Job Opportunities

Job Opportunities

Postdoctoral Postition, MRC Laboratory of Molecular Biology, Cambridge, UK

There is a three year postdoctoral position available to investigate macropinocytosis.

Macropinocytosis is a neglected and poorly understood cell biological process which has recently started attracting more attention and will, I believe, develop into an exciting field. Macropinocytosis is used by immune cells to gather antigens, can be used for feeding by tumour cells, and may be the route by which prions and tau deposits spread from cell to cell in the brain. Macropinocytosis is also the route by which Dictyostelium cells feed on liquid media.

Macropinosomes are organised around PIP3 patches in the plasma membrane, which have been extensively studied in Dicty, and we have recently identified a RasGAP that controls patch formation and whose mutation allows axenic growth. This, combined with the ease with which classical genetic selections can be applied to the problem, make Dicty an extremely attractive model in which to study macropinocytosis.

The project will primarily be with Dictyostelium cells, with collaborative possibilities on dendritic cells.

For more details:
The MRC Laboratory of Molecular Biology, now in a brand-new building.
The Kay lab, also here.
The project.

Informal enquiries can be made to Rob Kay, but applications have to be made through this site.

Closing date 18th December.

(posted November 19, 2014)

Postdoctoral Postition, University of Alberta, Canada

A 3 year postdoctoral position is available in the Dacks Lab at the University of Alberta, examining the evolution of the contractile vacuole. The contractile vacuole (CV) is an osmoregulatory organelle found in ecologically important and diverse freshwater and soil-dwelling organisms (eg. ciliates, dictyostelids). Nonetheless, CV cell biology is only now being assessed using modern methods. As the name implies, the CV is presumed to be a vacuole/lysosome homologue. This project will use molecular evolutionary and transcriptomic analysis to examine the evolution and function of the CV, specifically whether it is derived from a single homologous ancestor or derived independently from endolysosomal organelles.

The preferred candidate must have a doctorate degree (and be within 5 years of this degree) at the time of taking up the position, should have a background in microbial eukaryotic cell biology or evolution and have published in these areas. Technical expertise in cell biology of microbial eukaryotes, ideally Dictyostelium or a ciliate would be a significant asset. Salary will be competitive with UAlberta standards and includes benefits (~$37 000).

Interested applicants should email a cover letter, curriculum vitae and contact information for 2 potential referees to Joel Dacks. The position can begin as early as January 1st, 2015.

For more information:
The Dacks Lab
The Department of Cell Biology
The University of Alberta

Closing date 15th December.

(posted November 19, 2014)

Postdoctoral position: Imaging transcriptional dynamics in living cells Grade 7 (£33,353 - £40,313)


A post-doctoral position is available in the MRC Laboratory for Molecular Cell Biology, University College London. The project will be carried out in the laboratory of Dr Jonathan Chubb and will be for 2 years, in the first instance. The laboratory uses an innovative imaging technology to observe the activity (bursting) of single genes in living cells (Current Biology 16: 1018-25, PNAS 109:7350-5, Current Biology 24:205-11). Our goal is to understand the nature of gene pulsing, how it is integrated into robust cell and developmental decisions and how it is modulated by nuclear and chromatin architecture, cell signals and noise.

This will provide an excellent opportunity to develop a career niche in a dynamic field of biology. We are embedded in a world-class working environment offering remarkable opportunities for stimulating scientific exchange and professional development. Please contact Dr J R Chubb for further information. Information can also be found at Jonathan Chubb research group

Interested candidates with PhDs in molecular and cell biology would be considered. Experience with live cell imaging, basic programming (in Matlab, R or similar) would be useful although not essential. We would also be open to highly motivated candidates with a background in experimental physics.

A job description, person specification and the online application will become available at Research Associate Position. This site offers details of the application process and who to contact if you have any queries.

Closing Date: 12th December 2014; Start Date: 5th January 2015 (negotiable)
University College London is uniquely situated in the heart of London. We are committed to equal opportunities and welcome applications from all sections of the community.

(posted November 20, 2014)

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