Job Opportunities

Job Opportunities

Postdoctoral Research Associate in Understanding the role of heterogeneity in development, Faculty of Life Sciences, University of Manchester


Developmental cell fate choice and proportioning is characterised by its robustness and reproducibility. Consequently, heterogeneity (also termed noise and stochasticity) in cell behaviours, cell signalling and responses are often thought to be a hindrance. However, recent observations of ësalt-and-pepperí differentiation, which is seen in examples raging from competence in B. subtilis, lineage specification in the mouse blastocyst, to stalk and spore differentiation in Dictyostelium have challenged this view. In fact, in these cases such heterogeneity has been proposed to be required for normal cell fate choice and symmetry breaking.

We are seeking an enthusiastic and outstanding postdoctoral researcher to join a multidisciplinary team led by Prof. Chris Thompson to address the extent to which such heterogeneity is necessary, how something that is inherently variable can be harnessed to result in a reproducible outcome, and determine the source of this heterogeneity. This work will build upon our recent finding (Chattwood et al, eLife 2014) that the interplay between dynamic heterogeneity in Ras-GTPase activity and heterogeneity in nutritional status is required for normal lineage priming, salt and pepper differentiation and robust running of an ultradian cell fate oscillator.

You will use single cell RNA sequencing to identify groups of heterogeneously expressed genes within normal populations of cells. Computational approaches will be used to identify putative genes involved in lineage priming and cell fate choice. In addition, the role played by these genes will be tested in the lab through the analysis of gene knockout strains, live cell imaging, molecular genetics and biochemical approaches.
Candidates with extensive experience of using either computational approaches or wet lab approaches to understand the molecular basis and gene networks will be considered.

You should currently hold or be about to obtain a PhD in a relevant field.

The post funded by the Wellcome Trust and is available for up to 3 years.
Informal enquiries and further details can be obtained from Prof. Chris Thompson.
Tel: 0161 275 1588 or email

Chris Thompson
Professor of Evolutionary and Developmental Genetics,
Faculty of Life Sciences,
University of Manchester,
Michael Smith Building,
Oxford Road,
Manchester
UK
M13 9PT

Chris Thompson lab website

phone: 44 (0)161 275 1588

Treasurer British Society of Developmental Biology website
TBSDB email

(posted April 27, 2016)



Lecturer position (two) at at La Trobe University


Both positions will be within the Discipline of Microbiology. One position is a full time, ongoing position at Lecturer (Level B) or Senior Lecturer (Level C) level (depending on experience and qualifications). The second position is a part time lecturer position at 0.7 fraction of full time, fixed term until the end of 2020.

The University is interested in two research specializations for these two positions. One is in eukaryotic microbiology focusing either on the use of a eukaryotic microbe as a model for disease processes (infectious or genetic) or on a eukaryotic pathogen (preferably of humans and/or animals). The second is focused on bacterial infectious disease.

The University will seek to appoint the best applicant (regardless of research area) to the full time ongoing position. The part time, fixed term position will then be offered to the best candidate in the alternative research area.

Applications can be made online at our website

Deadline for applications: 06 May 2016
Suitably qualified individuals in the Dictyostelium community are encouraged to apply for one or both of these positions, depending on their research interests.

Dr. Paul Fisher
Professor of Microbiology
La Trobe University
VIC 3086
AUSTRALIA
Web: http://fishfam.homeip.net/mcbg

Web page: Paul Fisher Lab

(posted April 26, 2016)



Postdoc position, Beatson Institute, Glasgow


The mechanics of actin-based cell movement

Prof. Robert Insall

Cancer Research UK Beatson Institute in Glasgow is one of Europe's leading cancer research centres. It supports cutting edge research into the molecular mechanisms of cancer development. The Institute provides an outstanding research environment, underpinned by state-of-the-art core services and advanced technologies with special emphasis on imaging, metabolomics and in vivo models of cancer.

This Cancer Research UK funded project will use multiple approaches to investigate actin polymerization during cell migration and chemotaxis, and in particular the activation and dynamics of the SCAR/WAVE complex. The Insall laboratory approaches this problem using multiple experimental systems. It is envisaged this work will use a combination of protein biochemistry, Dictyostelium genetics and cancer cell molecular cell biology. Findings will be confirmed using computational analysis and modelling. The work will initially focus on how existing pseudopods and signalling pathways cooperate to activate Dictyostelium SCAR/WAVE and thus build pseudopods (see Ura et al., Curr Bio 22:553). Results will then be replicated in cultured melanoma cells. Techniques will involve some or all of: purification of proteins from wild type and genetically-engineered cells, Dictyostelium genetics and molecular biology to engineer new mutant strains, actin and Arp2/3 assays, high-level microscopy on multiple platforms including TIRF, FRET/FLIM and FRAP.

A relevant PhD is essential. Experience in actin or protein biochemistry, Dictyostelium genetics, fluorescence microscopy, cloning and genetics, and a good record of quality publications would be an advantage. You will have good knowledge of the literature, enthusiasm and flexibility to work on a wide range of techniques as needed. Initial 3 year fixed term contract (with possibility of up to 2 year extension).

For informal enquiries please email Prof Insall on email

All applications must be made via our website

Closing Date: 29 April 2016

(posted March 23, 2016)



Assistant Professor of Bioinformatics, University of Maine


Assistant Professor of Bioinformatics (id:32879)
Department: Molecular & Biomedical Sciences

The Department of Molecular and Biomedical Sciences at the University of Maine is seeking to fill a tenure-track position at the Assistant Professor level in the area of Bioinformatics/Computational Biology. The successful applicant will establish and lead a productive research program in the areas of bioinformatics/computational biology that provides research opportunities for both undergraduate and graduate students. Specific research areas of interest for this position include but are not limited to genomics and systems biology including gene expression, evolution, population genetics, and microbiomics. Analysis of other datasets such as lipidomics, metabolomics, transcriptomics, epigenomics, etc. are also of interest. The Department of Molecular and Biomedical Sciences has an active research core in the areas of host-pathogen interactions, toxicology, and cell signaling, and an outstanding zebrafish facility that supports broad research areas. Other units on campus also offer areas for collaboration such as wildlife genomics, mouse models, and others. As a founding and active member of The University of Maine's Graduate School of Biomedical Sciences and Engineering, the reach and collaborations available to members of the Department extend to the physical and computational sciences and to institutions across the state of Maine, including the Mt. Desert Island Biological Laboratory, The Jackson Laboratory, and Maine Medical Center Research Institute. The department is actively developing a new Masters degree program in Bioinformatics and includes a phage genomics course in its undergraduate core curriculum. The applicant will teach within the Department of Molecular and Biomedical Sciences with emphasis on the development of new courses in computational biology at the advanced undergraduate and graduate level. The position is a 75% research/25% teaching position with a start date of January 1, 2017 or later.

Knowledge, Skills & Qualifications:
PhD degree in the biomedical or computational science (or related field) is required by date of hire.
Strong post-doctoral or equivalent professional experience in the areas of bioinformatics/computational biology.
Strong research and publication record.
Strong interest in collaborative research.
Experience in teaching/training including course development or organization.
Experience in obtaining external funding would be considered an asset.
The successful candidate will be expected to take a leadership role in providing the vision for the anticipated expansion of the areas of bioinformatics/computational biology at The University of Maine
For more information on the Department of Molecular and Biomedical Sciences please consult our website

Located on the northern border of beautiful Downeast Maine, the University of Maine, Orono, is the flagship campus of the University of Maine System and is the principal graduate institution in the state. It is the state's land grant and sea grant university, enrolling 12,000 students. Numerous cultural activities, excellent public schools in neighborhoods where children can walk to school, high quality medical care, little traffic, and a reasonable cost of living make the greater Bangor area a wonderful place to live. The University of Maine is just 60 miles from Bar Harbor and Acadia National Park and there is access to a wealth of outdoor activities throughout the state. As an NSF ADVANCE institution, the University of Maine is committed to diversity in our workforce and to dual-career couples.

Appropriate background checks are required.

All UMS employees are required to comply with applicable policies and procedures, as well as to complete applicable workplace related screenings, and required employee trainings, such as Information Security, Safety Training, Workplace Violence and Sexual Harassment.

Materials must be submitted via Assistant Professor position. You will need to create a profile and application; upload a cover letter, a resume/curriculum vitae which fully describes your qualifications and experiences with specific reference to the required and preferred qualifications, academic transcripts, and copies of teaching evaluations; and provide contact information for three professional references. Incomplete application materials cannot be considered. Review of applications will begin May 1, 2015 and the position will remain open until filled.

The University of Maine is an EEO/AA employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, sexual orientation, age, disability, protected veteran status, or any other characteristic protected by law.

Robert Gundersen

Chair & Associate Professor
Molecular & Biomedical Sciences
5735 Hitchner Hall
University of Maine
Orono, ME 04469-5735
(207) 581-2802

(posted March 21, 2016)



Home| Contact dictyBase| SOPs| Site Map  Supported by NIH (NIGMS and NHGRI)