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Zhu, Q., Hulen, D., Liu, T., Clarke, M., (1997) ' The cluA- mutant of Dictyostelium identifies a novel class of proteins required for dispersion of mitochondria. ' Proc Natl Acad Sci U S A 94 7308-13
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Abstract:The cluA gene of Dictyostelium discoideum encodes a novel 150-kDa protein. Disruption of cluA results in clustering of mitochondria near the cell center. This is a striking difference from normal cells, whose mitochondria are dispersed uniformly throughout the cytoplasm. The mutant cell populations also exhibit an increased frequency of multinucleated cells, suggesting an impairment in cytokinesis. Both phenotypes are reversed by transformation of cluA- cells with a plasmid carrying a constitutively expressed cluA gene. The predicted sequence of the cluA gene product is homologous to sequences encoded by open reading frames in the genomes of Saccharomyces cerevisiae and Caenorhabditis elegans, but not to any known protein. The only exception is a short region with some homology to the 42-residue imperfect repeats present in the kinesin light chain, which probably function in protein-protein interaction. These studies identify a new class of proteins that appear to be required for the proper distribution of mitochondria.
Status: Published Type: Journal article Source: PUBMED PubMed ID: 9207087

Genes addressed in this paper
Topics in this paper
Mitosis X
Protein Physical Properties X
Protein Functional Domain X
Strains/Constructs X
Non-mammalian Gene Related X
Function/Process X
DNA/RNA Sequence Features X
Mutants/Phenotypes X
Antibodies X