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Mai, Tobias, Wolski, Karol, Puciul-Malinowska, Agnieszka, Kopyshev, Alexey, Graf, Ralph, Bruns, Michael, Zapotoczny, Szczepan, Taubert, Andreas, (2018) ' Anionic Polymer Brushes for Biomimetic Calcium Phosphate Mineralization-A Surface with Application Potential in Biomaterials. ' Polymers (Basel) 10
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Abstract:This article describes the synthesis of anionic polymer brushes and their mineralization with calcium phosphate. The brushes are based on poly(3-sulfopropyl methacrylate potassium salt) providing a highly charged polymer brush surface. Homogeneous brushes with reproducible thicknesses are obtained via surface-initiated atom transfer radical polymerization. Mineralization with doubly concentrated simulated body fluid yields polymer/inorganic hybrid films containing AB-Type carbonated hydroxyapatite (CHAP), a material resembling the inorganic component of bone. Moreover, growth experiments using Dictyostelium discoideum amoebae demonstrate that the mineral-free and the mineral-containing polymer brushes have a good biocompatibility suggesting their use as biocompatible surfaces in implantology or related fields.
Status: epublish Type: Journal article Source: PUBMED PubMed ID: 30961090