripheral cells during sexual reproduction | aberrant aggregation during macrocyst formation
DBS0236017GEG10K23 (tmcC- in KAX3)tmcCincreased number of peripheral cells during sexual reproduction | aberrant aggregation during macrocyst formation
DBS0236018GEG10V03 (tmcC- in V12)tmcCincreased number of peripheral cells during sexual reproduction | aberrant aggregation during macrocyst formation
CW0368GFP-VwkAvwkAdecreased growth rate | aberrant cytokinesis
DBS0266872GFP: pcnapcnawild type
DBS0350102GFP: pcppcpaberrant response to hypo-osmotic stress | aberrant contractile vacuole morphology
DBS0302615GFP: phgA(1-274: 283-438)/ phgA-phgAaberrant response to hypo-osmotic stress
DBS0302614GFP: phgA/ phgA-phgAwild type
DBS0236084GP138A-/ GP138B-/ GP138C-/ GP138D-cfrA | cfrB | cfrC | cfrDdecreased gene expression
DBS0236085GP138C-cfrCwild type
HL241HL241alg9aberrant protein modification
HL250HL250gmddecreased growth rate
HMW404HMW404manAabolished gene expression | abolished catalytic activity | abolished aggregation
DBS0350714HMW437manAwild type | abolished catalytic activity
DBS0236358HR42fbxAabolished culmination | decreased sporulation
AP1HSPC300-hspc300aberrant cytokinesis
AP2HSPC300-hspc300decreased basal F-actin level | decreased cell motility | decreased phototaxis | decreased pseudopod size | decreased cell size
HTY506HTY506pkaRaberrant spore morphology | decreased spore viability | decreased phosphorylation of actin | increased sporulation | precocious development | decreased intracellular cAMP level | aberrant fruiting body morphology
HTY507HTY507rdeAincreased intracellular cAMP level | precocious aggregation | decreased aggregate size | aberrant fruiting body morphology
DBS0236426I6KA-I6KAaberrant inositol phosphate metabolic process
DBS0236444JH.DcbfAabolished gene expression | decreased gene expression | increased gene expression | decreased growth rate | increased pinocytosis | increased cell size | decreased fruiting body size | decreased stalk width | abolished aggregation | increased phagocytosis
DBS0236532M2manAabolished growth
DBS0236716PAKc-pakCdecreased chemotaxis rate | decreased lateral pseudopod suppression
DBS0236779PIPkinA-pik6decreased gene expression | abolished aggregation
DBS0236840R7nosAdevelopment arrests at mound stage
DBS0266873RFP: pcnapcnawild type
DBS0264065V00262dagAabolished slug migration | abolished streaming | abolished aggregation | abolished culmination | abolished cAMP wave formation
DBS0264066V00347DDB_G0281917abolished culmination
DBS0264073V10108DDB_G0292162abolished slug migration | aberrant vegetative growth | abolished streaming | abolished aggregation | abolished culmination | abolished cAMP wave formation
DBS0264075V10113yakAabolished slug migration | aberrant vegetative growth | abolished streaming | abolished aggregation | abolished culmination | abolished cAMP wave formation | aberrant cAMP wave formation
DBS0264078V10116tipBaberrant aggregation | abolished slug migration | abolished culmination | aberrant cAMP wave formation
DBS0264079V10117DDB_G0285083aberrant slug migration | abolished culmination
DBS0264081V10119DDB_G0292194wild type
DBS0264083V10121DDB_G0269332wild type
DBS0264087V10125DDB_G0293302aberrant slug migration | aberrant cAMP wave formation
DBS0264088V10126tipCaberrant culmination | aberrant slug migration | aberrant cAMP wave formation
DBS0264089V10127DG1037abolished slug migration | abolished streaming | abolished aggregation | abolished culmination | abolished cAMP wave formation | aberrant cAMP wave formation
DBS0264098V10136DDB_G0293590wild type | aberrant culmination | aberrant slug migration | aberrant cAMP wave formation
DBS0264099V10137yelAaberrant aggregation | abolished slug migration | aberrant culmination | aberrant cAMP wave formation
DBS0264100V10138tipCwild type
DBS0264106V10144comHaberrant aggregation | abolished slug migration | abolished culmination
DBS0264108V10146yakAabolished slug migration | aberrant vegetative growth | abolished streaming | abolished aggregation | abolished culmination | abolished cAMP wave formation
DBS0264109V10147tipAaberrant streaming | aberrant aggregation | abolished slug migration | aberrant culmination | aberrant slug migration | abolished culmination | aberrant cAMP wave formation
DBS0264112V10150swp1wild type
DBS0264116V10155DDB_G0282093aberrant streaming | aberrant aggregation | abolished slug migration | aberrant culmination | aberrant slug migration | abolished streaming | abolished aggregation | abolished culmination | aberrant cAMP wave formation
DBS0264118V10157usp12aberrant streaming | aberrant culmination | aberrant slug migration | abolished culmination
DBS0264125V10164comEaberrant vegetative growth | aberrant culmination | aberrant slug migration | abolished culmination
DBS0264126V10165comDaberrant aggregation | abolished slug migration | aberrant culmination | aberrant cAMP wave formation
DBS0264128V10167DG1098wild type | aberrant cAMP wave formation
DBS0264129V10168prsCwild type | aberrant slug migration
DBS0264131V10170DDB_G0283015aberrant culmination | aberrant slug migration | abolished culmination | aberrant cAMP wave formation
DBS0264135V10174DDB_G0288581aberrant streaming | aberrant vegetative growth | aberrant culmination | aberrant slug migration | aberrant cAMP wave formation
DBS0264145V10185abcA5wild type | aberrant vegetative growth | aberrant culmination | aberrant cAMP wave formation
DBS0264150V10190yelAaberrant aggregation | abolished slug migration | aberrant culmination | aberrant cAMP wave formation
DBS0264151V10191sfbAaberrant culmination | aberrant slug migration | abolished culmination
DBS0264152V10192tipDaberrant aggregation | abolished slug migration | abolished culmination | aberrant cAMP wave formation
DBS0264154V10194modAaberrant culmination | aberrant slug migration
DBS0264155V10195migAaberrant streaming | aberrant culmination | aberrant slug migration | aberrant cAMP wave formation
DBS0264157V10197yelAabolished slug migration | aberrant culmination | aberrant slug migration
DBS0264158V10198splAaberrant streaming | aberrant aggregation | aberrant culmination | aberrant cAMP wave formation
DBS0264159V10199DG1037aberrant streaming | abolished slug migration | abolished aggregation | abolished culmination | aberrant cAMP wave formation
DBS0264160V10200DDB_G0289377aberrant culmination | aberrant slug migration | aberrant cAMP wave formation
DBS0264161V10201rgaAaberrant vegetative growth | aberrant culmination | aberrant slug migration | abolished culmination | aberrant cAMP wave formation
DBS0264163V10203modAwild type | aberrant vegetative growth | aberrant culmination
DBS0264164V10204DG1124aberrant streaming | aberrant aggregation | aberrant cAMP wave formation
DBS0264166V10206wimAwild type
DBS0264169V10209dcsAabolished culmination
DBS0264170V10210mkpAabolished slug migration | abolished streaming | abolished aggregation | abolished culmination | abolished cAMP wave formation
DBS0264171V10211migAaberrant streaming | aberrant culmination | aberrant cAMP wave formation
DBS0264172V10212tipCaberrant aggregation | abolished slug migration | aberrant vegetative growth | aberrant culmination | aberrant cAMP wave formation
DBS0264173V10213DG1098aberrant streaming | aberrant cAMP wave formation
DBS0264175V10215cbfBwild type
DBS0264176V10216DDB_G0292884wild type | aberrant vegetative growth
DBS0264180V10220potAwild type
DBS0264181V10221tipDaberrant culmination | aberrant slug migration | aberrant cAMP wave formation
DBS0264182V10222ctaAwild type
DBS0264183V10223erkAaberrant streaming | aberrant cAMP wave formation
DBS0264184V10224DG1091aberrant cAMP wave formation
DBS0264185V10225acrAaberrant culmination | aberrant slug migration | aberrant cAMP wave formation
DBS0264186V10226ggtAaberrant vegetative growth | aberrant culmination | aberrant slug migration | abolished aggregation | abolished culmination
DBS0264187V10227piaAabolished slug migration | abolished streaming | abolished aggregation | abolished culmination | abolished cAMP wave formation
DBS0264188V10228comGaberrant aggregation | aberrant streaming | abolished slug migration | aberrant vegetative growth | aberrant culmination | aberrant slug migration | abolished culmination | aberrant cAMP wave formation
DBS0264189V10229dcsAabolished culmination | aberrant cAMP wave formation
DBS0264190V10230ctrAaberrant aggregation | aberrant culmination | aberrant slug migration
DBS0264193V10233piaAabolished slug migration | abolished streaming | abolished aggregation | abolished culmination | abolished cAMP wave formation
DBS0264195V10235DDB_G0285985wild type
DBS0264196V10236DDB_G0270872_psaberrant streaming
DBS0264197V10237DDB_G0278621wild type
DBS0264198V10238DDB_G0269128aberrant culmination | aberrant slug migration
DBS0264199V10239kif12wild type | aberrant culmination
DBS0264201V10241lvsBaberrant culmination
DBS0264202V10242tagBaberrant aggregation | abolished slug migration | abolished culmination
DBS0264204V10244gbfAaberrant culmination | aberrant slug migration
DBS0264205V10245gefAabolished slug migration | abolished streaming | abolished aggregation | abolished culmination | abolished cAMP wave formation
DBS0264206V10246dicBaberrant streaming | aberrant cAMP wave formation
DBS0264207V10247yelAaberrant aggregation | abolished slug migration | aberrant culmination | abolished culmination | aberrant cAMP wave formation
DBS0264212V10252tagBaberrant aggregation | abolished slug migration | abolished culmination
DBS0264216V10256DDB_G0293302aberrant streaming | abolished slug migration | aberrant culmination | aberrant cAMP wave formation
DBS0264218V10258rdeAaberrant streaming | aberrant aggregation | abolished slug migration | aberrant culmination | abolished culmination | aberrant cAMP wave formation
DBS0264220V10260gacTaberrant culmination | aberrant slug migration | aberrant cAMP wave formation
DBS0264224V10264DDB_G0282787_RTEaberrant streaming | aberrant aggregation | wild type | abolished slug migration | abolished culmination | aberrant cAMP wave formation
DBS0264225V10265lvsDaberrant vegetative growth | aberrant culmination | aberrant cAMP wave formation
DBS0264227V10267DDB_G0292260_RTEaberrant streaming | aberrant aggregation
DBS0264228V10268dhkAaberrant streaming | aberrant culmination | aberrant slug migration | aberrant cAMP wave formation
DBS0264229V10269helCwild type | aberrant culmination | aberrant slug migration | abolished culmination
DBS0264230V10270mekAaberrant streaming | aberrant vegetative growth | aberrant culmination | aberrant cAMP wave formation
DBS0264231V10271lvsBabolished slug migration | abolished streaming | abolished aggregation | abolished culmination | aberrant cAMP wave formation
DBS0264232V10272modAabolished slug migration | abolished streaming | abolished aggregation | abolished culmination | aberrant cAMP wave formation
DBS0264233V10273DDB_G0283535wild type | aberrant vegetative growth
DBS0264234V10274DG1113aberrant vegetative growth | aberrant culmination | aberrant cAMP wave formation
DBS0264235V10275DG1122aberrant streaming | wild type | abolished slug migration | aberrant vegetative growth | abolished streaming | abolished aggregation | abolished culmination | aberrant cAMP wave formation
DBS0264236V10276DDB_G0270654wild type
DBS0264237V10277lvsEaberrant cAMP wave formation
DBS0264238V10278modAaberrant streaming | aberrant aggregation | abolished slug migration | aberrant culmination | aberrant slug migration | abolished culmination | aberrant cAMP wave formation
DBS0264240V10280mekAaberrant streaming | aberrant culmination | aberrant slug migration | abolished culmination | aberrant cAMP wave formation
DBS0264241V10281DDB_G0268266aberrant slug migration | aberrant cAMP wave formation
DBS0264242V10282phdAaberrant streaming | abolished slug migration | aberrant culmination
DBS0264245V10285scaAabolished slug migration | aberrant vegetative growth | abolished streaming | abolished aggregation | abolished culmination | aberrant cAMP wave formation
DBS0264246V10286amdAwild type | aberrant culmination
DBS0264247V10287helCwild type | aberrant culmination | aberrant slug migration
DBS0264251V10300DDB_G0278333aberrant culmination | aberrant slug migration | aberrant cAMP wave formation
DBS0264269V10322roco5aberrant culmination | aberrant slug migration | abolished culmination | aberrant cAMP wave formation
DBS0264272V10326DG1113wild type | aberrant cAMP wave formation
DBS0264275V10330DDB_G0282121wild type
DBS0264278V10342DDB_G0279727wild type
DBS0264281V10356DDB_G0275747aberrant slug migration
DBS0264283V10363msh5wild type
DBS0264284V10367DDB_G0282463aberrant vegetative growth | aberrant culmination | aberrant slug migration | abolished culmination | aberrant cAMP wave formation
DBS0264287V10431kcnma1wild type | aberrant culmination | aberrant slug migration
DBS0264288V10432DDB_G0291103wild type
DBS0264290V10435gefLabolished slug migration | aberrant culmination | aberrant slug migration | aberrant cAMP wave formation
DBS0264292V10438DDB_G0275671wild type
DBS0264295V10442pks3wild type
DBS0264297V10445DDB_G0290835aberrant slug migration
DBS0264303V10460abcC9aberrant slug migration
DBS0264316V10483yod1aberrant aggregation | aberrant culmination | aberrant slug migration | abolished culmination | aberrant cAMP wave formation
DBS0264318V10490gefVaberrant culmination | aberrant cAMP wave formation
DBS0264319V10492med23aberrant culmination | aberrant cAMP wave formation
DBS0264320V10495DDB_G0269128wild type | aberrant culmination | aberrant slug migration
DBS0264324V10514adprt3aberrant streaming | aberrant cAMP wave formation
DBS0264326V10519DDB_G0290575wild type
DBS0264330V10529cyp508B1aberrant streaming | aberrant aggregation | abolished slug migration | aberrant culmination | aberrant slug migration | aberrant cAMP wave formation
DBS0264331V10530DDB_G0270344wild type | aberrant slug migration | aberrant cAMP wave formation
DBS0264334V10534DDB_G0291812wild type | aberrant culmination
DBS0264335V10535DDB_G0277165aberrant streaming | aberrant cAMP wave formation
DBS0264337V10537gbpCaberrant streaming | wild type | abolished streaming | aberrant cAMP wave formation
DBS0264347V10567dagAabolished slug migration | abolished streaming | abolished aggregation | abolished culmination | abolished cAMP wave formation
DBS0264349V10570DDB_G0281115aberrant streaming | wild type | aberrant culmination | aberrant slug migration | aberrant cAMP wave formation
DBS0264356V10588dhkCaberrant streaming | wild type | aberrant cAMP wave formation
DBS0264373V10633gtaGabolished slug migration | aberrant culmination | aberrant slug migration | abolished culmination
DBS0264377V10642fscDwild type
DBS0264384V10670taf2wild type
DBS0264390V10682clcDabolished slug migration | abolished streaming | abolished aggregation | abolished culmination | abolished cAMP wave formation | aberrant cAMP wave formation
DBS0264425V11033nfaAaberrant streaming | aberrant aggregation | wild type | aberrant cAMP wave formation
DBS0264432V11040DDB_G0274177abolished slug migration | abolished streaming | abolished aggregation | abolished culmination | abolished cAMP wave formation
DBS0264438V11047DDB_G0269296wild type
DBS0264439V11048xrcc4wild type
DBS0264444V11053dscA-1 | dscA-2wild type | aberrant vegetative growth
DBS0264446V11055ku80aberrant vegetative growth | aberrant culmination
DBS0264464V11075cinCwild type | aberrant culmination
DBS0264480V11092cnrOwild type
DBS0264489V11105DDB_G0270350_psaberrant streaming | wild type | aberrant cAMP wave formation
DBS0264512V11128DDB_G0278945aberrant streaming | aberrant vegetative growth | aberrant cAMP wave formation
DBS0264575V30069DDB_G0284619aberrant streaming | aberrant cAMP wave formation
DBS0264607V30110alg9wild type | aberrant vegetative growth | aberrant cAMP wave formation
DBS0264630V30133DDB_G0272953aberrant streaming | wild type | aberrant cAMP wave formation
DBS0264634V30137DDB_G0289529wild type
DBS0264662V30165alg9aberrant streaming | wild type | aberrant culmination | aberrant cAMP wave formation
DBS0264668V30171DDB_G0285261aberrant streaming | wild type | aberrant vegetative growth | aberrant cAMP wave formation
DBS0264677V30180gpaFaberrant streaming | wild type | aberrant cAMP wave formation
DBS0264684V30188DDB_G0287723aberrant streaming | wild type | aberrant cAMP wave formation
DBS0264687V30191DDB_G0288219wild type | aberrant vegetative growth
DBS0264700V30213act9wild type | aberrant culmination
DBS0264715V30229dhx35wild type | aberrant cAMP wave formation
DBS0264716V30230regAaberrant streaming | aberrant aggregation | abolished slug migration | abolished culmination | aberrant cAMP wave formation
DBS0264731V30245DDB_G0279461wild type | aberrant culmination
DBS0264749V30264DDB_G0273651wild type
DBS0264752V30267DDB_G0283759wild type
DBS0264756V30271ncapGawild type
DBS0264763V30278DDB_G0286963wild type
DBS0264765V30280ppt1wild type
DBS0264768V30283DDB_G0270872_pswild type
DBS0264770V30285DDB_G0293762wild type | aberrant vegetative growth
DBS0264773V30288DDB_G0293300aberrant streaming | wild type | aberrant cAMP wave formation
DBS0264777V30292glpDwild type
DBS0264781V30296DDB_G0270212wild type
DBS0264785V30303pakEaberrant cAMP wave formation
DBS0264823V30341frmBaberrant streaming | wild type | aberrant culmination
DBS0264832V30350DDB_G0284059wild type
DBS0264835V30353DDB_G0282471wild type
DBS0264853V30371abpCaberrant aggregation | abolished slug migration | aberrant culmination | abolished culmination
DBS0264905V30427DDB_G0291926aberrant streaming | aberrant culmination | aberrant slug migration | aberrant cAMP wave formation
DBS0264910V30432malAwild type
DBS0264922V30446DDB_G0269430wild type
DBS0264924V30448DDB_G0269680wild type | aberrant cAMP wave formation
DBS0264941V30466dtfAwild type | aberrant cAMP wave formation
DBS0264992V30522DDB_G0288007aberrant streaming | wild type | aberrant cAMP wave formation
DBS0264994V30524prmt5aberrant streaming | aberrant culmination | aberrant slug migration | abolished culmination | aberrant cAMP wave formation
DBS0265002V30532lvsAwild type | abolished slug migration | abolished aggregation | abolished culmination | aberrant cAMP wave formation
DBS0265017V30547DDB_G0279105aberrant streaming | wild type | aberrant vegetative growth | aberrant culmination | aberrant cAMP wave formation
DBS0265029V30561DDB_G0277355wild type | aberrant culmination
DBS0265045V30578DDB_G0277165aberrant culmination | aberrant slug migration | aberrant cAMP wave formation
DBS0265049V30582DDB_G0291722wild type
DBS0265064V30604DDB_G0279461aberrant streaming | abolished slug migration | aberrant culmination | aberrant slug migration | aberrant cAMP wave formation
DBS0265066V30606adkBwild type
DBS0265099V30642tipCaberrant aggregation | abolished slug migration | abolished culmination | aberrant cAMP wave formation
DBS0265126V30673dicBaberrant aggregation | abolished slug migration | aberrant culmination | aberrant cAMP wave formation
DBS0265140V30688DDB_G0279727wild type | aberrant culmination
DBS0265170V30724cnrKwild type
DBS0265206V30766rhgAwild type
DBS0265226V30789itpawild type
DBS0265231V30794tpsAwild type
DBS0265247V30814adprt1Bwild type
DBS0265279V30846DDB_G0286091wild type
DBS0265286V30853DDB_G0292058wild type
DBS0265296V30863DDB_G0269128wild type
DBS0265302V30869DDB_G0292454wild type | aberrant vegetative growth
DBS0265303V30870gxcJJwild type | aberrant cAMP wave formation
DBS0265309V30876DDB_G0268248aberrant streaming | wild type | aberrant cAMP wave formation
DBS0265311V30879exoc2aberrant streaming | wild type | aberrant cAMP wave formation
DBS0265319V30887adcCwild type
DBS0265339V30912DDB_G0283821wild type | aberrant cAMP wave formation
DBS0265348V30921snpCwild type | aberrant culmination
DBS0265422V30995DDB_G0282959wild type
DBS0265466V31043DDB_G0275917aberrant aggregation | wild type | aberrant vegetative growth | aberrant slug migration | abolished culmination
DBS0265497V31075DDB_G0282985aberrant streaming | wild type | abolished slug migration | aberrant culmination | abolished aggregation | aberrant cAMP wave formation
DBS0265520V31102DDB_G0287865wild type
DBS0265529V31111vps13Eaberrant streaming | wild type | aberrant culmination | aberrant cAMP wave formation
DBS0265539V31121DDB_G0270912wild type | aberrant vegetative growth | aberrant cAMP wave formation
DBS0265567V31151DDB_G0275539wild type | aberrant vegetative growth | abolished culmination
DBS0265573V31157act9wild type
DBS0265588V31173ggtAaberrant streaming | aberrant vegetative growth | aberrant culmination | aberrant cAMP wave formation
DBS0265662V31255psiNaberrant streaming | wild type | aberrant culmination | aberrant cAMP wave formation
DBS0265688V31281DDB_G0286417aberrant streaming | wild type | aberrant culmination | aberrant cAMP wave formation
DBS0265701V31294DDB_G0268424wild type
DBS0265873V31480DDB_G0284177aberrant culmination
DBS0265890V31501DDB_G0282985wild type | aberrant culmination | aberrant cAMP wave formation
DBS0265908V31523tmem184Cwild type | aberrant culmination
DBS0265911V31528DDB_G0279945aberrant culmination
DBS0265938V31568rsc12aberrant culmination
DBS0265947V31583DDB_G0282943wild type
DBS0265992V31640DDB_G0274343wild type
DBS0266000V31649DDB_G0290383wild type | aberrant culmination
DBS0266021V31670DDB_G0281269wild type
DBS0266022V31671dhkAaberrant culmination | aberrant slug migration
DBS0266036V31685tipCaberrant streaming | aberrant aggregation | wild type | abolished slug migration | aberrant culmination | aberrant cAMP wave formation
DBS0266084V31738dcsAwild type | aberrant culmination | abolished culmination
DBS0266088V31742dstAaberrant culmination | aberrant slug migration | abolished culmination
DBS0266089V31743DDB_G0273459aberrant streaming | aberrant aggregation | aberrant culmination | aberrant slug migration | aberrant cAMP wave formation
DBS0266098V31752oplahwild type | aberrant cAMP wave formation
DBS0266149V31807gpt1wild type | abolished growth | aberrant vegetative growth
DBS0266153V31811gpt1wild type | aberrant vegetative growth | aberrant culmination | aberrant cAMP wave formation
DBS0266190V31853chlAaberrant aggregation | aberrant culmination | aberrant slug migration | aberrant cAMP wave formation
DBS0266195V31858DDB_G0286341aberrant streaming | wild type | aberrant cAMP wave formation
DBS0266246V31916psiFwild type | aberrant vegetative growth | aberrant culmination | aberrant cAMP wave formation
DBS0266249V31919DDB_G0276251aberrant streaming | aberrant culmination | aberrant slug migration | aberrant cAMP wave formation
DBS0266253V31923DDB_G0268314wild type | aberrant culmination
DBS0266258V31928DDB_G0268314wild type
DBS0266271V31941manAaberrant streaming | aberrant aggregation | aberrant culmination | aberrant slug migration | aberrant cAMP wave formation
DBS0266299V31970DDB_G0280581aberrant streaming | wild type | aberrant cAMP wave formation
DBS0266309V31982DDB_G0286341aberrant streaming | wild type | abolished streaming | aberrant cAMP wave formation
DBS0266316V31989DDB_G0270342wild type | abolished slug migration | aberrant culmination | abolished streaming | aberrant cAMP wave formation
DBS0237041VatMprvatMincreased protein localization to cytoplasm | decreased phagocytosis | decreased growth rate | aberrant intracellular pH level
DBS0237044VatMpr/ [act15]: vatMvatMwild type
DBS0237042VatMpr/ [act15]: vatM: GFPvatMdecreased growth rate
DBS0237236[AS]: [tet]: trrAtrrAdecreased growth rate | delayed development | abolished aggregation
DBS0237228[AS]GP138A/ [AS]GP138BcfrA | cfrBdecreased sexual fusion
DBS0350570[AS]PARPDDB_G0286613 | DDB_G0289141 | adprt1A | adprt1B | adprt2 | adprt3 | adprt4 | pARTf | pARTgdecreased non-apoptotic programmed cell death | aberrant positive regulation of mitochondrial membrane potential
DBS0350559[AS]act15: adprt1Aadprt1Adevelopment arrests at loose mound stage
DBS0304456[AS]alrA/ gcsA-alrA | gcsAdecreased growth rate in suspension | cell cycle arrest
DBS0237273[AS]calAcalAabolished cytokinesis
DBS0237222[AS]cf60cf60increased aggregate size | decreased number of aggregates
DBS0237223[AS]chcAchcAdecreased pinocytosis | delayed response to hypo-osmotic stress | decreased number of vacuoles | aberrant vacuole organization and biogenesis | abolished aggregation | decreased cell size
DBS0237224[AS]cmfAcmfAabolished aggregation
DBS0236982[AS]csbAcsbAdecreased cell-cell adhesion | abolished aggregation
DBS0237225[AS]cupBcupBabolished aggregation
DBS0237226[AS]dia1dia1decreased gene expression | precocious aggregation
DBS0238235[AS]dutAdutAwild type
DBS0350560[AS]ecmB: adprt1Aadprt1Adevelopment arrests at slug stage
DBS0350676[AS]erkAerkAaberrant vegetative growth
DBS0237229[AS]gpaAgpaAwild type
HPF414[AS]hspAhspAdecreased growth rate | aberrant fruiting body morphology
DBS0238749[AS]hspA/ snfAhspA | snfAwild type
DBS0252819[AS]hssAhssAwild type
DBS0237230[AS]ino1ino1abolished growth
DBS0304425[AS]mppA1mppA1delayed development
DBS0304424[AS]mppBmppBincreased gene expression
DBS0236725[AS]patApatAdecreased growth rate
DBS0237504[AS]pikEpikEaberrant stalk morphogenesis | decreased growth rate
DBS0237231[AS]ppiAppiAincreased stalk length
DBS0237232[AS]proAproAwild type
DBS0236827[AS]proA/ proB-proA | proBdecreased secretion of lysosomal enzyme | decreased exocytosis | decreased pinocytosis | increased basal F-actin level | abolished growth | development arrests at slug stage | aberrant cytokinesis | decreased cell motility
DBS0238036[AS]proA/ proB-/ [act15]: proAproA | proBwild type
DBS0238037[AS]proA/ proB-/ [act15]: proBproA | proBwild type
DBS0238035[AS]proA/ proB-/ [unk]: FLAG: proCproA | proB | proCwild type
DBS0350355[AS]proA/ proB-/ lmpA-lmpA | proA | proBwild type | decreased spore viability
DBS0350334[AS]proA/ proB-/ scrA-proA | proB | scrAdecreased secretion of lysosomal enzyme | decreased exocytosis | decreased pinocytosis
DBS0350117[AS]ptcBptcBdecreased growth rate
DBS0236851[AS]rapArapAdecreased pinocytosis | aberrant response to hyperosmotic stress | abolished growth | aberrant osmosensory signaling pathway | decreased phagocytosis | increased basal phosphorylated actin level
DBS0350574[AS]rps4rps4aberrant aggregation | decreased spore viability | aberrant actin cytoskeleton organization | aberrant vegetative growth | aberrant fruiting body morphology
DBS0236904[AS]rps4mrps4delayed aggregation | aberrant fruiting body morphology
DBS0237234[AS]smlAsmlAdecreased fruiting body size
DBS0238748[AS]snfAsnfAdecreased number of mitochondria | decreased intracellular ATP level | increased growth rate | decreased fruiting body size | aberrant mitochondrion organization
DBS0304498[AS]sslA1sslA1decreased fruiting body size
DBS0237235[AS]tcp1tcp1decreased growth rate | development arrests at mound stage | aberrant fruiting body morphology
DBS0350649[AS]vatBvatBdelayed aggregation | aberrant response to chemical stimulus | aberrant slug migration
DBS0306101[AS]vatPvatPdecreased growth rate | decreased extracellular Ca2+ uptake
DBS0306102[AS]vatPvatPdecreased extracellular Ca2+ uptake | decreased growth rate | delayed development
DBS0266892[KD]gtaCgtaCabolished stalk cell differentiation
DBS0266893[KD]gtaC/ [act15]: GFP: gtaCgtaCwild type
DBS0237276[OE]: GFP: gxcAgxcAabolished aggregation
DBS0237279[OE]: HA: rab21(Q66L)rab21aberrant cytoskeleton organisation | decreased phagocytosis
DBS0237274[OE]: chlimChLimincreased basal F-actin level | decreased phagocytosis | decreased growth rate
DBS0350519[OE]: egeAegeAdecreased protein level | abolished aggregation
DBS0237275[OE]: gbfAgbfAprecocious gene expression
DBS0237277[OE]: gpaDgpaDaberrant fruiting body morphology | decreased sporulation
JH258[OE]: gpaEgpaEprecocious tip formation | precocious gene expression
DBS0348921[OE]: ipkA1ipkA1aberrant inositol phosphate metabolic process | decreased response to lithium | aberrant gene expression
DBS0348922[OE]: itpk1itpk1aberrant inositol phosphate metabolic process | decreased response to lithium | aberrant gene expression
DBS0237281[OE]: limFlimFincreased basal F-actin level | increased phagocytosis
DBS0237282[OE]: pakCpakCdecreased cell motility
DBS0236962[OE]: pdiApdiAdelayed aggregation
DBS0237015[OE]: pdiApdiAaberrant tip formation | abolished slug formation | abolished culmination
DBS0237283[OE]: rasB(G12T)rasBaberrant cytokinesis
DBS0302685[OE]: sgcA(1-2000)(N1106A): GFP/ gca-/ sgcA-gcA | sgcAdecreased chemotaxis rate
DBS0302683[OE]: sgcA(878-2843)(N1106A): GFP/ gca-/ sgcA-gcA | sgcAdecreased chemotaxis rate
DBS0302681[OE]: sgcA(878-2843): GFP/ sgcA-gcA | sgcAaberrant chemotaxis to cAMP | decreased chemotaxis rate
DBS0302682[OE]: sgcA(N1106A): GFP/ gca-/ sgcA-gcA | sgcAaberrant streaming | aberrant chemotaxis to cAMP | increased lateral pseudopod formation | decreased chemotaxis rate
DBS0302684[OE]: sgcA: GFP/ gca-/ sgcA-gcA | sgcAincreased lateral pseudopod formation | decreased chemotaxis rate
DBS0237284[OE]GFP: gxcA(1-750: 764-1217)gxcAdevelopment arrests at loose mound stage
DBS0237285[OE]GFP: gxcA(1-750: 764-984)gxcAdevelopment arrests at loose mound stage
DBS0266621[OE]mipp1mipp1aberrant inositol phosphate metabolic process | aberrant gene expression | increased response to lithium
DBS0237299[RNAi]DDB_G0270366DDB_G0270366wild type
DBS0237300[RNAi]DDB_G0270368DDB_G0270368wild type
DBS0237301[RNAi]DDB_G0271700DDB_G0271700wild type
DBS0237304[RNAi]DDB_G0273449DDB_G0273449 | DDB_G0273577wild type
DBS0237303[RNAi]DDB_G0279609DDB_G0279609wild type
DBS0237306[RNAi]DDB_G0290063DDB_G0290063wild type
DBS0237302[RNAi]DDB_G0290225DDB_G0290225wild type
DBS0237298[RNAi]DDB_G0293116DDB_G0293116wild type
DBS0237305[RNAi]DDB_G0293762DDB_G0293762wild type
DBS0237294[RNAi]DidioMp05DidioMp05wild type
DBS0350172[RNAi]allCallCdevelopment arrests at loose mound stage | decreased protein level | decreased gene expression | increased growth rate | decreased cell size
DBS0350070[RNAi]canAcanAmultiple tips in culminant | aberrant response to cation stress | decreased fruiting body size | decreased stalk length
DBS0350727[RNAi]cepEcepEincreased number of centrosomes | aberrant cell separation during cytokinesis | aberrant sister chromosome segregation
DBS0350056[RNAi]cepGcepGaberrant microtubule cytoskeleton organization | aberrant protein localization to nuclear envelope | aberrant centromere complex assembly
DBS0235409[RNAi]cnbAcnbAmultiple tips in culminant | decreased gene expression | aberrant response to cation stress | aberrant stalk cell differentiation | decreased stalk length
DBS0349787[RNAi]ctnnActnnAaberrant protein secretion | aberrant tip formation | aberrant Golgi localization | abolished stalk formation | aberrant centrosome localization | abolished culmination | abolished cell polarity | aberrant protein localization
DBS0349923[RNAi]ctnnA/ [act15]: GFP-mhcActnnAaberrant stalk morphogenesis | aberrant protein localization
DBS0237537[RNAi]enlAenlAdecreased cell-substrate adhesion | aberrant cytokinesis
DBS0237295[RNAi]fimAfimAwild type
DBS0349944[RNAi]fttBfttBaberrant cytoskeleton organisation | aberrant cytokinesis | decreased growth rate
DBS0237308[RNAi]gmsAgmsAdecreased sexual fusion
DBS0237309[RNAi]gsrgsrprecocious culmination | decreased sorting to prestalk region | precocious gene expression
DBS0252820[RNAi]hssAhssAwild type
DBS0237307[RNAi]kctd9kctd9wild type
DBS0237310[RNAi]lipAlipAwild type
DBS0349871[RNAi]lkb1lkb1abolished prespore cell differentiation | delayed aggregation | aberrant response to osmotic stress | aberrant response to oxidative stress | aberrant regulation of protein kinase activity | aberrant development | increased prestalk cell differentiation | decreased sporulation | aberrant slug formation
DBS0350643[RNAi]nse1nse1aberrant streaming | increased sensitivity to UV light | decreased fruiting body size
DBS0350644[RNAi]nse4nse4aberrant streaming | decreased gene expression | increased sensitivity to UV light | decreased fruiting body size
DBS0237296[RNAi]pks16pks16wild type
DBS0237297[RNAi]psiMpsiMwild type
DBS0237311[RNAi]racF2racF2abolished growth
DBS0237312[RNAi]rasZrasZwild type
DBS0350488[RNAi]rmd1rmd1aberrant cell separation during cytokinesis
DBS0238734[RNAi]sdhAsdhAabolished aggregation | decreased phototaxis
DBS0304564[RNAi]sun1sun1aberrant nucleus morphology | increased cell size
DBS0349929[RNAi]tacAtacAaberrant response to cation stress | increased gene expression | delayed development | aberrant fruiting body morphology
DBS0350046[RNAi]tacctaccaberrant response to abiotic stimulus | decreased protein level | decreased length of astral microtubules
YLD53[RNAi]thg1thg1decreased growth rate
DBS0350794[RNAi]tlp3tlp3decreased growth rate
DBS0350795[RNAi]tlp4tlp4decreased growth rate
DBS0237313[RNAi]tmcBtmcBaberrant macrocyst differentiation
DBS0237314[RNAi]tmcCtmcCaberrant macrocyst differentiation
DBS0237315[RNAi]trap1trap1decreased gene expression | delayed development
DBS0237818[RNAi]wipAwipAdelayed pseudopod formation | decreased F-actin polymerization at the leading edge | decreased chemotaxis to cAMP | decreased filopodium formation
DBS0350052[TRE-Pmin]: arfA(Q71L): GFParfAaberrant filopodium formation | aberrant cytokinesis
DBS0350053[TRE-Pmin]: arfA(T31N): GFParfAwild type | decreased infection rate by Legionella pneumophila
DBS0350674[act15]: 6xHis: erkAerkAaberrant slug formation
DBS0349845[act15]: 7xHis: myoK: Ty1myoKaberrant cortical actin cytoskeleton stabilization | aberrant engulfment during phagocytosis | aberrant cell morphology
DBS0237100[act15]: CFP: racC(G15V)racCincreased basal F-actin level
DBS0237101[act15]: CFP: racC(T20N)racCaberrant cytokinesis | decreased basal F-actin level | abolished positive chemotaxis
DBS0266512[act15]: DDB_G0272656sigN4wild type
DBS0350566[act15]: FLAG: Rab14(Q67L)rab14increased lysosome size | aberrant post-lysosome organization and biogenesis
DBS0350049[act15]: FLAG: cycCcycCprecocious tip formation
DBS0350321[act15]: FLAG: hbx4hbx4aberrant aggregation | abolished gene expression | abolished slug migration | decreased growth rate | aberrant cytokinesis
DBS0350322[act15]: FLAG: hbx4/ [act15]: cadAcadA | hbx4wild type
DBS0350325[act15]: FLAG: hbx4/ [ecmAO]: lacZhbx4decreased spore viability | aberrant gene expression | increased prestalk cell differentiation
DBS0238107[act15]: FLAG: ppp4Cppp4cwild type
DBS0238108[act15]: FLAG: ppp4C(H113Q)ppp4cdevelopment arrests at mound stage | delayed development
DBS0237110[act15]: GFP(S65T)-racGracGincreased filopodium formation | decreased chemoattractant-mediated F-actin polymerization | decreased cell motility | increased phagocytosis
DBS0304572[act15]: GFP: abpD(1441-1736)abpDabolished localization to nuclear envelope
DBS0304571[act15]: GFP: abpD(1441-1738)abpDabolished protein localization to nuclear envelope | abolished localization to nuclear envelope
DBS0304573[act15]: GFP: abpD(1441-1738,1737P/ A)abpDabolished localization to nuclear envelope
DBS0237114[act15]: GFP: abpE(413-481)abpE-1 | abpE-2increased lateral pseudopod formation
DBS0237116[act15]: GFP: act15act15abolished cytokinesis | decreased cell motility | aberrant cell morphology
DBS0350593[act15]: GFP: cepLcepLdecreased cell polarity | decreased growth rate | decreased phagocytosis | increased cell size | increased cell-substrate adhesion | aberrant centrosome localization
DBS0350594[act15]: GFP: cepL(1-1114)cepLincreased number of centrosomes | decreased growth rate | aberrant vegetative growth | increased fruiting body size | decreased phagocytosis | increased cell-substrate adhesion | decreased chemotaxis rate | aberrant phototaxis
DBS0350595[act15]: GFP: cepL(1-763)cepLincreased number of centrosomes | decreased growth rate | aberrant vegetative growth | increased fruiting body size | decreased phagocytosis | increased cell-substrate adhesion | decreased chemotaxis rate | aberrant phototaxis
DBS0350596[act15]: GFP: cepL(763-1114)cepLdevelopment arrests at loose mound stage | delayed aggregation | increased cell-substrate adhesion | decreased chemotaxis rate | increased growth rate | abolished cell polarity | aberrant phototaxis | delayed gene expression | decreased cell size
DBS0350460[act15]: GFP: docDdocDincreased pseudopod formation | increased F-actin polymerization | increased cell motility
DBS0350288[act15]: GFP: forF(1-1087)forFdecreased pinocytosis | decreased phagocytosis | decreased growth rate
DBS0235662[act15]: GFP: forH(1-425)forHabolished localization to pseudopodium
DBS0304973[act15]: GFP: gefQ(173-651,818-1298)gefQincreased Ras guanyl-nucleotide exchange factor activity
DBS0304971[act15]: GFP: gefQ(683-833)gefQdecreased Ras guanyl-nucleotide exchange factor activity
DBS0304972[act15]: GFP: gefQ(910-1298)gefQaberrant cytokinesis | aberrant phototaxis
DBS0350422[act15]: GFP: gpbBgpbBaberrant vegetative growth | delayed development
DBS0350349[act15]: GFP: gtaC(1-467: 497-587)gtaCabolished localization to nucleus
DBS0350351[act15]: GFP: gtaC(229-587)gtaCabolished localization to cytoplasm
DBS0350359[act15]: GFP: gtaC(281-467: 497-587)gtaCaberrant localization to cytoplasm
DBS0350352[act15]: GFP: gtaC(281-587)gtaCabolished localization to cytoplasm
DBS0350360[act15]: GFP: gtaC(346-467: 497-587)gtaCaberrant cellular localization
DBS0350353[act15]: GFP: gtaC(346-587)gtaCabolished localization to cytoplasm
DBS0350350[act15]: GFP: gtaC(K469,470,494,496A/ R468,471A)gtaCabolished localization to nucleus
DBS0236070[act15]: GFP: hcpAhcpAdecreased growth rate | aberrant anaphase
DBS0236071[act15]: GFP: hcpBhcpBdecreased growth rate
DBS0237117[act15]: GFP: krsAkrsAdecreased slug migration
DBS0237118[act15]: GFP: limElimEaberrant cytokinesis
DBS0349983[act15]: GFP: lmnBlmnBaberrant chromatin assembly
DBS0350490[act15]: GFP: mhcA(T1823D/ T1833D/ T2029D)/ AX3mhcAdecreased growth rate | aberrant localization
DBS0237120[act15]: GFP: nek2nek2increased number of microtubule-organizing centers | aberrant nucleus morphology
DBS0350852[act15]: GFP: nkaPnkaPaberrant aggregation | decreased gene expression | increased gene expression | aberrant vegetative growth | increased chemotaxis rate
DBS0237121[act15]: GFP: numA(1-117: 168-340)numAaberrant cytokinesis
DBS0350338[act15]: GFP: pakApakAincreased phagocytosis
DBS0350337[act15]: GFP: pakA(797-1197)pakAdecreased phagocytosis | decreased cell motility
DBS0237122[act15]: GFP: pats1(2087-2351)pats1aberrant cytokinesis
DBS0237123[act15]: GFP: phg2(1-245)phg2decreased phagocytosis
DBS0235442[act15]: GFP: pldBpldBabolished aggregation
DBS0237702[act15]: GFP: rac1Arac1Aincreased filopodium formation | increased membrane ruffling
DBS0237703[act15]: GFP: rac1Brac1Bincreased filopodium formation | increased membrane ruffling
DBS0237704[act15]: GFP: rac1Crac1Cincreased filopodium formation | increased membrane ruffling
DBS0237125[act15]: GFP: racG(1-168): racH(164-200)racG | racHincreased filopodium formation | decreased chemoattractant-mediated F-actin polymerization | decreased phagocytosis
DBS0237127[act15]: GFP: racHracHdecreased pinocytosis | decreased phagocytosis | decreased growth rate | aberrant cytokinesis | aberrant cell morphology
DBS0237128[act15]: GFP: racH(1-163): racG(167-201)racG | racHdecreased chemoattractant-mediated F-actin polymerization
DBS0237130[act15]: GFP: racH(M13V)racHincreased F-actin polymerization | aberrant cytokinesis | aberrant cell morphology
DBS0237132[act15]: GFP: racH(T18N)racHaberrant cytokinesis | aberrant cell morphology
DBS0237133[act15]: GFP: racH: gemA(630-658)gemA | racHdelayed cytokinesis
DBS0238392[act15]: GFP: rapArapAincreased cell-substrate adhesion
DBS0238393[act15]: GFP: rapA(G12V)rapAincreased cell-substrate adhesion
DBS0238394[act15]: GFP: rapA(S17N)rapAdecreased cell-substrate adhesion
DBS0350112[act15]: GFP: rheb(D60I)rhebincreased phagocytosis
DBS0350111[act15]: GFP: rheb(Q64L)rhebdecreased phagocytosis
DBS0237134[act15]: GFP: sbdssbdswild type
DBS0237135[act15]: GFP: sbdssbdswild type
DBS0350715[act15]: GFP: src1(2-646)src1aberrant nuclear envelope morphology
DBS0304563[act15]: GFP: sun1(283-905)sun1increased number of centrosomes | decreased protein localization to nuclear envelope | increased cell size | aberrant nucleus morphology | aberrant perinuclear space | aberrant centrosome localization | aberrant sister chromosome segregation
DBS0350441[act15]: GFP: talA/ mhcA-/ talA-mhcA | talAaberrant protein localization
DBS0350648[act15]: HA: Rab14(N121I)rab14decreased pinocytosis | decreased response to hypo-osmotic stress | aberrant contractile vacuole morphology
DBS0350812[act15]: HA: rab7A(Q67L)rab7Aincreased exocytosis
DBS0350813[act15]: HA: rab7A(T22N)rab7Adecreased pinocytosis | increased secretion of lysosomal enzyme | decreased exocytosis | decreased phagocytosis | abolished macropinocytosis
DBS0238111[act15]: HA: smkAsmkAdecreased cell polarity | delayed development | decreased fruiting body size | decreased chemotaxis to cAMP
DBS0350429[act15]: RFP: abpEabpE-1 | abpE-2delayed aggregation
DBS0237201[act15]: YFP: myoEmyoEdecreased pinocytosis | increased phagocytosis
DBS0237817[act15]: YFP: wipAwipAincreased filopodium formation | increased F-actin polymerization at the leading edge
DBS0237819[act15]: YFP: wipA(K36A)wipAincreased filopodium formation | increased F-actin polymerization at the leading edge
DBS0237821[act15]: YFP: wipA(K93A/ S95A)wipAincreased filopodium formation | increased F-actin polymerization at the leading edge
DBS0237227[act15]: [AS]dia2dia2decreased extracellular cAMP level | aberrant cAMP signaling during aggregation | abolished aggregation
DBS0350673[act15]: abpC: GFPabpCdecreased cell motility
DBS0304574[act15]: abpDabpDabolished protein localization to nuclear envelope
DBS0237096[act15]: abpEabpE-1 | abpE-2aberrant aggregation | increased lateral pseudopod formation | decreased cell motility | delayed development | decreased fruiting body size
DBS0349940[act15]: acrA(1-731): YFPacrAaberrant spore coat morphology | decreased adenylate cyclase activity
DBS0350292[act15]: act15(Y144W)act15aberrant binding
DBS0350800[act15]: adprt1Aadprt1Aaberrant cell cycle | decreased growth rate | aberrant response to oxidative stress
DBS0238086[act15]: atg1atg1wild type
DBS0238091[act15]: atg1(1-628)atg1wild type
DBS0238088[act15]: atg1(K36A)atg1abolished macroautophagy | increased number of autophagosomes | aberrant cellular response to nitrogen starvation | abolished aggregation
DBS0238090[act15]: atg1(K36A/ 1-628)atg1wild type
DBS0350008[act15]: bzpN: GFPbzpNdecreased growth rate | abolished negative regulation of vegetative growth
DBS0237097[act15]: cak1: myccak1-1 | cak1-2increased resistance to DNA-damaging agents
JK1[act15]: carAcarA-1 | carA-2delayed aggregation
DBS0252737[act15]: carA(I104A)carA-1 | carA-2decreased cAMP binding
DBS0252732[act15]: carA(I104C)carA-1 | carA-2decreased protein kinase activation
DBS0252740[act15]: carA(I104D)carA-1 | carA-2increased cAMP binding | delayed aggregation | decreased protein kinase activation | aberrant cAMP wave formation
DBS0252744[act15]: carA(I104E)carA-1 | carA-2increased cAMP binding | delayed aggregation | aberrant cAMP wave formation
DBS0252741[act15]: carA(I104F)carA-1 | carA-2increased cAMP binding | decreased protein kinase activation
DBS0252738[act15]: carA(I104G)carA-1 | carA-2increased cAMP binding | decreased protein kinase activation
DBS0252747[act15]: carA(I104H)carA-1 | carA-2development arrests at loose mound stage | increased cAMP binding | decreased protein kinase activation | abolished cAMP wave formation
DBS0252749[act15]: carA(I104K)carA-1 | carA-2increased cAMP binding | decreased protein kinase activation | abolished aggregation | abolished cAMP wave formation
DBS0252739[act15]: carA(I104L)carA-1 | carA-2wild type
DBS0252742[act15]: carA(I104M)carA-1 | carA-2increased cAMP binding
DBS0252746[act15]: carA(I104N)carA-1 | carA-2development arrests at loose mound stage | increased cAMP binding | decreased protein kinase activation | abolished cAMP wave formation
DBS0252734[act15]: carA(I104P)carA-1 | carA-2decreased protein kinase activation
DBS0252745[act15]: carA(I104Q)carA-1 | carA-2development arrests at loose mound stage | increased cAMP binding | decreased protein kinase activation | abolished cAMP wave formation
DBS0252750[act15]: carA(I104R)carA-1 | carA-2development arrests at loose mound stage | increased cAMP binding | decreased protein kinase activation | abolished cAMP wave formation
DBS0252743[act15]: carA(I104S)carA-1 | carA-2increased cAMP binding | decreased protein kinase activation | aberrant cAMP wave formation
DBS0252735[act15]: carA(I104T)carA-1 | carA-2increased cAMP binding | aberrant cAMP wave formation
DBS0252736[act15]: carA(I104V)carA-1 | carA-2wild type
DBS0252733[act15]: carA(I104W)carA-1 | carA-2increased cAMP binding
DBS0252748[act15]: carA(I104Y)carA-1 | carA-2development arrests at loose mound stage | increased cAMP binding | decreased protein kinase activation | aberrant cAMP wave formation
DBS0350533[act15]: cdcD(R155C): RFPcdcDdecreased catalytic activity | aberrant protein modification | decreased phototaxis
DBS0350532[act15]: cdcD: RFPcdcDdecreased protein level | increased catalytic activity | decreased growth rate
DBS0237098[act15]: cdk5(D144N)cdk5decreased pinocytosis | increased aggregate size | delayed aggregation | decreased phagocytosis | decreased growth rate | decreased extracellular counting factor component(s) level | increased extracellular counting factor component(s) level | decreased sporulation | increased intracellular counting factor component(s) level
DBS0237099[act15]: cf60cf60aberrant regulation of aggregate size | increased number of aggregates
DBS0302445[act15]: cfaDcfaDdecreased growth rate | aberrant fruiting body morphology
DBS0350333[act15]: cnrF: GFPcnrFaberrant regulation of GTPase activity
DBS0302658[act15]: cnrN: myc/ smlA-cnrN | smlAdecreased fruiting body size
DBS0237102[act15]: cofAcofAincreased actin bundle formation | increased membrane ruffling | increased cell motility
DBS0350583[act15]: csaAcsaAdecreased cell-substrate adhesion | precocious aggregation | increased calcium-independent cell-cell adhesion
DBS0350684[act15]: csaA(1-488): gppA(469-544)csaA | gppAaberrant protein localization to cell surface
DBS0350642[act15]: cynA: GFPcynAaberrant cell motility | aberrant establishment and/ or maintenance of cell polarity | precocious aggregation
DBS0349864[act15]: cyrA: GFPcyrAincreased chemotaxis to cAMP
DBS0237104[act15]: dagAdagAwild type
DBS0237105[act15]: dgkAdgkAdevelopment arrests at loose mound stage | decreased chemotaxis rate | decreased myosin II assembly
DBS0237106[act15]: dhkC(394-661)dhkCdevelopment arrests at slug stage | increased slug migration
DBS0235716[act15]: dhkKdhkKprecocious aggregation | development arrests at mound stage
DBS0235705[act15]: dhkK(D1125N)dhkKaberrant cAMP signaling during aggregation | delayed development
DBS0235707[act15]: dhkK(H825Q)dhkKprecocious development | decreased fruiting body size
DBS0235709[act15]: dhkK(H825Q/ D1125N)dhkKaberrant slug migration | delayed culmination
DBS0237107[act15]: dng1dng1decreased growth rate | precocious aggregation | aberrant cAMP signaling during aggregation
DBS0350396[act15]: eif2s1(S53A)eif2s1aberrant spore morphology | decreased protein level | decreased spore viability
DBS0350424[act15]: eif2s1(S53A)/ [bzpR]: lacZeif2s1abolished translation
DBS0237562[act15]: enlA(92-497)enlAdecreased cell-substrate adhesion
DBS0237108[act15]: fbxA: FLAGfbxAdecreased prespore cell differentiation
DBS0350365[act15]: fip(1163-2038)fip-1 | fip-2aberrant prestalk 0 cell differentiation
DBS0237109[act15]: fpsfpsincreased resistance to bisphosphonate
DBS0350012[act15]: fps: GFPfpsincreased resistance to bisphosphonate
DBS0235979[act15]: fszA: GFPfszAincreased number of tubular mitochondria
DBS0349956[act15]: fttB(K49E): GFPfttBaberrant cytoskeleton organisation
DBS0237601[act15]: gbpDgbpDincreased Ras guanyl-nucleotide exchange factor activity | aberrant aggregation | decreased cell-cell adhesion | increased pseudopod formation | increased cell-substrate adhesion | decreased chemotaxis to cAMP | aberrant cell morphology
DBS0237136[act15]: gpaAgpaAincreased stalk length | aberrant cytokinesis | aberrant fruiting body morphology
DBS0350680[act15]: gpaEgpaEabolished growth | decreased chemotaxis to folate
DBS0237145[act15]: gpaGgpaGaberrant fruiting body morphology
DBS0237146[act15]: gpaHgpaHwild type
DBS0237147[act15]: gpaI(G38V): FLAGgpaIincreased aggregate size | delayed aggregation | decreased number of aggregates | aberrant fruiting body morphology
DBS0237148[act15]: gpaI(Q196L): FLAGgpaIincreased aggregate size | delayed aggregation | decreased number of aggregates | aberrant fruiting body morphology
DBS0350079[act15]: grlBgrlBdelayed aggregation
DBS0237149[act15]: grxAgrxAdecreased gene expression | delayed culmination
DBS0237151[act15]: grxA(C21S)grxAwild type
DBS0237152[act15]: grxA/ [act15]: lacZgrxAincreased sorting to prestalk region
DBS0237153[act15]: gsrgsrincreased sorting to prestalk region | delayed culmination
DBS0236152[act15]: hcpA(1-161: 218-225): GFPhcpAdecreased growth rate
DBS0236159[act15]: hcpB(1-197: 237-244): GFPhcpBdecreased growth rate
DBS0252821[act15]: hssAhssAwild type
DBS0350397[act15]: ifkA(881-1514(K1258G,F1320L))ifkAdecreased growth rate | increased protein level
DBS0350037[act15]: mekA(299-360)mekAdecreased aggregate size
DBS0350034[act15]: mekA(K321A)mekAdecreased aggregate size
DBS0350033[act15]: mekA(S444A/ T448A)mekAdecreased aggregate size
DBS0237203[act15]: mhkB: FLAGmhkBaberrant cytokinesis | decreased myosin II assembly
DBS0350026[act15]: mip1/ [act15]: mekA: FLAGmekA | mip1-1 | mip1-2aberrant protein localization to nucleus
DBS0237157[act15]: mkkAmkkAdevelopment arrests at mound stage | delayed development
DBS0237158[act15]: mkkA(K199A)mkkAprecocious development | decreased sporulation
DBS0237159[act15]: mkkA{deltaWD40}mkkAdevelopment arrests at mound stage | delayed development | aberrant fruiting body morphology
DBS0350331[act15]: mkpA: GFP: TAPmkpAincreased resistance to cisplatin
DBS0350332[act15]: mkpB(C294V)mkpB-1 | mkpB-2increased sensitivity to cisplatin | decreased slug size | aberrant development | delayed gene expression
DBS0350330[act15]: mkpB: GFP: TAPmkpB-1 | mkpB-2increased resistance to cisplatin
DBS0237160[act15]: mtaA(1-813)/ [dscB]tubA: GFPcepJaberrant microtubule cytoskeleton organization
DBS0237162[act15]: myc-cdk8cdk8multiple tips | precocious tip formation
DBS0350050[act15]: myc: cdk8/ [act15]: FLAG: cycCcdk8 | cycCprecocious tip formation
DBS0266837[act15]: myc: ptpCptpCaberrant signal transduction during aggregation | aberrant response to hyperosmotic stress | aberrant protein localization
DBS0350417[act15]: myc: ptpCptpCaberrant protein phosphorylation
DBS0266839[act15]: myc: ptpCΔ(C649S)ptpCaberrant protein localization to nucleus | increased protein tyrosine phosphorylation
DBS0266838[act15]: myc: ptpC(C649S)ptpCaberrant protein localization to nucleus | increased protein tyrosine phosphorylation
DBS0238398[act15]: myc: rapArapAincreased cell-substrate adhesion | decreased cell motility | aberrant cell morphology
DBS0238396[act15]: myc: rapA(G12V)rapAincreased protein localization to cell cortex | delayed aggregation | increased cell-substrate adhesion | decreased cell motility | increased protein kinase activation
DBS0238397[act15]: myc: rapA(S17N)rapAdecreased cell-substrate adhesion
DBS0237167[act15]: myc: rckArckAdelayed development
DBS0237163[act15]: myc: rckA(C551A)rckAdelayed slug formation | decreased chemotaxis rate
DBS0237164[act15]: myc: rckA(E510G)rckAdelayed slug formation | decreased chemotaxis rate
DBS0237165[act15]: myc: rckA(E510G/ N511A)rckAdelayed slug formation | decreased chemotaxis rate
DBS0237166[act15]: myc: rckA(K867A)rckAdelayed slug formation | precocious aggregation | decreased chemotaxis rate
DBS0350132[act15]: myc: splBsplBincreased protein localization to nucleus | increased protein tyrosine phosphorylation
DBS0349847[act15]: myoK: MycmyoKdecreased phagocytosis
DBS0237175[act15]: myoMmyoMaberrant streaming | delayed development | increased pseudopod size
DBS0237178[act15]: myoM-MtailmyoMaberrant streaming | aberrant response to hyperosmotic stress | aberrant response to hypo-osmotic stress | decreased growth rate | delayed development | increased pseudopod size
DBS0237179[act15]: myr: rckArckAdelayed development | decreased chemotaxis rate
DBS0349860[act15]: ndkCndkC-1 | ndkC-2decreased exocytosis | decreased pinocytosis | decreased phagocytosis | decreased growth rate | increased growth rate
DBS0237180[act15]: nramp1: GFPnramp1increased iron ion transport | decreased infection rate by Legionella pneumophila
DBS0350858[act15]: odcodcaberrant cell cycle
DBS0237182[act15]: pakApakAwild type
DBS0237183[act15]: pakA(K394A)pakAdevelopment arrests at mound stage | delayed development
DBS0237184[act15]: pakA[CA]pakAabolished aggregation
DBS0237185[act15]: pakA[G+K]pakAwild type
DBS0349855[act15]: pakB(1-337: 563-852)pakBdecreased phagocytosis
DBS0349903[act15]: pisApisAdecreased slug migration | aberrant tip formation | delayed aggregation | decreased fruiting body size
DBS0349902[act15]: pisA: GFPpisAdecreased slug migration | increased gene expression | decreased gene expression | delayed aggregation | delayed development | decreased phototaxis
DBS0350693[act15]: pkaCpkaCprecocious development
DBS0237188[act15]: pkaC(1-497)pkaCprecocious development | decreased intracellular cAMP level | decreased fruiting body size
DBS0237189[act15]: pkaR(G135E/ G261A)pkaRdecreased protein tyrosine phosphorylation | decreased cAMP binding | decreased protein kinase activity | abolished aggregation | abolished cAMP-induced cAMP pulse
DBS0350701[act15]: pkaR(G135E/ G261A)/ AX3pkaRdecreased gene expression | abolished cAMP-induced cAMP pulse
DBS0350609[act15]: pkaR(S133T,G135E)pkaRdecreased cAMP binding | decreased protein kinase activity | abolished aggregation | abolished cAMP-induced cAMP pulse
DBS0235538[act15]: pldBpldBdecreased F-actin polymerization | increased catalytic activity | increased exocytosis | aberrant chemotaxis to cAMP | abolished aggregation
DBS0349874[act15]: psaA: GFPpsaAaberrant sporulation
DBS0350751[act15]: pten(16-515): GFPptenabolished catalytic activity
DBS0350750[act15]: pten(186-515): GFPptenabolished catalytic activity
DBS0350752[act15]: pten(C124S): GFPptenabolished catalytic activity
DBS0350753[act15]: pten(G129E): GFPptenabolished catalytic activity
DBS0350318[act15]: rab11A: RFPrab11Aaberrant contractile vacuole organization and biogenesis | abolished response to hypo-osmotic stress | decreased contractile vacuole size
DBS0350469[act15]: racE(G20V): GFPracEdecreased F-actin polymerization | aberrant cytokinesis | decreased growth rate
DBS0350584[act15]: rapA(G12V)rapAincreased number of microtubule-organizing centers | aberrant nucleus morphology | decreased growth rate | aberrant cytokinesis | increased cell-substrate adhesion | aberrant protein localization
DBS0350262[act15]: rbg3rbg3increased lysosome size | decreased growth rate | delayed development
DBS0237192[act15]: rblArblAincreased cell cycle length
DBS0350671[act15]: regA(126-316): mycregAprecocious sporulation
DBS0349938[act15]: rgaArgaAaberrant cytokinesis | decreased cell motility | decreased basal F-actin level
DBS0350294[act15]: rheb: YFPrhebincreased cell size
DBS0350575[act15]: rps4rps4aberrant aggregation | decreased spore viability | aberrant actin cytoskeleton organization | aberrant vegetative growth | aberrant fruiting body morphology
DBS0236915[act15]: rzpArzpAincreased gene expression | decreased gene expression | delayed culmination
DBS0349793[act15]: sadA(921-S952)sadAdecreased cell-substrate adhesion
SA604[act15]: sgkA: FLAGsgkAincreased resistance to cisplatin | aberrant cytokinesis | increased resistance to carboplatin
DBS0304461[act15]: sir2Esir2Eincreased growth rate
DBS0238735[act15]: snfA(1-379): GFPsnfAincreased stalk width | increased intracellular ATP level | decreased growth rate | increased number of mitochondria | decreased phototaxis | decreased stalk length | aberrant mitochondrion organization
DBS0304457[act15]: sodA/ gcsA-gcsA | sodAwild type
DBS0237194[act15]: sodA: mycsodAdecreased gene expression | abolished aggregation
DBS0237195[act15]: spkA: FLAGspkA-1 | spkA-2aberrant aggregation | decreased cell polarity | aberrant F-actin organization | decreased chemotaxis rate
AK1209[act15]: tagA(1-890)tagAmultiple tips in mound
DBS0237198[act15]: torAtorAabolished growth
DBS0237199[act15]: trrAtrrAaberrant aggregation | decreased growth rate | decreased phagocytosis | delayed culmination
DBS0237200[act15]: vasPvasPincreased filopodium formation | increased basal F-actin level
DBS0349984[act6]: GFP: lmnB(1-712)lmnBabolished growth | increased sensitivity to fluid shear stress
DBS0237209[act6]: GFP: mtaAcepJincreased sensitivity to Nocodazole | aberrant cytokinesis | increased number of microtubule-organizing centers | decreased length of astral microtubules | decreased number of astral microtubules
DBS0350497[act6]: GFP: rab2Arab2Aaberrant response to hypo-osmotic stress | decreased phagocytosis | increased growth rate
DBS0350498[act6]: GFP: rab2A(N118I)rab2Aaberrant response to hypo-osmotic stress | aberrant cell-cell adhesion | increased growth rate | precocious development
DBS0350499[act6]: GFP: rab2A(Q64L)rab2Adecreased autophagic cell death | aberrant response to hypo-osmotic stress | aberrant cell-cell adhesion | increased growth rate | increased phagocytosis
DBS0306243[act6]: GFP: sun1sun1increased number of centrosomes | aberrant nucleus morphology | aberrant sister chromosome segregation | aberrant centromere complex assembly | aberrant centrosome organization
DBS0306244[act6]: GFP: sun1(1-722)sun1increased number of centrosomes | aberrant nucleus morphology | aberrant sister chromosome segregation | aberrant centromere complex assembly | aberrant centrosome organization
DBS0237204[act6]: canAcanAwild type
DBS0350685[act6]: csaAcsaAincreased slug size | increased calcium-independent cell-cell adhesion
DBS0237205[act6]: dia1dia1delayed aggregation
DBS0236905[act6]: mrps4mrps4precocious aggregation
DBS0235444[act6]: myc: eppA(S250A)eppAdecreased growth rate | delayed development | decreased intracellular cAMP level
DBS0235445[act6]: myc: eppA(S325A)eppAdecreased growth rate
DBS0266836[act6]: ptpBptpBdelayed aggregation | decreased fruiting body size
DBS0237218[act6]: ptpCptpCincreased aggregate size | decreased growth rate
DBS0237219[act6]: ptpC(C649S)ptpCincreased aggregate size | decreased growth rate
DBS0350807[act6]: rabS(N137I): GFPrabSaberrant response to hyperosmotic stress | aberrant response to hypo-osmotic stress
DBS0350806[act6]: rabS: GFPrabSaberrant response to hyperosmotic stress
DBS0304410[act6]: srsAsrsAincreased aggregate size | decreased gene expression | increased slug size | delayed aggregation | decreased sporulation | aberrant fruiting body morphology
DBS0237220[act6]: trap1trap1development arrests at loose mound stage | aberrant aggregation | abolished pinocytosis | increased gene expression | decreased gene expression | decreased growth rate
DBS0350695[act6]: yakAyakAincreased gene expression | abolished growth
DBS0350069[act6]: zizB: GFPzizBaberrant cell separation during cytokinesis | increased filopodium formation
DBS0304460[act]: alrA/ gcsA-alrA | gcsAwild type
DBS0349955[ampA]: RFP: ampAampAdevelopment arrests at mound stage
DBS0237221[arkA]: arkA: myc2arkAaberrant aggregation
HM2191[arpB]: arpB: GFParpBdecreased F-actin polymerization | decreased cell-substrate adhesion | decreased growth rate | decreased cell motility | increased bleb formation | decreased chemotaxis rate
DBS0235407[carA]: carA(1-317)carA-1 | carA-2delayed development
DBS0350705[cotC]: pkaCpkaCprecocious development | aberrant development | aberrant fruiting body morphology
DBS0350706[cotC]: pkaC/ [spiA]: lacZpkaC | spiAprecocious gene expression
DBS0350048[cycC]: cycC: TAPcycCdecreased protein level
DBS0237238[dscB]: GFP: rab8Arab8Awild type
DBS0237239[dscB]: GFP: rab8A(N128I)rab8Aincreased aggregate size | increased cell-cell adhesion | decreased fruiting body size
DBS0237240[dscB]: GFP: rab8A(Q74L)rab8Aaberrant cytoskeleton organisation | abolished aggregation
DBS0237241[dscB]: GFP: rab8Brab8Bincreased aggregate size
DBS0237242[dscB]: GFP: rab8B(Q74L)rab8Bincreased aggregate size
DBS0305081[dscB]: GFP: vamp7A(L35A)vamp7Aincreased localization to plasma membrane
DBS0350433[dscB]: abpB(E60K): GFPabpBabolished F-actin polymerization
DBS0350820[dscB]: cafAcafAincreased gene expression | precocious development
DBS0237237[dscB]: cycB(106-436)cycBcell cycle arrest
DBS0237243[dscB]: myc: rac1Brac1Bdecreased growth rate in suspension | increased rate of endocytosis | aberrant cytokinesis | delayed development
DBS0237244[dscB]: myc: rac1B(G12V)rac1Bdecreased rate of endocytosis | decreased growth rate in suspension | abolished aggregation | aberrant cell morphology
DBS0237245[dscB]: myc: rac1B(Q61L)rac1Bdecreased rate of endocytosis | decreased growth rate in suspension | abolished aggregation | aberrant cell morphology
DBS0237246[dscB]: myc: rac1B(T17N)rac1Bdecreased rate of endocytosis | decreased growth rate in suspension | abolished aggregation
DBS0350589[dscB]: rapArapAdecreased pinocytosis | aberrant F-actin organization | aberrant cell morphology | increased phagocytosis
DBS0350586[dscB]: rapA(D40E)rapAaberrant F-actin organization | aberrant cell morphology
DBS0350588[dscB]: rapA(F160L)rapAaberrant F-actin organization | aberrant cell morphology
DBS0350590[dscB]: rapA(G12T)rapAdecreased pinocytosis | increased phagocytosis
DBS0237247[dscB]: rapA(G12V)rapAaberrant osmosensory signaling pathway | aberrant F-actin organization | aberrant cell morphology
DBS0350585[dscB]: rapA(S19N)rapAdecreased phagocytosis | aberrant cell morphology
DBS0350587[dscB]: rapA(T63Q)rapAaberrant cell morphology
DBS0237248[dscB]: rasG(G12T)rasGincreased cell-cell adhesion | decreased protein kinase activation
DBS0350703[ecmA]: pkaCpkaCabolished tip formation | development arrests at mound stage
DBS0350659[ecmA]: pkaC(9-648)pkaCdevelopment arrests at tipped mound stage
DBS0350699[ecmA]: pkaR(G135E/ G261A)pkaRdecreased slug size | aberrant culminant morphology | delayed tip formation | aberrant slug migration | increased slug migration | aberrant prestalk cell differentiation
DBS0350700[ecmA]: pkaR(G135E/ G261A)/ [ecmB-frag]: lacZpkaRabolished stalk cell differentiation
DBS0350704[ecmB]: pkaCpkaCabolished tip formation | development arrests at mound stage
DBS0350639[ecmF]: expl3: mycexpl3aberrant stalk morphogenesis | delayed slug formation
DBS0304865[expl7]: expl7: GFPexpl7aberrant culminant morphology
DBS0237252[gpaA]: gpaA(G45V)gpaAdelayed development
DBS0237253[gpaA]: gpaA(Q206L)gpaAincreased basal disc size
DBS0237254[gpaB]: gpaB(Q208L)gpaBaberrant protein localization
DBS0237255[hairpin]dctdctaberrant cytokinesis
DBS0238412[inviable]arcB-arcBabolished growth
DBS0238407[inviable]arpB-arpBabolished growth
DBS0237257[inviable]cofA-cofAabolished growth
DBS0349945[inviable]fttBfttBabolished growth
DBS0349872[inviable]lkb1-lkb1abolished growth
DBS0237265[inviable]phlp2-phlp2abolished growth
DBS0349948[ndm]: ndm: RFPndmdevelopment arrests at mound stage
DBS0236086[pdsA-agg]: pdsApdsAprecocious development
DBS0236111[pdsA-ldev]: pdsApdsAdevelopment arrests at mound stage
DBS0236484[pkaC]: pkaCpkaCincreased gene expression | abolished SDF-2 production | decreased intracellular cAMP level | precocious development | precocious gene expression | aberrant fruiting body morphology
DBS0350709[pkaC]: pkaC/ [dscC]: lacZdscC-1 | dscC-2 | pkaCaberrant gene expression
DBS0350696[pkaC]: pkaC/ srfA-pkaC | srfAaberrant spore coat morphology | aberrant gene expression
DBS0237289[psmC1]: psmC1psmC1aberrant cytokinesis | delayed tip formation | delayed gene expression
DBS0349928[pspA]: lacZpspAmislocalized gene expression
DBS0350658[pspA]: pkaC(9-648)pkaCprecocious sporulation | aberrant fruiting body morphology
DBS0350697[pspA]: pkaR(G135E/ G261A)pkaRabolished gene expression | decreased gene expression | translucent sorus
DBS0237290[ptpA1]: ptpA1ptpA1-1 | ptpA1-2delayed aggregation | decreased growth rate | aberrant fruiting body morphology
DBS0237291[ptpB]ptpBptpBdecreased growth rate | development arrests at mound stage
DBS0237316[tet]: GFP(S65T): racG(G12V)racGincreased filopodium formation | decreased chemoattractant-mediated F-actin polymerization | decreased positive regulation of GTPase activity | increased phagocytosis | abolished chemotaxis to cAMP
DBS0237317[tet]: GFP(S65T): racG(T17N)racGabolished chemoattractant-mediated F-actin polymerization | abolished chemotaxis to cAMP
DBS0350110[tet]: RNAi: raptorraptordecreased growth rate
DBS0238351[tet]: [RNAi]cinCcinCdecreased translation | precocious aggregation | decreased growth rate
DBS0237318[tet]: ptenptendecreased cell motility | decreased protein kinase activation
DBS0237622[tet]: rapA(S17N)/ [act15]: gbpDgbpD | rapAincreased cell-substrate adhesion | increased cell polarity | aberrant cell morphology
DBS0350494[tgrB1]: [RNAi]abcB3/ [tgrC1]: GFPabcB3decreased extracellular cAMP level | delayed development
DBS0304911[tre]: paxBpaxBabolished sporulation | aberrant endocytosis | decreased cell-substrate adhesion | aberrant chemotaxis to folate | development arrests at mound stage | decreased cell motility | increased cell-cell adhesion
DBS0350267[tre]: secGsecGincreased filopodium formation | aberrant F-actin polymerization | development arrests at mound stage | aberrant actin cytoskeleton organization | abolished cell polarity | abolished chemotaxis to cAMP | delayed gene expression
DBS0350726[unk]: GFP: cepEcepEincreased number of centrosomes | aberrant cytokinesis
DBS0350447[unk]: PTEN(H385G/ N389A/ H390A)ptendecreased localization to plasma membrane | decreased fruiting body size
DBS0350576[unk]: mhkC(1-498)mhkCabolished protein localization to cell cortex | abolished protein phosphorylation
DBS0350405[unk]: myc: rgaA(K273E/ K282E)rgaAaberrant binding
DBS0350716[unk]: pdsApdsAaberrant development
DBS0350259[unk]: pikA(1-492(S7A/ S11A/ S109A/ S113A/ S177A/ S181A))pikAaberrant localization to plasma membrane
DBS0350558[unk]: pikI(T262E)pikIincreased catalytic activity
DBS0350258[unk]: rapA(G12V)rapAincreased positive regulation of GTPase activity
DBS0350837[unk]: rasD(G12T)/ [rasD]: rapArapA | rasDaberrant culmination | decreased prespore cell differentiation | aberrant gene expression | decreased stalk cell differentiation | multiple tips in mound
DBS0304636[unk]: rasG(Q61L)/ rasG-rasGincreased protein modification | aberrant cAMP signaling during aggregation
DBS0350597[unk]: roco4(1018-1292;F1107L,F1161L)roco4decreased small molecule binding
DBS0237773[unk]: scrA(97-443): GFPscrAaberrant cytoskeleton organisation | increased cell size | aberrant cytokinesis | decreased chemotaxis to cAMP
DBS0350464[unk]: vasP(1-197: 221-261: 285-380)vasPabolished F-actin polymerization
DBS0350463[unk]: vasP(1-261: 285-380)vasPaberrant F-actin organization
DBS0350465[unk]: vasP(1-340: 376-380)vasPdecreased F-actin polymerization | aberrant F-actin organization
DBS0237288[unk]skp1fpaA | fpaB-1aberrant fruiting body morphology
HAD186aarA-aarAaberrant stalk morphogenesis | aberrant tip formation | decreased gene expression | aberrant establishment and/ or maintenance of cell polarity | aberrant stalk formation | aberrant Golgi localization | aberrant centrosome localization | decreased sporulation
DBS0349920aarA-/ [act15]: GFP-mhcAaarAaberrant stalk morphogenesis | aberrant protein localization
DBS0350143abcA10-abcA10decreased spore viability | aberrant development
DBS0350135abcA3-abcA3decreased spore viability | aberrant development | aberrant fruiting body morphology
DBS0350138abcA4-abcA4aberrant fruiting body morphology
DBS0350139abcA5-abcA5decreased spore viability | aberrant development
DBS0350140abcA6-abcA6decreased fruiting body size
DBS0350141abcA7-abcA7aberrant development
DBS0350142abcA9-abcA9decreased spore viability | aberrant fruiting body morphology
DBS0350145abcB1-abcB1delayed culmination
DBS0350146abcB4-abcB4decreased spore viability
DBS0350147abcB5-abcB5decreased growth rate | delayed culmination
DBS0350153abcC13-abcC13decreased spore viability | aberrant development | delayed culmination
DBS0350154abcC14-abcC14decreased spore viability | decreased fruiting body size | aberrant development
DBS0350148abcC2-abcC2aberrant development | delayed culmination
DBS0350149abcC3-abcC3delayed culmination
DBS0350150abcC6-abcC6aberrant development | delayed culmination
DBS0350151abcC8-abcC8multiple tips in culminant | decreased spore viability | decreased growth rate
DBS0350155abcD2-abcD2decreased fruiting body size
DBS0350156abcF1-abcF1decreased spore viability | aberrant development | delayed culmination
DBS0350157abcF2-abcF2decreased spore viability | delayed tip formation
DBS0350158abcF4-abcF4aberrant development | aberrant fruiting body morphology
DBS0350164abcG10-abcG10decreased spore viability | delayed tip formation | decreased fruiting body size
DBS0350165abcG15-abcG15decreased spore viability | aberrant development
DBS0350166abcG16-abcG16delayed culmination
DBS0350167abcG17-abcG17-1 | abcG17-2decreased spore viability | decreased fruiting body size
DBS0350168abcG18-abcG18decreased spore viability
DBS0350169abcG19-abcG19delayed aggregation | decreased fruiting body size
DBS0350160abcG2-abcG2delayed tip formation | decreased fruiting body size
DBS0236539abcG2-/ abcG18-abcG18 | abcG2decreased rate of endocytosis | abolished growth | decreased growth rate
DBS0236540abcG2-/ abcG18-/ rtoA-abcG18 | abcG2 | rtoAabolished growth | decreased growth rate
DBS0350170abcG22-abcG22delayed tip formation | aberrant development
DBS0350171abcG24-abcG24decreased spore viability | delayed culmination
DBS0350161abcG5-abcG5delayed culmination
DBS0350162abcG6-abcG6decreased spore viability
DBS0350163abcG7-abcG7decreased spore viability | delayed tip formation | decreased fruiting body size
DBS0350159abcH2-abcH2decreased spore viability
DBS0266687abiA-abiAdecreased protein level | aberrant cytokinesis | decreased growth rate | decreased chemotaxis to folate | aberrant protein localization
DBS0266688abiA-abiAaberrant protein localization
DBS0350386abiA-/ abiA(45-136)abiAdecreased protein level | aberrant cytokinesis
DBS0350384abiA-/ abiA(45-332)abiAaberrant cytokinesis
DBS0266689abiA-/ scrA-abiA | scrAdecreased cell motility | decreased cell size
LAS53abkD-abkDaberrant socially cooperative development
DBS0235456abpA-/ abpC-abpA | abpCaberrant response to hyperosmotic stress | decreased phagocytosis | decreased growth rate | decreased cell motility | aberrant development
DBS0305672abpB-abpBincreased filopodium formation
DBS0235425abpB-/ fimA-abpB | fimAdecreased fruiting body size | decreased sporulation | decreased cell size
HG1264abpC-abpCaberrant actin cytoskeleton organization
DBS0236077abpC-abpCaberrant thermotaxis | decreased cell polarity | decreased cell motility | aberrant phototaxis
HG1270abpC-abpCaberrant phototaxis
DBS0237938abpC-/ [act15]: GFP: abpC(9-148)abpCaberrant phototaxis
DBS0235426abpC-/ [act15]: abpCabpCwild type
DBS0237945abpC-/ [act15]: abpC(1-348: 449-857): GFPabpCaberrant F-actin organization | aberrant phototaxis
DBS0237946abpC-/ [act15]: abpC(1-556: 644-857): GFPabpCaberrant F-actin organization | aberrant phototaxis
DBS0237941abpC-/ [act15]: abpC(1-739): GFPabpCaberrant phototaxis
DBS0237949abpC-/ [cotB]: abpC: GFPabpCaberrant phototaxis
DBS0237948abpC-/ [ecmA]: abpC: GFPabpCwild type
DBS0235427abpD-abpDdecreased cell-cell adhesion | decreased spore viability | delayed development | aberrant development
DBS0235428abpE-abpE-1 | abpE-2increased lateral pseudopod formation
DBS0349851abpE-abpE-1 | abpE-2aberrant phagosome maturation | precocious phagosome acidification | increased phagocytosis
DBS0349852abpE-/ [act15]: abpEabpE-1 | abpE-2decreased phagocytosis
DBS0350529abpG-abpGincreased basal F-actin level | decreased chemotaxis to cAMP | decreased fruiting body size
DBS0235562acaA-acaAabolished gene expression | decreased gene expression | abolished aggregation | decreased adenylate cyclase activity | abolished cell polarity | abolished streaming | decreased intracellular cAMP level
GP6acaA-acaAaberrant F-actin organization | increased lateral pseudopod formation | decreased chemotaxis rate | aberrant cell morphology
DBS0235429acaA-acaAdecreased gene expression
DBS0350720acaA-/ [acaA-agg]: acaA: mycacaAwild type | decreased gene expression | decreased fruiting body size
DBS0350721acaA-/ [acaA-psp]: acaA: mycacaAdecreased gene expression | decreased aggregate size | decreased fruiting body size
DBS0350722acaA-/ [acaA-pst]: acaA: mycacaAwild type
DBS0350702acaA-/ [act15]: HA: pkaCacaA | pkaCwild type | delayed development | decreased intracellular cAMP level
DBS0350725acaA-/ [act15]: HA: pkaC/ acrA-acaA | acrA | pkaCdecreased gene expression | abolished adenylate cyclase activity | development arrests at tipped mound stage
DBS0350737acaA-/ [act15]: acaAacaAaberrant slug formation
DBS0350738acaA-/ [act15]: acaA(1-390;398-1407)acaAabolished aggregation
DBS0350739acaA-/ [act15]: acaA(L394T/ K482N)acaAwild type
DBS0350603acaA-/ [act15]: cap: GFPacaA | capdevelopment arrests at loose mound stage | increased calcium-dependent cell-cell adhesion | wild type
DBS0350735acaA-/ [act15]: pkaR(G135E/ G261A)acaA | pkaRincreased intracellular cAMP level
DBS0350736acaA-/ [unk]: acaA(F306L/ S498G,K504E,E593V,I649T)acaAabolished cAMP wave formation
DBS0350734acaA-/ [unk]: acaA(N333D,G633S)acaAabolished adenylate cyclase activity
DBS0350733acaA-/ [unk]: acaA(V427I,S642F)acaAabolished activation of adenylate cyclase
DBS0350711acaA-/ [unk]: acgAacaA | acgAaberrant development
DBS0306125acapA-acapAwild type
DBS0350051acapA-acapAaberrant streaming | aberrant exocytosis | aberrant lysosome organization and biogenesis | aberrant filopodium formation | aberrant endocytosis | aberrant cytokinesis | decreased cell motility | decreased infection rate by Legionella pneumophila | delayed development
DBS0350055acapA-/ [act15]: acapA(R633Q): GFPacapAaberrant filopodium formation | aberrant post-lysosome organization and biogenesis
DBS0350054acapA-/ [act15]: acapA: GFPacapAincreased filopodium formation
DBS0306126acapA-/ acapB-acapA | acapBdecreased sporulation
DBS0306127acapB-acapBwild type
TL177acbA-acbAincreased sensitivity to cisplatin | abolished SDF production | decreased spore viability | abolished sorting to prestalk region
DBS0350194acbA-/ [act15]: acbA(Y72A)acbAabolished SDF production
AK1211acbA-/ tagA-acbA | tagAincreased prestalk B cell differentiation
DBS0235440acgA-acgAabolished response to MPBD | abolished response to SDF-1 | decreased spore viability | precocious spore germination | abolished SDF-1 production
DBS0237788acgA-acgAdecreased gene expression | decreased prespore cell differentiation
DBS0237790acgA-/ [acrA]: lacZacgA | acrAmislocalized gene expression
DG1100acrA-acrAdecreased gene expression | increased stalk length | spores inviable | decreased sporulation
DBS0349939acrA-acrAaberrant spore coat morphology | decreased stalk width
DBS0350723acrA-/ [act15]: acaA(L394S)acaA | acrAwild type
DBS0237786acrA-/ [act15]: acgA(1-401)acgA | acrAdecreased gene expression | decreased prespore cell differentiation | decreased sporulation
DBS0349970acrA-/ [act15]: acrA(D1010A)acrAdecreased adenylate cyclase activity
DBS0349971acrA-/ [act15]: acrA(D1174A)acrAincreased adenylate cyclase activity
DBS0349969acrA-/ [act15]: acrA(N796D/ D854A/ G856A)acrAwild type
DBS0350724acrA-/ [pkaC]: pkaCacrA | pkaCdecreased spore viability | decreased fruiting body size | precocious development
DBS0350443adcB-adcBwild type
DBS0350444adcC-adcCwild type
DBS0350445adcC-/ adcB-adcB | adcCaberrant endocytosis | delayed aggregation | decreased period cAMP wave formation | aberrant regulation of protein kinase activity
DBS0350538adprt1A-adprt1Aincreased sensitivity to DNA-damaging agents | decreased double strand break repair | decreased DNA mediated transformation
DBS0350541adprt1A-/ adprt2-adprt1A | adprt2increased sensitivity to DNA-damaging agents | decreased double strand break repair | decreased DNA mediated transformation | increased sensitivity to cisplatin
DBS0264268adprt1B-adprt1Bincreased sensitivity to DNA-damaging agents | wild type | decreased single strand break repair | aberrant cAMP wave formation
DBS0350539adprt2-adprt2increased sensitivity to DNA-damaging agents | decreased double strand break repair | increased sensitivity to cisplatin | decreased single strand break repair
DBS0238203adrm1-adrm1-1aberrant response to nutrients | precocious gene expression | precocious development
DBS0235457ahhA-ahhAaberrant culminant morphology
DBS0252637aip1-aip1decreased pinocytosis | delayed cytokinesis | increased basal F-actin level | decreased growth rate | decreased phagocytosis | aberrant nucleus morphology | decreased cell motility
DBS0266759alp-alpwild type
DBS0235513alrA-alrAincreased aggregate size | decreased intracellular glucose level | decreased cell motility | decreased extracellular counting factor component(s) level
DBS0235473alrA-/ [act15]: alrAalrAwild type
DBS0235474alxA-alxAdevelopment arrests at loose mound stage | decreased growth rate | aberrant fruiting body morphology
DBS0235475alxA-alxAabolished sporulation | decreased gene expression | development arrests at mound stage | aberrant fruiting body morphology
DBS0235488alxA-/ [act15]: FLAG: alxAalxAdelayed development
DBS0235476alxA-/ [act15]: alxA(1-596): myc2alxAwild type
DBS0235477alxA-/ [act15]: alxA(1-697): myc2alxAwild type
DBS0235478alxA-/ [act15]: alxA(155-697): myc2alxAaberrant fruiting body morphology
DBS0235479alxA-/ [act15]: alxA(293-697): myc2alxAaberrant fruiting body morphology
DBS0235480alxA-/ [act15]: alxA(460-794): myc2alxAaberrant fruiting body morphology
DBS0235481alxA-/ [act15]: alxA(D310A/ N311A)alxAwild type
DBS0235482alxA-/ [act15]: alxA(Q181E/ Q183)alxAwild type
DBS0235483alxA-/ [act15]: alxA(S700A/ S704A/ S708A)alxAwild type
DBS0235484alxA-/ [act15]: alxA(S700D/ S704D/ S708D)alxAwild type
DBS0235485alxA-/ [act15]: alxA(Y315D)alxAwild type
DBS0235486alxA-/ [act15]: alxA(Y315F)alxAwild type
DBS0235487alxA-/ [act15]: alxA: myc2alxAwild type
DBS0235489alyA-alyAincreased phagocytosis
DG1114amdA-amdAdecreased spore viability | translucent sorus | increased prestalk A cell differentiation
HM1158amdA-amdAdecreased fruiting body size | decreased sporulation | increased aspidocyte differentiation
DBS0235490amiB-amiBabolished aggregation
DBS0235491amiB-amiBdecreased cAMP-induced cGMP pulse | abolished down-regulation of growth phase genes | decreased gene expression | abolished aggregation | decreased chemotaxis to cAMP | decreased cAMP-induced cAMP pulse
DBS0235493ampA-ampAdelayed tip formation | increased cell-cell adhesion | increased cell-substrate adhesion | mislocalized gene expression | delayed development | precocious gene expression | decreased prestalk cell differentiation | delayed gene expression
DBS0349962ampA-ampAdecreased F-actin polymerization | wild type | aberrant chemotaxis to folate | increased cell-substrate adhesion | decreased pseudopod formation
DBS0349951ampA-/ lmbd2B-ampA | lmbd2Baberrant chemotaxis
DBS0235496ampA-/ pspD: lacZampAmislocalized gene expression
DBS0349963ampA-/ sma-ampA | smaincreased chemotaxis to folate | increased cell-substrate adhesion
DBS0349953ampA/ [ampA]: TAPampAincreased protein secretion | development arrests at mound stage
DBS0235495ampA/ [ampA]: ampAampAincreased pseudopod formation | decreased cell-substrate adhesion | increased pinocytosis | increased F-actin polymerization | aberrant chemotaxis to folate
DBS0349952ampA/ [ampA]: ampA/ lmbd2B-ampA | lmbd2Baberrant chemotaxis
BS155amtA-amtAdecreased slug migration | decreased aggregate size | decreased fruiting body size | increased growth rate | decreased extracellular ammonia level
DBS0267100amtA-amtAdecreased spore viability | decreased aggregate size | increased number of aggregates | decreased extracellular ammonia level | increased intracellular glucose level | decreased stalk length | increased intracellular ammonia level
DBS0267101amtA-/ [OE]: amtAamtAwild type
BS165amtA-/ amtC-amtA | amtCdecreased protein localization to nucleus | aberrant slug migration | decreased extracellular ammonia level | delayed gene expression
amtB-amtB
BS169amtB-/ amtA-amtA | amtBdecreased extracellular ammonia level
BS168amtB-/ amtC-amtB | amtCdecreased extracellular ammonia level
BS154amtC-amtCdecreased gene expression | development arrests at slug stage | mislocalized gene expression | decreased extracellular ammonia level | delayed culmination | aberrant protein localization | aberrant fruiting body morphology
DBS0235501amtC-/ [act15]: cudAamtC | cudAdelayed culmination
DBS0235502amtC-/ [ecmA]: cudAamtC | cudAdelayed culmination
DBS0235503amtC-/ [pspA]: cudAamtC | cudAdevelopment arrests at slug stage
BS163amtC-/ dhkC-amtC | dhkCmislocalized gene expression
DBS0236890amtC-/ regA-amtC | regAprecocious sporulation
DBS0350432aoxA-aoxAincreased sensitivity to hydrogen peroxide | aberrant cellular process | aberrant development
DBS0349869ap1b1-ap1b1aberrant aggregation | aberrant contractile vacuole organization and biogenesis | aberrant cell separation during cytokinesis | aberrant response to hypo-osmotic stress | decreased growth rate | decreased protein stabilization
DBS0305197ap2a1-ap2a1-1 | ap2a1-2aberrant cell separation during cytokinesis
DBS0350296aph1-aph1aberrant culmination | abolished catalytic activity | decreased prespore cell differentiation
DBS0350299aph1-/ ncstn-aph1 | ncstndecreased phagocytosis | decreased prespore cell differentiation
DBS0350300aph1-/ psenA-aph1 | psenAaberrant culmination | abolished catalytic activity | decreased prespore cell differentiation
DBS0350805apl-aplaberrant response to cisplatin
DBS0235505apm1-apm1aberrant contractile vacuole organization and biogenesis | decreased spore germination | aberrant response to hypo-osmotic stress | decreased growth rate | aberrant endosome morphology | delayed development | decreased stalk width
DBS0235506apm2-apm2aberrant cell separation during cytokinesis
DBS0305085apm2-/ [dscB]: GFP: vamp7Aapm2 | vamp7Aincreased protein localization to plasma membrane
DBS0235507apm3-apm3decreased pinocytosis | increased exocytosis | aberrant post-lysosome organization and biogenesis | aberrant endosome morphology
DBS0305083apm3-/ [dscB]: GFP: vamp7Aapm3 | vamp7Aincreased protein localization to plasma membrane
DBS0235508apm4-apm4wild type
DBS0235509aprA-aprAincreased cell death | increased aggregate size | decreased spore viability | aberrant cytokinesis | aberrant vegetative growth | increased growth rate | abolished chemorepellant activity | aberrant fruiting body morphology | decreased sporulation
DBS0235510aprA-/ [act15]: aprAaprAdecreased growth rate | aberrant fruiting body morphology
DBS0350009aprA-/ [act15]: bzpN: GFPaprA | bzpNabolished negative regulation of vegetative growth
DBS0238124aqpA-aqpAdecreased spore viability
HM2245arcB(I191L/ D197Y/ K206V/ A213V/ F223L/ P224S/ E232G/ I237T/ H245L/ S250S)arcBdecreased F-actin polymerization | decreased growth rate | decreased cell motility | decreased pseudopod formation | decreased chemotaxis rate
DBS0235511arkA-arkAincreased gene expression | aberrant fruiting body morphology
DBS0235512arkA-/ [arkA]: arkA: myc2arkAaberrant aggregation
DBS0350000arpB+/ aprB-/ [act15]: myc: arpB(T235A/ T236A)arpBwild type
DBS0349998arpB+/ aprB-/ [act15]: myc: arpB(Y200F/ T235A/ T236A)arpBdecreased chemoattractant-mediated F-actin polymerization | decreased cell polarity | delayed aggregation | decreased fruiting body size | decreased chemotaxis to cAMP | delayed gene expression
DJK45arpB+/ arpB-arpBwild type
DMZ10arpB+/ arpB-/ [act15]: myc: arpBarpBwild type
MZ10arpB-/ [act15]: myc: arpBarpBwild type
DBS0350191arpin-arpinincreased cell motility
DBS0350206arpin-/ [act15]: GFP: arpinarpinwild type
DBS0350654ase1A-ase1Aaberrant cytokinesis | aberrant microtubule cytoskeleton organization | aberrant spindle organization
DBS0350655ase1B-ase1Baberrant cell morphology
DBS0235514aslA-aslA-1 | aslA-2wild type
DBS0236305atg1-atg1aberrant macroautophagy | abolished autophagic vacuole formation
DBS0236304atg1-atg1aberrant macroautophagy | abolished autophagic vacuole formation
DBS0350450atg1-atg1aberrant vacuolation | aberrant defense response to bacterium | abolished autophagic cell death
DBS0350839atg1-atg1abolished protein localization
HR131atg1-atg1abolished sporulation | decreased growth rate in suspension | abolished macroautophagy | increased number of autophagosomes | aberrant autophagy | increased infection rate by a gram- bacterium | aberrant cellular response to nitrogen starvation | abolished SDF production | abolished stalk cell differentiation | abolished aggregation | decreased growth rate on bacterial plates | aberrant defense response to yeast | aberrant protein localization
DBS0238085atg1-/ [act15]: atg1atg1wild type
DBS0238092atg1-/ [act15]: atg1(1-628)atg1aberrant cellular response to nitrogen starvation | abolished aggregation
DBS0238087atg1-/ [act15]: atg1(K36A)atg1aberrant cellular response to nitrogen starvation | abolished aggregation
DBS0238089atg1-/ [act15]: atg1(K36A/ 1-628)atg1aberrant cellular response to nitrogen starvation | abolished aggregation
DBS0238093atg1-/ [act15]: atg1(P138S)atg1abolished aggregation
DBS0266655atg1-/ iplA-atg1 | iplAdecreased necrotic cell death
DBS0252632atg1-/ pcp-atg1 | pcpabolished autophagic vacuole formation
DBS0350838atg1-/ vmp1-atg1 | vmp1wild type | abolished protein localization
HR75atg5-atg5aberrant macroautophagy | abolished sporulation | aberrant cellular response to nitrogen starvation | multiple tips | abolished aggregation | aberrant protein localization
HR174 atg6-atg6Aaberrant macroautophagy | increased infection rate by a gram- bacterium | aberrant cellular response to nitrogen starvation | abolished SDF production | multiple tips | decreased fruiting body size | decreased stalk length | decreased sporulation | aberrant defense response to yeast
HR79atg7-atg7aberrant macroautophagy | abolished sporulation | increased infection rate by a gram- bacterium | aberrant cellular response to nitrogen starvation | abolished SDF production | multiple tips | aberrant protein localization
HR141atg8-atg8aaberrant macroautophagy | aberrant spore morphology | increased sensitivity to cisplatin | aberrant cellular response to nitrogen starvation | abolished SDF production | multiple tips | decreased fruiting body size | decreased sporulation
DBS0305977atg9-atg9increased stalk width | decreased pinocytosis | aberrant sorus morphology | aberrant autophagy | decreased phagocytosis | decreased growth rate | abolished catalytic activity | aberrant slug migration | aberrant protein modification | aberrant phagosome maturation | aberrant fruiting body morphology | aberrant slug formation | multiple tips in mound | abolished phototaxis
DBS0305978atg9-/ [act15]: GFP: atg9atg9wild type
DBS0305979atg9-/ [act15]: atg9: GFPatg9wild type
DBS0350535atg9-/ [act15]: cdcD(R155C): RFPatg9 | cdcDwild type | decreased growth rate | decreased phototaxis
DBS0350534atg9-/ [act15]: cdcD: RFPatg9 | cdcDdecreased growth rate | aberrant fruiting body morphology | abolished phototaxis
DBS0350731atg9-/ tipD-atg9 | tipDdecreased pinocytosis | aberrant phagosome maturation | development arrests at tipped mound stage
DBS0349965bzpN-bzpNaberrant cytokinesis | abolished negative regulation of vegetative growth | increased growth rate
DBS0349966bzpN-/ [act15]: bzpN: GFPbzpNwild type
DBS0350419bzpR-bzpRincreased stalk width | aberrant sorus morphology | decreased spore viability
TL97cadA-cadAdecreased calcium-dependent cell-cell adhesion | decreased protein level | increased gene expression | increased chemotaxis to cAMP | aberrant cytokinesis | multiple tips | aberrant development | decreased sporulation | delayed culmination | increased prestalk cell differentiation
DBS0235561cap-capaberrant contractile vacuole organization and biogenesis | decreased protein level | aberrant pinocytosis | aberrant cytokinesis | decreased cell motility | delayed development | aberrant response to osmotic stress
DBS0235563capB-truncatedcapBdecreased growth rate | delayed development
JB4carA-carA-1 | carA-2abolished aggregation
JS14carA-carA-1 | carA-2abolished protein tyrosine phosphorylation | decreased cAMP-induced cGMP pulse | abolished protein localization to nucleus | increased cell-substrate adhesion | abolished aggregation | decreased cAMP-induced cAMP pulse
DBS0350431carA-/ [unk]: carA(261-359;S299A,S302G,S303G,S304G,S308A,S324G,S325A,S331A)(369-392;S383A,S385A): eYFPcarA-1 | carA-2aberrant adaptation of signaling pathway | aberrant localization to plasma membrane
RI9carA-/ carC-carA-1 | carA-2 | carCdecreased gene expression | abolished protein localization to plasma membrane
RI4carA-/ carC-carA-1 | carA-2 | carCdecreased chemoattractant-mediated F-actin polymerization | abolished activation of GTPase activity | abolished aggregation | abolished cAMP-induced cGMP pulse | abolished cAMP-induced cAMP pulse
DBS0350568carA-/ carC-/ [act15]: carA(261-359;S299A,S302G,S303G,S304G,S308A,S324G,S325A,S331A)(369-392;S383A,S385A)carA-1 | carA-2 | carCaberrant F-actin polymerization | aberrant adaptation of adenylate cyclase | aberrant chemotaxis to cAMP | abolished streaming | aberrant cAMP wave formation
DBS0235570carB-carBdevelopment arrests at mound stage
DBS0350661carB-carBabolished tip formation | increased gene expression | decreased gene expression | development arrests at tight mound stage | abolished culmination
JB6carC-carCwild type
DBS0235568carD-carDdecreased slug migration | decreased slug size | increased gene expression | decreased gene expression | aberrant slug migration | aberrant fruiting body morphology | decreased stalk length | decreased prestalk cell differentiation
DBS0235573carmil-carmildecreased pinocytosis | decreased growth rate | decreased basal F-actin level | decreased aggregate size
DBS0266775catA-catAabolished catalase activity
X9catA-catAincreased sensitivity to hydrogen peroxide | abolished catalase activity
IR40catA-catAabolished catalase activity
IR41catA-catAabolished catalase activity
IR29catA-catAincreased sensitivity to hydrogen peroxide
DBS0235574catB-catBdelayed development | increased spore sensitivity to hydrogen peroxide
DBS0350249cbhA-cbhAdelayed development
DBS0350250cbhA-/ [cbhA]: cbhAcbhAwild type
DBS0304455cblA-cblA-1 | cblA-2abolished basal disc formation | aberrant slug formation | aberrant signal transduction
DBS0235575cbpJ-cbpJwild type
DBS0350238ccdc53-ccdc53abolished exocytosis | decreased growth rate | abolished F-actin polymerization | abolished phagosome re-neutralization
DBS0235661cdk8-cdk8decreased gene expression | mislocalized gene expression | abolished aggregation
DBS0350435cdk8-cdk8decreased gene expression | decreased spore viability | aberrant gene expression | abolished aggregation
DBS0350436cdk8-/ [act15]: myc: cdk8cdk8wild type
DBS0350437cdk8-/ [act15]: myc: cdk8(D194A)cdk8decreased spore viability | abolished aggregation
DBS0235578cdk8-/ [cdk8]: cdk8cdk8wild type
DBS0306226cenB-cenBincreased number of centrosomes | aberrant cell separation during cytokinesis | aberrant nuclear envelope morphology | abolished protein localization to microtubule organizing center | aberrant nucleus morphology | aberrant cytokinesis | decreased microtubule nucleation | aberrant centrosome organization
DBS0306227cenB-/ [act15]: RFP: cenBcenBwild type
DBS0349926cepC-cepCabolished growth | decreased growth rate | aberrant Golgi localization | aberrant spindle organization | aberrant centrosome organization
DBS0350265cepK-cepKdecreased protein level | decreased protein localization to nuclear envelope | aberrant chemotaxis to cAMP | decreased growth rate | decreased aggregate size | decreased fruiting body size | decreased cell size
DBS0302444cfaD-cfaDincreased cell death | decreased spore viability | aberrant vegetative growth | aberrant cytokinesis | increased growth rate | aberrant fruiting body morphology | decreased sporulation
DBS0350010cfaD-/ [act15]: bzpN: GFPbzpN | cfaDabolished negative regulation of vegetative growth
DBS0302446cfaD-/ [act15]: cfaDcfaDwild type
HO101chcA-chcAdecreased pinocytosis | aberrant cytokinesis | decreased growth rate
HO103chcA-chcAabolished sporulation | abolished cytokinesis | abolished gene expression | abolished growth | delayed aggregation | aberrant fruiting body morphology
DBS0350090chcA-/ [act15]: GFP: ap2a1ap2a1-1 | ap2a1-2 | chcAaberrant protein localization
DBS0235588chcA-/ [act15]: GFP: mhcAchcA | mhcAdecreased positive regulation of GTPase activity
DBS0302455chcA-/ [act15]: epnA: GFPchcA | epnAaberrant protein localization to coated pits
DBS0350091chcA-/ [act15]: gppA: GFPchcA | gppAaberrant protein localization to plasma membrane
DBS0235589chcA-/ [cotB]: lacZchcAmislocalized gene expression
DBS0235590chcA-/ [ecmA]: lacZchcAmislocalized gene expression
DBS0235591chcA-/ [ecmB]: lacZchcAmislocalized gene expression
DBS0235592chcA-/ [pspA]: lacZchcAmislocalized gene expression
DBS0350524chdA-chdAaberrant culmination | aberrant gene expression | decreased chemotaxis to cAMP
DBS0350525chdB-chdBaberrant gene expression | delayed development
DBS0350526chdC-chdCdecreased growth rate | development arrests at mound stage | aberrant gene expression | decreased chemotaxis to cAMP
DBS0350528chdC-/ [ecmA]: lacZchdCdecreased prestalk cell differentiation
DBS0350527chdC-/ [pspA]: lacZchdCdecreased prespore cell differentiation
HM1522chlA-chlAabolished DIF production | aberrant slug formation | aberrant fruiting body morphology
LAS1chtB-chtBdecreased socially cooperative development | increased growth rate
LAS5chtC-chtCdecreased socially cooperative development
DBS0235601clc-clcabolished cytokinesis | decreased protein localization to plasma membrane | aberrant response to hypo-osmotic stress | abolished growth | aberrant fruiting body morphology
DBS0235604clc-/ [act15]: GFP-clc(146-194)clcabolished cytokinesis | wild type | aberrant fruiting body morphology
DBS0235605clc-/ [act15]: GFP-clc(85-124)clcabolished cytokinesis | wild type | aberrant fruiting body morphology
DBS0235607clc-/ [act15]GFP: clc(1-124)clcabolished cytokinesis | wild type | aberrant fruiting body morphology
DBS0350408cldA-cldAdecreased gene expression
DBS0235608clmA-clmAaberrant response to hypo-osmotic stress | aberrant contractile vacuole morphology
DBS0350473cln3-cln3aberrant protein secretion | aberrant aggregation | decreased cell-cell adhesion | increased protein secretion | decreased protein level | decreased cell-substrate adhesion | increased pinocytosis | delayed aggregation | aberrant slug migration | precocious development | increased growth rate
DBS0350474cln3-/ [act15]: GFP: cln3cln3wild type
DBS0235609cluA-cluAdecreased mitochondrial fusion | decreased mitochondrial fission | aberrant cytokinesis | aberrant intracellular distribution of mitochondria | aberrant mitochondrion organization
DBS0349875cluA-/ [act15]: cluAcluAwild type
DBS0235613cnrB-cnrBwild type
DBS0350308cnrF-cnrFaberrant contractile vacuole organization and biogenesis | abolished response to hypo-osmotic stress | decreased contractile vacuole size | aberrant regulation of GTPase activity
DBS0350309cnrF-/ [act15]: cnrF: RFPcnrFwild type
DBS0350311cnrF-/ cnrF(E623Q/ D659Q)cnrFaberrant contractile vacuole organization and biogenesis | abolished response to hypo-osmotic stress | decreased contractile vacuole size | aberrant regulation of GTPase activity
DBS0350310cnrF-/ cnrF(R270A)cnrFaberrant contractile vacuole organization and biogenesis | abolished response to hypo-osmotic stress | decreased contractile vacuole size | aberrant regulation of GTPase activity
DBS0302655cnrN-cnrNaberrant streaming | increased cAMP-induced cAMP pulse | decreased spore viability | increased F-actin polymerization | aberrant cytokinesis | increased number of aggregates | increased growth rate | abolished positive regulation of chemorepellant activity | decreased sporulation
DBS0302656cnrN-/ [act15]: cnrNcnrNwild type
HG1770cnxA-cnxAdecreased extracellular Ca2+ uptake | increased cytosolic Ca2+ response
DBS0235615cofB-cofBwild type
DBS0235616cofC-cofC-1wild type
DBS0350522comA-comAaberrant response to hyperosmotic stress | aberrant phagocytosis | aberrant defense response to a microorganism
DBS0235617comB-comBabolished culmination
DG1016comB-comBabolished culmination
DBS0235618comC-comCaberrant streaming | aberrant aggregation
DBS0235619comD-comDabolished culmination
DBS0235620comE-comEtranslucent sorus | aberrant fruiting body morphology
DBS0235621comF-comF-1 | comF-2abolished aggregation
DBS0235622comG-comGdevelopment arrests at mound stage | multiple tips
DBS0235623comH-comHdevelopment arrests at mound stage
HG1570corA-corAincreased myosin II assembly | aberrant cytokinesis | decreased growth rate | decreased cell motility | aberrant cell morphology
HG1571corA-corAincreased myosin II assembly | aberrant cytokinesis | decreased growth rate | decreased cell motility | aberrant cell morphology
HG1569corA-corAincreased myosin II assembly | increased basal F-actin level | aberrant cytokinesis | decreased growth rate | decreased phagocytosis | increased infection rate by Mycobacterium marinum | decreased cell motility | aberrant cell morphology
DBS0350370corA-corAaberrant response to conditioned medium factor | decreased cell polarity | decreased gene expression | aberrant chemotaxis to cAMP | aberrant cAMP signaling during aggregation | abolished aggregation
DBS0350345corA-/ [act15]: GFP: mhkAcorA | mhkAwild type
DBS0350346corA-/ [act15]: GFP: mhkBcorA | mhkBwild type
DBS0350344corA-/ [act15]: GFP: mhkCcorA | mhkCdecreased catalytic activity | wild type
DBS0350343corA-/ [act15]: GFP: pakA(797-1197)corA | pakAwild type
DBS0350371corA-/ [act15]: corAcorAwild type
DBS0350341corA-/ [act15]: corA(I118A/ S119A/ P121A): GFPcorAwild type | aberrant binding | increased myosin II assembly
DBS0350851corA-/ aip1-aip1 | corAaberrant endocytosis | increased basal F-actin level | aberrant cytokinesis | increased cell size | development arrests at mound stage | decreased growth rate | aberrant nucleus morphology | increased protein level | decreased chemotaxis to cAMP
DBS0305825corB-corBaberrant phagocytosis | decreased growth rate | increased lateral pseudopod formation | increased cell-substrate adhesion
DBS0349942cosA-cosAincreased pseudopod formation | aberrant F-actin organization | decreased cell motility | decreased fruiting body size | decreased chemotaxis to cAMP
TL55cotA-cotAaberrant spore coat morphology | decreased spore viability | abolished cellulose binding
TL53cotA-/ cotB-cotA | cotBaberrant spore coat morphology
TL56cotA-/ cotB-/ cotC-cotA | cotB | cotCaberrant spore coat morphology | decreased spore viability | abolished cellulose binding
TL57cotA-/ cotB-/ cotC-cotA | cotB | cotCaberrant spore coat morphology
TL26cotB-cotBaberrant spore coat morphology | decreased spore viability | abolished cellulose binding
TL54cotB-/ cotC-cotB | cotCaberrant spore coat morphology
TL52cotC-cotCaberrant spore coat morphology
HW07cotE(1-235)cotEaberrant spore coat morphology
DBS0238297cpnA-cpnAdelayed response to hypo-osmotic stress | aberrant thermotaxis | increased aggregate size | decreased growth rate | aberrant cytokinesis | aberrant stalk cell differentiation | development arrests at slug stage | increased slug size | delayed development | aberrant fruiting body morphology | abolished phototaxis
DBS0238320cpnA-/ [act15]: GFP: cpnAcpnAdelayed response to hypo-osmotic stress | decreased culmination | delayed development
DBS0235627crlA-crlAabolished response to MPBD | increased aggregate size | decreased spore viability | delayed tip formation | decreased sorting to prestalk region | abolished SDF-1 production | increased growth rate
DBS0235628crlA-/ [crlA]: crlAcrlAincreased aggregate size
DBS0235629crlB-crlBwild type
DBS0235630crlC-crlCwild type
HG1768crtA-crtAdecreased extracellular Ca2+ uptake | increased cytosolic Ca2+ response
HG1772crtA-/ cnxA-cnxA | crtAdecreased growth rate | delayed response to cAMP | decreased extracellular Ca2+ uptake | decreased phagocytosis | increased cytosolic Ca2+ response
DBS0235633crtf-crtfabolished sporulation | decreased gene expression | abolished aggregation
AX2-T10csaA-csaAdecreased cell-cell adhesion | decreased culmination | delayed aggregation | increased cell-substrate adhesion | decreased sporulation | aberrant protein localization
TL73csaA-/ csbA-/ csbC-/ csbC-csaA | csbA | csbB | csbCaberrant culminant morphology
TL72csbA-/ csbB-/ csbC-csbA | csbB | csbCincreased resistance to cisplatin | aberrant culminant morphology
WTC127cshA-cshAdevelopment arrests at loose mound stage | decreased phagocytosis | decreased growth rate | delayed aggregation
DBS0235634csn5-KDcsn5decreased growth rate
DBS0235624ctnA-ctnAaberrant cellular metabolic process | decreased protein level | increased cAMP-induced cGMP pulse | increased aggregate size | decreased basal F-actin level | increased cell-cell adhesion | increased GTP-gamma-S-stimulated guanylyl cyclase activity | increased protein level | increased cell motility | increased intracellular glucose level | decreased cAMP-induced cAMP pulse | decreased myosin II assembly
DBS0235636ctnB-ctnBdecreased gene expression | increased number of aggregates | decreased fruiting body size
DBS0304927ctnnA-ctnnAwild type
DBS0304928ctnnA-/ mhcA-ctnnA | mhcAaberrant cytokinesis
DG1071ctr9-ctr9aberrant fruiting body morphology
DG1058ctrA-ctrAdecreased fruiting body size
DBS0235598ctxA-ctxAaberrant cytokinesis | decreased cell motility | aberrant cell morphology
HS1151ctxA-ctxAaberrant streaming | aberrant cytokinesis | decreased growth rate
DBS0237568ctxA-/ [RNAi]enlActxA | enlAwild type
DBS0349922ctxA-/ [act15]: GFP-mhcActxAaberrant stalk morphogenesis | aberrant tip formation | aberrant protein localization
DBS0237536ctxA-/ [act15]: enlA(92-497)ctxA | enlAwild type
DBS0235599ctxA-/ ctxB-ctxA | ctxBaberrant cellular response to fluid shear stress | abolished adenylate cyclase activity | aberrant cytokinesis | aberrant chemotaxis to cAMP | increased lateral pseudopod formation | decreased cell motility | aberrant regulation of GTPase activity | aberrant cell morphology | abolished culmination | abolished streaming | abolished aggregation | aberrant regulation of protein kinase activity
DBS0350293ctxA-/ ctxB-/ [act15]: GFP: arcAarcA | ctxA | ctxBaberrant protein localization to cell cortex
DBS0349972ctxA-/ ctxB-/ [act15]: acaA: YFPacaA | ctxA | ctxBaberrant fruiting body morphology
DBS0349973ctxA-/ ctxB-/ [act15]: carA: YFPcarA-1 | carA-2 | ctxA | ctxBabolished adenylate cyclase activity | abolished culmination | abolished streaming
DBS0235600ctxB-ctxBaberrant streaming | aberrant cytokinesis | aberrant cell morphology
DBS0350404ctxC-ctxCaberrant streaming | increased pinocytosis | decreased period cAMP wave formation | decreased chemotaxis to cAMP | increased growth rate | increased phagocytosis
DBS0235639cudA-cudAabolished sporulation | decreased gene expression | development arrests at slug stage | abolished stalk cell differentiation
DBS0238017cudA-cudAabolished gene expression
DBS0235640culA-culAmultiple tips | development arrests at tipped mound stage
DBS0235641culA-/ [cotC]: culAculAincreased sorus size | decreased stalk length | decreased sporulation
DBS0235642culA-/ [ecmA]: culAculAincreased sorus size | decreased stalk length
DBS0235643culA-/ [pkaC]pkaCculA | pkaCwild type
DBS0266745culB-culBdecreased fruiting body size | precocious gene expression | aberrant slug formation | decreased sporulation | multiple tips in mound
DBS0266761culB-/ [act15]: pkaCculB | pkaCabolished gene expression | abolished sporulation | precocious gene expression | abolished aggregation
DBS0266760culB-/ pkaR-culB | pkaRabolished gene expression | abolished sporulation | precocious gene expression | abolished aggregation
DBS0235651cybA-cybAabolished sporulation | aberrant development
DBS0350641cynA-cynAdecreased F-actin polymerization | aberrant cell motility | aberrant chemotaxis to cAMP | delayed aggregation | aberrant cell morphology
AK108dagA-dagAabolished gene expression | decreased gene expression | abolished activation of adenylate cyclase | abolished aggregation | decreased chemotaxis to cAMP
DBS0235652dagA-/ [act15]: dagAdagAwild type
DBS0235560dagA-/ acaA(L394S)acaA | dagAwild type
DBS0235653darA-darAdecreased cell polarity | decreased cell motility | decreased aggregate size | abolished aggregation
DBS0350531dclre1-dclre1increased sensitivity to DNA-damaging agents | aberrant double strand break repair | decreased DNA mediated transformation
DBS0236307dcsA-dcsAabolished cellulose biosynthesis
DG1099dcsA-dcsAabolished sporulation | aberrant spore coat morphology | abolished cellulose biosynthesis | abolished stalk formation | abolished stalk cell differentiation
DG1128dcsA-dcsAabolished sporulation | aberrant spore coat morphology | abolished cellulose biosynthesis | abolished stalk formation
TL127dcsA-dcsAabolished sporulation | aberrant spore coat morphology | abolished cellulose biosynthesis | aberrant stalk formation | abolished stalk formation | abolished stalk cell differentiation
TL128dcsA-/ [act15]: dcsAdcsAwild type
DBS0349967dcx-/ lis1(D327H)dcx | lis1abolished aggregation
DBS0349804detA-detAincreased aggregate size | decreased growth rate | delayed development
DBS0349807detA-/ [act6]: GFP: detAdetAwild type
DBS0349816detA-/ [act6]: GFP: detA/ [act6]: 3xHA: culDculD | detAincreased gene expression
DBS0349817detA-/ [act6]: GFP: detA/ [act6]: 3xHA: repEdetA | repEincreased gene expression
DBS0349813detA-/ [cotB]: GFPdetAdecreased prespore cell differentiation
DBS0349811detA-/ [ecm0]: lacZdetAaberrant prestalk 0 cell differentiation
DBS0349812detA-/ [ecmA0]: GFPdetAincreased prestalk cell differentiation
DBS0349808detA-/ [ecmA0]: lacZdetAincreased prestalk cell differentiation
DBS0349809detA-/ [ecmA]: lacZdetAincreased prestalk A cell differentiation
DBS0349810detA-/ [ecmB]: lacZdetAdelayed development
DBS0350392dgat1-dgat1aberrant cellular metabolic process
DBS0350393dgat1-/ dgat2-dgat1 | dgat2decreased growth rate
DBS0349911dgcA-dgcAdevelopment arrests at slug stage | abolished stalk cell differentiation
DBS0349917dgcA-/ [act15]: dgcA(1-124): YFPdgcAdevelopment arrests at slug stage
DBS0349918dgcA-/ [act15]: dgcA(1-273): YFPdgcAdevelopment arrests at slug stage
DBS0349914dgcA-/ [act15]: dgcA(125-521): YFPdgcAwild type
DBS0349915dgcA-/ [act15]: dgcA(274-521): YFPdgcAwild type
DBS0349916dgcA-/ [act15]: dgcA(350-521): YFPdgcAdevelopment arrests at slug stage
DBS0349913dgcA-/ [act15]: dgcA-Ppal: YFPdgcAwild type
DBS0349912dgcA-/ [act15]: dgcA: YFPdgcAwild type
DBS0235695dgkA-dgkAdecreased spore viability | increased myosin II assembly | decreased chemotaxis rate | aberrant development
AK299dhkA-dhkAaberrant stalk morphogenesis | increased gene expression | mislocalized gene expression | abolished response to SDF-2 | increased sporulation | decreased sporulation | aberrant fruiting body morphology
DBS0350665dhkA-/ [act15]: dhkA(D2076N)dhkAdecreased sporulation
DBS0350664dhkA-/ [act15]: dhkA(H1396Q)dhkAdecreased sporulation
DBS0350666dhkA-/ [act15]: dhkA(H2396Q)/ [act15]: dhkA(D2076N)dhkAwild type
DBS0235703dhkA-/ [pkaC]: pkaCdhkA | pkaCaberrant stalk morphogenesis
TL134dhkA-/ dhkB-dhkA | dhkBabolished sporulation | increased stalk length | decreased stalk width
HR49dhkA-/ fbxA-dhkA | fbxAdecreased intracellular cAMP level | aberrant fruiting body morphology | decreased sporulation
HR51dhkA-/ fbxA-dhkA | fbxAaberrant fruiting body morphology | decreased sporulation
HR50dhkA-/ fbxA-dhkA | fbxAabolished culmination | decreased sporulation
DBS0350663dhkA-/ pkaR-dhkA | pkaRdecreased sporulation
DBS0350662dhkA-/ regA-dhkA | regAdecreased sporulation
DBS0235704dhkB-dhkBprecocious spore germination | translucent sorus | decreased intracellular cAMP level
TL135dhkC-dhkCprecocious culmination | decreased spore germination | precocious aggregation | precocious development | precocious gene expression
DBS0350855dhkC-dhkCaberrant chemotaxis to cAMP in response to DIF-2
DBS0350379dhkD-dhkDaberrant culminant morphology | precocious gene expression | abolished streaming | aberrant development | aberrant slug formation
DBS0350381dhkD-/ [ecmAO]: lacZdhkDaberrant prestalk cell differentiation
DBS0350382dhkD-/ [ecmB]: lacZdhkDaberrant prestalk cell differentiation
DBS0350383dhkD-/ [pspA]: lacZdhkDaberrant prespore cell differentiation
LAS99dhkE-dhkEdecreased socially cooperative development
DBS0235710dhkK-dhkKaberrant slug migration | delayed culmination | delayed gene expression
DBS0235712dhkK-/ [act15]: dhkK(D1125N)dhkKaberrant fruiting body morphology
DBS0235714dhkK-/ regA-dhkK | regAprecocious development
DBS0348046dhkM-dhkMabolished autophagic vacuole formation | aberrant autophagic cell death
DBS0348047dhkM-dhkMabolished cellulose biosynthesis | abolished autophagic vacuole formation | abolished autophagic cell death | abolished F-actin depolymerization
DBS0350173dhkM-dhkMdecreased autophagic vacuole formation | delayed development
DBS0235719dia1-/ [act6]: trap1dia1 | trap1aberrant aggregation | decreased fruiting body size
DBS0235895dimA-dimAincreased standing slug length | thin standing slug | abolished prestalk cell differentiation | increased slug size | decreased prestalk 0 cell differentiation | increased prespore cell differentiation | aberrant fruiting body morphology
DBS0235899dimA-/ dimB-dimA | dimBincreased standing slug length | thin standing slug | increased slug size | aberrant chemotaxis to cAMP
DBS0235901dimB-dimBdecreased prestalk B cell differentiation | increased gene expression | aberrant chemotaxis to cAMP | aberrant gene expression | abolished response to DIF
DBS0235903dimB-/ [act15]: dimA: GFPdimA | dimBabolished protein localization to nucleus
DBS0235904dimB-/ [act15]: dimB: GFPdimBwild type
DBS0349992dimB-/ [btg]: lacZbtg | dimBincreased gene expression
DBS0235902dimB-/ [cotB]: lacZdimBincreased prespore cell differentiation
DBS0350573dimB-/ [dimB]: dimB(S590A)dimBwild type
DBS0235906dimB-/ [ecmAO]: lacZdimBdecreased prestalk 0 cell differentiation
DBS0349974dimB-/ [ecmB]: lacZdimBabolished gene expression
DBS0235907dimB-/ [ecmO]: lacZdimBaberrant prestalk cell differentiation
DBS0350495dio3-dio3decreased cell-cell adhesion | aberrant aggregation | decreased gene expression | decreased growth rate | decreased prespore cell differentiation | decreased chemotaxis to folate | decreased intracellular cAMP level | increased prestalk cell differentiation | decreased phototaxis
DBS0350496dio3-/ [act15]: GFP: dio3dio3wild type
DBS0302609disgorgin(1-571: 581-733)DDB_G0280955aberrant contractile vacuole organization and biogenesis
DBS0302608disgorgin(1-571: 581-733)/ disgorgin-DDB_G0280955aberrant contractile vacuole organization and biogenesis | aberrant cellular localization
DBS0302597disgorgin-DDB_G0280955aberrant contractile vacuole organization and biogenesis | aberrant response to hypo-osmotic stress
DBS0302603disgorgin-/ GFP: disgorginDDB_G0280955wild type
DBS0302602disgorgin-/ OE]: disgorgin(Delta-Fbox)DDB_G0280955wild type
DBS0302606disgorgin-/ [OE]: GFP: lvsDDDB_G0280955 | lvsDwild type
DBS0302599disgorgin-/ [OE]: disgorginDDB_G0280955wild type
DBS0302601disgorgin-/ [OE]: disgorgin(Q551A)DDB_G0280955aberrant contractile vacuole organization and biogenesis
DBS0302600disgorgin-/ [OE]: disgorgin(R515A)DDB_G0280955aberrant contractile vacuole organization and biogenesis
DBS0302607disgorgin-/ [OE]: lvsADDB_G0280955 | lvsAaberrant contractile vacuole organization and biogenesis
DBS0302611disgorgin-/ [OE]: phgADDB_G0280955 | phgAaberrant contractile vacuole organization and biogenesis
DBS0302678disgorgin-/ [OE]: rab8ADDB_G0280955 | rab8Aaberrant contractile vacuole organization and biogenesis
DBS0302604disgorgin-/ lvsA-DDB_G0280955 | lvsAwild type
DBS0302605disgorgin-/ lvsD-DDB_G0280955 | lvsDaberrant contractile vacuole organization and biogenesis
DBS0304919dlpA-dlpAaberrant cell separation during cytokinesis | aberrant cytokinesis | aberrant F-actin organization | increased cell size | decreased growth rate | increased F-actin depolymerization | aberrant protein localization
DBS0304920dlpB-dlpBaberrant cell separation during cytokinesis | aberrant cytokinesis | increased cell size | decreased growth rate
DBS0304921dlpC-dlpCaberrant cytokinesis
DBS0235913dmpA-dmpAaberrant streaming | translucent sorus | delayed development | decreased stalk cell differentiation | decreased sporulation | aberrant fruiting body morphology
HM1030dmtA-dmtAthin standing slug | decreased outer basal disc size | wild type | abolished DIF production | abolished prestalk 0 cell differentiation | delayed tip formation | decreased prestalk 0 cell differentiation | decreased lower cup size | delayed development | aberrant fruiting body morphology | decreased prestalk cell differentiation
DBS0350410dmtA-/ [act15]: dmtAdmtAwild type
DBS0349975dmtA-/ [dimB]: dimBdimB | dmtAdecreased prestalk B cell differentiation
HM1196dmtA-/ stlA-dmtA | stlBdecreased outer basal disc size | decreased prestalk 0 cell differentiation
DBS0235914dnapkcs-dnapkcsincreased sensitivity to DNA-damaging agents | decreased double strand break repair | decreased DNA mediated transformation
DBS0266875dnapkcs-/ GFP: pcnadnapkcs | pcnaaberrant response to DNA damaging agents
DBS0350561dnapkcs-/ adprt2-adprt2 | dnapkcsincreased sensitivity to DNA-damaging agents | increased sensitivity to cisplatin
DBS0235915dng1-dng1decreased growth rate | delayed aggregation
DBS0235917dnmA-dnmAdecreased cytosine methylation in genomic DNA
DBS0235916dnmA-dnmAaberrant culminant morphology | translucent sorus | decreased cytosine methylation in genomic DNA | decreased sporulation
DBS0350457docA-docAdecreased chemotaxis to cAMP
DG2015docA-docAdevelopment arrests at mound stage
LAS32docA-docAdecreased socially cooperative development
DBS0350458docD-docDdecreased cell motility | decreased chemotaxis to cAMP
DBS0350459docD-/ docA-docA | docDdelayed development | decreased chemotaxis to cAMP | aberrant fruiting body morphology
DBS0235920dokA-dokAaberrant response to hyperosmotic stress | translucent sorus | decreased sporulation
DBS0349789dotA-dotAdecreased growth rate | increased sensitivity to UV light | decreased spore size | delayed development | abolished histone H3-K79 methylation
HAD172dpoA-dpoAaberrant development
HAD200dpoA-dpoAaberrant development
HAD201dpoA-dpoAaberrant development
HAD202dpoA-dpoAaberrant development
HAD203dpoA-dpoAaberrant development
HAD205dpoA-/ gskA-dpoA | gskAaberrant development
HM1467drcA-drcAabolished catalytic activity
DBS0238474drkC-drkCdecreased phagocytosis | decreased phagolysosome formation
DBS0238511drkC-/ [act15]: drkC(1-497): YFPdrkCdecreased phagocytosis
DBS0238513drkC-/ [act15]: drkC(K518R): YFPdrkCdecreased phagocytosis
DBS0238475drkC-/ [act15]: drkC: YFPdrkCwild type
DBS0235922drnA-drnA-1decreased gene expression
DBS0350218drnB-/ [act15]: pre-miRNAdrnBabolished microRNA processing
DBS0350210drnB-/ [act6]: lacZ/ [RNAi]lacZdrnBabolished production of siRNA involved in RNA interference | abolished transitive RNA interference
DBS0235924dscA-dscA-1 | dscA-2aberrant cell morphology
DBS0350775dscA-dcsAdecreased cell motility
DBS0235925dstA-dstAabolished gene expression | increased gene expression | decreased gene expression | delayed aggregation | mislocalized gene expression | decreased cell motility | abolished stalk cell differentiation | abolished sorting to prestalk region | aberrant fruiting body morphology
DBS0235926dstA-dstAdelayed aggregation | mislocalized gene expression | decreased cell motility | abolished stalk cell differentiation | abolished sorting to prestalk region | aberrant fruiting body morphology
DBS0238237dstA-/ GFP: dstA(237-707): ORF+dstAabolished culmination | decreased stalk length
DBS0238236dstA-/ GFP: dstA(237-707): ORF+/ [OE]dutA(751-1322)dstA | dutAdecreased stalk length
DBS0252824dstA-/ GFP: dstA(237-707): ORF+/ [act15]: 2C2C | dstAaberrant fruiting body morphology
DBS0252823dstA-/ GFP: dstA(237-707): ORF+/ [act15]: 7E7E | dstA | hssBwild type
DBS0252826dstA-/ GFP: dstA(237-707): ORF+/ [act15]: DDB_G0276165DDB_G0276165 | dstAaberrant fruiting body morphology
DBS0252825dstA-/ GFP: dstA(237-707): ORF+/ [act15]: DDB_G0282325DDB_G0282325 | dstAaberrant fruiting body morphology
DBS0252816dstA-/ GFP: dstA(237-707): ORF+/ [act15]: hssAdstA | hssAwild type
DBS0252822dstA-/ GFP: dstA(237-707): ORF+/ [act15]: hssBdstA | hssBwild type
DBS0235928dstA-/ [act15]: dstAdstAwild type
DBS0235929dstA-/ [cprB]: dstAdstAwild type
DBS0235930dstA-/ [ecmAO]: dstAdstAwild type
DBS0235927dstA-/ dstB-dstA | dstBwild type
DBS0235931dstB-dstBdecreased gene expression | increased gene expression | decreased growth rate
DBS0235933dstB-/ [act15]: dstBdstBwild type
DBS0235934dstB-/ [act15]: dstB(L1025R)dstBwild type
DBS0235935dstB-/ [act15]: dstB(Y1143F)dstBwild type
DBS0235932dstB-/ dstC-dstB | dstCwild type
DBS0238125dstC-dstCabolished gene expression | aberrant response to cation stress | aberrant response to osmotic stress
DBS0350425dstC-dstCaberrant protein phosphorylation
DBS0235937dtfA-dtfAdecreased cell-cell adhesion | aberrant sorting to prestalk region | delayed tip formation | aberrant cytokinesis | aberrant fruiting body morphology
DBS0350500dupA-dupAdecreased infection rate by Legionella pneumophila | abolished aggregation
DBS0350502dupA-dupAdecreased infection rate by Legionella pneumophila
DBS0238234dutA-dutAwild type
DBS0235939dwwA-dwwAaberrant cytokinesis | aberrant F-actin organization | aberrant cell morphology
DBS0350411dydA-dydAincreased myosin II assembly | increased chemoattractant-mediated F-actin polymerization | increased CRAC localization to the plasma membrane | decreased chemotaxis to cAMP
DBS0350414dydA-/ dydA(1-278: 501-1211)dydAincreased myosin II assembly | increased chemoattractant-mediated F-actin polymerization | aberrant chemotaxis to cAMP | decreased localization to cell cortex
DBS0350415dydA-/ dydA(1-586: 703-1211)dydAdecreased chemotaxis to cAMP | decreased localization to cell cortex
DBS0350060dymA-dymAaberrant cell separation during cytokinesis | aberrant F-actin organization | increased cell size | decreased growth rate | aberrant protein localization
DBS0347874dymA-dymAdecreased pinocytosis | aberrant cell separation during cytokinesis | decreased cell polarity | aberrant mitochondrion morphology | decreased phagolysosome size | increased cell size | increased basal disc size | decreased growth rate | aberrant stalk formation | aberrant nucleus morphology | aberrant endosome morphology | aberrant phagosome maturation | delayed development | aberrant pseudopod formation | abolished phagosome acidification | increased phagocytosis | aberrant fruiting body morphology | aberrant intracellular distribution of mitochondria
DBS0349839dymA-/ [dymA]: dymAdymAwild type
DBS0350803dymA-/ ehd-dymA | ehdaberrant phagosome maturation | decreased phagosomal proteolysis
DBS0347875dymB-dymBaberrant response to hypo-osmotic stress | aberrant F-actin organization | decreased growth rate | increased cell-cell adhesion | increased cell-substrate adhesion | decreased catalase activity | increased growth rate | increased phagocytosis | decreased cell size
HJW117ecmA-ecmAincreased standing slug length | weak slime trail | thin standing slug
HJW01ecmB-ecmBwild type
HJW03ecmB-ecmBwild type
DBS0235944ecmF-ecmFwild type
DBS0235945egeA-egeAdecreased gene expression | decreased activation of adenylate cyclase | abolished aggregation
DBS0350520egeA-/ [unk]: YFP: carAcarA-1 | carA-2 | egeAdevelopment arrests at mound stage
DBS0350521egeA-/ [unk]: pkaCegeA | pkaCdecreased gene expression | abolished aggregation
DBS0235946egeB-egeBdevelopment arrests at mound stage
DBS0350802ehd-ehdaberrant endosome morphology | aberrant phagosome maturation | decreased phagosomal proteolysis
DBS0350804ehd-/ [act15]: dymA: GFPdymA | ehdaberrant phagosome maturation | decreased phagosomal proteolysis
DBS0302590elmoA-elmoAincreased protein localization to pseudopodium | decreased culmination | increased pseudopod formation | increased F-actin polymerization | decreased cell motility | delayed development | abolished cell polarity | increased phagocytosis
DBS0302598elmoA-/ [act15]: elmoA(1-903/ 959-977): GFPelmoAdecreased cell motility | increased phagocytosis
DBS0302591elmoA-/ [act15]: elmoA: GFPelmoAwild type
DBS0350065elmoE-elmoEdecreased culmination | decreased F-actin polymerization at the leading edge | decreased chemotaxis to cAMP
DBS0302448epnA-epnAaberrant spore morphology | decreased spore viability | aberrant cytokinesis | abolished protein phosphorylation | aberrant protein localization
DBS0302457epnA-/ [act15]: GFP: epnA(253-677)epnAaberrant spore morphology | abolished localization to coated pits | abolished localization to plasma membrane
DBS0302456epnA-/ [act15]: epnA(1-133): GFPepnAaberrant localization to coated pits
DBS0302474epnA-/ [act15]: epnA(R65A/ K78A): GFPepnAaberrant spore morphology | abolished localization to coated pits | abolished localization to plasma membrane | abolished phosphatidylinositol-4,5-bisphosphate binding
DBS0302475epnA-/ [act15]: epnA(T107A): GFPepnAaberrant spore morphology
DBS0302454epnA-/ [act15]: epnA: GFPepnAwild type
DBS0235947eppA-eppAdecreased growth rate | delayed development | decreased chemotaxis to folate | decreased chemotaxis to cAMP | decreased intracellular cAMP level
DBS0235948eppA-/ [act6]: myc: eppAeppAwild type
DBS0350028erkA-erkAdecreased aggregate size | decreased chemotaxis to cAMP
DBS0350622erkA-erkAaberrant streaming | aberrant tip formation
DBS0350623erkA-erkAdecreased aggregate size | precocious development
DBS0350681erkA-/ [act15]: gpaEerkA | gpaEwild type
DBS0350029erkA-/ [act15]: mekA: FLAGerkA | mekAincreased protein localization to cell cortex
HS174erkB-erkBabolished gene expression | decreased catalytic activity | decreased gene expression | aberrant phagocytosis | decreased cell motility | decreased chemotaxis to folate | abolished aggregation | decreased chemotaxis to cAMP | aberrant cell morphology | aberrant development | decreased cAMP-induced cAMP pulse | decreased sporulation
AK240erkB-erkBabolished aggregation | decreased cAMP-induced cAMP pulse | decreased sporulation
DBS0350606erkB-erkBdecreased prespore cell differentiation
DBS0350683erkB-/ [ecmA]: lacZerkBaberrant sorting to prestalk region
DBS0350682erkB-/ [unk]: erkB(P140S)erkBabolished sporulation
DBS0235949erkB-/ regA-erkB | regAincreased cAMP-induced cAMP pulse | abolished aggregation
DBS0350530exo1-exo1increased sensitivity to DNA-damaging agents | decreased double strand break repair | abolished DNA mediated transformation
DBS0304864expl7-expl7wild type
DBS0235951fadA-fadAincreased resistance to heat shock
DBS0235952fadB-fadBwild type
DBS0350240fam21-fam21abolished exocytosis | aberrant post-lysosome organization and biogenesis | aberrant vegetative growth | aberrant autophagic cell death | aberrant phagosome maturation | decreased phagosomal proteolysis
DBS0236034fam45-fam45wild type
DBS0236040fam91-fam91wild type
DBS0350717far1-far1decreased F-actin polymerization | decreased growth rate | decreased engulfment during phagocytosis | decreased chemotaxis to folate | decreased protein kinase activation | decreased folic acid binding
DBS0235953fbxA-fbxAdecreased sporulation
HR6fbxA-fbxAdecreased socially cooperative development
DBS0235954fbxA-/ [ecmA]: GFP(S65T)fbxAincreased prespore cell differentiation
HR46fbxA-/ regA-fbxA | regAaberrant fruiting body morphology | decreased sporulation
HR48fbxA-/ regA-fbxA | regAaberrant fruiting body morphology | decreased sporulation
DBS0235956fbxA1-fbxAdevelopment arrests at slug stage | increased slug migration | aberrant fruiting body morphology | delayed culmination
DBS0235957fbxA2-fbxAdevelopment arrests at slug stage | increased slug migration | aberrant fruiting body morphology | delayed culmination
DBS0235958fbxA3-fbxAdevelopment arrests at slug stage | increased slug migration | aberrant fruiting body morphology | delayed culmination
DG1148fcpA-fcpAaberrant fruiting body morphology
DBS0235960fcsA-fcsAdecreased fatty acid level
DBS0350128fcsB-fcsBdecreased catalytic activity | decreased phagocytosis
DBS0350129fcsB-/ fcsA-fcsA | fcsBdecreased catalytic activity | decreased growth rate | delayed development
DBS0350336febA-febAwild type
DBS0235961fimA-fimAdecreased cell size
HM1253fncD2-fncD2increased sensitivity to cisplatin
HM1351 fncD2-/ rev3-fncD2 | rev3increased sensitivity to cisplatin
HM1405fncD2-/ xpf-fncD2 | xpfincreased sensitivity to cisplatin
HM1416fncE-fncEincreased sensitivity to cisplatin
HM1356fncI-fncIincreased sensitivity to cisplatin
HM1302fncL-fncLincreased sensitivity to cisplatin
HM1407fncM-fncMincreased sensitivity to cisplatin
DBS0235966forA-forAwild type
DBS0350667forA-forAaberrant cellular response to fluid shear stress | decreased cell motility | increased cell motility
DBS0350669forA-/ [act15]: GFP: mhcAforA | mhcAaberrant bleb formation
DBS0235967forA-/ forB-forA | forBwild type
DBS0235968forB-forBwild type
DBS0235969forC-forCaberrant culmination | development arrests at tipped mound stage | aberrant fruiting body morphology
DBS0350280forC-forCabolished slug formation | delayed aggregation | aberrant development | decreased chemotaxis to cAMP | decreased sporulation | delayed gene expression
DBS0304905forC-/ [act15]: GFP: forCforCwild type
DBS0350287forF-forFdecreased fruiting body size | aberrant phototaxis | increased chemotaxis rate
DBS0350835forG-forGdecreased growth rate | decreased phagocytosis | aberrant F-actin organization | aberrant actin cytoskeleton organization | decreased macropinocytosis
DBS0235970forH-forHdecreased cell-substrate adhesion | decreased chemotaxis rate | increased cell motility | aberrant pseudopod formation | aberrant cell morphology | decreased filopodium formation
DBS0235971forH-/ [act15]: GFP: forHforHincreased filopodium formation | decreased cell motility | increased cell-substrate adhesion
DBS0302506frmA-frmAdelayed aggregation | decreased cell motility | increased cell-substrate adhesion | decreased aggregate size | aberrant cell morphology
DBS0304440frmA-/ [unk]: GFPfrmAdecreased gene expression | increased cell-cell adhesion | delayed development | aberrant development | abolished phototaxis
DBS0302507frmA-/ [unk]: frmA-HAfrmAwild type
DBS0350252fspA-fspAdecreased gene expression | aberrant chemotaxis to folate | aberrant vegetative growth
DBS0350253fspA-/ [unk]: fspA: FLAGfspAwild type
DBS0235976fszA- fszAdecreased number of mitochondria | increased number of tubular mitochondria
DBS0235978fszA-/ fszB- fszA | fszBincreased number of tubular mitochondria
DBS0235980fszB- fszBdecreased number of mitochondria | increased number of tubular mitochondria | decreased growth rate
DG1066fut1-fut1aberrant fruiting body morphology
DBS0305025gabT-gabTprecocious development | decreased sporulation
DBS0305026gabT-[pkaC]: pkaCgabT | pkaCaberrant protein secretion
DG1094gacT-gacTaberrant fruiting body morphology
DBS0235989gadA-gadAabolished SDF production | decreased sporulation
DBS0350071gadA-gadAdecreased spore viability
DBS0350077gadA-/ gadB-gadA | gadBdelayed aggregation
DBS0350072gadB-gadBdelayed aggregation
DBS0349924gapA-gapAaberrant cellular response to fluid shear stress
DBS0350399gapA-gapAincreased myosin II assembly | increased F-actin polymerization | increased lateral pseudopod formation | decreased chemotaxis to cAMP
DBS0350403gapA-/ iqgC-gapA | iqgCdecreased protein kinase activation | decreased chemotaxis to cAMP
TL198gbfA-gbfAabolished gene expression | development arrests at mound stage
DBS0305094gbfA-gbfAabolished autophagic cell death | abolished autophagic vacuole formation
DBS0235992gbpA-/ gbpB-pdeD | pdeEincreased protein kinase activation
DBS0235993gbpB-pdeEaberrant chemotaxis to cAMP
DBS0235994gbpC-gbpCdecreased protein kinase activation | decreased fruiting body size
DBS0235995gbpC-gbpCdecreased cell polarity | aberrant myosin II organization | aberrant chemotaxis to cAMP | decreased chemotaxis rate | aberrant cell morphology | decreased fruiting body size
DBS0302680gbpC-gbpCabolished protein localization to nucleus | decreased aggregate size | abolished protein phosphorylation | abolished aggregation
DBS0304912gbpC-/ [act15]: gbpCgbpCwild type
DBS0304917gbpC-/ [act15]: gbpC(1-1698: 2005-2631)gbpCdecreased chemotaxis to cAMP
DBS0349868gbpC-/ [act15]: gbpC(1-2331: 2470-2631): GFPgbpCaberrant streaming | decreased chemotaxis to cAMP
DBS0304918gbpC-/ [act15]: gbpC(311-2631)gbpCdecreased chemotaxis to cAMP
DBS0304916gbpC-/ [act15]: gbpC(F1892A)gbpCdecreased chemotaxis to cAMP
DBS0304915gbpC-/ [act15]: gbpC(F2082A/ E2084A/ F2564A/ E2566A)gbpCdecreased chemotaxis to cAMP
DBS0304913gbpC-/ [act15]: gbpC(K342N)gbpCdecreased chemotaxis to cAMP
DBS0304914gbpC-/ [act15]: gbpC(K905W)gbpCdecreased chemotaxis to cAMP
DBS0235996gbpC-/ gbpD-gbpC | gbpDdecreased cell polarity | decreased chemotaxis rate
DBS0235997gbpD-gbpDdecreased lateral pseudopod formation | decreased cell-substrate adhesion | increased cell polarity | increased chemotaxis rate
DBS0235998gbpD-/ [act15]: gbpDgbpDaberrant F-actin organization | increased cell-substrate adhesion | increased lateral pseudopod formation | decreased chemotaxis rate | abolished aggregation
DG1120gbqA-gbqAaberrant fruiting body morphology
DBS0236000gca-/ sgcA-gcA | sgcAdecreased protein kinase activation
DBS0302679gca-/ sgcA-gcA | sgcAaberrant streaming | aberrant chemotaxis to cAMP | increased lateral pseudopod formation | decreased chemotaxis rate | decreased aggregate size | decreased fruiting body size
DBS0236002gcsA-gcsAabolished gene expression | aberrant initiation of development | abolished growth | decreased gene expression | increased gene expression | development arrests at mound stage | cell cycle arrest | spores inviable
DBS0350387gcsA-/ [act15]: carAcarA-1 | carA-2 | gcsAaberrant initiation of development
DBS0236003gcsA-/ [act15]: gcsAgcsAdecreased spore viability | development arrests at mound stage
DBS0350388gcsA-/ [act15]: yakAgcsA | yakAwild type
DBS0236004gdt1-gdt1increased gene expression | decreased growth rate | precocious aggregation
DBS0237190gdt1-/ [act15]: pkaR(G135E/ G261A)gdt1 | pkaRincreased gene expression | abolished aggregation
DBS0236095gdt1-/ gpaB-gdt1 | gpaBincreased gene expression | abolished aggregation
DBS0236006gdt2-gdt2increased gene expression | precocious aggregation
DBS0252697gefA-gefAdecreased cell motility
RI19gefA-gefAdecreased chemoattractant-mediated F-actin polymerization | decreased cAMP-induced cGMP pulse | decreased positive regulation of GTPase activity | decreased gene expression | decreased chemotaxis rate | abolished activation of adenylate cyclase | abolished aggregation | decreased cAMP-induced cAMP pulse | increased protein kinase activation
JB10gefA-gefAabolished aggregation
DBS0350821gefA-gefAdecreased F-actin polymerization | decreased activation of GTPase activity | aberrant chemotaxis to cAMP | decreased protein kinase activation | abolished aggregation
DBS0350449gefA-/ dscB]: rasG(S17N)gefA | rasGdecreased chemoattractant-mediated F-actin polymerization | decreased positive regulation of GTPase activity | aberrant chemotaxis to cAMP | decreased protein kinase activation
DBS0236009gefB-gefBaberrant cytoskeleton organisation | abolished pinocytosis | increased basal F-actin level | abolished growth | delayed aggregation | decreased phagocytosis | decreased growth rate | decreased aggregate size | aberrant cell morphology | aberrant fruiting body morphology
DBS0236010gefB-/ rasS-gefB | rasSdecreased phagocytosis | increased cell motility
DBS0236868gefC-gefCwild type
DBS0236869 (DBS0235543)gefD-gefDwild type
DBS0236870gefE-gefEaberrant thermotaxis | aberrant phototaxis
DBS0350569gefE-gefEdecreased positive regulation of GTPase activity | decreased response to DIF
DBS0236011gefG-gefGwild type
DBS0350822gefH-gefHdecreased F-actin polymerization | decreased activation of GTPase activity | aberrant chemotaxis to cAMP | delayed development | decreased protein kinase activation
DBS0350823gefH-/ gefA-gefA | gefHdecreased F-actin polymerization | aberrant chemotaxis to cAMP | abolished activation of GTPase activity | decreased protein kinase activation | abolished aggregation
DBS0236012gefK-gefKwild type
DBS0236871gefL-gefLaberrant thermotaxis | aberrant phototaxis
HSB61gefM-gefMincreased cAMP-induced cGMP pulse | aberrant activation of adenylate cyclase activity | development arrests at mound stage | decreased chemotaxis rate | decreased lateral pseudopod suppression | decreased cAMP-induced cAMP pulse
DBS0304968gefQ-gefQabolished Ras guanyl-nucleotide exchange factor activity | decreased positive regulation of GTPase activity | increased myosin II assembly | decreased growth rate | increased lateral pseudopod formation | abolished sorting to prestalk region | decreased fruiting body size | abolished phototaxis | multiple tips in mound
DBS0304985gefQ-/ [act15]: GFP: gefQ(172-654)gefQabolished Ras guanyl-nucleotide exchange factor activity | decreased phototaxis
DBS0304986gefQ-/ [act15]: GFP: gefQ(910-1298)gefQdecreased phototaxis
DBS0236014gefR-gefRwild type
DBS0349892gefS-gefSwild type
DBS0349904gemA-gemAdecreased growth rate | decreased intracellular ATP level
DBS0237700gflB-gflBdecreased culmination | aberrant signal transduction during aggregation | increased F-actin polymerization at the leading edge | delayed aggregation | aberrant CRAC localization to the plasma membrane | decreased aggregate size | decreased chemotaxis to cAMP | decreased myosin II assembly
DBS0350814gflB-/ [act15]: GFP: gflB(380-1601,T1180E)gflBdecreased chemotaxis to cAMP
DG1109ggtA-ggtAaberrant fruiting body morphology
DBS0266723glcS-/ DH1glcSaberrant stalk morphogenesis | decreased spore size | decreased intracellular glycogen level | decreased fruiting body size
DBS0266765glcS-/ HMXglcSabolished cellulose biosynthesis | decreased autophagic vacuole formation | aberrant cell morphology
DBS0350514glk-glkincreased infection rate by Legionella pneumophila
DBS0236078glpD-glpDaberrant glycogen metabolism
DBS0236079gmsA-gmsAdecreased sexual fusion
DBS0236080gmsA-gmsAdecreased sexual fusion
DBS0238384gnt14-gnt14wild type
DBS0238382gnt15-gnt15decreased gene expression | decreased growth rate | increased calcium-independent cell-cell adhesion | abolished aggregation | abolished culmination
DBS0238383gnt15-gnt15decreased gene expression | decreased growth rate | increased calcium-independent cell-cell adhesion | abolished aggregation | abolished culmination
DBS0238390gnt15-/ [act15]: FLAG: gnt15gnt15wild type
DBS0238391gnt15-/ [act15]: FLAG: gnt15gnt15wild type
DBS0236082gol-golincreased resistance to cisplatin
DBS0236087gpaA-gpaAincreased stalk length | decreased stalk width
JH131gpaA-gpaAwild type
DBS0236091gpaA-/ [ecmB]: lacZgpaAdecreased gene expression
DBS0236092gpaA-/ [gpaA]: gpaA(G45V)gpaAdelayed development
DBS0236093gpaA-/ [gpaA]: gpaA(Q206L)gpaAincreased basal disc size
DBS0238605gpaA-/ rpkA-gpaA | rpkAdelayed aggregation | abolished aggregation
DBS0236575gpaB-gpaBdecreased cAMP-induced cGMP pulse | abolished activation of GTPase activity | decreased protein kinase activation | decreased cAMP-induced cAMP pulse
JH104gpaB-gpaBdecreased gene expression | abolished activation of adenylate cyclase | abolished aggregation
DBS0236096gpaB-/ [act15]: gpaBgpaBabolished aggregation
DBS0266942gpaB-/ [act15]: gpaBgpaBdelayed aggregation
DBS0266939gpaB-/ [act15]: gpaB(1-345): gpaD(337-345)gpaB | gpaDabolished aggregation
DBS0237137gpaB-/ [act15]: gpaB(D154V)gpaBaberrant aggregation | decreased cAMP-induced cGMP pulse | decreased activation of adenylate cyclase | decreased chemotaxis rate | decreased cAMP-induced cAMP pulse
DBS0237138gpaB-/ [act15]: gpaB(E190G)gpaBaberrant aggregation | decreased cAMP-induced cGMP pulse | decreased activation of adenylate cyclase | decreased cAMP-induced cAMP pulse
DBS0237139gpaB-/ [act15]: gpaB(I104S)gpaBaberrant aggregation | decreased cAMP-induced cGMP pulse | decreased activation of adenylate cyclase | decreased chemotaxis rate | decreased cAMP-induced cAMP pulse
DBS0237140gpaB-/ [act15]: gpaB(L110S)gpaBaberrant aggregation | decreased cAMP-induced cGMP pulse | decreased activation of adenylate cyclase | decreased chemotaxis rate | decreased cAMP-induced cAMP pulse
DBS0237141gpaB-/ [act15]: gpaB(L76P)gpaBabolished aggregation
DBS0237142gpaB-/ [act15]: gpaB(N74D)gpaBdecreased cAMP-induced cGMP pulse | decreased activation of adenylate cyclase | decreased chemotaxis rate | abolished aggregation | decreased cAMP-induced cAMP pulse
DBS0237143gpaB-/ [act15]: gpaB(R64G)gpaBdecreased chemotaxis rate | abolished aggregation
DBS0237144gpaB-/ [act15]: gpaB(S155P)gpaBdecreased chemotaxis rate | abolished aggregation
DBS0236097gpaB-/ [gpaA]: gpaBgpaBabolished aggregation
DBS0236099gpaB-/ [gpaB]: gpaBgpaBwild type
DBS0236098gpaB-/ [gpaB]: gpaB(Q208L)gpaBaberrant protein localization
DBS0350373gpaB-/ regA-gpaB | regAdecreased number of aggregates
DBS0235986gpaC-gpaCaberrant activation of adenylate cyclase activity | decreased gene expression | increased protein kinase activity | abolished aggregation
JH417gpaD-gpaDdecreased gene expression | abolished SDF production | decreased accumulation of cGMP | decreased chemotaxis to folate | decreased protein kinase activation | aberrant fruiting body morphology | decreased sporulation
DBS0266944gpaD-/ [act15]: gpaBgpaB | gpaDdecreased accumulation of cGMP | decreased chemotaxis to folate | aberrant fruiting body morphology
DBS0266946gpaD-/ [act15]: gpaB(1-345): gpaD(337-345)gpaB | gpaDdecreased accumulation of cGMP | aberrant fruiting body morphology
DBS0266943gpaD-/ [act15]: gpaDgpaDwild type
DBS0350608gpaD-/ [act15]: gpaD(Q200L)gpaDdevelopment arrests at loose mound stage | decreased chemotaxis to folate | decreased protein kinase activation
DBS0350607gpaD-/ [act15]: gpaD(R107E,R108E)gpaDabolished culmination
DBS0266945gpaD-/ [act15]: gpaEgpaD | gpaEdecreased accumulation of cGMP | decreased chemotaxis to folate | aberrant fruiting body morphology
DBS0266947gpaD-/ [act15]: gpaE(1-339): gpaD(337-345)gpaD | gpaEdecreased accumulation of cGMP | decreased chemotaxis to folate | aberrant fruiting body morphology
DBS0350374gpaD-/ regA-gpaD | regAaberrant aggregation | abolished slug migration | decreased sporulation
DBS0350378gpaD-/ regA-/ [ecmB]: lacZgpaD | regAincreased prestalk 0 cell differentiation
DBS0236101gpaE(G196T)gpaEwild type
DBS0236103gpaE(Q198L)gpaEwild type
JH257gpaE-gpaEincreased chemotaxis to folate | delayed tip formation | increased cell size | decreased sorting to prestalk region | delayed gene expression
DBS0266941gpaE-/ [act15]: gpaEgpaEprecocious tip formation
DBS0266948gpaE-/ [act15]: gpaE(1-339): gpaD(337-345)gpaD | gpaEprecocious tip formation
DBS0350678gpaE-/ [act15]: gpaE(K10E/ K11E)gpaEdelayed tip formation | delayed gene expression
DBS0350624gpaE-/ erkA-erkA | gpaEwild type | decreased aggregate size | precocious development
LW1gpaG-gpaGwild type | aberrant gamma-aminobutyric acid signaling pathway | abolished SDF production
DBS0236107gpaH-gpaHwild type | increased cell death | decreased spore viability | abolished negative chemotaxis | increased growth rate
DBS0236108gpaH-gpaHwild type
DBS0236109gpaI-gpaIincreased cell death | precocious aggregation | decreased aggregate size | increased number of aggregates | decreased fruiting body size | increased growth rate
LW5gpbA-gpbAincreased resistance to N-Phenylthiourea | abolished aggregation
LW6gpbA-gpbAdecreased CRAC localization to the plasma membrane | decreased cAMP-induced cGMP pulse | decreased positive regulation of GTPase activity | increased cell death | decreased phagocytosis | decreased engulfment during phagocytosis | abolished F-actin polymerization | decreased chemotaxis to folate | decreased protein kinase activation | decreased chemotaxis to cAMP | increased growth rate | decreased cAMP-induced cAMP pulse | aberrant protein localization
LW14gpbA-/ [OE]: carAcarA-1 | carA-2 | gpbAdecreased protein kinase activation
DBS0350470gpbA-/ [act15]: GFP: capcap | gpbAdecreased phagocytosis
HO547gpbA-/ [act6]: FRB: [act15]: RFP: gpbA/ [act15]: cnxA: CFP: FKBP/ [act15]: limE(1-145): GFPgpbAaberrant cortical actin cytoskeleton organization
HO543gpbA-/ [act6]: FRB: [act15]: RFP: gpbA/ [act15]: cnxA: YFP: FKBPgpbAabolished chemotaxis to folate | decreased electrotaxis
DBS0350832gpbA-/ [unk]: gpbA(Q208L)gpbAaberrant adaptation of signaling pathway
DBS0350477gpr89-gpr89aberrant spore morphology | aberrant mitochondrion morphology | abolished growth | decreased gene expression | decreased cell motility | abolished sorting to prestalk region | decreased fruiting body size | precocious gene expression | aberrant slug formation | decreased phototaxis | delayed gene expression
DBS0350479gpr89-/ [act15]: gpr89: GFPgpr89wild type
DBS0304814grlA-grlAdecreased gene expression | abolished SDF production | delayed gene expression | decreased sporulation | delayed culmination
DBS0304815grlA-/ [act15]: grlA: GFPgrlAaberrant tip formation
DBS0350074grlB-grlBdecreased small molecule binding | delayed aggregation | delayed gene expression
DBS0350078grlB-/ grlE-grlB | grlEdecreased small molecule binding | delayed aggregation
DBS0236112grlE-grlEabolished SDF production | aberrant gamma-aminobutyric acid signaling pathway | decreased sporulation
DBS0236113grlE-grlEdelayed aggregation | aberrant gene expression | decreased chemotaxis to cAMP
DBS0350075grlE-grlEdecreased spore viability | delayed aggregation
DBS0238865grlJ-grlJaberrant spore morphology | decreased spore viability | increased slug size | precocious development | decreased fruiting body size | precocious gene expression
DBS0350283grlJ-grlJaberrant spore morphology | increased resistance to N-Phenylthiourea
DBS0238866grlJ-/ [act15]: grlJ: GFPgrlJwild type
DBS0350284grlJ-/ [act15]: grlJ: GFPgrlJwild type
DBS0238686grpA-grpAdecreased spore germination | abolished protein secretion
DBS0238687grpA-/ [act15]: grpA-FLAGgrpAwild type
ARK200gskA-gskAincreased gene expression | decreased gene expression | aberrant CRAC localization to the plasma membrane | decreased chemotaxis to cAMP | abolished streaming | aberrant protein localization to plasma membrane | decreased sporulation
DBS0236114gskA-gskAaberrant aggregation | decreased slug migration | aberrant sorus morphology | abolished CRAC localization to the plasma membrane | decreased gene expression | aberrant cAMP signaling during aggregation | abolished protein phosphorylation | decreased chemotaxis to folate | decreased stalk length | abolished chemotaxis to cAMP
HM338gskA-gskAprecocious aggregation | aberrant spindle elongation | decreased prespore cell differentiation | aberrant fruiting body morphology | increased prestalk cell differentiation | decreased sporulation
DBS0349930gskA-/ [act15]: GFP: tacAgskA | tacAincreased protein localization to nucleus
DBS0349881gskA-/ [act15]: gskA(Y214F)gskAabolished streaming
DBS0349800gskA-/ [ecmA]: LacZgskAaberrant gene expression
DBS0349801gskA-/ [ecmB]: LacZgskAaberrant gene expression
DBS0350260gskA-/ [unk]: pikA(1-492(S7D/ S11D/ S109D/ S113D/ S177D/ S181D))gskA | pikAwild type
DBS0350427gskA-/ gskA(K85R): GFPgskAaberrant aggregation
DBS0350426gskA-/ gskA: GFPgskAwild type
DBS0266891gtaC-gtaCabolished stalk cell differentiation in vitro | aberrant streaming | decreased aggregate size | aberrant prestalk B cell differentiation
DBS0350347gtaC-gtaCabolished gene expression | decreased fruiting body size | abolished aggregation
DBS0350348gtaC-/ [act15]: GFP: gtaCgtaCwild type
DBS0350357gtaC-/ [act15]: GFP: gtaC(C500,503,522,525S)gtaCaberrant gene expression | abolished aggregation | decreased fruiting body size
DBS0350358gtaC-/ [act15]: GFP: gtaC(T376A/ S379,380A/ C500,503,522,525S)gtaCaberrant localization to nucleus
DBS0350361gtaC-/ [act15]: gtaC: (468-496): GFP: gtaCgtaCdevelopment arrests at mound stage | decreased aggregate size | precocious development
DBS0236120gxcA-gxcAdecreased chemoattractant-mediated F-actin polymerization | decreased positive regulation of GTPase activity | delayed development
DBS0236121gxcB-gxcBdecreased exocytosis | aberrant cytoskeleton organisation | delayed development
DBS0350256gxcC-gxcCdelayed development
DBS0350257gxcC-/ [act15]: GFP: gxcCgxcCwild type
DBS0238825gxcDD-gxcDDaberrant streaming | delayed development
LAS105gxcKK-gxcKKdecreased socially cooperative development
DBS0350268gxcT-gxcTdecreased cell polarity | aberrant cytokinesis | decreased growth rate | aberrant CRAC localization to the plasma membrane | delayed aggregation | increased lateral pseudopod formation | aberrant regulation of GTPase activity | decreased chemotaxis to cAMP | decreased fruiting body size
DBS0350269gxcT-/ [act15]: GFP: gxcTgxcTwild type
DBS0350656hatA-/ [hatB]: hatBhatA | hatBaberrant cellular response to stress
DBS0236129hbx2-hbx2wild type
DBS0236130hbx2-hbx2wild type
DBS0236131hbx2-/ warA-hbx2 | warAincreased basal disc size | development arrests at mound stage | decreased prespore cell differentiation | increased prestalk 0 cell differentiation
DBS0350324hbx4-/ [ecmAO]: lacZhbx4increased prespore cell differentiation
DBS0236153hcpA-hcpAdecreased growth rate
DBS0236157hcpB-hcpBwild type
DBS0305109hdaB-hdaBdecreased sporulation | decreased histone deacetylase activity
HM1012helC-helCdecreased gene expression | delayed development | aberrant fruiting body morphology
HM444helC-helCdecreased gene expression | delayed development | aberrant fruiting body morphology
DG1059helE-helEincreased slug migration
DBS0236163helF-helFincreased stalk cell differentiation | increased slug size | delayed development | increased post-transciptional gene silencing by RNA
DBS0350362hfnA-hfnAincreased phototaxis | decreased slug size | increased slug migration
DBS0350363hfnA-/ [ecmO]: lacZhfnAaberrant prestalk 0 cell differentiation | aberrant slug formation
DBS0350364hfnA-/ abpC-abpC | hfnAwild type | aberrant prestalk 0 cell differentiation | decreased phototaxis
DBS0238583hipA-hipAaberrant spore morphology | decreased spore viability | aberrant spore coat morphology
DBS0305951hipA-/ epnA-epnA | hipAaberrant spore morphology | decreased spore viability
DBS0350289hspc300-/ [act15]: myc: hspc300hspc300wild type
DBS0252818hssA-hssAwild type
DBS0349776htt-httdecreased growth rate in suspension | aberrant cell separation during cytokinesis | decreased chemotaxis rate | delayed development | delayed gene expression | decreased myosin II assembly
DBS0349788htt-httaberrant aggregation | development arrests at loose mound stage | aberrant cellular response to starvation | abolished potassium-dependent chemotaxis to cAMP | aberrant spore morphology | decreased spore viability | aberrant response to hypo-osmotic stress | aberrant F-actin organization | abolished chemotaxis to calcium | abolished streaming | aberrant development | abolished culmination | multiple tips in mound | decreased sporulation | aberrant prespore cell differentiation | abolished calcium-independent cell-cell adhesion | abolished protein level
DBS0349786htt-/ [act15]: htt: GFPhttwild type | aberrant protein level
DBS0350438ibrA-ibrAaberrant contractile vacuole organization and biogenesis | aberrant substrate adhesion-dependent cell spreading | aberrant response to hypo-osmotic stress | decreased phagocytosis | decreased growth rate | aberrant cytokinesis | decreased contractile vacuole discharge
DBS0349794ibrA-ibrAaberrant stalk formation
DBS0252699icmA-icmA-1 | icmA-2abolished sporulation | aberrant signal transduction during aggregation | abolished growth | development arrests at mound stage | abolished cell polarity | abolished streaming | aberrant protein localization to nucleus | aberrant cAMP wave formation | delayed gene expression | aberrant fruiting body morphology | aberrant protein localization
DBS0252702icmA-/ [act15]: TAP: YFP: rasGicmA-1 | icmA-2 | rasGabolished C-terminal protein amino acid methylation
DBS0252701icmA-/ [act15]: hICMTicmA-1 | icmA-2wild type
DBS0252700icmA-/ [act15]: icmAicmA-1 | icmA-2wild type
DBS0236421icpA-icpAaberrant mitosis | aberrant cytokinesis | aberrant protein localization
DBS0238521icpA-/ [act15]: GFP: icpA(1-1013)icpAaberrant protein localization
BS153ifkA-ifkAincreased aggregate size | precocious aggregation | decreased extracellular counting factor component(s) level | precocious gene expression
BS161ifkA-/ ifkB-ifkA | ifkBincreased aggregate size | increased cell-cell adhesion | increased cell-substrate adhesion | aberrant fruiting body morphology | multiple tips in mound
BS160ifkB-ifkBincreased gene expression
DBS0236425ino1-ino1decreased intracellular myo-inositol level | abolished growth | decreased phagocytosis | increased intracellular 2,3-bisphosphoglycerate level | multiple tips in mound
DBS0350801ino1-ino1aberrant cellular metabolic process | increased number of autophagosomes | decreased intracellular myo-inositol level | decreased cell-substrate adhesion | abolished growth | aberrant phosphatidylinositol metabolism | aberrant cytokinesis | aberrant fruiting body morphology
DBS0266326iplA-iplAabolished cellulose biosynthesis | abolished autophagic vacuole formation | abolished autophagic cell death
HM1038iplA-iplAabolished cAMP-induced Ca2+ influx | aberrant cell motility | precocious aggregation | delayed aggregation | aberrant chemotaxis | increased chemotaxis to arachidonic acid
DBS0350439iplA-/ [act15]: GFP: iplAiplAwild type
DBS0252878iptA-iptAdecreased spore viability
DBS0350400iqgC-iqgCdecreased myosin II assembly
DBS0236031kctd9-kctd9wild type
DBS0350057keaA-keaAdecreased gene expression | delayed aggregation | decreased growth rate | aberrant cAMP signaling during aggregation | decreased intracellular cAMP level
DBS0350472kif1-kif1aberrant transport
DBS0350038kif11-kif11wild type
DBS0236489kif12-kif12aberrant myosin II organization | aberrant cytokinesis | aberrant protein localization
DBS0236490kif12-/ [act15]: FLAG: kif12kif12wild type
DBS0302534kif13-kif13decreased spindle stabilization | precocious spindle elongation
DBS0350039kif4-kif4decreased growth rate
DBS0350042kif4-/ [act15]: dhcA(1384-4725)dhcA | kif4aberrant spindle organization
DBS0350021kif5-kif5wild type
DBS0350022kif5-/ [act15]: FLAG: kif5kif5aberrant cytokinesis | aberrant cell morphology
DBS0350023kif5-/ [act15]: FLAG: kif5(342-990)kif5aberrant cell morphology
DBS0350024kif5-/ [act15]: GFP: kif5(805-990)kif5aberrant cytokinesis
DBS0236494kif7-kif7aberrant cell motility
DBS0349964kif9-kif9aberrant mitosis | decreased growth rate | aberrant centrosome localization | aberrant centromere complex assembly | aberrant protein localization | aberrant centrosome organization | aberrant spindle organization
DBS0236491kil1-kil1abolished resistance to a bacterium | aberrant defense response to yeast
DBS0350043kil2-kil2aberrant response to cation stress | abolished resistance to a bacterium | aberrant phagocytosis | decreased phagosomal proteolysis | aberrant defense response to yeast
DBS0350044kil2-/ [act15]: kil1kil1 | kil2abolished resistance to a bacterium
DBS0236492krsA-krsAdecreased chemotaxis to cAMP
DBS0238720krsA-krsAaberrant response to hyperosmotic stress | precocious culmination | abolished activation of adenylate cyclase | decreased aggregate size | decreased intracellular cAMP level | precocious gene expression | abolished streaming | decreased cell size
DBS0236493krsA-/ [act15]: GFP: krsAkrsAwild type
DBS0238721krsA-/ [act15]: GFP: krsAkrsAwild type
DBS0238722krsA-/ [act15]: GFP: krsA(K49R)krsAaberrant streaming
DBS0238723krsA-/ [act15]: GFP: krsA(T173A)krsAabolished streaming
DBS0238725krsA-/ [act15]: GFP: krsA(deltaC)krsAaberrant streaming
DBS0238724krsA-/ [act15]: GFP: krsA(deltaKinase)krsAabolished streaming
DBS0238726krsA-/ [act15]: GFP: krsA(deltaNS)krsAabolished streaming
DBS0350598krsB-krsBaberrant streaming | decreased cell motility | increased cell-substrate adhesion | delayed development | decreased chemotaxis to cAMP
DBS0350599krsB-/ [tet]: krsB(T176A): GFPkrsBaberrant streaming
DBS0350600krsB-/ krsA-krsA | krsBaberrant streaming | delayed development
DBS0236495ku80-ku80increased sensitivity to DNA-damaging agents | decreased double strand break repair | decreased DNA mediated transformation
DBS0350536ku80-/ dclre1-dclre1 | ku80wild type
DBS0350537ku80-/ myc: ku80(1-782)ku80decreased DNA mediated transformation
DBS0236498lagD-tgrD1aberrant aggregation | aberrant cAMP signaling during aggregation | abolished streaming
DBS0236499limB-limBdecreased cell polarity | decreased cell-substrate adhesion | decreased gene expression | development arrests at mound stage | aberrant F-actin organization | aberrant cell-cell adhesion | decreased chemotaxis rate | abolished sorting to prestalk region | delayed gene expression
DBS0236502limB-/ [act15]: paxB: GFPlimB | paxBdevelopment arrests at mound stage
DBS0236500limB-/ [cotC]: limBlimBdevelopment arrests at mound stage
DBS0236501limB-/ [ecmAO]: limBlimBwild type
DBS0236729limB-/ paxB-limB | paxBdevelopment arrests at mound stage
DBS0350563limC-limCdelayed aggregation | decreased growth rate | aberrant cytokinesis | aberrant response to osmotic stress
DBS0350564limD1-limD1decreased cell polarity | delayed aggregation | decreased growth rate | aberrant F-actin organization | aberrant cytokinesis | increased lateral pseudopod formation | aberrant response to osmotic stress | decreased chemotaxis to cAMP
DBS0350565limD1-/ limC-limC | limD1decreased cell polarity | abolished growth | delayed aggregation | aberrant F-actin organization | aberrant cytokinesis | aberrant response to osmotic stress | decreased chemotaxis to cAMP
DBS0236503limE-limEaberrant cytokinesis
DBS0236506limF-limFdecreased phagocytosis
DBS0236511lipA-lipAwild type
DBS0236512lipA-lipAwild type
DG1006lipA-lipAabolished culmination
DG1056lipB-captCaberrant fruiting body morphology
DBS0236515lis1(D327H)lis1aberrant microtubule cytoskeleton organization | increased basal phosphorylated actin level | aberrant Golgi localization
DBS0349950lmbd2B-lmbd2Bincreased pseudopod formation | aberrant chemotaxis | delayed development | aberrant cell morphology
DBS0349982lmnB-lmnBaberrant chromatin assembly | aberrant centrosome localization
DBS0350354lmpA-lmpAdecreased fruiting body size | decreased sporulation
DBS0350452lpten-lptenaberrant cell motility | decreased lateral pseudopod suppression
DBS0350453lpten-/ [act15]: lpten: RFPlptenwild type
DBS0236516lrrA-lrrAdecreased cell polarity | increased aggregate size | decreased cell-substrate adhesion | increased basal F-actin level | decreased spore viability | decreased gene expression | development arrests at mound stage | abolished positive chemotaxis | abolished aggregation | aberrant cell morphology | delayed gene expression
DBS0350407lrrB-lrrBaberrant thermotaxis | delayed slug formation | decreased gene expression | aberrant culminant morphology | aberrant gene expression | aberrant phototaxis | aberrant development
DBS0350478lrrB-/ [ecmB]: lacZlrrBaberrant prestalk B cell differentiation
DBS0350476lrrB-/ [ecmO]: lacZlrrBaberrant prestalk 0 cell differentiation
DBS0236517lst8-lst8decreased F-actin polymerization | aberrant activation of adenylate cyclase activity | decreased chemotaxis rate | abolished aggregation | decreased myosin II assembly
DBS0350106lst8-lst8increased phagocytosis
DBS0350114lst8-/ [act15]: GFP: rheb(Q64L)lst8 | rhebincreased phagocytosis
AD60lvsA-lvsAaberrant contractile vacuole organization and biogenesis | abolished cytokinesis | decreased pinocytosis | aberrant response to hypo-osmotic stress | decreased phagocytosis | increased cell-substrate adhesion
AD63lvsA-lvsAabolished cytokinesis | abolished cAMP-induced Ca2+ influx
DBS0237207lvsA-/ [act6]: GFP: lvsA(1828- 3619)lvsAabolished cytokinesis
DBS0236521lvsB-lvsBincreased secretion of lysosomal enzyme | increased lysosome size | increased exocytosis | aberrant post-lysosome organization and biogenesis | increased pinocytosis | aberrant protein localization
DBS0350567lvsB-/ [act15]: FLAG: Rab14(N121I)lvsB | rab14wild type
DBS0238218lvsB-[act6]: TAP: GFP: lvsBlvsBwild type
DBS0236522lvsC-lvsCwild type
DBS0236523lvsD-lvsDwild type
DBS0236524lvsE-lvsEwild type
DBS0236525lvsF-lvsFwild type
DBS0349933macA-macAaberrant macrocyst differentiation | decreased sexual fusion
DBS0236536malA-malAwild type
DBS0350211mef2A-mef2Aaberrant streaming | decreased growth rate | aberrant development | decreased sporulation
DBS0350212mef2A-mef2Aaberrant streaming | decreased growth rate | aberrant gene expression | aberrant development | decreased sporulation
DBS0350213mef2A-/ [ecmA]: lacZmef2Aaberrant prestalk A cell differentiation
DBS0350214mef2A-/ [ecmB]: lacZmef2Aaberrant prestalk B cell differentiation
DBS0350215mef2A-/ [pspA]: lacZmef2Adecreased prespore cell differentiation
DBS0236543mekA-mekAdecreased aggregate size | precocious development | abolished chemotaxis to cAMP
DBS0350030mekA-/ [act15]: Myc: erkAerkA | mekAabolished protein localization to cell cortex
DBS0350036mekA-/ [act15]: mekA(299-360)mekAdecreased aggregate size
DBS0350035mekA-/ [act15]: mekA(K321A)mekAdecreased aggregate size
DBS0350032mekA-/ [act15]: mekA(S444A/ T448A)mekAdecreased aggregate size
DBS0350031mekA-/ [act15]: mekA(S444E/ T448E)mekAdevelopment arrests at mound stage
DBS0238098mekA-/ ppp4C-mekA | ppp4cdecreased aggregate size
DBS0238109mekA-/ ppp4C-/ [act15]: FLAG: pppCppp4cdecreased aggregate size | precocious development
DBS0236542mekA-/ smkA-mekA | smkAdecreased aggregate size
DBS0236544mfeA-mfeAdecreased protein level | development arrests at mound stage | aberrant cAMP signaling during aggregation
DBS0266843mgp1-mgp1aberrant contractile vacuole organization and biogenesis | increased phototaxis | increased filopodium formation | decreased cell motility | decreased fruiting body size | abolished streaming | decreased stalk width | decreased stalk length
DBS0266846mgp1-/ mgp2-mgp1 | mgp2aberrant contractile vacuole organization and biogenesis | increased filopodium formation | aberrant culmination | decreased cell motility | decreased phototaxis | decreased stalk length
DBS0266844mgp2-mgp2increased aggregate size | increased slug size
HS1mhcA-mhcAaberrant response to hypo-osmotic stress | development arrests at mound stage | aberrant cytokinesis | decreased growth rate | increased F-actin polymerization | aberrant regulation of GTPase activity | aberrant regulation of protein kinase activity
HS2205mhcA-mhcAabolished cell motility | decreased cell motility
HS2207mhcA-mhcAabolished cytokinesis | development arrests at mound stage
DBS0350064mhcA-mhcAdecreased cell polarity | decreased cell motility
HS2206mhcA-mhcAabolished bleb formation
HK321mhcA-mhcAaberrant cell morphology
HK323mhcA-mhcAdecreased cell motility
DBS0266674mhcA-/ [act15]: GFP: abpC(9-148)abpC | mhcAdecreased uropod retraction | decreased pseudopod retraction
DBS0237564mhcA-/ [act15]: GFP: ctxA/ [RNAi]enlActxA | enlA | mhcAaberrant cytokinesis, contractile ring contraction
DBS0266675mhcA-/ [act15]: GFP: mhcA(E476K)mhcAdecreased pseudopod retraction
DBS0350489mhcA-/ [act15]: GFP: mhcA/ [RNAi]rmd1mhcA | rmd1aberrant protein localization
DBS0236548mhcA-/ [act15]: GFP: pats1(2087-2351)mhcA | pats1aberrant cytokinesis
DBS0350291mhcA-/ [act15]: gppA: GFPgppA | mhcAaberrant contractile vacuole morphology | decreased contractile vacuole discharge
DBS0236549mhcA-/ [act15]: limE(1-145): GFPlimE | mhcAincreased F-actin polymerization
DBS0350808mhcA-/ [act15]: mhcA(1-933: 1455-2116]mhcAwild type | aberrant cytokinesis | aberrant fruiting body morphology
DBS0238158mhcA-/ [act15]: mhcA(81-2116)mhcAdecreased growth rate | development arrests at tipped mound stage
CW0401mhcA-/ [act15]: mhcA(T1823A/ T1833A/ T2029A)mhcAdecreased growth rate in suspension | increased myosin II assembly | aberrant chemotaxis
DBS0236550mhcA-/ [act15]: mhcA(T1823A/ T1833A/ T2029A)mhcAdecreased filopodium formation
DBS0236551mhcA-/ [act15]: mhcA(T1823D/ T1833D/ T2029D)mhcAincreased filopodium formation
DBS0238399mhcA-/ [act15]: rapA(G12V)mhcA | rapAincreased basal F-actin level | aberrant myosin II organization | increased cell polarity
DBS0236552mhcA-/ [mhcA]: mhcA(1-1224)mhcAaberrant cytokinesis | development arrests at mound stage
DBS0238157mhcA-/ [mhcA]: mhcA(1-1224)/ [act15]: mhcA(R689H)mhcAdecreased actin filament sliding
DBS0236547mhcA-/ [unk]: GFP: icpAicpA | mhcAaberrant protein localization
DBS0350668mhcA-/ forA-forA | mhcAabolished cell motility | decreased cell motility
CW0371mhkA-mhkAincreased myosin II assembly | aberrant chemotaxis | decreased cell motility | aberrant protein localization to pseudopodium
DBS0236557mhkA-/ [act15]: mhkAmhkAdecreased growth rate | development arrests at mound stage | aberrant cytokinesis | decreased myosin II assembly
CW0431mhkA-/ mhkB-/ mhkC-mhkA | mhkB | mhkCdecreased growth rate in suspension | increased myosin II assembly | aberrant cytokinesis | aberrant chemotaxis | decreased cell motility
DBS0236556mhkA-/ mhkC-mhkA | mhkCincreased myosin II assembly | decreased growth rate | aberrant cytokinesis
CW0394mhkA/ mhkBmhkA | mhkBdecreased growth rate in suspension | increased myosin II assembly | aberrant cytokinesis
CW0166mhkB-mhkBincreased myosin II assembly | decreased cell motility
CW0403mhkC-mhkCincreased myosin II assembly | aberrant cytokinesis | aberrant chemotaxis
DG1069mhkC-mhkCaberrant fruiting body morphology
CW0435mhkD-mhkDincreased myosin II assembly | decreased cell motility
DBS0236559midA-midAdecreased pinocytosis | aberrant spore morphology | decreased thermotaxis | increased autophagy | decreased mitochondrial fission | decreased growth rate | decreased phagocytosis | increased intracellular glutamate level | decreased intracellular glycogen level | increased extracellular ammonia level | increased slug migration | decreased cell size | decreased phototaxis
DBS0350123midA-/ [act15]: GFP: atg18atg18 | midAincreased number of autophagosomes
DBS0350136midA-/ [act15]: GFP: tktmidA | tkt-1 | tkt-2increased autophagy
DG1020migA-migAabolished slug migration | decreased fruiting body size | aberrant fruiting body morphology
DBS0350025mip1-mip1-1 | mip1-2increased aggregate size | decreased chemotaxis to cAMP
DBS0350027mip1-/ [act15]: mekA: FLAGmekA | mip1-1 | mip1-2aberrant protein localization to cytoplasm
DBS0266620mipp1-mipp1aberrant inositol phosphate metabolic process | increased response to lithium
DBS0309109mipp1-/ dpoA-dpoA | mipp1aberrant inositol phosphate metabolic process | increased response to lithium
DBS0236560mkcA-mkcAdecreased gene expression
DBS0236561mkcA-/ tagB-mkcA | tagBdecreased sporulation
DBS0236562mkcA-/ tagC-mkcA | tagCdecreased sporulation
DG1101mkcB-mkcBdecreased fruiting body size
DBS0236564mkkA-mkkAprecocious culmination | decreased sorus size | increased stalk length
DG1121mkpA-mkpAabolished aggregation
DBS0236566mlcE-mlcEdecreased growth rate in suspension | aberrant cytokinesis | delayed aggregation | decreased cell motility | mislocalized gene expression | aberrant development
DBS0238058mlcE-/ [act15]: myc: mlcEmlcEwild type
DBS0236567mlcR-mlcRaberrant myosin II organization | aberrant cytokinesis | development arrests at mound stage
HS183mlkA-mlkAaberrant cytokinesis
DBS0349919mlkA-/ [act15]: GFP-mhcAmlkAaberrant stalk morphogenesis
DG1033modA-modAabolished catalytic activity | aberrant fruiting body morphology
DBS0266903mpl1-mpl1decreased cell motility | decreased chemotaxis to cAMP | abolished streaming | abolished aggregation
DBS0266904mpl1-/ [act15]: flag: mpl1mpl1wild type
DBS0349986mrfA-mrfAaberrant slug migration | delayed development
DBS0350391mrfA-/ [act15]: myc: mrfA(K772A): FLAGmrfAaberrant protein modification
DBS0350390mrfA-/ [act15]: myc: mrfA(S767A): FLAGmrfAaberrant protein modification | delayed development
DBS0350389mrfA-/ [act15]: myc: mrfA: FLAGmrfAwild type
DBS0349987mrfA-/ [emcA]: lacZmrfAdecreased prestalk A cell differentiation
DBS0349988mrfA-/ dimB-/ [emcA]: lacZdimB | mrfAdecreased prestalk A cell differentiation
DBS0236569mrps4-mrps4delayed aggregation | aberrant fruiting body morphology
DBS0304881mrps4-mrps4delayed aggregation
DBS0304882mtDNA-DidioMp05 | DidioMp21 | DidioMp26 | DidioMp27 | DidioMp30 | DidioMp35 | DidioMp36 | ai2a | ai2b | ai3 | ai4 | atp1 | atp4 | atp6 | atp8 | atp9 | cox1/ 2 | cox3 | cytB | mrpl11 | mrpl14 | mrpl16 | mrpl2 | mrpl6 | mrps12 | mrps13 | mrps14 | mrps19 | mrps2 | mrps4 | mrps7 | mrps8 | nad1 | nad11 | nad2 | nad3 | nad4 | nad4L | nad5 | nad6 | nad7 | nad9 | rnlAabolished growth | abolished aggregation
HM1464mus81-mus81wild type
DBS0236570mybB-mybBdecreased cAMP-induced cGMP pulse | decreased gene expression | decreased activation of adenylate cyclase | abolished aggregation | decreased cAMP-induced cAMP pulse
DBS0236571mybB-mybBabolished aggregation
HM388mybC-mybCdecreased SDF production | decreased gene expression | abolished culmination
DBS0236572mybE-mybEincreased gene expression | increased slug size | abolished outer basal disc formation
DBS0349993mybE-/ [btg]: lacZbtg | mybEincreased gene expression
DBS0237709mybE-/ [mrrA]: lacZmrrA | mybEaberrant prestalk cell differentiation
DBS0236573mybE-/ mybE: GFPmybEwild type | aberrant prestalk cell differentiation
HDT1myoA-myoAdelayed aggregation | decreased cell motility | decreased chemotaxis rate | decreased lateral pseudopod suppression
HDT2myoA-myoAincreased secretion of lysosomal enzyme
HDT5myoA-/ myoBmyoA | myoBdecreased pinocytosis | decreased growth rate in suspension | aberrant cytoskeleton organisation | increased secretion of lysosomal enzyme | decreased cell motility | decreased fruiting body size
DBS0236579myoB-myoBincreased secretion of lysosomal enzyme
DBS0236580myoB-myoBdecreased phagocytosis | delayed aggregation | decreased cell motility | decreased lateral pseudopod suppression
DBS0349853myoB-myoBdecreased phagolysosome size | aberrant phagosome maturation | delayed phagosome re-neutralization
DBS0236583myoB-/ [AS]myoDmyoB | myoDdecreased pinocytosis | aberrant aggregation | decreased growth rate | decreased phagocytosis | decreased cell motility | decreased aggregate size
DBS0236584myoB-/ [AS]myoD/ [KD]myoCmyoB | myoC | myoDsmall pinosomes | decreased pinocytosis | aberrant aggregation | decreased growth rate | decreased phagocytosis | decreased cell motility | increased number of pinosomes | decreased aggregate size
HDT6myoB-/ myoC-myoB | myoCincreased secretion of lysosomal enzyme | decreased growth rate in suspension | aberrant cytoskeleton organisation | decreased fruiting body size
DBS0236585myoC-myoCdecreased phagocytosis
DBS0236587myoD-myoDwild type
HDT8myoF-myoFwild type
DBS0350251myoG-myoGdecreased protein localization to plasma membrane | decreased F-actin polymerization | aberrant chemotaxis to cAMP | abolished cell polarity | abolished aggregation
DBS0236589myoI-myoIdecreased spore germination
DBS0236592myoI-myoIdecreased cell-substrate adhesion | aberrant cytokinesis | decreased phagocytosis | aberrant cell morphology
HDT15myoI-myoIdecreased phagocytosis
HDT17myoI-myoIdecreased cell-cell adhesion | decreased protein level | decreased cell-substrate adhesion | decreased phagocytosis | decreased filopodium formation
DBS0266889myoI-/ [act15]: GFP: myoImyoIwild type
DBS0266890myoI-/ [act15]: GFP: myoI(809-1154)myoIdecreased phagocytosis
DBS0237617myoI-/ [act15]: gbpDgbpD | myoIincreased pseudopod formation | increased cell-substrate adhesion | aberrant cell morphology
HTD7myoJ-myoJwild type
DBS0349844myoK-myoKaberrant cortical actin cytoskeleton stabilization | delayed aggregation | decreased phagocytosis | aberrant engulfment during phagocytosis | decreased chemotaxis rate | aberrant cell morphology
DBS0349846myoK-/ [act15]: YFP: myoK(1-121: 262-858)myoKdecreased phagocytosis
DBS0349850myoK-/ [act15]: myoKmyoKincreased phagocytosis
DBS0349854myoK-/ [act15]: pakB(1-337: 563-852)myoK | pakBwild type
DBS0236595myoM-myoMwild type
SB12napA-napAdecreased cell-cell adhesion | decreased cell polarity | decreased cell-substrate adhesion | decreased cell motility | decreased basal F-actin level | decreased cell size | decreased phototaxis
SB14napA-/ pirA-napA | pirAdecreased basal F-actin level
HC476ncsA-ncsAincreased intracellular cAMP level | precocious gene expression | precocious development
HC477ncsA-ncsAincreased intracellular cAMP level | precocious gene expression | precocious development
DBS0350297ncstn-ncstnaberrant culmination | abolished catalytic activity | decreased prespore cell differentiation
DBS0350307ncstn-ncstnwild type
DBS0350301ncstn-/ psenA-ncstn | psenAaberrant culmination | decreased prespore cell differentiation
DBS0349947ndm-ndmaberrant chemotaxis | increased pinocytosis | decreased fruiting body size | aberrant pseudopod formation
DBS0349895ndrA-ndrAdecreased engulfment during phagocytosis
DBS0349896ndrA-/ [unk]: GFP: ndrAndrAwild type
DBS0350446ndrC-ndrCincreased positive regulation of GTPase activity | increased number of centrosomes | aberrant cell separation during cytokinesis
DBS0350121ndufaf5-ndufaf5aberrant spore morphology | decreased growth rate | delayed development | aberrant phototaxis | spores inviable | decreased fruiting body size
DBS0350125ndufaf5--/ [act15]: ndufaf5(G86V): GFP: TAPndufaf5decreased growth rate
DBS0350126ndufaf5--/ [act15]: ndufaf5(L165F): GFP: TAPndufaf5decreased growth rate
DBS0350127ndufaf5--/ [act15]: ndufaf5(L235P): GFP: TAPndufaf5decreased growth rate
DBS0350124ndufaf5--/ [act15]: ndufaf5: GFP: TAPndufaf5wild type
DBS0350122ndufaf5-/ [act15]: GFP: atg18atg18 | ndufaf5increased number of autophagosomes
DBS0350134ndufaf5-/ [act15]: GFP: tktndufaf5 | tkt-1 | tkt-2increased autophagy
DBS0350137ndufaf5-/ [act15]: [AS]snfAndufaf5 | snfAaberrant phototaxis
DBS0304633nfaA-nfaAincreased pseudopod formation | increased chemoattractant-mediated F-actin polymerization | increased basal F-actin level | delayed aggregation | decreased cell motility | aberrant cAMP signaling during aggregation | aberrant regulation of GTPase activity | aberrant regulation of protein kinase activity | aberrant protein localization to plasma membrane | decreased chemotaxis to cAMP
DBS0304634nfaA-/ rasG-nfaA | rasGdecreased cell polarity
DBS0236604nhe1-nhe1abolished potassium-dependent chemotaxis to cAMP | decreased intracellular pH level | decreased cell polarity | decreased F-actin polymerization | aberrant F-actin organization | abolished chemotaxis to calcium | decreased chemotaxis rate | delayed development | abolished cell polarity | abolished chemotaxis to cAMP
DBS0350003nhe1-/ [act15]: GFP: aip1aip1 | nhe1decreased cell polarity | decreased chemotaxis to cAMP
DBS0350006nhe1-/ [act15]: GFP: aip1(E125A, E167A, F181A, F193A)aip1 | nhe1abolished aggregation | abolished chemotaxis to cAMP
DBS0350001nhe1-/ [act15]: aip1(168-597)aip1 | nhe1delayed development
DBS0350002nhe1-/ [act15]: aip1(383-597): FLAGaip1 | nhe1decreased F-actin polymerization | abolished cell polarity | abolished chemotaxis to cAMP
DBS0349841nhe1-/ [act15]: mhcA: GFPmhcA | nhe1aberrant protein localization
DBS0236605nhe1-/ [act15]: nhe1: HAnhe1wild type
DBS0350508nlp-nlpwild type
DBS0350509nlp-/ slp-nlp | slpdecreased F-actin polymerization | aberrant organelle organization and biogenesis | abolished protein localization | decreased chemotaxis to cAMP
DBS0236606nosA null (15-S-12)nosAdevelopment arrests at mound stage
DBS0236607nosA null (2E4)nosAdevelopment arrests at mound stage
DBS0235950nosA-nosAdevelopment arrests at mound stage | aberrant protein modification
DBS0236608noxA-noxAabolished sporulation | aberrant development
DBS0236611noxA-/ [act15]: noxA: myc2noxAaberrant fruiting body morphology
DBS0236610noxA-/ noxBnoxA | noxBabolished sporulation | decreased superoxide production | aberrant development
DBS0350768noxA-/ noxB-/ noxC-noxA | noxB | noxCaberrant defense response to bacterium
DBS0236612noxB-noxBabolished sporulation | decreased superoxide production | aberrant development
DBS0236613noxC-noxCabolished sporulation | aberrant development
DBS0238849npcA-npcAwild type
DBS0236695nramp1-nramp1increased infection rate by Mycobacterium avium | increased infection rate by Legionella pneumophila | abolished iron ion transport
DBS0236696nramp1-/ [act15]: nramp1: GFPnramp1decreased infection rate by Legionella pneumophila
DBS0236697nramp1-/ [act15]: nramp1: GFPnramp1decreased infection rate by Legionella pneumophila
DBS0350092nramp2-nrampBdelayed aggregation | increased infection rate by Legionella pneumophila
DBS0350093nramp2-/ nramp1-nramp1 | nrampBdelayed aggregation | increased infection rate by Legionella pneumophila | multiple tips
HM1060nsfA(A1847G, A1939T, T1977C, T2005G, A2025T, A2366T)nsfAdecreased rate of endocytosis | decreased phagocytosis | decreased F-actin polymerization at the leading edge | abolished cell motility
HM1067nsfA(A1854T, T1984A, C2131A, A2398T, T2574A)nsfAdecreased rate of endocytosis | abolished cell motility | decreased F-actin polymerization at the leading edge | decreased cell motility | increased phagocytosis
DBS0350196nsfA(A1854T, T1984A, C2131A, A2398T, T2574A)nsfA | pkaCabolished SDF production
DBS0236955nxnA-nxnAdecreased culmination | decreased growth rate | delayed development | decreased chemotaxis to cAMP | decreased lysosomal enzyme activity
DBS0236702nxnA-/ [act15]: GFP: nxnB nxnA | nxnBdevelopment arrests at mound stage
DBS0350857odc-odcabolished growth | aberrant cell cycle
DBS0236704osbA-osbAincreased slug migration | precocious development
DBS0238357p2xA-p2xAaberrant response to hypo-osmotic stress
DBS0304487p2xA-p2xAwild type
DBS0350312p2xA-p2xAaberrant contractile vacuole organization and biogenesis | abolished response to hypo-osmotic stress | decreased contractile vacuole size | aberrant regulation of GTPase activity
DBS0350484p2xA-/ AX2p2xAwild type | aberrant contractile vacuole discharge
DBS0350485p2xA-/ AX4p2xAaberrant contractile vacuole discharge | aberrant response to hypo-osmotic stress
DBS0238362p2xA-/ [act15]: p2xA: GFPp2xAwild type
DBS0350315p2xA-/ p2xA(K67A/ K289A)p2xAabolished response to hypo-osmotic stress
DBS0350314p2xA-/ p2xA(R285K)p2xAdecreased response to hypo-osmotic stress
DBS0350313p2xA-/ p2xA(R63A)p2xAprecocious response to hypo-osmotic stress
DBS0306169p2xA-/ p2xB-/ p2xC-/ p2xD-/ p2xE-p2xA | p2xB | p2xC | p2xD | p2xEdelayed response to hypo-osmotic stress | decreased growth rate
DBS0306166p2xB-p2xBwild type
DBS0306167p2xC-p2xCwild type
DBS0306168p2xD-p2xDwild type
DBS0304486p2xE-p2xEwild type
DBS0304465padA(1-276)padAaberrant streaming | aberrant aggregation | decreased cell-cell adhesion | decreased gene expression | development arrests at slug stage | delayed aggregation | aberrant stalk cell differentiation | aberrant chemotaxis to cAMP | delayed development | aberrant fruiting body morphology
DBS0350013pah-pahabolished growth | abolished catalytic activity
DBS0350014pah-/ [act15]: 6xHis: pahpahwild type
DBS0350016pah-/ [act15]: 6xHis: pah(92-415)pahabolished growth
DBS0350015pah-/ [act15]: 6xHis: pah(92-441)pahwild type
DBS0236705pakA-pakAaberrant cytokinesis | delayed development | decreased myosin II assembly
DBS0236706pakA-pakAwild type
DBS0349885pakA-pakAdelayed development | decreased chemotaxis to cAMP
DBS0236707pakA-/ [act15]: pakApakAwild type
DBS0350810pakA-/ [act15]: pakA(T579A)pakAdecreased chemotaxis to cAMP
DBS0349889pakA-/ [act15]: pakA: GFPpakAwild type
DBS0236709pakB-pakBdecreased growth rate
DBS0236712pakB-/ [act15]: GFP-pak(1-600)pakBabolished cytokinesis
DBS0236710pakB-/ [act15]: GFP-pakB(1-337: 563-851)pakBabolished cytokinesis | increased pinocytosis | increased phagocytosis
DBS0350428pakB-/ [act15]: RFP: abpEabpE-1 | abpE-2 | pakBaberrant establishment and/ or maintenance of cell polarity | decreased chemotaxis to cAMP | abolished aggregation | aberrant protein localization
DBS0350430pakB-/ [act15]: RFP: abpE/ [act15]: GFP: pak(1-180)abpE-1 | abpE-2 | pakBwild type
DBS0236715pakB-/ pakC-pakB | pakCdecreased chemotaxis rate
DBS0236719pakC(R34C)pakCdecreased chemotaxis rate | decreased lateral pseudopod suppression
DBS0236720pakC(S466A/ P470A)pakCdecreased chemotaxis rate | decreased lateral pseudopod suppression
DBS0350281pakD-pakDaberrant F-actin polymerization | aberrant actin cytoskeleton organization | aberrant establishment and/ or maintenance of cell polarity | aberrant vegetative growth | abolished aggregation | decreased chemotaxis to cAMP
DBS0350282pakD-/ [act15]: pakDpakDdevelopment arrests at mound stage
DBS0350395pakD-/ [act15]: pakD: GFPpakDwild type
HC392patB-patBabolished growth
DBS0236726pats1-pats1aberrant cytokinesis
DBS0350097pats1-pats1aberrant cytokinesis
LAS45pats1-pats1decreased socially cooperative development
DBS0236727pats1-/ [act15]: GFP: pats1(2087-2351)pats1aberrant cytokinesis
DBS0236728paxB-paxBdecreased exocytosis | decreased cell-substrate adhesion | decreased gene expression | abolished slug migration | increased chemotaxis to cAMP | development arrests at mound stage | decreased sorting to prestalk region | aberrant fruiting body morphology | increased phagocytosis
DBS0304926paxB-paxBaberrant cell separation during cytokinesis | decreased cell-substrate adhesion | aberrant cytokinesis | decreased cell motility
DBS0304930paxB-/ [act15]: GFP: paxBpaxBwild type
DBS0350094paxB-/ [act15]: pldBpaxB | pldBwild type | increased phagocytosis
DBS0236730paxB-/ [ecmA]: paxB: GFPpaxBdecreased sorting to prestalk region
DBS0236732paxB-/ [pspA]: paxB: GFPpaxBdecreased sorting to prestalk region
DBS0304929paxB-/ mhcA-mhcA | paxBaberrant cytokinesis
DBS0236733pcp-pcpwild type | aberrant response to hypo-osmotic stress
DBS0236734pde4-pde4decreased culmination | multiple tips in culminant | delayed slug formation | delayed culmination
DBS0236735pde4-/ [act15]: pde4: GFPpde4wild type
DBS0236736pdeD-pdeDdecreased cAMP-induced Ca2+ influx | delayed cAMP-induced Ca2+ influx | decreased Ca2+-induced Ca2+ influx
DBS0350517pdeD-pdeDdecreased 3',5'-cyclic-GMP phosphodiesterase activity | aberrant streaming | increased fruiting body size
DBS0350518pdeD-/ [act15]: pdeD: YFPpdeDwild type
DBS0350797pdkA-pdkAdecreased protein kinase activation
DBS0350817pdkA-pdkAdecreased aggregate size | decreased protein kinase activation
DBS0350799pdkA-/ pdkB-pdkA | pdkBdecreased cell polarity | aberrant chemotaxis to cAMP | development arrests at mound stage | decreased protein kinase activation
DBS0350819pdkA-/ pdkB-pdkA | pdkBaberrant development
DBS0350818pdkB-pdkBdecreased aggregate size
DBS0237029pdsA-pdsAaberrant streaming | aberrant chemotaxis to cAMP
UK7pdsA-pdsAdecreased 3',5'-cyclic-AMP phosphodiesterase activity | decreased gene expression | abolished aggregation | aberrant development
HPX235pdsA-pdsAabolished catalytic activity | abolished aggregation
DBS0236741pefA-pefAwild type
DBS0236742pefA-/ pefB-pefA | pefBwild type
DBS0236744pefB-pefBwild type
DBS0236745pefB-/ cybA-cybA | pefBwild type
DBS0236746pefB-/ noxA-noxA | pefBwild type
DBS0236747pefB-/ noxA-/ [act15]: pefBnoxA | pefBaberrant development
DBS0236748pefB-/ noxB-noxB | pefBwild type
DBS0236749pefB-/ noxC-noxC | pefBabolished sporulation | aberrant development
HW260pgtA-pgtAincreased cell size
DBS0305022pgtB-pgtBaberrant cellular metabolic process | aberrant response to hyperosmotic stress | aberrant spore coat morphology
DBS0305024pgtB-/ pgtC-pgtB | pgtCaberrant cellular metabolic process | aberrant response to hyperosmotic stress | aberrant spore coat morphology
DBS0305023pgtC-pgtCaberrant cellular metabolic process | aberrant response to hyperosmotic stress
DBS0236752phdA-phdAdecreased basal F-actin level | decreased aggregate size | decreased chemotaxis rate | decreased fruiting body size
DBS0236753phdA-/ [act15]: phdAphdAwild type
DBS0236754phdA-/ [act15]: phdA: GFPphdAwild type
DBS0236755phg1A-phg1Aincreased secretion of lysosomal enzyme | decreased protein level | decreased cell-substrate adhesion | abolished resistance to a bacterium | decreased gene expression | aberrant cytokinesis | decreased phagocytosis | decreased growth rate | development arrests at slug stage | decreased protein localization to cell surface | aberrant phagocytosis | increased lysosomal pH | decreased protein stabilization | decreased lysosomal enzyme activity
DBS0236757phg1A-/ [act15]: kil1kil1 | phg1Aincreased secretion of lysosomal enzyme | wild type | increased lysosomal pH | decreased protein stabilization | decreased lysosomal enzyme activity
DBS0304869phg1A-/ [act15]: phg1A(1-276): phg1B221-587)phg1A | phg1Bdecreased phagocytosis
DBS0304868phg1A-/ [act15]: phg1Bphg1A | phg1Bincreased secretion of lysosomal enzyme | wild type | decreased cell-substrate adhesion | aberrant protein level | decreased phagocytosis
DBS0304870phg1A-/ [act15]: phg1B(1-220): phg1a(277-642)phg1A | phg1Bdecreased phagocytosis
DBS0304872phg1A-/ phg1B-phg1A | phg1Bincreased secretion of lysosomal enzyme | decreased cell-substrate adhesion | decreased phagocytosis | decreased growth rate | development arrests at tipped mound stage | abolished culmination
DBS0304866phg1B-phg1Bincreased secretion of lysosomal enzyme | decreased protein level | decreased phagocytosis | decreased growth rate | abolished culmination
DBS0236758phg2-phg2decreased cell-substrate adhesion | decreased phagocytosis | aberrant cytokinesis | aberrant F-actin organization | decreased cell motility | aberrant response to nutrients | aberrant cell morphology | precocious development | precocious gene expression
DBS0238400phg2-phg2increased filopodium formation | increased basal F-actin level | increased cell-substrate adhesion | decreased chemotaxis to cAMP | aberrant cell morphology | increased phagocytosis
DBS0350578phg2-phg2abolished gene expression | decreased protein phosphorylation | aberrant protein localization to nucleus
DBS0236760phg2-/ [act15]: GFP: phg2(199-1389)phg2decreased phagocytosis
DBS0237615phg2-/ [act15]: gbpDgbpD | phg2increased pseudopod formation | aberrant cell morphology | abolished chemotaxis to cAMP
DBS0350580phg2-/ [act15]: myc: ptpCphg2 | ptpCabolished protein phosphorylation
HG1648phgA-phgAaberrant contractile vacuole organization and biogenesis | aberrant response to hypo-osmotic stress
DBS0302610phgA-/ [OE]: disgorginDDB_G0280955 | phgAaberrant contractile vacuole organization and biogenesis
DBS0236761phgA-/ lvsA-/ [act6]: GFP: lvsAlvsA | phgAaberrant protein localization
DBS0236762phlp1-phlp1decreased cAMP-induced cGMP pulse | aberrant regulation of protein modification | decreased growth rate | abolished positive chemotaxis | abolished aggregation | decreased cAMP-induced cAMP pulse | aberrant protein localization
DBS0236763phlp1-/ [OE]: phpl1phlp1wild type
DBS0236764phlp3-phlp3wild type
DBS0350824phr-phraberrant chemotaxis to cAMP | delayed development
HW288phyA-phyAabolished sporulation | decreased peptidyl-proline hydroxylation | abolished stalk formation | abolished culmination
DBS0266771phyA-/ [ecmA]: phyA(D132N): mycphyAdecreased peptidyl-proline hydroxylation
DBS0266770phyA-/ [ecmA]: phyA(R276A): mycphyAabolished peptidyl-proline hydroxylation | abolished culmination
DBS0236767pia-piaAaberrant activation of adenylate cyclase activity
HSB1piaA(G917D)piaAdecreased activation of adenylate cyclase | abolished aggregation
DBS0236769piaA(G917D)/ [act15]: piaApiaAdelayed aggregation
DBS0236770piaA-piaAaberrant cytokinesis
DBS0236771piaA-piaAabolished aggregation | decreased myosin II assembly | increased phagocytosis
DBS0304637piaA-piaAdecreased cell polarity | decreased cell motility | decreased chemotaxis rate | aberrant protein tyrosine phosphorylation
DBS0349879piaA-piaAdecreased protein phosphorylation | decreased protein kinase activity | abolished protein phosphorylation | decreased chemotaxis to cAMP | aberrant protein localization to plasma membrane | increased activation of GTPase activity
DBS0236772pikA-pikAwild type
DBS0236766pikA-/ pikB-pikA | pikBaberrant negative chemotaxis | abolished protein localization to plasma membrane | aberrant chemotaxis to cAMP | decreased cell motility | abolished protein kinase activation | abolished protein localization | decreased basal F-actin level | decreased chemotaxis to folate | decreased chemotaxis to cAMP | aberrant protein localization to cell cortex | decreased cAMP-induced cAMP pulse | decreased myosin II assembly
DBS0236773pikA-/ pikB-pikA | pikBdecreased pinocytosis | aberrant aggregation | decreased exocytosis | abolished CRAC localization to the plasma membrane | increased intracellular cAMP level | aberrant adaptation of adenylate cyclase | abolished SDF production | abolished growth | aberrant macropinocytosis | delayed aggregation | aberrant F-actin organization | aberrant phagolysosome formation | aberrant phagosome maturation | multiple tips | decreased phosphatidylinositol biosynthesis | abolished streaming | aberrant cell morphology | decreased cAMP-induced cAMP pulse
HM1141pikA-/ pikB-pikA | pikBdecreased pinocytosis | decreased growth rate | decreased cell motility
DBS0350471pikA-/ pikB-/ [act15]: GFP: capcap | pikA | pikBwild type
DBS0252703pikA-/ pikB-/ pikC-pikA | pikB | pikCdecreased protein localization | increased cell motility
HM1200pikA-/ pikB-/ pikC-/ pikF-/ pikG-pikA | pikB | pikC | pikF | pikGaberrant aggregation | decreased pinocytosis | decreased protein tyrosine phosphorylation | increased chemotaxis to folate | decreased growth rate | decreased cell motility | aberrant signal transduction
HM1284pikA-/ pikB-/ pikC-/ pikF-/ pikG-/ pikH-pikA | pikB | pikC | pikF | pikG | pikHdecreased cell motility | increased infection rate by Legionella pneumophila
HM1295pikA-/ pikB-/ pikC-/ pikF-/ pikG-/ pten-pikA | pikB | pikC | pikF | pikG | ptenaberrant aggregation | decreased growth rate | decreased cell motility | increased resistance to N-Phenylthiourea | increased infection rate by Legionella pneumophila
DBS0238073pikA-/ pikB-/ plaA-pikA | pikB | plaAdecreased chemoattractant-mediated F-actin polymerization | delayed aggregation | aberrant chemotaxis to cAMP | abolished positive chemotaxis
DBS0236774pikB-pikBwild type
DBS0236776pikC-pikCwild type
DBS0236777pikD1pikDabolished slug migration | delayed aggregation | decreased aggregate size | decreased sporulation | aberrant fruiting body morphology
DBS0236778pikE-pikEwild type
HM1241pikF-pikFdecreased pinocytosis | decreased growth rate | aberrant pinosome maturation
LAS31pikG-pikGaberrant socially cooperative development
HM1513pikI-pikIdecreased chemoattractant-mediated F-actin polymerization | decreased catalytic activity | decreased cAMP-induced cGMP pulse | decreased cAMP-induced Ca2+ influx | decreased growth rate | aberrant chemotaxis to cAMP | decreased protein kinase activation | increased bleb formation | decreased cAMP-induced cAMP pulse
DBS0350828pinA-/ [ecmAO]: lacZpinAaberrant prestalk cell differentiation
DBS0350827pinA-/ [pspA]: lacZpinAaberrant prespore cell differentiation
SB16pirA-pirAincreased cell motility | decreased cell size
SB3pirA-pirAincreased pseudopod formation | increased basal F-actin level | increased cell size | decreased cell motility
DBS0349901pisA-pisAincreased gene expression | precocious development | decreased fruiting body size | aberrant prestalk cell differentiation
DBS0236783pkaC-pkaCabolished gene expression | increased protein phosphorylation | decreased gene expression | abolished catalytic activity | decreased protein kinase activation | abolished aggregation
DBS0350694pkaC-/ [act15]: pkaCpkaCabolished culmination
DBS0350708pkaC-/ [act6]: pkaC(303-648)pkaCwild type
DBS0350707pkaC-/ [act6]: pkaC(330-648)pkaCabolished aggregation
DBS0350710pkaC-/ [dscC]: LUCpkaCdecreased gene expression
DBS0236782pkaC-/ gdt1-gdt1 | pkaCincreased gene expression | abolished aggregation
HTY217pkaR(A31T)pkaRabolished protein kinase activation | precocious development
DBS0235411pkaR-pkaRdecreased spore germination | aberrant response to lithium | increased gene expression | precocious sporulation | aberrant chemotaxis to cAMP | aberrant response to valproic acid | decreased cell motility | increased lateral pseudopod formation | aberrant cAMP signaling during aggregation | decreased fruiting body size | aberrant cell morphology | abolished streaming
DBS0236784pkbA-pkbAdecreased pinocytosis | decreased protein phosphorylation | aberrant macropinocytosis | abolished protein kinase activation | abolished protein localization | aberrant phagosome maturation | aberrant protein localization to cell cortex | increased phagocytosis | decreased myosin II assembly
DBS0350113pkbA-/ [act15]: GFP: rheb(Q64L)pkbA | rhebdecreased phagocytosis
DBS0236785pkbA-/ pkgB-pkbA | pkgBabolished growth | aberrant chemotaxis to cAMP | decreased chemotaxis rate | abolished protein phosphorylation | abolished aggregation | increased activation of GTPase activity
DBS0304640pkbA-/ pkgB-pkbA | pkgBabolished growth
DBS0350475pkd2-pkd2increased resistance to naringenin | decreased growth rate
DBS0350367pkd2-pkd2aberrant cellular response to fluid shear stress | aberrant exocytosis
DBS0236786pkgB-pkgBdecreased protein phosphorylation | abolished SDF production | development arrests at mound stage
DBS0350328pkgB-pkgBaberrant development
DBS0304638pkgB-pkgBdecreased cell-substrate adhesion | development arrests at mound stage | decreased chemotaxis rate | increased cell motility
DBS0236787pkgB-/ [act15]: pkbApkbA | pkgBwild type
DBS0236789pkgB-/ [act15]: pkgB(K182M)pkgBdevelopment arrests at mound stage
DBS0350329pkgB-/ [emcB]: lacZpkgBabolished gene expression
DBS0236790pkgB-/ [gbfA]: pkbApkbA | pkgBwild type
DBS0236791pkgB-/ [gbfA]: pkgBpkgBwild type
DBS0350319pks17-pks17decreased fatty acid level | aberrant gene expression | delayed development | decreased fruiting body size
LAS44pks2-pks2decreased socially cooperative development
LAS19pks26-pks26aberrant socially cooperative development
DBS0238068plaA-plaAaberrant chemotaxis to cAMP | abolished aggregation
DBS0238067plaA-plaAabolished aggregation
DBS0306196plaA-plaAaberrant chemotaxis to cAMP | decreased necrotic cell death
DBS0350831plaA-/ piaA-piaA | plaAaberrant F-actin organization | decreased chemotaxis to cAMP
DBS0350486plaA-/ sgcA-plaA | sgcAaberrant chemotaxis to cAMP
DBS0350487plaA-/ sgcA-/ pkgB-pkgB | plaA | sgcAaberrant chemotaxis to cAMP
DG1067plbG-plbGdecreased stalk width | decreased stalk length
HAD236plc-plcdecreased CRAC localization to the plasma membrane | aberrant chemotaxis to cAMP | decreased protein localization to cytoplasm | decreased protein kinase activation | abolished aggregation
HD1.19plc-plcaberrant negative chemotaxis
HD10plc-plcwild type
DBS0267125plc-/ [OE]: dagA(PH): GFP/ [OE]: plcdagA | plcincreased CRAC localization to the plasma membrane | decreased chemotaxis to cAMP | aberrant protein localization
DBS0350047plc-/ [act15]: pten: GFPplc | ptenwild type | aberrant protein localization to cytoplasm
DBS0236796pldB-pldBdecreased catalytic activity | precocious aggregation
DBS0236797pldB-/ [act15]: pldB: GFPpldBabolished aggregation
DBS0350604pldB-/ [unk]: GFPpldBincreased sorting to prestalk region
DBS0350605pldB-/ [unk]: lacZpldBincreased sorting to prestalk region
DBS0236799plip-plipdelayed aggregation
DBS0350007png-pngdelayed aggregation | decreased aggregate size | aberrant fruiting body morphology
DBS0350492png-/ [ecmAO]: lacZpngaberrant prestalk cell differentiation
DBS0350491png-/ [ecmA]: lacZpngaberrant prestalk A cell differentiation
DBS0350493png-/ [pspA]: lacZpngdecreased prespore cell differentiation
DBS0236820ponA-ponAprecocious aggregation | decreased lateral pseudopod traction | decreased actin nucleation on plasma membranes | aberrant development
DBS0236821ponA-ponAprecocious aggregation | decreased lateral pseudopod traction | decreased actin nucleation on plasma membranes | aberrant development
DG1057potA-potAaberrant fruiting body morphology
DBS0236824ppk1-ppk1decreased growth rate | decreased phagocytosis | decreased fruiting body size | delayed culmination | decreased sporulation
ASH01ppk1-ppk1decreased growth rate | aberrant spore germination | decreased intracellular ATP level | aberrant macromolecule biosynthesis | decreased fruiting body size
DBS0236825ppk1-/ [act15]: ppk1ppk1wild type
DBS0238099ppp4C-ppp4cdevelopment arrests at mound stage | delayed development
DBS0238110ppp4C-/ [act15]: smkAppp4c | smkAdevelopment arrests at mound stage | delayed development
DBS0238033proC-proCdecreased cell polarity | increased lateral pseudopod formation | decreased chemotaxis rate
DBS0238034proC-/ [unk]: FLAG: proCproCwild type
DBS0266716pscA-pscAwild type
DBS0266803psenA-psenAaberrant culmination | decreased prespore cell differentiation
DBS0350302psenA-psenAdecreased prespore cell differentiation | increased cytosolic Ca2+ response
DBS0350304psenA-/ psenB-psenA | psenBincreased intracellular cAMP level | abolished prespore cell differentiation | development arrests at mound stage | aberrant gene expression | increased cytosolic Ca2+ response | decreased stalk cell differentiation
DBS0350305psenA-/ psenB-/ [act15]: GFP: psenBpsenA | psenBwild type
DBS0350306psenA-/ psenB-/ [act15]: psenB(D348A/ D394A)psenA | psenBwild type
DBS0350295psenB-psenBdecreased phagocytosis | abolished catalytic activity
DBS0350303psenB-psenBdecreased prespore cell differentiation | increased cytosolic Ca2+ response
DBS0350298psenB-/ psenA-psenA | psenBaberrant culmination | decreased phagocytosis | abolished catalytic activity | decreased prespore cell differentiation
HOK2psiA-psiAabolished prespore cell division
DBS0236021psiM-psiMwild type
DBS0236022psiM-psiMwild type
DBS0236828pslA-pslAabolished gene expression | abolished sporulation | abolished stalk cell differentiation in vitro | decreased sorus size | increased aggregate size | increased stalk length | mislocalized gene expression
DBS0236829psmC1-psmC1curly fingers | increased resistance to spectinomycin | abolished slug migration | increased cell size
HW70pspB-pspBaberrant spore coat morphology | precocious spore germination
DBS0302352psrA-psrAdecreased culmination | increased protein phosphorylation | decreased activation of GTPase activity | increased protein kinase B activation | decreased cell motility | delayed development | delayed gene expression | increased protein kinase activation
DBS0302356psrA-/ [act15]: FLAG: gskAgskA | psrAincreased protein kinase activation
DBS0302353psrA-/ [act15]: ecmA: lacZpsrAaberrant gene expression
DBS0302354psrA-/ [act15]: ecmB: lacZpsrAaberrant gene expression
DBS0302357psrA-/ [act15]: gskA(K84M/ K85M)gskA | psrAdecreased culmination | decreased gene expression | delayed development | increased protein kinase activation
DBS0302355psrA-/ [act15]: psrApsrAwild type
DBS0350829psrA-/ [unk]: FLAG: rasD(G12T)psrA | rasDincreased protein kinase activation
HM1289pten-ptenaberrant cell motility | decreased cell motility | abolished aggregation | decreased chemotaxis to cAMP | decreased lateral pseudopod suppression
DBS0236830pten-ptenabolished CRAC localization to the plasma membrane | decreased F-actin polymerization | increased pseudopod formation | decreased positive regulation of GTPase activity | decreased growth rate | increased F-actin polymerization | abolished protein localization to plasma membrane | decreased phagocytosis | increased lateral pseudopod formation | decreased cell motility | increased CRAC localization to the plasma membrane | decreased chemotaxis to cAMP | abolished aggregation | aberrant pseudopod formation | decreased lateral pseudopod suppression | aberrant signal transduction
DBS0349884pten-ptendecreased cell polarity | aberrant cytokinesis | increased protein kinase activity | decreased chemotaxis to cAMP
DBS0350660pten-ptendecreased uropod retraction | decreased growth rate | aberrant cytokinesis | decreased protein localization
DBS0350454pten-/ [act15]: lpten: RFPlpten | ptenwild type
DBS0349890pten-/ [act15]: pakA: GFPpakA | ptenaberrant cytokinesis
DBS0350754pten-/ [act15]: pten(186-515): GFPptendecreased chemotaxis to cAMP | aberrant development
DBS0350755pten-/ [act15]: pten(C124S): GFPptendecreased chemotaxis to cAMP | aberrant development
DBS0236831pten-/ [act15]: pten: GFPptenwild type
DBS0349888pten-/ gefS-gefS | ptenaberrant cytokinesis | decreased chemotaxis to cAMP
DBS0349891pten-/ pakA-pakA | ptendecreased chemotaxis to cAMP
DBS0349893pten-/ pakA-/ [act15]: pakA(T585A): GFPpakA | ptendecreased chemotaxis to cAMP
DBS0349900pten-/ pakA-/ [act15]: pakA(T585E): GFPpakA | ptenaberrant cytokinesis | decreased chemotaxis to cAMP
DBS0349899pten-/ pakA-/ [act15]: pakA: GFPpakA | ptenaberrant cytokinesis
DBS0349887pten-/ piaA-piaA | ptendecreased protein kinase activity | decreased chemotaxis to cAMP
DBS0349880pten-/ pkbA-pkbA | ptendecreased chemotaxis to cAMP
DBS0349886pten-/ pkgB-pkgB | ptenaberrant cytokinesis | increased protein kinase activation
DBS0236832ptpA1-ptpA1-1 | ptpA1-2decreased prespore cell differentiation | increased prestalk 0 cell differentiation | precocious development
DBS0236833ptpB-ptpBincreased slug size
DBS0350675ptpB-/ [act15]: 6xHis: erkAerkA | ptpBaberrant streaming
DBS0236834ptpC+/ -ptpCaberrant cytokinesis | decreased growth rate
DBS0236835pufA-pufAincreased protein kinase activity | increased protein level | precocious development | aberrant fruiting body morphology
DBS0304391pyk3-pyk3increased gene expression | decreased gene expression | increased prespore cell differentiation | delayed culmination
DBS0350577pyk3-pyk3decreased protein phosphorylation | decreased gene expression | aberrant protein localization to nucleus
DBS0350581pyk3-pyk3decreased protein phosphorylation | decreased gene expression
DBS0304393pyk3-/ [act15]: T7: pyk3pyk3wild type
DBS0350579pyk3-/ phg2-phg2 | pyk3abolished gene expression | decreased protein phosphorylation | aberrant protein localization to nucleus
DBS0236836pykA-pykAdecreased growth rate | abolished aggregation
DBS0236837pyr56-pyr56increased resistance to 5-Fluoroorotic acid (5-FOA) | uracil auxotroph
DBS0236838pyr56-pyr56increased resistance to 5-Fluoroorotic acid (5-FOA) | uracil auxotroph
DBS0350017qdpr-qdprdecreased spore viability | abolished catalytic activity
DBS0350018qdpr-/ [act15]: pahpah | qdprdecreased growth rate
DBS0236839qkgA-qkgA-1 | qkgA-2increased aggregate size | delayed aggregation | aberrant vegetative growth | aberrant nucleus organization | increased growth rate | abolished negative chemotaxis
DBS0350011qkgA-/ [act15]: bzpN: GFPbzpN | qkgA-1 | qkgA-2abolished negative regulation of vegetative growth
DBS0350263rab7A-rab7Adecreased growth rate
DBS0236841racB-racBdecreased chemoattractant-mediated F-actin polymerization | delayed aggregation | decreased basal F-actin level | decreased chemotaxis rate | aberrant fruiting body morphology | decreased myosin II assembly
DBS0236842racC-racCdecreased protein localization to plasma membrane | aberrant streaming | decreased chemotaxis rate | aberrant cell morphology | aberrant protein localization
DBS0350272racC-racCaberrant cytokinesis | decreased growth rate
DBS0237191racC-/ [act15]: CFP: racCracCincreased chemoattractant-mediated F-actin polymerization
DBS0235413racE-racEabolished cytokinesis
DBS0350271racE-racEdecreased cell polarity | aberrant CRAC localization to the plasma membrane | aberrant cytokinesis | delayed aggregation | decreased growth rate | increased lateral pseudopod formation | aberrant regulation of GTPase activity | decreased chemotaxis to cAMP
DBS0349949racE-/ [act15]: fttBfttB | racEdecreased growth rate
DBS0349946racE-/ [act15]: fttB: GFPfttB | racEabolished protein localization to cell cortex
DBS0236843racF2-racF2increased aggregate size | increased cell-cell adhesion | decreased sexual fusion
DBS0236849racG-racGdecreased cell motility
DBS0236850racH-racHdecreased exocytosis | increased infection rate by Legionella pneumophila | aberrant protein localization
DBS0266936rapgap1-rapgap1decreased positive regulation of GTPase activity | increased basal F-actin level | increased cell-substrate adhesion | decreased cell motility | decreased myosin II assembly | increased protein kinase activation
DBS0266937rapgap1-/ [act15]: GFP: rapgap1rapgap1increased positive regulation of GTPase activity | decreased cell-substrate adhesion | increased myosin II assembly | increased basal F-actin level | increased lateral pseudopod formation | increased cell motility
DBS0350316rapgap9-rapgap9increased filopodium formation | increased basal F-actin level | aberrant cytokinesis | decreased spore size | increased cell-substrate adhesion | decreased chemotaxis to cAMP
DBS0350317rapgap9-/ [act15]: GFP: rapgap9rapgap9wild type
DBS0350628rapgapB-rapgapBaberrant aggregation | increased Ras guanyl-nucleotide exchange factor activity | aberrant F-actin organization | increased cell-substrate adhesion | aberrant regulation of GTPase activity
DBS0350630rapgapB-/ [ecmAO]: RFPecmA | rapgapBaberrant cell-cell adhesion
DBS0350631rapgapB-/ [ecmA]: lacZrapgapBaberrant sorting to prestalk region
DBS0350632rapgapB-/ [ecmO]: lacZrapgapBaberrant sorting to prestalk region
DBS0350629rapgapB-/ [pspA]: RFPpspA | rapgapBaberrant cell-cell adhesion
DBS0236852rasB-rasBdecreased growth rate
DBS0350836rasB-rasBdecreased phagocytosis | aberrant F-actin organization
DBS0236853rasC-/ AX2rasCincreased rate of endocytosis | aberrant F-actin organization | increased cell size | decreased cell motility | decreased protein kinase activation | abolished aggregation | aberrant pseudopod formation
DBS0236854rasC-/ JH10rasCwild type | aberrant gene expression | decreased protein kinase activation | abolished aggregation | abolished chemotaxis to cAMP
DBS0237614rasC-/ [act15]: gbpDgbpD | rasCincreased cell-substrate adhesion | aberrant cell morphology
DBS0350740rasC-/ [rasC]: rasGrasC | rasGabolished activation of adenylate cyclase | abolished aggregation
DBS0350742rasC-/ [rasC]: rasG(1-77(D30A)): rasC(79-189)rasC | rasGwild type
DBS0350741rasC-/ [rasC]: rasG(D30A)rasC | rasGaberrant aggregation | decreased activation of adenylate cyclase
DBS0236855rasC-/ dmpA-dmpA | rasCabolished streaming
DBS0236856rasC-/ pikD1pikD | rasCincreased chemotaxis to cAMP | aberrant gene expression | decreased protein kinase activation | abolished aggregation | increased cell polarity | aberrant fruiting body morphology
DBS0236857rasC-/ rasD-rasC | rasDabolished aggregation
DBS0236858rasC-/ rasG-rasC | rasGaberrant cell separation during cytokinesis | wild type | decreased gene expression | abolished growth | abolished guanylyl cyclase activity | abolished chemotaxis to folate | decreased growth rate | aberrant chemotaxis to folate | abolished protein kinase activation | decreased activation of adenylate cyclase | decreased cell motility | increased protein level | abolished aggregation | delayed gene expression | abolished chemotaxis to cAMP
DBS0266697rasC-/ rasG-/ [act15]: carAcarA-1 | carA-2 | rasC | rasGabolished growth | abolished activation of GTPase activity | decreased growth rate | decreased activation of adenylate cyclase | abolished protein kinase activation | abolished cAMP-induced cGMP pulse | abolished chemotaxis to cAMP
DBS0350480rasC-/ rasG-/ [rasG]: rasDrasC | rasD | rasGdecreased chemotaxis to folate
DBS0350482rasC-/ rasG-/ [rasG]: rasD(1-104): rasG(103-189)rasC | rasD | rasGdecreased chemotaxis to folate
DBS0350481rasC-/ rasG-/ [rasG]: rasGrasC | rasGwild type
DBS0350483rasC-/ rasG-/ [rasG]: rasG(1-104): rasD(103-187)rasC | rasD | rasGwild type
DBS0236859rasD(G12T)rasDdevelopment arrests at mound stage | development arrests at tipped mound stage
DBS0236860rasD-rasDaberrant thermotaxis | aberrant phototaxis
DBS0236862rasG-/ AX2rasGdecreased pinocytosis | decreased cAMP-induced cGMP pulse | decreased gene expression | delayed aggregation | decreased protein kinase activation | delayed gene expression
IR15rasG-/ AX2rasGdecreased chemoattractant-mediated F-actin polymerization | decreased cell polarity | increased cell size | decreased growth rate | decreased protein kinase activation
IR17rasG-/ AX3rasGaberrant cytokinesis | increased cell size | decreased cell motility
DBS0236863rasG-/ JH10rasGaberrant cell separation during cytokinesis | decreased cAMP-induced cGMP pulse | wild type | decreased gene expression | delayed aggregation | abolished activation of GTPase activity | aberrant chemotaxis to folate | decreased growth rate | decreased protein kinase activation | delayed gene expression
DBS0236864rasG-/ [OE]: rasBrasB | rasGdecreased growth rate
DBS0350572rasG-/ [act15]: FLAG: rasG(K169R,K173R,K176R,K178R)rasGaberrant cytokinesis
DBS0350571rasG-/ [act15]: FLAG: rasG(K169R,K173R,K176R,K178R,K179R,K180R,K184R)rasGdecreased protein modification
DBS0350448rasG-/ [dscB]: rasG(S17N)rasGdecreased chemoattractant-mediated F-actin polymerization | decreased positive regulation of GTPase activity | decreased protein kinase activation | decreased chemotaxis to cAMP
DBS0236872rasS-rasSdecreased pinocytosis | decreased cell polarity | aberrant pinosome maturation
DBS0236873rasS-rasSaberrant cytoskeleton organisation | decreased rate of endocytosis | increased basal F-actin level | abolished growth | decreased growth rate | increased cell motility
DBS0236874rasZ-rasZwild type
DBS0350261rbg3-rbg3precocious development | increased growth rate
DBS0236877rblA-rblAdecreased gene expression | increased gene expression | decreased spore viability | abolished negative regulation of vegetative growth | decreased growth rate | aberrant vegetative growth | increased sorting to prestalk region | precocious development | increased prestalk cell differentiation in response to DIF-1 | decreased cell size
DBS0349999rblA-/ [act15]: GFPrblAincreased sorting to prestalk region
DBS0349996rblA-/ [act15]: GFP/ [act15]: myc: btgbtg | rblAincreased sorting to prestalk region
DBS0349994rblA-/ [btg]: lacZbtg | rblAdecreased gene expression
DBS0236878rbrA-rbrAincreased gene expression | decreased gene expression | development arrests at slug stage | mislocalized gene expression | decreased sorting to prestalk region | decreased phototaxis | decreased sporulation
DBS0236879rbrA-/ [unk]: rbrArbrAwild type
DBS0236880rckA-rckAdelayed slug formation | increased aggregate size | precocious aggregation | delayed gene expression | increased chemotaxis rate
DBS0236885rckA-/ [act15]: myc: rckArckAdelayed development | decreased chemotaxis rate
DBS0236881rckA-/ [act15]: myc: rckA(C551A)rckAdelayed slug formation | decreased chemotaxis rate
DBS0236882rckA-/ [act15]: myc: rckA(E510G)rckAwild type | decreased chemotaxis rate
DBS0236883rckA-/ [act15]: myc: rckA(E510G/ N511A)rckAdelayed slug formation | decreased chemotaxis rate
DBS0236884rckA-/ [act15]: myc: rckA(K867A)rckAdevelopment arrests at mound stage | decreased chemotaxis rate
FR17rdeA-rdeAprecocious aggregation | decreased aggregate size | precocious development | precocious gene expression | aberrant fruiting body morphology
HH201rdeA-rdeAincreased intracellular cAMP level | aberrant chemotaxis to cAMP in response to DIF-2
WTC10rdeA-rdeAincreased intracellular cAMP level | aberrant chemotaxis to cAMP in response to DIF-2
FR17rdeA-rdeAprecocious aggregation | decreased aggregate size | precocious development | precocious gene expression | aberrant fruiting body morphology
DBS0236886rdeA-/ [act15]: rdeArdeAwild type
DBS0350688rdeA-/ acaA-acaA | rdeAincreased intracellular cAMP level | decreased number of spores
DBS0350468rdiA-rdiAdecreased pinocytosis | decreased protein localization to cell cortex | decreased F-actin polymerization | decreased protein level | aberrant contractile vacuole morphology | decreased growth rate | aberrant cytokinesis
DBS0236887recA-recAincreased sensitivity to hydrogen peroxide | increased sensitivity to mitomycin C (MMC) | increased sensitivity to UV light
DBS0266664redA-redAdevelopment arrests at mound stage | aberrant mound color
DBS0350511redA-redAincreased infection rate by Legionella pneumophila
DG1047redA-redAdevelopment arrests at mound stage | aberrant mound color
DBS0236889regA-regAincreased resistance to cisplatin | increased intracellular cAMP level | aberrant chemotaxis to cAMP | aberrant fruiting body morphology
DBS0236958regA-regAdecreased spore germination | precocious sporulation | abolished protein localization to cell cortex | aberrant chemotaxis to cAMP | increased lateral pseudopod formation
HM332regA-regAdecreased lateral pseudopod suppression
HR45regA-regAaberrant fruiting body morphology
HM1015regA-regAincreased intracellular cAMP level
DBS0350372regA-regAprecocious sporulation | increased sporulation
DBS0235706regA-/ [act15]: dhkK(D1125N)dhkK | regAprecocious development | aberrant fruiting body morphology
DBS0235708regA-/ [act15]: dhkK(H825Q)dhkK | regAprecocious development | aberrant fruiting body morphology
DBS0350689regA-/ [regA]: regAregAwild type
DBS0350670regA-/ [regA]: regA(D212N)regAprecocious sporulation
DBS0350380regA-/ dhkD-dhkD | regAaberrant fruiting body morphology
DBS0236891regA-/ tagB-regA | tagBdecreased sporulation
DBS0236892regA-/ tagC-regA | tagCdecreased sporulation
DBS0266818repB(1-754)repBincreased sensitivity to DNA-damaging agents
HM1351rev3-rev3increased sensitivity to cisplatin
HM1451rev3-/ xpf-rev3 | xpfincreased sensitivity to cisplatin
DBS0236893rgaA-rgaAaberrant cytokinesis | abolished sorting to prestalk region | abolished stalk cell differentiation | decreased protein kinase activation | abolished culmination | decreased sporulation
DBS0349935rgaA-rgaAaberrant stalk morphogenesis | aberrant cellular response to fluid shear stress | increased basal F-actin level | aberrant F-actin organization | multiple tips | increased growth rate | increased cell motility
DBS0350398rgaA-rgaAincreased lateral pseudopod formation | decreased myosin II assembly | increased chemotaxis rate
DBS0349921rgaA-/ [act15]: GFP-mhcArgaAaberrant stalk morphogenesis | aberrant tip formation | aberrant protein localization
DBS0349937rgaA-/ ctxA-ctxA | rgaAaberrant cytokinesis | abolished protein localization
DBS0349936rgaA-/ gapA-gapA | rgaAaberrant cellular response to fluid shear stress | aberrant cytokinesis | abolished protein localization | increased cell motility
DBS0350401rgaA-/ gapA-gapA | rgaAincreased myosin II assembly | increased F-actin polymerization | decreased chemotaxis to cAMP | increased protein kinase activation
DBS0350406rgaA-/ gapA-/ [unk]: myc: gapA(R308E/ K317E)gapA | rgaAincreased protein kinase activation
DBS0350402rgaA-/ iqgC-iqgC | rgaAdecreased myosin II assembly | increased protein kinase activation
DBS0350019rgfA-rgfAwild type
DBS0350020rgfA-/ [act15]: rgfArgfAdecreased chemotaxis to folate | delayed development
DBS0350108rheb-rhebincreased phagocytosis
DBS0236894rhgA-rhgAwild type
DBS0350192ric8-ric8abolished gene expression | abolished chemotaxis to folate | decreased chemotaxis to cAMP | abolished aggregation | aberrant signal transduction
DBS0350193ric8-/ [act15]: GFP: ric8ric8wild type
DBS0236900ripA-ripAdecreased cell polarity | decreased guanylyl cyclase activity | abolished activation of adenylate cyclase | decreased chemotaxis rate | abolished aggregation | aberrant regulation of protein kinase activity | decreased myosin II assembly | increased phagocytosis
DBS0350115ripA-/ [act15]: GFP: rheb(Q64L)rheb | ripAincreased phagocytosis
DBS0236902ripA-/ [unk]: ripA(K680E/ R681E)ripAdecreased chemotaxis rate | aberrant development
DBS0236901ripA-/ [unk]ripAripAwild type
DBS0350770ripA-[act15]: GFP: rapA(G12V)rapA | ripAdecreased protein kinase activation
DBS0236903rnpA-rnpAincreased gene expression
DBS0350096roco11-roco11increased stalk length
DBS0350095roco4-roco4delayed slug formation | aberrant stalk formation | delayed culmination
DBS0350100roco4-/ [unk]: roco4(1018-1292(G1179S))roco4increased catalytic activity
DBS0350098roco4-/ [unk]: roco4(1018-1292(S1187A))roco4abolished catalytic activity
DBS0350099roco4-/ [unk]: roco4(1018-1292(S1189A))roco4decreased catalytic activity
DBS0238225rpkA-rpkAdevelopment arrests at loose mound stage | aberrant response to conditioned medium factor | decreased cell polarity | aberrant cellular response to nitrogen starvation | decreased phagocytosis | decreased cell motility | increased infection rate by Legionella pneumophila | abolished aggregation
DBS0236906rrpA-rrpAabolished post-transciptional gene silencing by RNA
DBS0350178rrpA-/ rrpB-/ rrpC-rrpA | rrpB | rrpCincreased gene expression | decreased gene expression
DBS0350189rrpA-/ rrpB-/ rrpC-/ [act6]: lacZ/ [RNAi]lacZrrpA | rrpB | rrpCabolished transitive RNA interference
DBS0350176rrpA-/ rrpC-rrpA | rrpCincreased gene expression | decreased gene expression
DBS0350187rrpA-/ rrpC-/ [act6]: lacZ/ [AS]lacZrrpA | rrpCaberrant production of siRNA involved in RNA interference
DBS0350182rrpA-/ rrpC-/ [act6]: lacZ/ [RNAi]lacZrrpA | rrpCabolished transitive RNA interference
DBS0350177rrpB-/ rrpC-rrpB | rrpCincreased gene expression | decreased gene expression
DBS0350185rrpB-/ rrpC-/ [act6]: lacZ/ [AS]lacZrrpB | rrpCaberrant production of siRNA involved in RNA interference
DBS0350184rrpB-/ rrpC-/ [act6]: lacZ/ [RNAi]lacZrrpB | rrpCabolished transitive RNA interference
DBS0350209rrpC-rrpCdecreased gene expression | increased gene expression
DBS0350219rrpC-/ [act15]: pre-miRNArrpCincreased microRNA processing
DBS0350216rrpC-/ [act6]: LacZ/ [RNAi]lacZrrpCabolished transitive RNA interference
DBS0350217rrpC-/ [act6]: lacZ/ [AS]lacZrrpCaberrant production of siRNA involved in RNA interference
DBS0236875rtoA-rtoAdecreased rate of endocytosis | decreased infection rate by Legionella pneumophila | increased prestalk cell differentiation | delayed culmination
DBS0236911rtoA-rtoAdelayed development
DBS0236914rzpA-rzpAaberrant aggregation | decreased slug migration | increased aggregate size | increased gene expression | decreased gene expression | delayed development
sadAsadA-sadAabolished protein localization to cell surface | decreased phagocytosis | decreased protein stabilization
DBS0236921sadA-sadAabolished cell-substrate adhesion | decreased phagocytosis | aberrant cytokinesis | aberrant F-actin organization | increased growth rate | aberrant cell morphology
DBS0349790sadA-/ [act15]: sadA(1-923): GFPsadAdecreased cell-substrate adhesion
DBS0349792sadA-/ [act15]: sadA(S924A/ S925A): GFPsadAwild type
DBS0349791sadA-/ [act15]: sadA(S924E/ S925E): GFPsadAdecreased cell-substrate adhesion
DBS0236922sadA-/ [act15]: sadA: GFPsadAwild type
DG1105scaA-scaAabolished aggregation
DBS0350825scaA-scaAdecreased F-actin polymerization | aberrant chemotaxis to cAMP | abolished activation of GTPase activity | decreased protein kinase activation | abolished aggregation
DBS0236924scrA-scrAdecreased exocytosis | decreased pinocytosis | decreased phagocytosis | decreased basal F-actin level | increased lateral pseudopod formation | abolished protein localization | multiple tips | decreased fruiting body size | precocious development | decreased cell size
IR46scrA-scrAaberrant cytokinesis | decreased cell motility | aberrant spindle stabilization | decreased cell size
IR48scrA-scrAdecreased growth rate | aberrant cytokinesis | decreased phototaxis
DBS0236925scrA-scrAincreased filopodium formation | aberrant F-actin organization
DBS0349927scrA-/ [act15]: wasA: GFP/ [ act8]: RFP: arcDscrAdecreased cell polarity | decreased pseudopod formation
DBS0350063scrA-/ [tet]: scrA/ mhcA-mhcA | scrAaberrant cytokinesis
DBS0237774scrA-/ [unk]: scrA(97-443): GFPscrAaberrant cytoskeleton organisation | increased cell size | aberrant cytokinesis | decreased chemotaxis to cAMP
DBS0237779scrA-/ [unk]: scrA: GFPscrAwild type
SB18scrA-/ napA-napA | scrAdecreased cell motility | decreased basal F-actin level
SB7scrA-/ pirA-pirA | scrAdecreased cell size
HM1163sec1-/ sec1(M213K/ E258G/ M427V/ K527I/ T541N/ F558S/ N581D)sec1abolished cell motility
HM1325sec1-/ sec1(M250L/ A296V/ M427L/ S435R/ K505N/ V552D/ H570Q)sec1aberrant response to hypo-osmotic stress | aberrant plasma membrane organization and biogenesis | abolished cell motility | aberrant cell morphology
DBS0350286sec1-/ sec1(M250L/ A296V/ M427L/ S435R/ K505N/ V552D/ H570Q)/ gppA: GFPgppA | sec1abolished contractile vacuole discharge
DBS0350101sec7-sec7aberrant cell motility | decreased phagocytosis | decreased growth rate | aberrant phototaxis | decreased protein secretion
DBS0306234secG-secGdecreased cell-substrate adhesion | decreased chemotaxis rate
DBS0350264sepA-sepAaberrant cytokinesis | delayed aggregation | decreased growth rate | decreased fruiting body size
DBS0236928set1-set1precocious aggregation | abolished histone H3-K4 methylation | precocious gene expression
HG1132sevA-sevAwild type
DG1008sfbA-sfbAdecreased fruiting body size
SA576sgkA-sgkAincreased sensitivity to cisplatin | increased sensitivity to carboplatin | decreased growth rate
HM1093sgkA-/ sgkB-sgkA | sgkBincreased sensitivity to cisplatin | increased sensitivity to carboplatin | decreased growth rate
HM1091sgkB-sgkBincreased sensitivity to cisplatin | increased sensitivity to carboplatin | decreased growth rate
SA555sglA-sglAaberrant cytoskeleton organisation | increased stalk width | increased resistance to cisplatin | increased aggregate size | decreased gene expression | abolished slug migration | decreased cell motility | decreased chemotaxis rate | decreased fruiting body size | decreased lateral pseudopod suppression | decreased sporulation
SA554sglA-sglAdelayed aggregation | decreased aggregate size
DBS0236934shkA-shkAaberrant aggregation | decreased cell polarity | aberrant F-actin organization | decreased phagocytosis | aberrant cytokinesis | decreased chemotaxis rate | decreased fruiting body size
DBS0236935sibA-sibAdecreased cell-substrate adhesion | decreased phagocytosis
DBS0302653sibC-sibCdecreased phagocytosis
DBS0236936sigB-sigBwild type
DBS0236937sigD-sigDwild type
DBS0266513sigN(group1)-sigN1 | sigN105-1 | sigN2 | sigN25 | sigN3 | sigN4 | sigN5wild type
DBS0266514sigN(group2)-DDB_G0271820 | sigN10 | sigN11 | sigN12 | sigN14 | sigN6 | sigN7 | sigN8 | sigN9wild type
DBS0350859sir2D-sir2Ddecreased gene expression | increased gene expression | delayed aggregation | decreased growth rate | decreased autophagy | decreased aggregate size | decreased stalk length | multiple tips in mound
DBS0350860sir2D-/ [ecmAO]: lacZsir2Ddecreased prestalk cell differentiation
DBS0350861sir2D-/ [pspA]: lacZsir2Daberrant prespore cell differentiation
DBS0349958sma-smaincreased chemotaxis to folate | decreased gene expression | increased cell-substrate adhesion | increased cell-cell adhesion | decreased cell size
DBS0349957sma-/ ampA/ [ampA]: ampAampA | smadecreased chemotaxis to folate
DBS0350327smdA-/ [pspA]: lacZsmdAmislocalized gene expression
DBS0236938smkA-smkAaberrant cytokinesis | delayed development | decreased chemotaxis rate | decreased myosin II assembly
HDB7YAsmlA-smlAdecreased secretion of lysosomal enzyme | decreased cell-cell adhesion | aberrant cellular metabolic process | decreased cAMP-induced cGMP pulse | decreased GTP-gamma-S-stimulated guanylyl cyclase activity | increased cAMP-induced cAMP pulse | increased resistance to cisplatin | decreased protein level | increased basal F-actin level | increased myosin II assembly | increased protein level | increased extracellular counting factor component(s) level | increased cell motility | decreased fruiting body size | increased intracellular counting factor component(s) level
DBS0302657smlA-/ cnrN-cnrN | smlAdecreased fruiting body size
DBS0236940smlA-/ ctnA-ctnA | smlAincreased cell-cell adhesion
DBS0304496smlA-/ sslA1(CR11)smlA | sslA1increased fruiting body size
DBS0302523sodC-sodCaberrant cytokinesis
DBS0302524sodC-sodCdecreased chemoattractant-mediated F-actin polymerization | aberrant aggregation | decreased positive regulation of GTPase activity | increased basal F-actin level | increased protein localization to plasma membrane | decreased chemotaxis rate | aberrant protein localization to plasma membrane | aberrant cell morphology
HL351spiA-spiAdecreased spore viability
DBS0236943spkA-1-/ spkA-2-spkA-1 | spkA-2decreased cell polarity | decreased cell-substrate adhesion | aberrant cytokinesis | decreased chemotaxis rate | decreased aggregate size | aberrant cell morphology | decreased fruiting body size
DBS0236944spkA-1-/ spkA-2-/ [act15]: spkA: FLAGspkA-1 | spkA-2aberrant aggregation | decreased cell polarity | aberrant F-actin organization | decreased chemotaxis rate
DBS0236945splA-splAaberrant spore morphology | increased sorus size | translucent sorus | spores inviable | decreased stalk length
DBS0350131splB-splBabolished protein tyrosine phosphorylation | abolished protein localization to nucleus | decreased gene expression | abolished response to DIF
DBS0350582splB-/ pyk3-pyk3 | splBabolished gene expression | abolished protein localization to nucleus | abolished protein phosphorylation | aberrant development
DBS0236947spnA-spnAabolished prespore cell differentiation | development arrests at mound stage | abolished prestalk cell differentiation | aberrant development
DBS0236948spnA-/ arkA-arkA | spnAdecreased gene expression | increased sorus size | decreased stalk length | delayed gene expression
DBS0236949sr-srdecreased intracellular pteridine level | decreased spore viability | decreased cytochrome C oxidase activity | decreased growth rate
DBS0236950srfA(1-8): lacZsrfAdecreased slug migration | aberrant fruiting body morphology | delayed culmination
DBS0236951srfA-srfAaberrant spore morphology | aberrant spore coat morphology | decreased spore viability | decreased gene expression
DBS0266691srfB-srfBprecocious aggregation | decreased growth rate | increased pinocytosis | aberrant cytokinesis | increased lateral pseudopod formation | aberrant cAMP signaling during aggregation | abolished streaming | precocious gene expression
DBS0304409srsA-srsAdecreased gene expression | increased gene expression | increased aggregate size | delayed aggregation
DBS0304497sslA1-/ sslA1(CR11)sslA1decreased cAMP-induced cGMP pulse | increased fruiting body size | decreased cAMP-induced cAMP pulse
DBS0236952stkA-stkAincreased gene expression | decreased gene expression | increased prestalk cell differentiation | aberrant fruiting body morphology | delayed gene expression
HM1157stlA-stlAaberrant cellular metabolic process | aberrant streaming | aberrant aggregation | abolished sporulation | wild type | increased gene expression | decreased gene expression | abolished MPBD production | translucent sorus | abolished SDF-1 production | decreased intracellular cAMP level | decreased chemotaxis to cAMP
DBS0350222stlA-/ [cotB]: lacZstlAdecreased sporulation | aberrant prespore cell differentiation
DBS0350224stlA-/ stlB-/ [ecmA]: lacZstlA | stlBdecreased prestalk cell differentiation
HM1154stlB-stlBabolished DIF production | abolished prestalk B cell differentiation | decreased prestalk 0 cell differentiation | abolished lower cup formation | abolished outer basal disc formation | decreased prestalk cell differentiation | aberrant fruiting body morphology
DBS0350409stlB-/ [act15]: stlBstlBwild type
DBS0349941sunB-sunBaberrant cytokinesis | multiple tips
DBS0304547svkA-svkAdelayed cell separation during cytokinesis | aberrant cytokinesis | aberrant fruiting body morphology
DBS0236055swip-swipaberrant protein localization to cytoplasm | abolished exocytosis | abolished F-actin polymerization | abolished phagosome re-neutralization
AK1200tagA-tagAabolished SDF production | aberrant fruiting body morphology
AK859tagA-tagAdecreased spore viability | abolished SDF production | multiple tips in mound | increased prestalk A cell differentiation
AK1201tagA-/ [ecmA]: GFPtagAabolished sorting to prestalk region
AK228tagB-tagBabolished sporulation | development arrests at mound stage | abolished DIF production | aberrant prestalk A cell differentiation
DBS0350637tagB-/ [pkaC]: pkaCpkaC | tagBabolished SDF-1 production | aberrant response to SDF-1
DBS0350672tagB-/ pkaR-pkaR | tagBdecreased sporulation
DBS0236974tagB-/ psmA1-psmA1 | tagBabolished sporulation
DBS0236975tagC-tagCdevelopment arrests at mound stage | spores inviable
DBS0350698tagC-/ [pkaC]: pkaCpkaC | tagCdevelopment arrests at mound stage | abolished SDF-2 production
DBS0236976talA-talAdecreased protein level | decreased cell-substrate adhesion | aberrant cytokinesis | decreased phagocytosis | aberrant cell morphology
HG1666talA-talAdecreased cell-cell adhesion | decreased cell-substrate adhesion | aberrant cytokinesis | decreased growth rate | decreased phagocytosis | increased cell-substrate adhesion
HG1663talA-talAdecreased cell-substrate adhesion
HG1664talA-talAdecreased uropod retraction | decreased growth rate | decreased phagocytosis | aberrant cytokinesis, contractile ring contraction
HG1665talA-talAdecreased cell-cell adhesion | aberrant cytokinesis
DBS0304585talA-/ [act15]: FLAG: talBtalA | talBdecreased cell-substrate adhesion
DBS0237616talA-/ [act15]: gbpDgbpD | talAincreased pseudopod formation | increased cell-substrate adhesion | aberrant cell morphology
DBS0238395talA-/ [act15]: rapA(G12V)rapA | talAincreased cell-substrate adhesion
DBS0350442talA-/ sibA-sibA | talAwild type
DBS0304581talA-/ talB-talA | talBdevelopment arrests at loose mound stage | abolished cell-substrate adhesion | aberrant cytokinesis | abolished cell motility
DBS0304582talA-/ talB-/ [act15]: FLAG: talBtalA | talBwild type
DBS0350713talA-/ talB-/ [act15]: talB(K16A)talA | talBdecreased cell-substrate adhesion
HKT104talB-talBdecreased slug migration | decreased cell motility | development arrests at tipped mound stage | increased protein level
DBS0302472talB-talBabolished autophagic vacuole formation | abolished autophagic cell death
DBS0304586talB-/ [act15]: talA: GFPtalA | talBaberrant fruiting body morphology
DBS0350712talB-/ [act15]: talB(K16A)talBdevelopment arrests at tipped mound stage
DBS0304820tgrB1-tgrB1development arrests at loose mound stage | delayed sporulation | decreased cell motility | decreased sporulation
AK1549tgrB1-/ QS31[tgrB1]: tgrB1/ tgrC1-/ QS31[tgrC1]: tgrC1tgrB1 | tgrC1wild type
AK1552tgrB1-/ QS38[tgrB1]: tgrB1/ tgrC1-/ QS38[tgrC1]: tgrC1tgrB1 | tgrC1wild type
AK1555tgrB1-/ QS45[tgrB1]: tgrB1/ tgrC1-/ QS45[tgrC1]: tgrC1tgrB1 | tgrC1wild type
AK1546tgrB1-/ QS4[tgrB1]: tgrB1/ tgrC1-/ QS4[tgrC1]: tgrC1tgrB1 | tgrC1wild type
AK1540tgrB1-/ tgrC1-tgrB1 | tgrC1development arrests at loose mound stage | abolished cell-cell self recognition
AK1664tgrB1-/ tgrC1-/ alg9(-19ins)alg9 | tgrB1 | tgrC1decreased sporulation
AK127tgrC1-tgrC1development arrests at loose mound stage | aberrant aggregation | abolished gene expression | increased aggregate size | decreased gene expression
DBS0304821tgrC1-tgrC1abolished sporulation | development arrests at loose mound stage | decreased cell motility
AK1657tgrC1-/ QS38[tgrC1]: tgrC1/ alg9(-19ins)alg9 | tgrC1delayed development | decreased fruiting body size | decreased sporulation
AK1661tgrC1-/ alg9(-19ins)alg9 | tgrC1delayed development | decreased fruiting body size | decreased sporulation
DBS0350743tgrC1-/ alg9(-19ins)-REMIalg9 | tgrC1decreased sporulation
DBS0350625tgrC1-/ stcA-stcA | tgrC1decreased aggregate size | delayed development | decreased sporulation
DBS0350626tgrC1-/ stcB-stcB | tgrC1delayed development | decreased aggregate size | decreased sporulation
DBS0350627tgrC1-/ stcC-stcC | tgrC1aberrant streaming | delayed development | decreased fruiting body size | decreased sporulation
AK244tipA-tipAincreased aggregate size | decreased gene expression | development arrests at mound stage | multiple tips
JS64tipA-/ tipB-/ [act15]: lacZtipA | tipBincreased aggregate size | development arrests at mound stage | multiple tips in mound
JS98tipA-/ tipC-/ [ecmA]: lacZtipA | tipCdevelopment arrests at loose mound stage
JS128tipA-/ tipD-/ [ecmA]: lacZtipA | tipDdevelopment arrests at loose mound stage
JS56tipB-tipBincreased aggregate size | development arrests at mound stage | multiple tips | multiple tips in mound
JS99tipB-/ tipC-/ [ecmA]: lacZtipB | tipCdevelopment arrests at tipped mound stage | multiple tips in mound
JS129tipB-/ tipD-/ [ecmA]: lacZtipB | tipDdevelopment arrests at tipped mound stage | multiple tips in mound
JS55tipC-tipCincreased aggregate size | development arrests at mound stage | decreased number of autophagosomes | decreased autophagy | multiple tips
DBS0350729tipC-/ [unk]: tipC(2725-3848): GFPtipCdecreased fruiting body size
JS130tipC-/ tipD-/ [ecmA]: lacZtipC | tipDdevelopment arrests at loose mound stage
JS93tipD-tipDincreased aggregate size | development arrests at mound stage | aberrant vacuole organization and biogenesis | decreased autophagy | multiple tips
DBS0350730tipD-tipDdecreased pinocytosis | increased gene expression | aberrant phagosome maturation | aberrant fruiting body morphology | aberrant slug formation | multiple tips in mound
DBS0304519tirA-tirAaberrant defense response to bacterium | decreased growth rate | aberrant phagocytosis | increased infection rate by Legionella pneumophila
YLD31Atlp2-tlp2decreased growth rate
DBS0350285tom1-tom1decreased rate of endocytosis
DBS0237017torA-torAdelayed aggregation | decreased growth rate | decreased cell motility | decreased chemotaxis rate
DBS0237018torA-/ [act15]: torA: GFPtorAabolished growth
DBS0350506tpp1-tpp1aberrant response to chemical stimulus
DBS0350504tpp1-tpp1decreased catalytic activity | aberrant response to chemical stimulus | aberrant autophagic cell death | aberrant cell morphology | precocious development
DBS0350505tpp1-/ [cotB]: tpp1tpp1wild type
DBS0350507tpp1-/ stpA-stpA | tpp1wild type
DBS0237924triA-triAdecreased cell-cell adhesion | aberrant streaming | increased stalk width | aberrant upper cup formation | aberrant cell motility | decreased spore viability | aberrant culminant morphology | decreased spore size | decreased cell fate determination | increased number of aggregates | decreased cell fate commitment
DBS0237996triA-triAaberrant culminant morphology
DBS0237997triA-triAaberrant culminant morphology
DBS0237998triA-/ [act15]: GFPtriAaberrant culminant morphology
DBS0237999triA-/ [ecmAO]: lacZ: [ecmAO]: gustriAincreased prestalk 0 cell differentiation
DBS0238001triA-/ [psA]: lacZ: [psA]: gustriAincreased prespore cell differentiation
DBS0237022tsg101-tsg101decreased fruiting body size
DBS0350816tspC-tspCaberrant response to osmotic stress
HM1725tstD-tstDdecreased growth rate | decreased membrane organization during endocytosis | increased growth rate
DBS0302370tsuA-tsuAincreased period of cAMP wave formation | aberrant chemotaxis to folate | aberrant chemotaxis to cAMP | delayed aggregation | decreased aggregate size | abolished cell polarity | decreased fruiting body size
DBS0302383tsuA-/ [unk]: tsuA(1-1774): YFPtsuAabolished localization to microtubules | decreased aggregate size | abolished localization to microtubule organizing center | decreased fruiting body size
DBS0302385tsuA-/ [unk]: tsuA(1-260): YFPtsuAabolished localization to microtubules | abolished localization to microtubule organizing center | decreased aggregate size | decreased fruiting body size
DBS0302384tsuA-/ [unk]: tsuA(1774-2247): YFPtsuAabolished localization to microtubules | abolished localization to microtubule organizing center | decreased aggregate size | decreased fruiting body size
DBS0302382tsuA-/ [unk]: tsuA(K34R): YFPtsuAdecreased aggregate size | decreased fruiting body size
DBS0302381tsuA-/ [unk]: tsuA: YFPtsuAwild type
DBS0237024ubcB-ubcBdevelopment arrests at mound stage | multiple tips
DBS0306165ube2t-ube2tincreased sensitivity to cisplatin
DBS0237025ubpA-ubpAdecreased gene expression | decreased chemotaxis rate | abolished aggregation | decreased cAMP-induced cAMP pulse
DBS0237026ubpB-ubpBaberrant sorus morphology | increased gene expression | decreased gene expression | precocious development
DBS0237027ufc1-ufc1wild type
DBS0237028ugpB-/ DH1ugpBaberrant cell differentiation | decreased intracellular glycogen level | spores inviable | decreased fruiting body size | delayed culmination
DBS0266763ugpB-/ DH1ugpBdecreased stalk length
DBS0266764ugpB-/ HMXugpBabolished cellulose biosynthesis | decreased autophagic vacuole formation | aberrant cell morphology
DBS0350591uppA-uppAdecreased catalytic activity
DBS0237031vacA-vacAwild type
DBS0237032vacB-vacBdecreased exocytosis
DBS0237034vasP-vasPabolished filopodium formation
DBS0237035vasP-vasPdecreased cell-substrate adhesion | aberrant F-actin organization | decreased chemotaxis rate | decreased lateral pseudopod suppression | decreased cell size | abolished filopodium formation | decreased filopodium formation
DBS0237033vasP-/ [act15]: GFP: vasP(1-264/ 285-380)vasPabolished filopodium formation
DBS0237836vasP-/ [act15]: YFP: wipAvasP | wipAdecreased filopodium formation
DBS0237842vasP-/ [act15]: YFP: wipA/ [act15]: vasP: FLAGvasP | wipAincreased filopodium formation
DBS0237036vasP-/ [act15]: myr: vasPvasPincreased filopodium formation | increased basal F-actin level | aberrant cytokinesis
DBS0237040vasP-/ [act15]: vasPvasPdecreased filopodium formation
DBS0237840vasP-/ [act15]: vasPvasPincreased filopodium formation | increased basal F-actin level
DBS0237037vasP-/ [act15]: vasP(1-110: 231-380)vasPincreased basal F-actin level | aberrant cytokinesis | decreased filopodium formation
DBS0237038vasP-/ [act15]: vasP(1-228)vasPdecreased filopodium formation
DBS0237039vasP-/ [act15]: vasP(111-380)vasPincreased filopodium formation | increased basal F-actin level
DBS0350466vasP-/ [unk]: vasP(1-197: 221-380)vasPwild type
DBS0350467vasP-/ [unk]: vasP(1-261: 285-380)vasPdecreased cell motility | abolished filopodium formation
DBS0350602vilA-vilAdecreased chemotaxis to cAMP | decreased phototaxis
DBS0236058vmp1-vmp1aberrant aggregation | decreased exocytosis | increased cell death | aberrant response to hypo-osmotic stress | decreased gene expression | decreased growth rate | decreased macropinocytosis | aberrant vacuole organization and biogenesis | aberrant autophagic cell death | aberrant protein localization | aberrant signal transduction
DG1118vps46-vps46increased sorus size
DBS0237046vwkA-vwkAincreased myosin II assembly | aberrant response to hypo-osmotic stress | decreased growth rate | aberrant cytokinesis | aberrant contractile vacuole morphology | delayed development | increased protein level | decreased contractile vacuole discharge | aberrant fruiting body morphology
DBS0350290vwkA-/ [act15]: GFP: mhcAmhcA | vwkAaberrant myosin II organization
TL61wacA-wacAwild type
TL99wacA-wacAwild type
DBS0237048warA-warAdevelopment arrests at slug stage | increased basal disc size | decreased prespore cell differentiation | increased prestalk 0 cell differentiation
DBS0237049warA-warAdevelopment arrests at slug stage | increased basal disc size | decreased prespore cell differentiation | increased prestalk 0 cell differentiation
DBS0237050warA-/ hbx2-hbx2 | warAincreased basal disc size | development arrests at mound stage | decreased prespore cell differentiation | increased prestalk 0 cell differentiation
DBS0237051wasA1-wasAaberrant F-actin organization | decreased cell motility | delayed development
DBS0237052wasA1-/ [tet]: YFP: wasA2wasAdecreased F-actin polymerization | aberrant F-actin organization | abolished positive chemotaxis | abolished aggregation
DBS0237812wasA1-/ [tet]: YFP: wasA2/ [act15]: wasAwasAincreased F-actin polymerization at the leading edge
DBS0237811wasA1-/ [tet]: YFP: wasA2/ [act15]: wasA(Y33A/ W39A/ F90A/ F91A)wasAdecreased F-actin polymerization | decreased F-actin polymerization at the leading edge
DBS0237820wasA1-/ [tet]: YFP: wasA2/ [act15]: wipAwasA | wipAabolished positive chemotaxis
DBS0350254wasB-wasBaberrant chemotaxis to cAMP | increased F-actin polymerization | increased protein level | aberrant pseudopod formation | aberrant protein localization
DBS0350255wasB-/ [act15]: YFP: wasBwasBwild type
DG1053wimA-wimAaberrant fruiting body morphology
DG1064wimA-wimAaberrant fruiting body morphology
DBS0349863wshA-wshAdecreased secretion of lysosomal enzyme | aberrant lysosome organization and biogenesis | increased protein localization | abolished exocytosis | decreased infection rate by Mycobacterium marinum | aberrant vegetative growth | aberrant autophagic cell death | aberrant phagosome maturation | decreased phagosomal proteolysis | abolished phagosome re-neutralization
DBS0350451wshA-/ atg1-atg1 | wshAwild type
DBS0350248wshA-/ fam21-/ [act15]: GFP: fam21fam21 | wshAabolished F-actin polymerization
DBS0350247wshA-/ fam21-/ [act15]: GFP: wshAfam21 | wshAaberrant post-lysosome organization and biogenesis
HM1456xpc-xpcwild type
HM1403xpf-xpfincreased sensitivity to cisplatin
AK235yakA-yakAabolished aggregation
AK800yakA-yakAdecreased gene expression | aberrant cell cycle | aberrant gene expression | decreased protein kinase activation | abolished aggregation | decreased intracellular cAMP level | aberrant response to oxidative stress
DBS0237091yakA-/ [crlA]: crlAcrlA | yakAabolished growth
DBS0350058yakA-/ keaA-keaA | yakAwild type
AK804yakA-/ pufA-pufA | yakAincreased protein kinase activity | increased protein level | increased growth rate | precocious development | aberrant fruiting body morphology
DG1014yelA-yelAdecreased spore viability | precocious sporulation | development arrests at mound stage | aberrant mound color
DBS0349797zak2-zak2decreased gene expression | decreased protein kinase activation | decreased sporulation | aberrant fruiting body morphology
DBS0349883zak2-/ [act15]: GFPzak2decreased sporulation
DBS0349798zak2-/ [ecmA]: LacZzak2aberrant gene expression
DBS0349882zak2-/ [ecmA]: zakAzak2 | zakAaberrant gene expression
ARK100-110zakA-zakAincreased gene expression | decreased gene expression | decreased protein kinase activity | abolished streaming | decreased chemotaxis to cAMP | delayed culmination | aberrant fruiting body morphology | decreased sporulation
DBS0238142zakA-zakAdevelopment arrests at tipped mound stage
DBS0349803zakA-/ [ecmB]: LacZzakAaberrant gene expression
DG1050zipA-zipAdecreased fruiting body size
DBS0350068zizB-zizBdelayed development | decreased chemotaxis to cAMP | aberrant fruiting body morphology

Last updated January 28, 2017

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