Dictyostelium Mutants

Phenotypes for Dictyostelium mutants

View other mutant types: All mutant strains - Null - Overexpression - Multiple - Other - Developmental

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Systematic Name Strain Descriptor Associated gene(s) Phenotypes
DBS0350657 [csaA]: csaAcsaAaberrant aggregation | increased calcium-independent cell-cell adhesion
DBS0350826 pinA-pinAdecreased growth rate | decreased aggregate size | decreased sporulation
DBS02354121C7gp130decreased cell-substrate adhesion | delayed development | increased growth rate
DBS02354142F5gp130decreased cell-substrate adhesion | delayed development | increased growth rate
DBS02386015NT-5NTmultiple tips in culminant | delayed tip formation | multiple tips in mound
DBS0235584CF45-1-cf45-1increased aggregate size | decreased cell motility | increased cell-cell adhesion | decreased aggregate size | increased intracellular glucose level
DBS0235585CF50-cf50-1increased aggregate size | increased gene expression | increased cell-cell adhesion | decreased extracellular counting factor component(s) level | increased protein level
DBS0235594CHE10cbpCdecreased slug migration | precocious aggregation | decreased aggregate size | decreased fruiting body size | delayed culmination
DBS0235595CHI2cbpCincreased slug migration
DBS0235612CMFR1-cmfBdecreased gene expression | abolished aggregation
DBS0235659DD3-3-DD3-3decreased gene expression | precocious aggregation
DG1007DDB_G0269232-DDB_G0269232abolished culmination
LAS29DDB_G0273201-DDB_G0273201decreased socially cooperative development
LAS8DDB_G0273809-DDB_G0273091decreased socially cooperative development
LAS8DDB_G0273809-DDB_G0273809decreased socially cooperative development
LAS43DDB_G0274429-DDB_G0274429decreased socially cooperative development
LAS26DDB_G0277239-DDB_G0277239decreased socially cooperative development
LAS34DDB_G0278585-DDB_G0278585decreased socially cooperative development
LAS70DDB_G0279405-DDB_G0279405decreased socially cooperative development
LAS103DDB_G0280089-DDB_G0280089decreased socially cooperative development
LAS54DDB_G0280299-DDB_G0280299decreased socially cooperative development
LAS92DDB_G0283373-DDB_G0283373decreased socially cooperative development
LAS106DDB_G0283595-DDB_G0283595decreased socially cooperative development
LAS3DDB_G0287153-DDB_G0287153decreased socially cooperative development
LAS10DDB_G0288547-DDB_G0288547decreased socially cooperative development
LAS9DDB_G0289789-DDB_G0289789decreased socially cooperative development
LAS7DDB_G0290685-DDB_G0290685decreased socially cooperative development
DG1003DDB_G0291992-DDB_G0291992aberrant culminant morphology
LAS39DDB_G0292148-DDB_G0292148decreased socially cooperative development
DBS0350073DDB_G0293074-DDB_G0293074decreased spore viability | delayed aggregation
DG1039DG1039-DDB_G0284037aberrant fruiting body morphology
DG1040DG1040-DDB_G0276029aberrant fruiting body morphology
DG1041DG1041-DDB_G0269126aberrant fruiting body morphology
DG1054DG1054-DDB_G0277719aberrant fruiting body morphology
DG1060DG1060-DDB_G0281953aberrant fruiting body morphology
DG1062DG1062-DDB_G0286351aberrant fruiting body morphology
DG1074DG1074-DDB_G0272108aberrant fruiting body morphology
DG1080DG1080-DDB_G0281559aberrant fruiting body morphology
DG1091DG1091-DG1091decreased fruiting body size
DG1098DG1098-DG1098decreased fruiting body size
DG1104DG1104-DDB_G0283535abolished aggregation
DG1106DG1106-keaAabolished aggregation
DG1110DG1110-DDB_G0269128aberrant fruiting body morphology
DG1112DG1112-DG1112decreased stalk width
DG1113DG1113-DG1113increased stalk length
DG1122DG1122-DG1122aberrant fruiting body morphology
DG1124DG1124-DG1124development arrests at loose mound stage
DG2033DG2033-DG2033development arrests at mound stage
DG2044DG2044-DG2044development arrests at loose mound stage
DL118DL118gnt2decreased slug size | decreased calcium-independent cell-cell adhesion | decreased fruiting body size
DBS0266692Dd5P4-Dd5P4decreased growth rate | decreased phagocytosis | decreased engulfment during phagocytosis | multiple tips in mound
DBS0266695Dd5P4-/ [act15]: GAP5P4Dd5P4decreased growth rate | multiple tips in mound
DBS0266694Dd5P4-/ [act15]: cat5P4Dd5P4decreased growth rate | multiple tips in mound
CW0391FLAG-VwkAvwkAincreased myosin II assembly | aberrant response to hypo-osmotic stress | decreased growth rate | aberrant cytokinesis | development arrests at mound stage | increased protein level
DBS0236015GEG04K11 (tmcB- in KAX3)tmcBsmall macrocysts | increased number of peripheral cells during sexual reproduction | aberrant aggregation during macrocyst formation
DBS0236016GEG04V12 (tmcB- in V12)tmcBsmall macrocysts | increased number of peripheral cells during sexual reproduction | aberrant aggregation during macrocyst formation
DBS0236017GEG10K23 (tmcC- in KAX3)tmcCincreased number of peripheral cells during sexual reproduction | aberrant aggregation during macrocyst formation
DBS0236018GEG10V03 (tmcC- in V12)tmcCincreased number of peripheral cells during sexual reproduction | aberrant aggregation during macrocyst formation
HL220HL220gnt2abolished gene expression | aberrant spore coat morphology | decreased calcium-independent cell-cell adhesion
HMW404HMW404manAabolished gene expression | abolished catalytic activity | abolished aggregation
DBS0236358HR42fbxAabolished culmination | decreased sporulation
HTY506HTY506pkaRaberrant spore morphology | decreased spore viability | decreased phosphorylation of actin | increased sporulation | precocious development | decreased intracellular cAMP level | aberrant fruiting body morphology
HTY507HTY507rdeAincreased intracellular cAMP level | precocious aggregation | decreased aggregate size | aberrant fruiting body morphology
DBS0236444JH.DcbfAabolished gene expression | decreased gene expression | increased gene expression | decreased growth rate | increased pinocytosis | increased cell size | decreased fruiting body size | decreased stalk width | abolished aggregation | increased phagocytosis
DBS0236779PIPkinA-pik6decreased gene expression | abolished aggregation
DBS0236840R7nosAdevelopment arrests at mound stage
DBS0264065V00262dagAabolished slug migration | abolished streaming | abolished aggregation | abolished culmination | abolished cAMP wave formation
DBS0264066V00347DDB_G0281917abolished culmination
DBS0264073V10108DDB_G0292162abolished slug migration | aberrant vegetative growth | abolished streaming | abolished aggregation | abolished culmination | abolished cAMP wave formation
DBS0264075V10113yakAabolished slug migration | aberrant vegetative growth | abolished streaming | abolished aggregation | abolished culmination | abolished cAMP wave formation | aberrant cAMP wave formation
DBS0264078V10116tipBaberrant aggregation | abolished slug migration | abolished culmination | aberrant cAMP wave formation
DBS0264079V10117DDB_G0285083aberrant slug migration | abolished culmination
DBS0264087V10125DDB_G0293302aberrant slug migration | aberrant cAMP wave formation
DBS0264088V10126tipCaberrant culmination | aberrant slug migration | aberrant cAMP wave formation
DBS0264089V10127DG1037abolished slug migration | abolished streaming | abolished aggregation | abolished culmination | abolished cAMP wave formation | aberrant cAMP wave formation
DBS0264098V10136DDB_G0293590wild type | aberrant culmination | aberrant slug migration | aberrant cAMP wave formation
DBS0264099V10137yelAaberrant aggregation | abolished slug migration | aberrant culmination | aberrant cAMP wave formation
DBS0264106V10144comHaberrant aggregation | abolished slug migration | abolished culmination
DBS0264108V10146yakAabolished slug migration | aberrant vegetative growth | abolished streaming | abolished aggregation | abolished culmination | abolished cAMP wave formation
DBS0264109V10147tipAaberrant streaming | aberrant aggregation | abolished slug migration | aberrant culmination | aberrant slug migration | abolished culmination | aberrant cAMP wave formation
DBS0264116V10155DDB_G0282093aberrant streaming | aberrant aggregation | abolished slug migration | aberrant culmination | aberrant slug migration | abolished streaming | abolished aggregation | abolished culmination | aberrant cAMP wave formation
DBS0264118V10157usp12aberrant streaming | aberrant culmination | aberrant slug migration | abolished culmination
DBS0264125V10164comEaberrant vegetative growth | aberrant culmination | aberrant slug migration | abolished culmination
DBS0264126V10165comDaberrant aggregation | abolished slug migration | aberrant culmination | aberrant cAMP wave formation
DBS0264128V10167DG1098wild type | aberrant cAMP wave formation
DBS0264129V10168prsCwild type | aberrant slug migration
DBS0264131V10170DDB_G0283015aberrant culmination | aberrant slug migration | abolished culmination | aberrant cAMP wave formation
DBS0264135V10174DDB_G0288581aberrant streaming | aberrant vegetative growth | aberrant culmination | aberrant slug migration | aberrant cAMP wave formation
DBS0264145V10185abcA5wild type | aberrant vegetative growth | aberrant culmination | aberrant cAMP wave formation
DBS0264150V10190yelAaberrant aggregation | abolished slug migration | aberrant culmination | aberrant cAMP wave formation
DBS0264151V10191sfbAaberrant culmination | aberrant slug migration | abolished culmination
DBS0264152V10192tipDaberrant aggregation | abolished slug migration | abolished culmination | aberrant cAMP wave formation
DBS0264154V10194modAaberrant culmination | aberrant slug migration
DBS0264155V10195migAaberrant streaming | aberrant culmination | aberrant slug migration | aberrant cAMP wave formation
DBS0264157V10197yelAabolished slug migration | aberrant culmination | aberrant slug migration
DBS0264158V10198splAaberrant streaming | aberrant aggregation | aberrant culmination | aberrant cAMP wave formation
DBS0264159V10199DG1037aberrant streaming | abolished slug migration | abolished aggregation | abolished culmination | aberrant cAMP wave formation
DBS0264160V10200DDB_G0289377aberrant culmination | aberrant slug migration | aberrant cAMP wave formation
DBS0264161V10201rgaAaberrant vegetative growth | aberrant culmination | aberrant slug migration | abolished culmination | aberrant cAMP wave formation
DBS0264163V10203modAwild type | aberrant vegetative growth | aberrant culmination
DBS0264164V10204DG1124aberrant streaming | aberrant aggregation | aberrant cAMP wave formation
DBS0264169V10209dcsAabolished culmination
DBS0264170V10210mkpAabolished slug migration | abolished streaming | abolished aggregation | abolished culmination | abolished cAMP wave formation
DBS0264171V10211migAaberrant streaming | aberrant culmination | aberrant cAMP wave formation
DBS0264172V10212tipCaberrant aggregation | abolished slug migration | aberrant vegetative growth | aberrant culmination | aberrant cAMP wave formation
DBS0264173V10213DG1098aberrant streaming | aberrant cAMP wave formation
DBS0264181V10221tipDaberrant culmination | aberrant slug migration | aberrant cAMP wave formation
DBS0264183V10223erkAaberrant streaming | aberrant cAMP wave formation
DBS0264184V10224DG1091aberrant cAMP wave formation
DBS0264185V10225acrAaberrant culmination | aberrant slug migration | aberrant cAMP wave formation
DBS0264186V10226ggtAaberrant vegetative growth | aberrant culmination | aberrant slug migration | abolished aggregation | abolished culmination
DBS0264187V10227piaAabolished slug migration | abolished streaming | abolished aggregation | abolished culmination | abolished cAMP wave formation
DBS0264188V10228comGaberrant aggregation | aberrant streaming | abolished slug migration | aberrant vegetative growth | aberrant culmination | aberrant slug migration | abolished culmination | aberrant cAMP wave formation
DBS0264189V10229dcsAabolished culmination | aberrant cAMP wave formation
DBS0264190V10230ctrAaberrant aggregation | aberrant culmination | aberrant slug migration
DBS0264193V10233piaAabolished slug migration | abolished streaming | abolished aggregation | abolished culmination | abolished cAMP wave formation
DBS0264196V10236DDB_G0270872_psaberrant streaming
DBS0264198V10238DDB_G0269128aberrant culmination | aberrant slug migration
DBS0264199V10239kif12wild type | aberrant culmination
DBS0264201V10241lvsBaberrant culmination
DBS0264202V10242tagBaberrant aggregation | abolished slug migration | abolished culmination
DBS0264204V10244gbfAaberrant culmination | aberrant slug migration
DBS0264205V10245gefAabolished slug migration | abolished streaming | abolished aggregation | abolished culmination | abolished cAMP wave formation
DBS0264206V10246dicBaberrant streaming | aberrant cAMP wave formation
DBS0264207V10247yelAaberrant aggregation | abolished slug migration | aberrant culmination | abolished culmination | aberrant cAMP wave formation
DBS0264212V10252tagBaberrant aggregation | abolished slug migration | abolished culmination
DBS0264216V10256DDB_G0293302aberrant streaming | abolished slug migration | aberrant culmination | aberrant cAMP wave formation
DBS0264218V10258rdeAaberrant streaming | aberrant aggregation | abolished slug migration | aberrant culmination | abolished culmination | aberrant cAMP wave formation
DBS0264220V10260gacTaberrant culmination | aberrant slug migration | aberrant cAMP wave formation
DBS0264224V10264DDB_G0282787_RTEaberrant streaming | aberrant aggregation | wild type | abolished slug migration | abolished culmination | aberrant cAMP wave formation
DBS0264225V10265lvsDaberrant vegetative growth | aberrant culmination | aberrant cAMP wave formation
DBS0264227V10267DDB_G0292260_RTEaberrant streaming | aberrant aggregation
DBS0264228V10268dhkAaberrant streaming | aberrant culmination | aberrant slug migration | aberrant cAMP wave formation
DBS0264229V10269helCwild type | aberrant culmination | aberrant slug migration | abolished culmination
DBS0264230V10270mekAaberrant streaming | aberrant vegetative growth | aberrant culmination | aberrant cAMP wave formation
DBS0264231V10271lvsBabolished slug migration | abolished streaming | abolished aggregation | abolished culmination | aberrant cAMP wave formation
DBS0264232V10272modAabolished slug migration | abolished streaming | abolished aggregation | abolished culmination | aberrant cAMP wave formation
DBS0264234V10274DG1113aberrant vegetative growth | aberrant culmination | aberrant cAMP wave formation
DBS0264235V10275DG1122aberrant streaming | wild type | abolished slug migration | aberrant vegetative growth | abolished streaming | abolished aggregation | abolished culmination | aberrant cAMP wave formation
DBS0264237V10277lvsEaberrant cAMP wave formation
DBS0264238V10278modAaberrant streaming | aberrant aggregation | abolished slug migration | aberrant culmination | aberrant slug migration | abolished culmination | aberrant cAMP wave formation
DBS0264240V10280mekAaberrant streaming | aberrant culmination | aberrant slug migration | abolished culmination | aberrant cAMP wave formation
DBS0264241V10281DDB_G0268266aberrant slug migration | aberrant cAMP wave formation
DBS0264242V10282phdAaberrant streaming | abolished slug migration | aberrant culmination
DBS0264245V10285scaAabolished slug migration | aberrant vegetative growth | abolished streaming | abolished aggregation | abolished culmination | aberrant cAMP wave formation
DBS0264246V10286amdAwild type | aberrant culmination
DBS0264247V10287helCwild type | aberrant culmination | aberrant slug migration
DBS0264251V10300DDB_G0278333aberrant culmination | aberrant slug migration | aberrant cAMP wave formation
DBS0264269V10322roco5aberrant culmination | aberrant slug migration | abolished culmination | aberrant cAMP wave formation
DBS0264272V10326DG1113wild type | aberrant cAMP wave formation
DBS0264281V10356DDB_G0275747aberrant slug migration
DBS0264284V10367DDB_G0282463aberrant vegetative growth | aberrant culmination | aberrant slug migration | abolished culmination | aberrant cAMP wave formation
DBS0264287V10431kcnma1wild type | aberrant culmination | aberrant slug migration
DBS0264290V10435gefLabolished slug migration | aberrant culmination | aberrant slug migration | aberrant cAMP wave formation
DBS0264297V10445DDB_G0290835aberrant slug migration
DBS0264303V10460abcC9aberrant slug migration
DBS0264316V10483yod1aberrant aggregation | aberrant culmination | aberrant slug migration | abolished culmination | aberrant cAMP wave formation
DBS0264318V10490gefVaberrant culmination | aberrant cAMP wave formation
DBS0264319V10492med23aberrant culmination | aberrant cAMP wave formation
DBS0264320V10495DDB_G0269128wild type | aberrant culmination | aberrant slug migration
DBS0264324V10514adprt3aberrant streaming | aberrant cAMP wave formation
DBS0264330V10529cyp508B1aberrant streaming | aberrant aggregation | abolished slug migration | aberrant culmination | aberrant slug migration | aberrant cAMP wave formation
DBS0264331V10530DDB_G0270344wild type | aberrant slug migration | aberrant cAMP wave formation
DBS0264334V10534DDB_G0291812wild type | aberrant culmination
DBS0264335V10535DDB_G0277165aberrant streaming | aberrant cAMP wave formation
DBS0264337V10537gbpCaberrant streaming | wild type | abolished streaming | aberrant cAMP wave formation
DBS0264347V10567dagAabolished slug migration | abolished streaming | abolished aggregation | abolished culmination | abolished cAMP wave formation
DBS0264349V10570DDB_G0281115aberrant streaming | wild type | aberrant culmination | aberrant slug migration | aberrant cAMP wave formation
DBS0264356V10588dhkCaberrant streaming | wild type | aberrant cAMP wave formation
DBS0264373V10633gtaGabolished slug migration | aberrant culmination | aberrant slug migration | abolished culmination
DBS0264390V10682clcDabolished slug migration | abolished streaming | abolished aggregation | abolished culmination | abolished cAMP wave formation | aberrant cAMP wave formation
DBS0264425V11033nfaAaberrant streaming | aberrant aggregation | wild type | aberrant cAMP wave formation
DBS0264432V11040DDB_G0274177abolished slug migration | abolished streaming | abolished aggregation | abolished culmination | abolished cAMP wave formation
DBS0264446V11055ku80aberrant vegetative growth | aberrant culmination
DBS0264464V11075cinCwild type | aberrant culmination
DBS0264489V11105DDB_G0270350_psaberrant streaming | wild type | aberrant cAMP wave formation
DBS0264512V11128DDB_G0278945aberrant streaming | aberrant vegetative growth | aberrant cAMP wave formation
DBS0264575V30069DDB_G0284619aberrant streaming | aberrant cAMP wave formation
DBS0264607V30110alg9wild type | aberrant vegetative growth | aberrant cAMP wave formation
DBS0264630V30133DDB_G0272953aberrant streaming | wild type | aberrant cAMP wave formation
DBS0264662V30165alg9aberrant streaming | wild type | aberrant culmination | aberrant cAMP wave formation
DBS0264668V30171DDB_G0285261aberrant streaming | wild type | aberrant vegetative growth | aberrant cAMP wave formation
DBS0264677V30180gpaFaberrant streaming | wild type | aberrant cAMP wave formation
DBS0264684V30188DDB_G0287723aberrant streaming | wild type | aberrant cAMP wave formation
DBS0264700V30213act9wild type | aberrant culmination
DBS0264715V30229dhx35wild type | aberrant cAMP wave formation
DBS0264716V30230regAaberrant streaming | aberrant aggregation | abolished slug migration | abolished culmination | aberrant cAMP wave formation
DBS0264731V30245DDB_G0279461wild type | aberrant culmination
DBS0264773V30288DDB_G0293300aberrant streaming | wild type | aberrant cAMP wave formation
DBS0264785V30303pakEaberrant cAMP wave formation
DBS0264823V30341frmBaberrant streaming | wild type | aberrant culmination
DBS0264853V30371abpCaberrant aggregation | abolished slug migration | aberrant culmination | abolished culmination
DBS0264905V30427DDB_G0291926aberrant streaming | aberrant culmination | aberrant slug migration | aberrant cAMP wave formation
DBS0264924V30448DDB_G0269680wild type | aberrant cAMP wave formation
DBS0264941V30466dtfAwild type | aberrant cAMP wave formation
DBS0264992V30522DDB_G0288007aberrant streaming | wild type | aberrant cAMP wave formation
DBS0264994V30524prmt5aberrant streaming | aberrant culmination | aberrant slug migration | abolished culmination | aberrant cAMP wave formation
DBS0265002V30532lvsAwild type | abolished slug migration | abolished aggregation | abolished culmination | aberrant cAMP wave formation
DBS0265017V30547DDB_G0279105aberrant streaming | wild type | aberrant vegetative growth | aberrant culmination | aberrant cAMP wave formation
DBS0265029V30561DDB_G0277355wild type | aberrant culmination
DBS0265045V30578DDB_G0277165aberrant culmination | aberrant slug migration | aberrant cAMP wave formation
DBS0265064V30604DDB_G0279461aberrant streaming | abolished slug migration | aberrant culmination | aberrant slug migration | aberrant cAMP wave formation
DBS0265099V30642tipCaberrant aggregation | abolished slug migration | abolished culmination | aberrant cAMP wave formation
DBS0265126V30673dicBaberrant aggregation | abolished slug migration | aberrant culmination | aberrant cAMP wave formation
DBS0265140V30688DDB_G0279727wild type | aberrant culmination
DBS0265303V30870gxcJJwild type | aberrant cAMP wave formation
DBS0265309V30876DDB_G0268248aberrant streaming | wild type | aberrant cAMP wave formation
DBS0265311V30879exoc2aberrant streaming | wild type | aberrant cAMP wave formation
DBS0265339V30912DDB_G0283821wild type | aberrant cAMP wave formation
DBS0265348V30921snpCwild type | aberrant culmination
DBS0265466V31043DDB_G0275917aberrant aggregation | wild type | aberrant vegetative growth | aberrant slug migration | abolished culmination
DBS0265497V31075DDB_G0282985aberrant streaming | wild type | abolished slug migration | aberrant culmination | abolished aggregation | aberrant cAMP wave formation
DBS0265529V31111vps13Eaberrant streaming | wild type | aberrant culmination | aberrant cAMP wave formation
DBS0265539V31121DDB_G0270912wild type | aberrant vegetative growth | aberrant cAMP wave formation
DBS0265567V31151DDB_G0275539wild type | aberrant vegetative growth | abolished culmination
DBS0265588V31173ggtAaberrant streaming | aberrant vegetative growth | aberrant culmination | aberrant cAMP wave formation
DBS0265662V31255psiNaberrant streaming | wild type | aberrant culmination | aberrant cAMP wave formation
DBS0265688V31281DDB_G0286417aberrant streaming | wild type | aberrant culmination | aberrant cAMP wave formation
DBS0265873V31480DDB_G0284177aberrant culmination
DBS0265890V31501DDB_G0282985wild type | aberrant culmination | aberrant cAMP wave formation
DBS0265908V31523tmem184Cwild type | aberrant culmination
DBS0265911V31528DDB_G0279945aberrant culmination
DBS0265938V31568rsc12aberrant culmination
DBS0266000V31649DDB_G0290383wild type | aberrant culmination
DBS0266022V31671dhkAaberrant culmination | aberrant slug migration
DBS0266036V31685tipCaberrant streaming | aberrant aggregation | wild type | abolished slug migration | aberrant culmination | aberrant cAMP wave formation
DBS0266084V31738dcsAwild type | aberrant culmination | abolished culmination
DBS0266088V31742dstAaberrant culmination | aberrant slug migration | abolished culmination
DBS0266089V31743DDB_G0273459aberrant streaming | aberrant aggregation | aberrant culmination | aberrant slug migration | aberrant cAMP wave formation
DBS0266098V31752oplahwild type | aberrant cAMP wave formation
DBS0266153V31811gpt1wild type | aberrant vegetative growth | aberrant culmination | aberrant cAMP wave formation
DBS0266190V31853chlAaberrant aggregation | aberrant culmination | aberrant slug migration | aberrant cAMP wave formation
DBS0266195V31858DDB_G0286341aberrant streaming | wild type | aberrant cAMP wave formation
DBS0266246V31916psiFwild type | aberrant vegetative growth | aberrant culmination | aberrant cAMP wave formation
DBS0266249V31919DDB_G0276251aberrant streaming | aberrant culmination | aberrant slug migration | aberrant cAMP wave formation
DBS0266253V31923DDB_G0268314wild type | aberrant culmination
DBS0266271V31941manAaberrant streaming | aberrant aggregation | aberrant culmination | aberrant slug migration | aberrant cAMP wave formation
DBS0266299V31970DDB_G0280581aberrant streaming | wild type | aberrant cAMP wave formation
DBS0266309V31982DDB_G0286341aberrant streaming | wild type | abolished streaming | aberrant cAMP wave formation
DBS0266316V31989DDB_G0270342wild type | abolished slug migration | aberrant culmination | abolished streaming | aberrant cAMP wave formation
DBS0237236[AS]: [tet]: trrAtrrAdecreased growth rate | delayed development | abolished aggregation
DBS0237228[AS]GP138A/ [AS]GP138BcfrAdecreased sexual fusion
DBS0237228[AS]GP138A/ [AS]GP138BcfrBdecreased sexual fusion
DBS0350559[AS]act15: adprt1Aadprt1Adevelopment arrests at loose mound stage
DBS0350897[AS]carAcarA-1abolished aggregation
DBS0350897[AS]carAcarA-2abolished aggregation
DBS0237222[AS]cf60cf60increased aggregate size | decreased number of aggregates
DBS0237223[AS]chcAchcAdecreased pinocytosis | delayed response to hypo-osmotic stress | decreased number of vacuoles | aberrant vacuole organization and biogenesis | abolished aggregation | decreased cell size
DBS0237224[AS]cmfAcmfAabolished aggregation
DBS0236982[AS]csbAcsbAdecreased cell-cell adhesion | abolished aggregation
DBS0237225[AS]cupBcupBabolished aggregation
DBS0237226[AS]dia1dia1decreased gene expression | precocious aggregation
DBS0350560[AS]ecmB: adprt1Aadprt1Adevelopment arrests at slug stage
HPF414[AS]hspAhspAdecreased growth rate | aberrant fruiting body morphology
DBS0304425[AS]mppA1mppA1delayed development
DBS0237504[AS]pikEpikEaberrant stalk morphogenesis | decreased growth rate
DBS0237231[AS]ppiAppiAincreased stalk length
DBS0236827[AS]proA/ proB-proAdecreased secretion of lysosomal enzyme | decreased exocytosis | decreased pinocytosis | increased basal F-actin level | abolished growth | development arrests at slug stage | aberrant cytokinesis | decreased cell motility
DBS0236827[AS]proA/ proB-proBdecreased secretion of lysosomal enzyme | decreased exocytosis | decreased pinocytosis | increased basal F-actin level | abolished growth | development arrests at slug stage | aberrant cytokinesis | decreased cell motility
DBS0350355[AS]proA/ proB-/ lmpA-lmpAwild type | decreased spore viability
DBS0350355[AS]proA/ proB-/ lmpA-proAwild type | decreased spore viability
DBS0350355[AS]proA/ proB-/ lmpA-proBwild type | decreased spore viability
DBS0350574[AS]rps4rps4aberrant aggregation | decreased spore viability | aberrant actin cytoskeleton organization | aberrant vegetative growth | aberrant fruiting body morphology
DBS0236904[AS]rps4mrps4delayed aggregation | aberrant fruiting body morphology
DBS0237234[AS]smlAsmlAdecreased fruiting body size
DBS0238748[AS]snfAsnfAdecreased number of mitochondria | decreased intracellular ATP level | increased growth rate | decreased fruiting body size | aberrant mitochondrion organization
DBS0304498[AS]sslA1sslA1decreased fruiting body size
DBS0237235[AS]tcp1tcp1decreased growth rate | development arrests at mound stage | aberrant fruiting body morphology
DBS0350649[AS]vatBvatBdelayed aggregation | aberrant response to chemical stimulus | aberrant slug migration
DBS0306102[AS]vatPvatPdecreased extracellular Ca2+ uptake | decreased growth rate | delayed development
DBS0266892[KD]gtaCgtaCabolished stalk cell differentiation
DBS0237276[OE]: GFP: gxcAgxcAabolished aggregation
DBS0350519[OE]: egeAegeAdecreased protein level | abolished aggregation
DBS0237277[OE]: gpaDgpaDaberrant fruiting body morphology | decreased sporulation
JH258[OE]: gpaEgpaEprecocious tip formation | precocious gene expression
DBS0236962[OE]: pdiApdiAdelayed aggregation
DBS0237015[OE]: pdiApdiAaberrant tip formation | abolished slug formation | abolished culmination
DBS0302682[OE]: sgcA(N1106A): GFP/ gca-/ sgcA-gcAaberrant streaming | aberrant chemotaxis to cAMP | increased lateral pseudopod formation | decreased chemotaxis rate
DBS0302682[OE]: sgcA(N1106A): GFP/ gca-/ sgcA-sgcAaberrant streaming | aberrant chemotaxis to cAMP | increased lateral pseudopod formation | decreased chemotaxis rate
DBS0237284[OE]GFP: gxcA(1-750: 764-1217)gxcAdevelopment arrests at loose mound stage
DBS0237285[OE]GFP: gxcA(1-750: 764-984)gxcAdevelopment arrests at loose mound stage
DBS0350172[RNAi]allCallCdevelopment arrests at loose mound stage | decreased protein level | decreased gene expression | increased growth rate | decreased cell size
DBS0350070[RNAi]canAcanAmultiple tips in culminant | aberrant response to cation stress | decreased fruiting body size | decreased stalk length
DBS0235409[RNAi]cnbAcnbAmultiple tips in culminant | decreased gene expression | aberrant response to cation stress | aberrant stalk cell differentiation | decreased stalk length
DBS0349787[RNAi]ctnnActnnAaberrant protein secretion | aberrant tip formation | aberrant Golgi localization | abolished stalk formation | aberrant centrosome localization | abolished culmination | abolished cell polarity | aberrant protein localization
DBS0349923[RNAi]ctnnA/ [act15]: GFP-mhcActnnAaberrant stalk morphogenesis | aberrant protein localization
DBS0237308[RNAi]gmsAgmsAdecreased sexual fusion
DBS0237309[RNAi]gsrgsrprecocious culmination | decreased sorting to prestalk region | precocious gene expression
DBS0349871[RNAi]lkb1lkb1abolished prespore cell differentiation | delayed aggregation | aberrant response to osmotic stress | aberrant response to oxidative stress | aberrant regulation of protein kinase activity | aberrant development | increased prestalk cell differentiation | decreased sporulation | aberrant slug formation
DBS0350643[RNAi]nse1nse1aberrant streaming | increased sensitivity to UV light | decreased fruiting body size
DBS0350644[RNAi]nse4nse4aberrant streaming | decreased gene expression | increased sensitivity to UV light | decreased fruiting body size
DBS0238734[RNAi]sdhAsdhAabolished aggregation | decreased phototaxis
DBS0349929[RNAi]tacAtacAaberrant response to cation stress | increased gene expression | delayed development | aberrant fruiting body morphology
DBS0237313[RNAi]tmcBtmcBaberrant macrocyst differentiation
DBS0237314[RNAi]tmcCtmcCaberrant macrocyst differentiation
DBS0237315[RNAi]trap1trap1decreased gene expression | delayed development
DBS0350674[act15]: 6xHis: erkAerkAaberrant slug formation
DBS0350049[act15]: FLAG: cycCcycCprecocious tip formation
DBS0350321[act15]: FLAG: hbx4hbx4aberrant aggregation | abolished gene expression | abolished slug migration | decreased growth rate | aberrant cytokinesis
DBS0350325[act15]: FLAG: hbx4/ [ecmAO]: lacZhbx4decreased spore viability | aberrant gene expression | increased prestalk cell differentiation
DBS0238108[act15]: FLAG: ppp4C(H113Q)ppp4cdevelopment arrests at mound stage | delayed development
DBS0350594[act15]: GFP: cepL(1-1114)cepLincreased number of centrosomes | decreased growth rate | aberrant vegetative growth | increased fruiting body size | decreased phagocytosis | increased cell-substrate adhesion | decreased chemotaxis rate | aberrant phototaxis
DBS0350595[act15]: GFP: cepL(1-763)cepLincreased number of centrosomes | decreased growth rate | aberrant vegetative growth | increased fruiting body size | decreased phagocytosis | increased cell-substrate adhesion | decreased chemotaxis rate | aberrant phototaxis
DBS0350596[act15]: GFP: cepL(763-1114)cepLdevelopment arrests at loose mound stage | delayed aggregation | increased cell-substrate adhesion | decreased chemotaxis rate | increased growth rate | abolished cell polarity | aberrant phototaxis | delayed gene expression | decreased cell size
DBS0350422[act15]: GFP: gpbBgpbBaberrant vegetative growth | delayed development
DBS0237117[act15]: GFP: krsAkrsAdecreased slug migration
DBS0350852[act15]: GFP: nkaPnkaPaberrant aggregation | decreased gene expression | increased gene expression | aberrant vegetative growth | increased chemotaxis rate
DBS0235442[act15]: GFP: pldBpldBabolished aggregation
DBS0238111[act15]: HA: smkAsmkAdecreased cell polarity | delayed development | decreased fruiting body size | decreased chemotaxis to cAMP
DBS0350429[act15]: RFP: abpEabpE-1delayed aggregation
DBS0350429[act15]: RFP: abpEabpE-2delayed aggregation
DBS0237227[act15]: [AS]dia2dia2decreased extracellular cAMP level | aberrant cAMP signaling during aggregation | abolished aggregation
DBS0237096[act15]: abpEabpE-1aberrant aggregation | increased lateral pseudopod formation | decreased cell motility | delayed development | decreased fruiting body size
DBS0237096[act15]: abpEabpE-2aberrant aggregation | increased lateral pseudopod formation | decreased cell motility | delayed development | decreased fruiting body size
DBS0349940[act15]: acrA(1-731): YFPacrAaberrant spore coat morphology | decreased adenylate cyclase activity
DBS0238088[act15]: atg1(K36A)atg1abolished macroautophagy | increased number of autophagosomes | aberrant cellular response to nitrogen starvation | abolished aggregation
JK1[act15]: carAcarA-1delayed aggregation
JK1[act15]: carAcarA-2delayed aggregation
DBS0252740[act15]: carA(I104D)carA-1increased cAMP binding | delayed aggregation | decreased protein kinase activation | aberrant cAMP wave formation
DBS0252740[act15]: carA(I104D)carA-2increased cAMP binding | delayed aggregation | decreased protein kinase activation | aberrant cAMP wave formation
DBS0252744[act15]: carA(I104E)carA-1increased cAMP binding | delayed aggregation | aberrant cAMP wave formation
DBS0252744[act15]: carA(I104E)carA-2increased cAMP binding | delayed aggregation | aberrant cAMP wave formation
DBS0252747[act15]: carA(I104H)carA-1development arrests at loose mound stage | increased cAMP binding | decreased protein kinase activation | abolished cAMP wave formation
DBS0252747[act15]: carA(I104H)carA-2development arrests at loose mound stage | increased cAMP binding | decreased protein kinase activation | abolished cAMP wave formation
DBS0252749[act15]: carA(I104K)carA-1increased cAMP binding | decreased protein kinase activation | abolished aggregation | abolished cAMP wave formation
DBS0252749[act15]: carA(I104K)carA-2increased cAMP binding | decreased protein kinase activation | abolished aggregation | abolished cAMP wave formation
DBS0252746[act15]: carA(I104N)carA-1development arrests at loose mound stage | increased cAMP binding | decreased protein kinase activation | abolished cAMP wave formation
DBS0252746[act15]: carA(I104N)carA-2development arrests at loose mound stage | increased cAMP binding | decreased protein kinase activation | abolished cAMP wave formation
DBS0252745[act15]: carA(I104Q)carA-1development arrests at loose mound stage | increased cAMP binding | decreased protein kinase activation | abolished cAMP wave formation
DBS0252745[act15]: carA(I104Q)carA-2development arrests at loose mound stage | increased cAMP binding | decreased protein kinase activation | abolished cAMP wave formation
DBS0252750[act15]: carA(I104R)carA-1development arrests at loose mound stage | increased cAMP binding | decreased protein kinase activation | abolished cAMP wave formation
DBS0252750[act15]: carA(I104R)carA-2development arrests at loose mound stage | increased cAMP binding | decreased protein kinase activation | abolished cAMP wave formation
DBS0252743[act15]: carA(I104S)carA-1increased cAMP binding | decreased protein kinase activation | aberrant cAMP wave formation
DBS0252743[act15]: carA(I104S)carA-2increased cAMP binding | decreased protein kinase activation | aberrant cAMP wave formation
DBS0252735[act15]: carA(I104T)carA-1increased cAMP binding | aberrant cAMP wave formation
DBS0252735[act15]: carA(I104T)carA-2increased cAMP binding | aberrant cAMP wave formation
DBS0252748[act15]: carA(I104Y)carA-1development arrests at loose mound stage | increased cAMP binding | decreased protein kinase activation | aberrant cAMP wave formation
DBS0252748[act15]: carA(I104Y)carA-2development arrests at loose mound stage | increased cAMP binding | decreased protein kinase activation | aberrant cAMP wave formation
DBS0237098[act15]: cdk5(D144N)cdk5decreased pinocytosis | increased aggregate size | delayed aggregation | decreased phagocytosis | decreased growth rate | decreased extracellular counting factor component(s) level | increased extracellular counting factor component(s) level | decreased sporulation | increased intracellular counting factor component(s) level
DBS0237099[act15]: cf60cf60aberrant regulation of aggregate size | increased number of aggregates
DBS0302445[act15]: cfaDcfaDdecreased growth rate | aberrant fruiting body morphology
DBS0302658[act15]: cnrN: myc/ smlA-cnrNdecreased fruiting body size
DBS0302658[act15]: cnrN: myc/ smlA-smlAdecreased fruiting body size
DBS0350583[act15]: csaAcsaAdecreased cell-substrate adhesion | precocious aggregation | increased calcium-independent cell-cell adhesion
DBS0350642[act15]: cynA: GFPcynAaberrant cell motility | aberrant establishment and/ or maintenance of cell polarity | precocious aggregation
DBS0237105[act15]: dgkAdgkAdevelopment arrests at loose mound stage | decreased chemotaxis rate | decreased myosin II assembly
DBS0237106[act15]: dhkC(394-661)dhkCdevelopment arrests at slug stage | increased slug migration
DBS0235716[act15]: dhkKdhkKprecocious aggregation | development arrests at mound stage
DBS0235705[act15]: dhkK(D1125N)dhkKaberrant cAMP signaling during aggregation | delayed development
DBS0235707[act15]: dhkK(H825Q)dhkKprecocious development | decreased fruiting body size
DBS0235709[act15]: dhkK(H825Q/ D1125N)dhkKaberrant slug migration | delayed culmination
DBS0237107[act15]: dng1dng1decreased growth rate | precocious aggregation | aberrant cAMP signaling during aggregation
DBS0350396[act15]: eif2s1(S53A)eif2s1aberrant spore morphology | decreased protein level | decreased spore viability
DBS0237108[act15]: fbxA: FLAGfbxAdecreased prespore cell differentiation
DBS0350365[act15]: fip(1163-2038)fip-1aberrant prestalk 0 cell differentiation
DBS0350365[act15]: fip(1163-2038)fip-2aberrant prestalk 0 cell differentiation
DBS0237601[act15]: gbpDgbpDincreased Ras guanyl-nucleotide exchange factor activity | aberrant aggregation | decreased cell-cell adhesion | increased pseudopod formation | increased cell-substrate adhesion | decreased chemotaxis to cAMP | aberrant cell morphology
DBS0237136[act15]: gpaAgpaAincreased stalk length | aberrant cytokinesis | aberrant fruiting body morphology
DBS0237145[act15]: gpaGgpaGaberrant fruiting body morphology
DBS0237147[act15]: gpaI(G38V): FLAGgpaIincreased aggregate size | delayed aggregation | decreased number of aggregates | aberrant fruiting body morphology
DBS0237148[act15]: gpaI(Q196L): FLAGgpaIincreased aggregate size | delayed aggregation | decreased number of aggregates | aberrant fruiting body morphology
DBS0350079[act15]: grlBgrlBdelayed aggregation
DBS0237149[act15]: grxAgrxAdecreased gene expression | delayed culmination
DBS0237152[act15]: grxA/ [act15]: lacZgrxAincreased sorting to prestalk region
DBS0237153[act15]: gsrgsrincreased sorting to prestalk region | delayed culmination
DBS0350037[act15]: mekA(299-360)mekAdecreased aggregate size
DBS0350034[act15]: mekA(K321A)mekAdecreased aggregate size
DBS0350033[act15]: mekA(S444A/ T448A)mekAdecreased aggregate size
DBS0237157[act15]: mkkAmkkAdevelopment arrests at mound stage | delayed development
DBS0237158[act15]: mkkA(K199A)mkkAprecocious development | decreased sporulation
DBS0237159[act15]: mkkA{deltaWD40}mkkAdevelopment arrests at mound stage | delayed development | aberrant fruiting body morphology
DBS0350332[act15]: mkpB(C294V)mkpB-1increased sensitivity to cisplatin | decreased slug size | aberrant development | delayed gene expression
DBS0350332[act15]: mkpB(C294V)mkpB-2increased sensitivity to cisplatin | decreased slug size | aberrant development | delayed gene expression
DBS0237162[act15]: myc-cdk8cdk8multiple tips | precocious tip formation
DBS0350050[act15]: myc: cdk8/ [act15]: FLAG: cycCcdk8precocious tip formation
DBS0350050[act15]: myc: cdk8/ [act15]: FLAG: cycCcycCprecocious tip formation
DBS0266837[act15]: myc: ptpCptpCaberrant signal transduction during aggregation | aberrant response to hyperosmotic stress | aberrant protein localization
DBS0238396[act15]: myc: rapA(G12V)rapAincreased protein localization to cell cortex | delayed aggregation | increased cell-substrate adhesion | decreased cell motility | increased protein kinase activation
DBS0237167[act15]: myc: rckArckAdelayed development
DBS0237163[act15]: myc: rckA(C551A)rckAdelayed slug formation | decreased chemotaxis rate
DBS0237164[act15]: myc: rckA(E510G)rckAdelayed slug formation | decreased chemotaxis rate
DBS0237165[act15]: myc: rckA(E510G/ N511A)rckAdelayed slug formation | decreased chemotaxis rate
DBS0237166[act15]: myc: rckA(K867A)rckAdelayed slug formation | precocious aggregation | decreased chemotaxis rate
DBS0237175[act15]: myoMmyoMaberrant streaming | delayed development | increased pseudopod size
DBS0237178[act15]: myoM-MtailmyoMaberrant streaming | aberrant response to hyperosmotic stress | aberrant response to hypo-osmotic stress | decreased growth rate | delayed development | increased pseudopod size
DBS0237179[act15]: myr: rckArckAdelayed development | decreased chemotaxis rate
DBS0237183[act15]: pakA(K394A)pakAdevelopment arrests at mound stage | delayed development
DBS0237184[act15]: pakA[CA]pakAabolished aggregation
DBS0350901[act15]: pdeE: YFPpdeEdevelopment arrests at loose mound stage | decreased cAMP-induced cAMP pulse
DBS0349903[act15]: pisApisAdecreased slug migration | aberrant tip formation | delayed aggregation | decreased fruiting body size
DBS0349902[act15]: pisA: GFPpisAdecreased slug migration | increased gene expression | decreased gene expression | delayed aggregation | delayed development | decreased phototaxis
DBS0350693[act15]: pkaCpkaCprecocious development
DBS0237188[act15]: pkaC(1-497)pkaCprecocious development | decreased intracellular cAMP level | decreased fruiting body size
DBS0237189[act15]: pkaR(G135E/ G261A)pkaRdecreased protein tyrosine phosphorylation | decreased cAMP binding | decreased protein kinase activity | abolished aggregation | abolished cAMP-induced cAMP pulse
DBS0350701[act15]: pkaR(G135E/ G261A)/ AX3pkaRdecreased gene expression | abolished cAMP-induced cAMP pulse
DBS0350609[act15]: pkaR(S133T,G135E)pkaRdecreased cAMP binding | decreased protein kinase activity | abolished aggregation | abolished cAMP-induced cAMP pulse
DBS0235538[act15]: pldBpldBdecreased F-actin polymerization | increased catalytic activity | increased exocytosis | aberrant chemotaxis to cAMP | abolished aggregation
DBS0349874[act15]: psaA: GFPpsaAaberrant sporulation
DBS0350262[act15]: rbg3rbg3increased lysosome size | decreased growth rate | delayed development
DBS0350671[act15]: regA(126-316): mycregAprecocious sporulation
DBS0350575[act15]: rps4rps4aberrant aggregation | decreased spore viability | aberrant actin cytoskeleton organization | aberrant vegetative growth | aberrant fruiting body morphology
DBS0236915[act15]: rzpArzpAincreased gene expression | decreased gene expression | delayed culmination
DBS0238735[act15]: snfA(1-379): GFPsnfAincreased stalk width | increased intracellular ATP level | decreased growth rate | increased number of mitochondria | decreased phototaxis | decreased stalk length | aberrant mitochondrion organization
DBS0237194[act15]: sodA: mycsodAdecreased gene expression | abolished aggregation
DBS0237195[act15]: spkA: FLAGspkA-1aberrant aggregation | decreased cell polarity | aberrant F-actin organization | decreased chemotaxis rate
DBS0237195[act15]: spkA: FLAGspkA-2aberrant aggregation | decreased cell polarity | aberrant F-actin organization | decreased chemotaxis rate
AK1209[act15]: tagA(1-890)tagAmultiple tips in mound
DBS0237199[act15]: trrAtrrAaberrant aggregation | decreased growth rate | decreased phagocytosis | delayed culmination
DBS0350498[act6]: GFP: rab2A(N118I)rab2Aaberrant response to hypo-osmotic stress | aberrant cell-cell adhesion | increased growth rate | precocious development
DBS0350499[act6]: GFP: rab2A(Q64L)rab2Adecreased autophagic cell death | aberrant response to hypo-osmotic stress | aberrant cell-cell adhesion | increased growth rate | increased phagocytosis
DBS0350685[act6]: csaAcsaAincreased slug size | increased calcium-independent cell-cell adhesion
DBS0237205[act6]: dia1dia1delayed aggregation
DBS0236905[act6]: mrps4mrps4precocious aggregation
DBS0235444[act6]: myc: eppA(S250A)eppAdecreased growth rate | delayed development | decreased intracellular cAMP level
DBS0266836[act6]: ptpBptpBdelayed aggregation | decreased fruiting body size
DBS0237218[act6]: ptpCptpCincreased aggregate size | decreased growth rate
DBS0237219[act6]: ptpC(C649S)ptpCincreased aggregate size | decreased growth rate
DBS0304410[act6]: srsAsrsAincreased aggregate size | decreased gene expression | increased slug size | delayed aggregation | decreased sporulation | aberrant fruiting body morphology
DBS0237220[act6]: trap1trap1development arrests at loose mound stage | aberrant aggregation | abolished pinocytosis | increased gene expression | decreased gene expression | decreased growth rate
DBS0349955[ampA]: RFP: ampAampAdevelopment arrests at mound stage
DBS0237221[arkA]: arkA: myc2arkAaberrant aggregation
DBS0235407[carA]: carA(1-317)carA-1delayed development
DBS0235407[carA]: carA(1-317)carA-2delayed development
DBS0350705[cotC]: pkaCpkaCprecocious development | aberrant development | aberrant fruiting body morphology
DBS0237239[dscB]: GFP: rab8A(N128I)rab8Aincreased aggregate size | increased cell-cell adhesion | decreased fruiting body size
DBS0237240[dscB]: GFP: rab8A(Q74L)rab8Aaberrant cytoskeleton organisation | abolished aggregation
DBS0237241[dscB]: GFP: rab8Brab8Bincreased aggregate size
DBS0237242[dscB]: GFP: rab8B(Q74L)rab8Bincreased aggregate size
DBS0350820[dscB]: cafAcafAincreased gene expression | precocious development
DBS0237243[dscB]: myc: rac1Brac1Bdecreased growth rate in suspension | increased rate of endocytosis | aberrant cytokinesis | delayed development
DBS0237244[dscB]: myc: rac1B(G12V)rac1Bdecreased rate of endocytosis | decreased growth rate in suspension | abolished aggregation | aberrant cell morphology
DBS0237245[dscB]: myc: rac1B(Q61L)rac1Bdecreased rate of endocytosis | decreased growth rate in suspension | abolished aggregation | aberrant cell morphology
DBS0237246[dscB]: myc: rac1B(T17N)rac1Bdecreased rate of endocytosis | decreased growth rate in suspension | abolished aggregation
DBS0350703[ecmA]: pkaCpkaCabolished tip formation | development arrests at mound stage
DBS0350659[ecmA]: pkaC(9-648)pkaCdevelopment arrests at tipped mound stage
DBS0350699[ecmA]: pkaR(G135E/ G261A)pkaRdecreased slug size | aberrant culminant morphology | delayed tip formation | aberrant slug migration | increased slug migration | aberrant prestalk cell differentiation
DBS0350700[ecmA]: pkaR(G135E/ G261A)/ [ecmB-frag]: lacZpkaRabolished stalk cell differentiation
DBS0350704[ecmB]: pkaCpkaCabolished tip formation | development arrests at mound stage
DBS0350639[ecmF]: expl3: mycexpl3aberrant stalk morphogenesis | delayed slug formation
DBS0304865[expl7]: expl7: GFPexpl7aberrant culminant morphology
DBS0237252[gpaA]: gpaA(G45V)gpaAdelayed development
DBS0237253[gpaA]: gpaA(Q206L)gpaAincreased basal disc size
DBS0349948[ndm]: ndm: RFPndmdevelopment arrests at mound stage
DBS0236086[pdsA-agg]: pdsApdsAprecocious development
DBS0236111[pdsA-ldev]: pdsApdsAdevelopment arrests at mound stage
DBS0236484[pkaC]: pkaCpkaCincreased gene expression | abolished SDF-2 production | decreased intracellular cAMP level | precocious development | precocious gene expression | aberrant fruiting body morphology
DBS0350696[pkaC]: pkaC/ srfA-pkaCaberrant spore coat morphology | aberrant gene expression
DBS0350696[pkaC]: pkaC/ srfA-srfAaberrant spore coat morphology | aberrant gene expression
DBS0237289[psmC1]: psmC1psmC1aberrant cytokinesis | delayed tip formation | delayed gene expression
DBS0350658[pspA]: pkaC(9-648)pkaCprecocious sporulation | aberrant fruiting body morphology
DBS0350697[pspA]: pkaR(G135E/ G261A)pkaRabolished gene expression | decreased gene expression | translucent sorus
DBS0237290[ptpA1]: ptpA1ptpA1-1delayed aggregation | decreased growth rate | aberrant fruiting body morphology
DBS0237290[ptpA1]: ptpA1ptpA1-2delayed aggregation | decreased growth rate | aberrant fruiting body morphology
DBS0237291[ptpB]ptpBptpBdecreased growth rate | development arrests at mound stage
DBS0238351[tet]: [RNAi]cinCcinCdecreased translation | precocious aggregation | decreased growth rate
DBS0350494[tgrB1]: [RNAi]abcB3/ [tgrC1]: GFPabcB3decreased extracellular cAMP level | delayed development
DBS0304911[tre]: paxBpaxBabolished sporulation | aberrant endocytosis | decreased cell-substrate adhesion | aberrant chemotaxis to folate | development arrests at mound stage | decreased cell motility | increased cell-cell adhesion
DBS0350267[tre]: secGsecGincreased filopodium formation | aberrant F-actin polymerization | development arrests at mound stage | aberrant actin cytoskeleton organization | abolished cell polarity | abolished chemotaxis to cAMP | delayed gene expression
DBS0350447[unk]: PTEN(H385G/ N389A/ H390A)ptendecreased localization to plasma membrane | decreased fruiting body size
DBS0350837[unk]: rasD(G12T)/ [rasD]: rapArapAaberrant culmination | decreased prespore cell differentiation | aberrant gene expression | decreased stalk cell differentiation | multiple tips in mound
DBS0350837[unk]: rasD(G12T)/ [rasD]: rapArasDaberrant culmination | decreased prespore cell differentiation | aberrant gene expression | decreased stalk cell differentiation | multiple tips in mound
DBS0304636[unk]: rasG(Q61L)/ rasG-rasGincreased protein modification | aberrant cAMP signaling during aggregation
DBS0237288[unk]skp1fpaAaberrant fruiting body morphology
DBS0237288[unk]skp1fpaB-1aberrant fruiting body morphology
HAD186aarA-aarAaberrant stalk morphogenesis | aberrant tip formation | decreased gene expression | aberrant establishment and/ or maintenance of cell polarity | aberrant stalk formation | aberrant Golgi localization | aberrant centrosome localization | decreased sporulation
DBS0349920aarA-/ [act15]: GFP-mhcAaarAaberrant stalk morphogenesis | aberrant protein localization
DBS0350143abcA10-abcA10decreased spore viability | aberrant development
DBS0350135abcA3-abcA3decreased spore viability | aberrant development | aberrant fruiting body morphology
DBS0350138abcA4-abcA4aberrant fruiting body morphology
DBS0350139abcA5-abcA5decreased spore viability | aberrant development
DBS0350140abcA6-abcA6decreased fruiting body size
DBS0350142abcA9-abcA9decreased spore viability | aberrant fruiting body morphology
DBS0350145abcB1-abcB1delayed culmination
DBS0350146abcB4-abcB4decreased spore viability
DBS0350147abcB5-abcB5decreased growth rate | delayed culmination
DBS0350153abcC13-abcC13decreased spore viability | aberrant development | delayed culmination
DBS0350154abcC14-abcC14decreased spore viability | decreased fruiting body size | aberrant development
DBS0350148abcC2-abcC2aberrant development | delayed culmination
DBS0350149abcC3-abcC3delayed culmination
DBS0350150abcC6-abcC6aberrant development | delayed culmination
DBS0350151abcC8-abcC8multiple tips in culminant | decreased spore viability | decreased growth rate
DBS0350155abcD2-abcD2decreased fruiting body size
DBS0350156abcF1-abcF1decreased spore viability | aberrant development | delayed culmination
DBS0350157abcF2-abcF2decreased spore viability | delayed tip formation
DBS0350158abcF4-abcF4aberrant development | aberrant fruiting body morphology
DBS0350164abcG10-abcG10decreased spore viability | delayed tip formation | decreased fruiting body size
DBS0350165abcG15-abcG15decreased spore viability | aberrant development
DBS0350166abcG16-abcG16delayed culmination
DBS0350167abcG17-abcG17-1decreased spore viability | decreased fruiting body size
DBS0350167abcG17-abcG17-2decreased spore viability | decreased fruiting body size
DBS0350168abcG18-abcG18decreased spore viability
DBS0350169abcG19-abcG19delayed aggregation | decreased fruiting body size
DBS0350160abcG2-abcG2delayed tip formation | decreased fruiting body size
DBS0350170abcG22-abcG22delayed tip formation | aberrant development
DBS0350171abcG24-abcG24decreased spore viability | delayed culmination
DBS0350161abcG5-abcG5delayed culmination
DBS0350162abcG6-abcG6decreased spore viability
DBS0350163abcG7-abcG7decreased spore viability | delayed tip formation | decreased fruiting body size
DBS0350159abcH2-abcH2decreased spore viability
LAS53abkD-abkDaberrant socially cooperative development
DBS0235425abpB-/ fimA-abpBdecreased fruiting body size | decreased sporulation | decreased cell size
DBS0235425abpB-/ fimA-fimAdecreased fruiting body size | decreased sporulation | decreased cell size
DBS0235427abpD-abpDdecreased cell-cell adhesion | decreased spore viability | delayed development | aberrant development
DBS0350529abpG-abpGincreased basal F-actin level | decreased chemotaxis to cAMP | decreased fruiting body size
DBS0235562acaA-acaAabolished gene expression | decreased gene expression | abolished aggregation | decreased adenylate cyclase activity | abolished cell polarity | abolished streaming | decreased intracellular cAMP level
DBS0350720acaA-/ [acaA-agg]: acaA: mycacaAwild type | decreased gene expression | decreased fruiting body size
DBS0350721acaA-/ [acaA-psp]: acaA: mycacaAdecreased gene expression | decreased aggregate size | decreased fruiting body size
DBS0350702acaA-/ [act15]: HA: pkaCacaAwild type | delayed development | decreased intracellular cAMP level
DBS0350702acaA-/ [act15]: HA: pkaCpkaCwild type | delayed development | decreased intracellular cAMP level
DBS0350725acaA-/ [act15]: HA: pkaC/ acrA-acaAdecreased gene expression | abolished adenylate cyclase activity | development arrests at tipped mound stage
DBS0350725acaA-/ [act15]: HA: pkaC/ acrA-acrAdecreased gene expression | abolished adenylate cyclase activity | development arrests at tipped mound stage
DBS0350725acaA-/ [act15]: HA: pkaC/ acrA-pkaCdecreased gene expression | abolished adenylate cyclase activity | development arrests at tipped mound stage
DBS0350737acaA-/ [act15]: acaAacaAaberrant slug formation
DBS0350738acaA-/ [act15]: acaA(1-390;398-1407)acaAabolished aggregation
DBS0350603acaA-/ [act15]: cap: GFPacaAdevelopment arrests at loose mound stage | increased calcium-dependent cell-cell adhesion | wild type
DBS0350603acaA-/ [act15]: cap: GFPcapdevelopment arrests at loose mound stage | increased calcium-dependent cell-cell adhesion | wild type
DBS0350735acaA-/ [act15]: pkaR(G135E/ G261A)acaAincreased intracellular cAMP level
DBS0350735acaA-/ [act15]: pkaR(G135E/ G261A)pkaRincreased intracellular cAMP level
DBS0350736acaA-/ [unk]: acaA(F306L/ S498G,K504E,E593V,I649T)acaAabolished cAMP wave formation
DBS0350733acaA-/ [unk]: acaA(V427I,S642F)acaAabolished activation of adenylate cyclase
DBS0350051acapA-acapAaberrant streaming | aberrant exocytosis | aberrant lysosome organization and biogenesis | aberrant filopodium formation | aberrant endocytosis | aberrant cytokinesis | decreased cell motility | decreased infection rate by Legionella pneumophila | delayed development
DBS0306126acapA-/ acapB-acapAdecreased sporulation
DBS0306126acapA-/ acapB-acapBdecreased sporulation
TL177acbA-acbAincreased sensitivity to cisplatin | abolished SDF production | decreased spore viability | abolished sorting to prestalk region
AK1211acbA-/ tagA-acbAincreased prestalk B cell differentiation
AK1211acbA-/ tagA-tagAincreased prestalk B cell differentiation
DBS0235440acgA-acgAabolished response to MPBD | abolished response to SDF-1 | decreased spore viability | precocious spore germination | abolished SDF-1 production
DBS0237788acgA-acgAdecreased gene expression | decreased prespore cell differentiation
DG1100acrA-acrAdecreased gene expression | increased stalk length | spores inviable | decreased sporulation
DBS0349939acrA-acrAaberrant spore coat morphology | decreased stalk width
DBS0237786acrA-/ [act15]: acgA(1-401)acgAdecreased gene expression | decreased prespore cell differentiation | decreased sporulation
DBS0237786acrA-/ [act15]: acgA(1-401)acrAdecreased gene expression | decreased prespore cell differentiation | decreased sporulation
DBS0350724acrA-/ [pkaC]: pkaCacrAdecreased spore viability | decreased fruiting body size | precocious development
DBS0350724acrA-/ [pkaC]: pkaCpkaCdecreased spore viability | decreased fruiting body size | precocious development
DBS0350445adcC-/ adcB-adcBaberrant endocytosis | delayed aggregation | decreased period cAMP wave formation | aberrant regulation of protein kinase activity
DBS0350445adcC-/ adcB-adcCaberrant endocytosis | delayed aggregation | decreased period cAMP wave formation | aberrant regulation of protein kinase activity
DBS0264268adprt1B-adprt1Bincreased sensitivity to DNA-damaging agents | wild type | decreased single strand break repair | aberrant cAMP wave formation
DBS0238203adrm1-adrm1-1aberrant response to nutrients | precocious gene expression | precocious development
DBS0235457ahhA-ahhAaberrant culminant morphology
DBS0235513alrA-alrAincreased aggregate size | decreased intracellular glucose level | decreased cell motility | decreased extracellular counting factor component(s) level
DBS0235474alxA-alxAdevelopment arrests at loose mound stage | decreased growth rate | aberrant fruiting body morphology
DBS0235475alxA-alxAabolished sporulation | decreased gene expression | development arrests at mound stage | aberrant fruiting body morphology
DBS0235488alxA-/ [act15]: FLAG: alxAalxAdelayed development
DBS0235478alxA-/ [act15]: alxA(155-697): myc2alxAaberrant fruiting body morphology
DBS0235479alxA-/ [act15]: alxA(293-697): myc2alxAaberrant fruiting body morphology
DBS0235480alxA-/ [act15]: alxA(460-794): myc2alxAaberrant fruiting body morphology
DG1114amdA-amdAdecreased spore viability | translucent sorus | increased prestalk A cell differentiation
HM1158amdA-amdAdecreased fruiting body size | decreased sporulation | increased aspidocyte differentiation
DBS0235490amiB-amiBabolished aggregation
DBS0235491amiB-amiBdecreased cAMP-induced cGMP pulse | abolished down-regulation of growth phase genes | decreased gene expression | abolished aggregation | decreased chemotaxis to cAMP | decreased cAMP-induced cAMP pulse
DBS0235493ampA-ampAdelayed tip formation | increased cell-cell adhesion | increased cell-substrate adhesion | mislocalized gene expression | delayed development | precocious gene expression | decreased prestalk cell differentiation | delayed gene expression
DBS0349953ampA/ [ampA]: TAPampAincreased protein secretion | development arrests at mound stage
BS155amtA-amtAdecreased slug migration | decreased aggregate size | decreased fruiting body size | increased growth rate | decreased extracellular ammonia level
DBS0267100amtA-amtAdecreased spore viability | decreased aggregate size | increased number of aggregates | decreased extracellular ammonia level | increased intracellular glucose level | decreased stalk length | increased intracellular ammonia level
BS165amtA-/ amtC-amtAdecreased protein localization to nucleus | aberrant slug migration | decreased extracellular ammonia level | delayed gene expression
BS165amtA-/ amtC-amtCdecreased protein localization to nucleus | aberrant slug migration | decreased extracellular ammonia level | delayed gene expression
BS154amtC-amtCdecreased gene expression | development arrests at slug stage | mislocalized gene expression | decreased extracellular ammonia level | delayed culmination | aberrant protein localization | aberrant fruiting body morphology
DBS0235501amtC-/ [act15]: cudAamtCdelayed culmination
DBS0235501amtC-/ [act15]: cudAcudAdelayed culmination
DBS0235502amtC-/ [ecmA]: cudAamtCdelayed culmination
DBS0235502amtC-/ [ecmA]: cudAcudAdelayed culmination
DBS0235503amtC-/ [pspA]: cudAamtCdevelopment arrests at slug stage
DBS0235503amtC-/ [pspA]: cudAcudAdevelopment arrests at slug stage
DBS0236890amtC-/ regA-amtCprecocious sporulation
DBS0236890amtC-/ regA-regAprecocious sporulation
DBS0349869ap1b1-ap1b1aberrant aggregation | aberrant contractile vacuole organization and biogenesis | aberrant cell separation during cytokinesis | aberrant response to hypo-osmotic stress | decreased growth rate | decreased protein stabilization
DBS0350296aph1-aph1aberrant culmination | abolished catalytic activity | decreased prespore cell differentiation
DBS0350299aph1-/ ncstn-aph1decreased phagocytosis | decreased prespore cell differentiation
DBS0350299aph1-/ ncstn-ncstndecreased phagocytosis | decreased prespore cell differentiation
DBS0350300aph1-/ psenA-aph1aberrant culmination | abolished catalytic activity | decreased prespore cell differentiation
DBS0350300aph1-/ psenA-psenAaberrant culmination | abolished catalytic activity | decreased prespore cell differentiation
DBS0235505apm1-apm1aberrant contractile vacuole organization and biogenesis | decreased spore germination | aberrant response to hypo-osmotic stress | decreased growth rate | aberrant endosome morphology | delayed development | decreased stalk width
DBS0235509aprA-aprAaberrant cellular homeostasis | increased cell death | increased aggregate size | decreased spore viability | aberrant cytokinesis | aberrant vegetative growth | increased growth rate | abolished chemorepellant activity | aberrant fruiting body morphology | decreased sporulation
DBS0235510aprA-/ [act15]: aprAaprAdecreased growth rate | aberrant fruiting body morphology
DBS0238124aqpA-aqpAdecreased spore viability
DBS0235511arkA-arkAincreased gene expression | aberrant fruiting body morphology
DBS0235512arkA-/ [arkA]: arkA: myc2arkAaberrant aggregation
DBS0349998arpB+/ aprB-/ [act15]: myc: arpB(Y200F/ T235A/ T236A)arpBdecreased chemoattractant-mediated F-actin polymerization | decreased cell polarity | delayed aggregation | decreased fruiting body size | decreased chemotaxis to cAMP | delayed gene expression
DBS0350450atg1-atg1aberrant vacuolation | increased infection rate by a gram- bacterium | aberrant defense response to bacterium | abolished autophagic cell death
HR131atg1-atg1abolished sporulation | decreased growth rate in suspension | abolished macroautophagy | increased number of autophagosomes | aberrant autophagy | increased infection rate by a gram- bacterium | aberrant cellular response to nitrogen starvation | abolished SDF production | abolished stalk cell differentiation | abolished aggregation | decreased growth rate on bacterial plates | aberrant defense response to yeast | aberrant protein localization
DBS0238092atg1-/ [act15]: atg1(1-628)atg1aberrant cellular response to nitrogen starvation | abolished aggregation
DBS0238087atg1-/ [act15]: atg1(K36A)atg1aberrant cellular response to nitrogen starvation | abolished aggregation
DBS0238089atg1-/ [act15]: atg1(K36A/ 1-628)atg1aberrant cellular response to nitrogen starvation | abolished aggregation
DBS0238093atg1-/ [act15]: atg1(P138S)atg1abolished aggregation
DBS0266655atg1-/ iplA-atg1decreased necrotic cell death
DBS0266655atg1-/ iplA-iplAdecreased necrotic cell death
DBS0350884atg101-atg101decreased autophagy | multiple tips
DBS0350883atg13-atg13aberrant autophagy | abolished aggregation
HR75atg5-atg5aberrant macroautophagy | abolished sporulation | aberrant cellular response to nitrogen starvation | multiple tips | abolished aggregation | aberrant protein localization
HR174 atg6-atg6Aaberrant macroautophagy | increased infection rate by a gram- bacterium | aberrant cellular response to nitrogen starvation | abolished SDF production | multiple tips | decreased fruiting body size | decreased stalk length | decreased sporulation | aberrant defense response to yeast
HR79atg7-atg7aberrant macroautophagy | abolished sporulation | increased infection rate by a gram- bacterium | aberrant cellular response to nitrogen starvation | abolished SDF production | multiple tips | aberrant protein localization
HR141atg8-atg8aaberrant macroautophagy | aberrant spore morphology | increased sensitivity to cisplatin | aberrant cellular response to nitrogen starvation | abolished SDF production | multiple tips | decreased fruiting body size | decreased sporulation
DBS0305977atg9-atg9increased stalk width | decreased pinocytosis | aberrant sorus morphology | aberrant autophagy | decreased phagocytosis | decreased growth rate | abolished catalytic activity | aberrant slug migration | aberrant protein modification | aberrant phagosome maturation | aberrant fruiting body morphology | aberrant slug formation | multiple tips in mound | abolished phototaxis
DBS0350534atg9-/ [act15]: cdcD: RFPatg9decreased growth rate | aberrant fruiting body morphology | abolished phototaxis
DBS0350534atg9-/ [act15]: cdcD: RFPcdcDdecreased growth rate | aberrant fruiting body morphology | abolished phototaxis
DBS0350731atg9-/ tipD-atg9decreased pinocytosis | aberrant phagosome maturation | development arrests at tipped mound stage
DBS0350731atg9-/ tipD-tipDdecreased pinocytosis | aberrant phagosome maturation | development arrests at tipped mound stage
DBS0350419bzpR-bzpRincreased stalk width | aberrant sorus morphology | decreased spore viability
TL97cadA-cadAdecreased calcium-dependent cell-cell adhesion | decreased protein level | increased gene expression | increased chemotaxis to cAMP | aberrant cytokinesis | multiple tips | aberrant development | decreased sporulation | delayed culmination | increased prestalk cell differentiation
DBS0235561cap-capaberrant contractile vacuole organization and biogenesis | decreased protein level | aberrant pinocytosis | aberrant cytokinesis | decreased cell motility | delayed development | aberrant response to osmotic stress
DBS0235563capB-truncatedcapBdecreased growth rate | delayed development
JB4carA-carA-1abolished aggregation
JB4carA-carA-2abolished aggregation
JS14carA-carA-1abolished protein tyrosine phosphorylation | decreased cAMP-induced cGMP pulse | abolished protein localization to nucleus | increased cell-substrate adhesion | aberrant regulation of GTPase activity | abolished aggregation | aberrant regulation of protein kinase activity | decreased cAMP-induced cAMP pulse
JS14carA-carA-2abolished protein tyrosine phosphorylation | decreased cAMP-induced cGMP pulse | abolished protein localization to nucleus | increased cell-substrate adhesion | aberrant regulation of GTPase activity | abolished aggregation | aberrant regulation of protein kinase activity | decreased cAMP-induced cAMP pulse
RI4carA-/ carC-carA-1decreased chemoattractant-mediated F-actin polymerization | abolished activation of GTPase activity | abolished aggregation | abolished cAMP-induced cGMP pulse | abolished cAMP-induced cAMP pulse
RI4carA-/ carC-carA-2decreased chemoattractant-mediated F-actin polymerization | abolished activation of GTPase activity | abolished aggregation | abolished cAMP-induced cGMP pulse | abolished cAMP-induced cAMP pulse
RI4carA-/ carC-carCdecreased chemoattractant-mediated F-actin polymerization | abolished activation of GTPase activity | abolished aggregation | abolished cAMP-induced cGMP pulse | abolished cAMP-induced cAMP pulse
DBS0350568carA-/ carC-/ [act15]: carA(261-359;S299A,S302G,S303G,S304G,S308A,S324G,S325A,S331A)(369-392;S383A,S385A)carA-1aberrant F-actin polymerization | aberrant adaptation of adenylate cyclase | aberrant chemotaxis to cAMP | abolished streaming | aberrant cAMP wave formation
DBS0350568carA-/ carC-/ [act15]: carA(261-359;S299A,S302G,S303G,S304G,S308A,S324G,S325A,S331A)(369-392;S383A,S385A)carA-2aberrant F-actin polymerization | aberrant adaptation of adenylate cyclase | aberrant chemotaxis to cAMP | abolished streaming | aberrant cAMP wave formation
DBS0350568carA-/ carC-/ [act15]: carA(261-359;S299A,S302G,S303G,S304G,S308A,S324G,S325A,S331A)(369-392;S383A,S385A)carCaberrant F-actin polymerization | aberrant adaptation of adenylate cyclase | aberrant chemotaxis to cAMP | abolished streaming | aberrant cAMP wave formation
DBS0235570carB-carBdevelopment arrests at mound stage
DBS0350661carB-carBabolished tip formation | increased gene expression | decreased gene expression | development arrests at tight mound stage | abolished culmination
DBS0235568carD-carDdecreased slug migration | decreased slug size | increased gene expression | decreased gene expression | aberrant slug migration | aberrant fruiting body morphology | decreased stalk length | decreased prestalk cell differentiation
DBS0235573carmil-carmildecreased pinocytosis | decreased growth rate | decreased basal F-actin level | decreased aggregate size
DBS0235574catB-catBdelayed development | increased spore sensitivity to hydrogen peroxide
DBS0350249cbhA-cbhAdelayed development
DBS0304455cblA-cblA-1abolished basal disc formation | aberrant slug formation | aberrant signal transduction
DBS0304455cblA-cblA-2abolished basal disc formation | aberrant slug formation | aberrant signal transduction
DBS0235661cdk8-cdk8decreased gene expression | mislocalized gene expression | abolished aggregation
DBS0350435cdk8-cdk8decreased gene expression | decreased spore viability | aberrant gene expression | abolished aggregation
DBS0350437cdk8-/ [act15]: myc: cdk8(D194A)cdk8decreased spore viability | abolished aggregation
DBS0350265cepK-cepKdecreased protein level | decreased protein localization to nuclear envelope | aberrant chemotaxis to cAMP | decreased growth rate | decreased aggregate size | decreased fruiting body size | decreased cell size
DBS0302444cfaD-cfaDaberrant cellular homeostasis | increased cell death | decreased spore viability | aberrant vegetative growth | aberrant cytokinesis | increased growth rate | aberrant fruiting body morphology | decreased sporulation
HO103chcA-chcAabolished sporulation | abolished cytokinesis | abolished gene expression | abolished growth | delayed aggregation | aberrant fruiting body morphology
DBS0350524chdA-chdAaberrant culmination | aberrant gene expression | decreased chemotaxis to cAMP
DBS0350525chdB-chdBaberrant gene expression | delayed development
DBS0350526chdC-chdCdecreased growth rate | development arrests at mound stage | aberrant gene expression | decreased chemotaxis to cAMP
DBS0350528chdC-/ [ecmA]: lacZchdCdecreased prestalk cell differentiation
DBS0350527chdC-/ [pspA]: lacZchdCdecreased prespore cell differentiation
HM1522chlA-chlAabolished DIF production | aberrant slug formation | aberrant fruiting body morphology
LAS1chtB-chtBdecreased socially cooperative development | increased growth rate
LAS5chtC-chtCdecreased socially cooperative development
DBS0235601clc-clcabolished cytokinesis | decreased protein localization to plasma membrane | aberrant response to hypo-osmotic stress | abolished growth | aberrant fruiting body morphology
DBS0235604clc-/ [act15]: GFP-clc(146-194)clcabolished cytokinesis | wild type | aberrant fruiting body morphology
DBS0235605clc-/ [act15]: GFP-clc(85-124)clcabolished cytokinesis | wild type | aberrant fruiting body morphology
DBS0235607clc-/ [act15]GFP: clc(1-124)clcabolished cytokinesis | wild type | aberrant fruiting body morphology
DBS0350473cln3-cln3aberrant protein secretion | aberrant aggregation | decreased cell-cell adhesion | increased protein secretion | decreased protein level | decreased cell-substrate adhesion | increased pinocytosis | delayed aggregation | aberrant slug migration | precocious development | increased growth rate
DBS0302655cnrN-cnrNaberrant streaming | increased cAMP-induced cAMP pulse | decreased spore viability | increased F-actin polymerization | aberrant cytokinesis | increased number of aggregates | increased growth rate | abolished positive regulation of chemorepellant activity | decreased sporulation
HG1770cnxA-cnxAdecreased extracellular Ca2+ uptake | increased cytosolic Ca2+ response
DBS0235617comB-comBabolished culmination
DG1016comB-comBabolished culmination
DBS0235618comC-comCaberrant streaming | aberrant aggregation
DBS0235619comD-comDabolished culmination
DBS0235620comE-comEtranslucent sorus | aberrant fruiting body morphology
DBS0235621comF-comF-1abolished aggregation
DBS0235621comF-comF-2abolished aggregation
DBS0235622comG-comGdevelopment arrests at mound stage | multiple tips
DBS0235623comH-comHdevelopment arrests at mound stage
DBS0350370corA-corAaberrant response to conditioned medium factor | decreased cell polarity | decreased gene expression | aberrant chemotaxis to cAMP | aberrant cAMP signaling during aggregation | abolished aggregation
DBS0350851corA-/ aip1-aip1aberrant endocytosis | increased basal F-actin level | aberrant cytokinesis | increased cell size | development arrests at mound stage | decreased growth rate | aberrant nucleus morphology | increased protein level | decreased chemotaxis to cAMP
DBS0350851corA-/ aip1-corAaberrant endocytosis | increased basal F-actin level | aberrant cytokinesis | increased cell size | development arrests at mound stage | decreased growth rate | aberrant nucleus morphology | increased protein level | decreased chemotaxis to cAMP
DBS0349942cosA-cosAincreased pseudopod formation | aberrant F-actin organization | decreased cell motility | decreased fruiting body size | decreased chemotaxis to cAMP
TL55cotA-cotAaberrant spore coat morphology | decreased spore viability | abolished cellulose binding
TL53cotA-/ cotB-cotAaberrant spore coat morphology
TL53cotA-/ cotB-cotBaberrant spore coat morphology
TL56cotA-/ cotB-/ cotC-cotAaberrant spore coat morphology | decreased spore viability | abolished cellulose binding
TL56cotA-/ cotB-/ cotC-cotBaberrant spore coat morphology | decreased spore viability | abolished cellulose binding
TL56cotA-/ cotB-/ cotC-cotCaberrant spore coat morphology | decreased spore viability | abolished cellulose binding
TL57cotA-/ cotB-/ cotC-cotAaberrant spore coat morphology
TL57cotA-/ cotB-/ cotC-cotBaberrant spore coat morphology
TL57cotA-/ cotB-/ cotC-cotCaberrant spore coat morphology
TL26cotB-cotBaberrant spore coat morphology | decreased spore viability | abolished cellulose binding
TL54cotB-/ cotC-cotBaberrant spore coat morphology
TL54cotB-/ cotC-cotCaberrant spore coat morphology
TL52cotC-cotCaberrant spore coat morphology
HW07cotE(1-235)cotEaberrant spore coat morphology
DBS0238297cpnA-cpnAdelayed response to hypo-osmotic stress | aberrant thermotaxis | increased aggregate size | decreased growth rate | aberrant cytokinesis | aberrant stalk cell differentiation | development arrests at slug stage | increased slug size | delayed development | aberrant fruiting body morphology | abolished phototaxis
DBS0238320cpnA-/ [act15]: GFP: cpnAcpnAdelayed response to hypo-osmotic stress | decreased culmination | delayed development
DBS0235627crlA-/ KAX3crlAabolished response to MPBD | increased aggregate size | decreased spore viability | delayed tip formation | decreased sorting to prestalk region | abolished SDF-1 production | increased growth rate
DBS0235628crlA-/ [crlA]: crlAcrlAincreased aggregate size
HG1768crtA-crtAdecreased extracellular Ca2+ uptake | increased cytosolic Ca2+ response
HG1772crtA-/ cnxA-cnxAdecreased growth rate | delayed response to cAMP | decreased extracellular Ca2+ uptake | decreased phagocytosis | increased cytosolic Ca2+ response
HG1772crtA-/ cnxA-crtAdecreased growth rate | delayed response to cAMP | decreased extracellular Ca2+ uptake | decreased phagocytosis | increased cytosolic Ca2+ response
DBS0235633crtf-crtfabolished sporulation | decreased gene expression | abolished aggregation
AX2-T10csaA-csaAdecreased cell-cell adhesion | decreased culmination | delayed aggregation | increased cell-substrate adhesion | decreased sporulation | aberrant protein localization
TL73csaA-/ csbA-/ csbC-/ csbC-csaAaberrant culminant morphology
TL73csaA-/ csbA-/ csbC-/ csbC-csbAaberrant culminant morphology
TL73csaA-/ csbA-/ csbC-/ csbC-csbBaberrant culminant morphology
TL73csaA-/ csbA-/ csbC-/ csbC-csbCaberrant culminant morphology
TL72csbA-/ csbB-/ csbC-csbAincreased resistance to cisplatin | aberrant culminant morphology
TL72csbA-/ csbB-/ csbC-csbBincreased resistance to cisplatin | aberrant culminant morphology
TL72csbA-/ csbB-/ csbC-csbCincreased resistance to cisplatin | aberrant culminant morphology
WTC127cshA-cshAdevelopment arrests at loose mound stage | decreased phagocytosis | decreased growth rate | delayed aggregation
DBS0235624ctnA-ctnAaberrant cellular metabolic process | decreased protein level | increased cAMP-induced cGMP pulse | increased aggregate size | decreased basal F-actin level | increased cell-cell adhesion | increased GTP-gamma-S-stimulated guanylyl cyclase activity | increased protein level | increased cell motility | increased intracellular glucose level | decreased cAMP-induced cAMP pulse | decreased myosin II assembly
DBS0235636ctnB-ctnBdecreased gene expression | increased number of aggregates | decreased fruiting body size
DG1071ctr9-ctr9aberrant fruiting body morphology
DG1058ctrA-ctrAdecreased fruiting body size
HS1151ctxA-ctxAaberrant streaming | aberrant cytokinesis | decreased growth rate
DBS0349922ctxA-/ [act15]: GFP-mhcActxAaberrant stalk morphogenesis | aberrant tip formation | aberrant protein localization
DBS0235599ctxA-/ ctxB-ctxAaberrant cellular response to fluid shear stress | abolished adenylate cyclase activity | aberrant cytokinesis | aberrant chemotaxis to cAMP | increased lateral pseudopod formation | decreased cell motility | aberrant regulation of GTPase activity | aberrant cell morphology | abolished culmination | abolished streaming | abolished aggregation | aberrant regulation of protein kinase activity
DBS0235599ctxA-/ ctxB-ctxBaberrant cellular response to fluid shear stress | abolished adenylate cyclase activity | aberrant cytokinesis | aberrant chemotaxis to cAMP | increased lateral pseudopod formation | decreased cell motility | aberrant regulation of GTPase activity | aberrant cell morphology | abolished culmination | abolished streaming | abolished aggregation | aberrant regulation of protein kinase activity
DBS0349972ctxA-/ ctxB-/ [act15]: acaA: YFPacaAaberrant fruiting body morphology
DBS0349972ctxA-/ ctxB-/ [act15]: acaA: YFPctxAaberrant fruiting body morphology
DBS0349972ctxA-/ ctxB-/ [act15]: acaA: YFPctxBaberrant fruiting body morphology
DBS0349973ctxA-/ ctxB-/ [act15]: carA: YFPcarA-1abolished adenylate cyclase activity | abolished culmination | abolished streaming
DBS0349973ctxA-/ ctxB-/ [act15]: carA: YFPcarA-2abolished adenylate cyclase activity | abolished culmination | abolished streaming
DBS0349973ctxA-/ ctxB-/ [act15]: carA: YFPctxAabolished adenylate cyclase activity | abolished culmination | abolished streaming
DBS0349973ctxA-/ ctxB-/ [act15]: carA: YFPctxBabolished adenylate cyclase activity | abolished culmination | abolished streaming
DBS0235600ctxB-ctxBaberrant streaming | aberrant cytokinesis | aberrant cell morphology
DBS0350404ctxC-ctxCaberrant streaming | increased pinocytosis | decreased period cAMP wave formation | decreased chemotaxis to cAMP | increased growth rate | increased phagocytosis
DBS0235639cudA-cudAabolished sporulation | decreased gene expression | development arrests at slug stage | abolished stalk cell differentiation
DBS0235640culA-culAmultiple tips | development arrests at tipped mound stage
DBS0235641culA-/ [cotC]: culAculAincreased sorus size | decreased stalk length | decreased sporulation
DBS0235642culA-/ [ecmA]: culAculAincreased sorus size | decreased stalk length
DBS0266745culB-culBdecreased fruiting body size | precocious gene expression | aberrant slug formation | decreased sporulation | multiple tips in mound
DBS0266761culB-/ [act15]: pkaCculBabolished gene expression | abolished sporulation | precocious gene expression | abolished aggregation
DBS0266761culB-/ [act15]: pkaCpkaCabolished gene expression | abolished sporulation | precocious gene expression | abolished aggregation
DBS0266760culB-/ pkaR-culBabolished gene expression | abolished sporulation | precocious gene expression | abolished aggregation
DBS0266760culB-/ pkaR-pkaRabolished gene expression | abolished sporulation | precocious gene expression | abolished aggregation
DBS0235651cybA-cybAabolished sporulation | aberrant development
DBS0350641cynA-cynAdecreased F-actin polymerization | aberrant cell motility | aberrant chemotaxis to cAMP | delayed aggregation | aberrant cell morphology
AK108dagA-dagAabolished gene expression | decreased gene expression | abolished activation of adenylate cyclase | abolished aggregation | decreased chemotaxis to cAMP
DBS0235653darA-darAdecreased cell polarity | decreased cell motility | decreased aggregate size | abolished aggregation
DG1099dcsA-dcsAabolished sporulation | aberrant spore coat morphology | abolished cellulose biosynthesis | abolished stalk formation | abolished stalk cell differentiation
DG1128dcsA-dcsAabolished sporulation | aberrant spore coat morphology | abolished cellulose biosynthesis | abolished stalk formation
TL127dcsA-dcsAabolished sporulation | aberrant spore coat morphology | abolished cellulose biosynthesis | aberrant stalk formation | abolished stalk formation | abolished stalk cell differentiation
DBS0349967dcx-/ lis1(D327H)dcxabolished aggregation
DBS0349967dcx-/ lis1(D327H)lis1abolished aggregation
DBS0349804detA-detAincreased aggregate size | decreased growth rate | delayed development
DBS0349813detA-/ [cotB]: GFPdetAdecreased prespore cell differentiation
DBS0349811detA-/ [ecm0]: lacZdetAaberrant prestalk 0 cell differentiation
DBS0349812detA-/ [ecmA0]: GFPdetAincreased prestalk cell differentiation
DBS0349808detA-/ [ecmA0]: lacZdetAincreased prestalk cell differentiation
DBS0349809detA-/ [ecmA]: lacZdetAincreased prestalk A cell differentiation
DBS0349810detA-/ [ecmB]: lacZdetAdelayed development
DBS0349911dgcA-dgcAdevelopment arrests at slug stage | abolished stalk cell differentiation
DBS0349917dgcA-/ [act15]: dgcA(1-124): YFPdgcAdevelopment arrests at slug stage
DBS0349918dgcA-/ [act15]: dgcA(1-273): YFPdgcAdevelopment arrests at slug stage
DBS0349916dgcA-/ [act15]: dgcA(350-521): YFPdgcAdevelopment arrests at slug stage
DBS0235695dgkA-dgkAdecreased spore viability | increased myosin II assembly | decreased chemotaxis rate | aberrant development
AK299dhkA-dhkAaberrant stalk morphogenesis | increased gene expression | mislocalized gene expression | abolished response to SDF-2 | increased sporulation | decreased sporulation | aberrant fruiting body morphology
DBS0350665dhkA-/ [act15]: dhkA(D2076N)dhkAdecreased sporulation
DBS0350664dhkA-/ [act15]: dhkA(H1396Q)dhkAdecreased sporulation
DBS0235703dhkA-/ [pkaC]: pkaCdhkAaberrant stalk morphogenesis
DBS0235703dhkA-/ [pkaC]: pkaCpkaCaberrant stalk morphogenesis
TL134dhkA-/ dhkB-dhkAabolished sporulation | increased stalk length | decreased stalk width
TL134dhkA-/ dhkB-dhkBabolished sporulation | increased stalk length | decreased stalk width
HR49dhkA-/ fbxA-dhkAdecreased intracellular cAMP level | aberrant fruiting body morphology | decreased sporulation
HR49dhkA-/ fbxA-fbxAdecreased intracellular cAMP level | aberrant fruiting body morphology | decreased sporulation
HR51dhkA-/ fbxA-dhkAaberrant fruiting body morphology | decreased sporulation
HR51dhkA-/ fbxA-fbxAaberrant fruiting body morphology | decreased sporulation
HR50dhkA-/ fbxA-dhkAabolished culmination | decreased sporulation
HR50dhkA-/ fbxA-fbxAabolished culmination | decreased sporulation
DBS0350663dhkA-/ pkaR-dhkAdecreased sporulation
DBS0350663dhkA-/ pkaR-pkaRdecreased sporulation
DBS0350662dhkA-/ regA-dhkAdecreased sporulation
DBS0350662dhkA-/ regA-regAdecreased sporulation
DBS0235704dhkB-dhkBprecocious spore germination | translucent sorus | decreased intracellular cAMP level
TL135dhkC-dhkCprecocious culmination | decreased spore germination | precocious aggregation | precocious development | precocious gene expression
DBS0350379dhkD-dhkDaberrant culminant morphology | precocious gene expression | abolished streaming | aberrant development | aberrant slug formation
DBS0350381dhkD-/ [ecmAO]: lacZdhkDaberrant prestalk cell differentiation
DBS0350382dhkD-/ [ecmB]: lacZdhkDaberrant prestalk cell differentiation
DBS0350383dhkD-/ [pspA]: lacZdhkDaberrant prespore cell differentiation
LAS99dhkE-dhkEdecreased socially cooperative development
DBS0235710dhkK-dhkKaberrant slug migration | delayed culmination | delayed gene expression
DBS0235712dhkK-/ [act15]: dhkK(D1125N)dhkKaberrant fruiting body morphology
DBS0235714dhkK-/ regA-dhkKprecocious development
DBS0235714dhkK-/ regA-regAprecocious development
DBS0348046dhkM-dhkMabolished autophagic vacuole formation | aberrant autophagic cell death
DBS0348047dhkM-dhkMabolished cellulose biosynthesis | abolished autophagic vacuole formation | abolished autophagic cell death | abolished F-actin depolymerization
DBS0350173dhkM-dhkMdecreased autophagic vacuole formation | delayed development
DBS0235719dia1-/ [act6]: trap1dia1aberrant aggregation | decreased fruiting body size
DBS0235719dia1-/ [act6]: trap1trap1aberrant aggregation | decreased fruiting body size
DBS0235895dimA-dimAincreased standing slug length | thin standing slug | abolished prestalk cell differentiation | increased slug size | decreased prestalk 0 cell differentiation | increased prespore cell differentiation | aberrant fruiting body morphology
DBS0235899dimA-/ dimB-dimAincreased standing slug length | thin standing slug | increased slug size | aberrant chemotaxis to cAMP
DBS0235899dimA-/ dimB-dimBincreased standing slug length | thin standing slug | increased slug size | aberrant chemotaxis to cAMP
DBS0235901dimB-dimBdecreased prestalk B cell differentiation | increased gene expression | aberrant chemotaxis to cAMP | aberrant gene expression | abolished response to DIF
DBS0235902dimB-/ [cotB]: lacZdimBincreased prespore cell differentiation
DBS0235906dimB-/ [ecmAO]: lacZdimBdecreased prestalk 0 cell differentiation
DBS0235907dimB-/ [ecmO]: lacZdimBaberrant prestalk cell differentiation
DBS0350495dio3-dio3decreased cell-cell adhesion | aberrant aggregation | decreased gene expression | decreased growth rate | decreased prespore cell differentiation | decreased chemotaxis to folate | decreased intracellular cAMP level | increased prestalk cell differentiation | decreased phototaxis
DBS0235913dmpA-dmpAaberrant streaming | translucent sorus | delayed development | decreased stalk cell differentiation | decreased sporulation | aberrant fruiting body morphology
HM1030dmtA-dmtAthin standing slug | decreased outer basal disc size | wild type | abolished DIF production | abolished prestalk 0 cell differentiation | delayed tip formation | decreased prestalk 0 cell differentiation | decreased lower cup size | delayed development | aberrant fruiting body morphology | decreased prestalk cell differentiation
DBS0349975dmtA-/ [dimB]: dimBdimBdecreased prestalk B cell differentiation
DBS0349975dmtA-/ [dimB]: dimBdmtAdecreased prestalk B cell differentiation
HM1196dmtA-/ stlA-dmtAdecreased outer basal disc size | decreased prestalk 0 cell differentiation
HM1196dmtA-/ stlA-stlBdecreased outer basal disc size | decreased prestalk 0 cell differentiation
DBS0235915dng1-dng1decreased growth rate | delayed aggregation
DBS0235916dnmA-dnmAaberrant culminant morphology | translucent sorus | decreased cytosine methylation in genomic DNA | decreased sporulation
DG2015docA-docAdevelopment arrests at mound stage
LAS32docA-docAdecreased socially cooperative development
DBS0350459docD-/ docA-docAdelayed development | decreased chemotaxis to cAMP | aberrant fruiting body morphology
DBS0350459docD-/ docA-docDdelayed development | decreased chemotaxis to cAMP | aberrant fruiting body morphology
DBS0235920dokA-dokAaberrant response to hyperosmotic stress | translucent sorus | decreased sporulation
DBS0349789dotA-dotAdecreased growth rate | increased sensitivity to UV light | decreased spore size | delayed development | abolished histone H3-K79 methylation
DBS0235925dstA-dstAabolished gene expression | increased gene expression | decreased gene expression | delayed aggregation | mislocalized gene expression | decreased cell motility | abolished stalk cell differentiation | abolished sorting to prestalk region | aberrant fruiting body morphology
DBS0235926dstA-dstAdelayed aggregation | mislocalized gene expression | decreased cell motility | abolished stalk cell differentiation | abolished sorting to prestalk region | aberrant fruiting body morphology
DBS0238237dstA-/ GFP: dstA(237-707): ORF+dstAabolished culmination | decreased stalk length
DBS0238236dstA-/ GFP: dstA(237-707): ORF+/ [OE]dutA(751-1322)dstAdecreased stalk length
DBS0238236dstA-/ GFP: dstA(237-707): ORF+/ [OE]dutA(751-1322)dutAdecreased stalk length
DBS0252824dstA-/ GFP: dstA(237-707): ORF+/ [act15]: 2C2Caberrant fruiting body morphology
DBS0252824dstA-/ GFP: dstA(237-707): ORF+/ [act15]: 2CdstAaberrant fruiting body morphology
DBS0252826dstA-/ GFP: dstA(237-707): ORF+/ [act15]: DDB_G0276165DDB_G0276165aberrant fruiting body morphology
DBS0252826dstA-/ GFP: dstA(237-707): ORF+/ [act15]: DDB_G0276165dstAaberrant fruiting body morphology
DBS0252825dstA-/ GFP: dstA(237-707): ORF+/ [act15]: DDB_G0282325DDB_G0282325aberrant fruiting body morphology
DBS0252825dstA-/ GFP: dstA(237-707): ORF+/ [act15]: DDB_G0282325dstAaberrant fruiting body morphology
DBS0235937dtfA-dtfAdecreased cell-cell adhesion | aberrant sorting to prestalk region | delayed tip formation | aberrant cytokinesis | aberrant fruiting body morphology
DBS0350500dupA-dupAdecreased infection rate by Legionella pneumophila | abolished aggregation
DBS0347874dymA-dymAdecreased pinocytosis | aberrant cell separation during cytokinesis | decreased cell polarity | aberrant mitochondrion morphology | decreased phagolysosome size | increased cell size | increased basal disc size | decreased growth rate | aberrant stalk formation | aberrant nucleus morphology | aberrant endosome morphology | aberrant phagosome maturation | delayed development | aberrant pseudopod formation | abolished phagosome acidification | increased phagocytosis | aberrant fruiting body morphology | aberrant intracellular distribution of mitochondria
HJW117ecmA-ecmAincreased standing slug length | weak slime trail | thin standing slug
DBS0235945egeA-egeAdecreased gene expression | decreased activation of adenylate cyclase | abolished aggregation
DBS0350520egeA-/ [unk]: YFP: carAcarA-1development arrests at mound stage
DBS0350520egeA-/ [unk]: YFP: carAcarA-2development arrests at mound stage
DBS0350520egeA-/ [unk]: YFP: carAegeAdevelopment arrests at mound stage
DBS0350521egeA-/ [unk]: pkaCegeAdecreased gene expression | abolished aggregation
DBS0350521egeA-/ [unk]: pkaCpkaCdecreased gene expression | abolished aggregation
DBS0235946egeB-egeBdevelopment arrests at mound stage
DBS0302590elmoA-elmoAincreased protein localization to pseudopodium | decreased culmination | increased pseudopod formation | increased F-actin polymerization | decreased cell motility | delayed development | abolished cell polarity | increased phagocytosis
DBS0350065elmoE-elmoEdecreased culmination | decreased F-actin polymerization at the leading edge | decreased chemotaxis to cAMP
DBS0302448epnA-epnAaberrant spore morphology | decreased spore viability | aberrant cytokinesis | abolished protein phosphorylation | aberrant protein localization
DBS0302457epnA-/ [act15]: GFP: epnA(253-677)epnAaberrant spore morphology | abolished localization to coated pits | abolished localization to plasma membrane
DBS0302474epnA-/ [act15]: epnA(R65A/ K78A): GFPepnAaberrant spore morphology | abolished localization to coated pits | abolished localization to plasma membrane | abolished phosphatidylinositol-4,5-bisphosphate binding
DBS0302475epnA-/ [act15]: epnA(T107A): GFPepnAaberrant spore morphology
DBS0235947eppA-eppAdecreased growth rate | delayed development | decreased chemotaxis to folate | decreased chemotaxis to cAMP | decreased intracellular cAMP level
DBS0350028erkA-erkAdecreased aggregate size | decreased chemotaxis to cAMP
DBS0350622erkA-erkAaberrant streaming | aberrant tip formation
DBS0350623erkA-erkAdecreased aggregate size | precocious development
HS174erkB-erkBabolished gene expression | decreased catalytic activity | decreased gene expression | aberrant phagocytosis | decreased cell motility | decreased chemotaxis to folate | abolished aggregation | decreased chemotaxis to cAMP | aberrant cell morphology | aberrant development | decreased cAMP-induced cAMP pulse | decreased sporulation
AK240erkB-erkBabolished aggregation | decreased cAMP-induced cAMP pulse | decreased sporulation
DBS0350606erkB-erkBdecreased prespore cell differentiation
DBS0350683erkB-/ [ecmA]: lacZerkBaberrant sorting to prestalk region
DBS0350682erkB-/ [unk]: erkB(P140S)erkBabolished sporulation
DBS0235949erkB-/ regA-erkBincreased cAMP-induced cAMP pulse | abolished aggregation
DBS0235949erkB-/ regA-regAincreased cAMP-induced cAMP pulse | abolished aggregation
DBS0350240fam21-fam21abolished exocytosis | aberrant post-lysosome organization and biogenesis | aberrant vegetative growth | aberrant autophagic cell death | aberrant phagosome maturation | decreased phagosomal proteolysis
DBS0235953fbxA-fbxAdecreased sporulation
HR6fbxA-fbxAdecreased socially cooperative development
DBS0235954fbxA-/ [ecmA]: GFP(S65T)fbxAincreased prespore cell differentiation
HR46fbxA-/ regA-fbxAaberrant fruiting body morphology | decreased sporulation
HR46fbxA-/ regA-regAaberrant fruiting body morphology | decreased sporulation
HR48fbxA-/ regA-fbxAaberrant fruiting body morphology | decreased sporulation
HR48fbxA-/ regA-regAaberrant fruiting body morphology | decreased sporulation
DBS0235956fbxA1-fbxAdevelopment arrests at slug stage | increased slug migration | aberrant fruiting body morphology | delayed culmination
DBS0235957fbxA2-fbxAdevelopment arrests at slug stage | increased slug migration | aberrant fruiting body morphology | delayed culmination
DBS0235958fbxA3-fbxAdevelopment arrests at slug stage | increased slug migration | aberrant fruiting body morphology | delayed culmination
DG1148fcpA-fcpAaberrant fruiting body morphology
DBS0350129fcsB-/ fcsA-fcsAdecreased catalytic activity | decreased growth rate | delayed development
DBS0350129fcsB-/ fcsA-fcsBdecreased catalytic activity | decreased growth rate | delayed development
DBS0235969forC-forCaberrant culmination | development arrests at tipped mound stage | aberrant fruiting body morphology
DBS0350280forC-forCabolished slug formation | delayed aggregation | aberrant development | decreased chemotaxis to cAMP | decreased sporulation | delayed gene expression
DBS0350287forF-forFdecreased fruiting body size | aberrant phototaxis | increased chemotaxis rate
DBS0302506frmA-frmAdelayed aggregation | decreased cell motility | increased cell-substrate adhesion | decreased aggregate size | aberrant cell morphology
DBS0304440frmA-/ [unk]: GFPfrmAdecreased gene expression | increased cell-cell adhesion | delayed development | aberrant development | abolished phototaxis
DG1066fut1-fut1aberrant fruiting body morphology
DBS0305025gabT-gabTprecocious development | decreased sporulation
DG1094gacT-gacTaberrant fruiting body morphology
DBS0235989gadA-gadAabolished SDF production | decreased sporulation
DBS0350071gadA-gadAdecreased spore viability
DBS0350077gadA-/ gadB-gadAdelayed aggregation
DBS0350077gadA-/ gadB-gadBdelayed aggregation
DBS0350072gadB-gadBdelayed aggregation
TL198gbfA-gbfAabolished gene expression | development arrests at mound stage
DBS0305094gbfA-gbfAabolished autophagic cell death | abolished autophagic vacuole formation
DBS0235994gbpC-gbpCdecreased protein kinase activation | decreased fruiting body size
DBS0235995gbpC-gbpCdecreased cell polarity | aberrant myosin II organization | aberrant chemotaxis to cAMP | decreased chemotaxis rate | aberrant cyclic nucleotide binding | aberrant cell morphology | decreased fruiting body size
DBS0302680gbpC-gbpCabolished protein localization to nucleus | decreased aggregate size | abolished protein phosphorylation | abolished aggregation
DBS0349868gbpC-/ [act15]: gbpC(1-2331: 2470-2631): GFPgbpCaberrant streaming | decreased chemotaxis to cAMP
DBS0235996gbpC-/ gbpD-gbpCdecreased cell polarity | delayed aggregation | decreased chemotaxis rate
DBS0235996gbpC-/ gbpD-gbpDdecreased cell polarity | delayed aggregation | decreased chemotaxis rate
DBS0235998gbpD-/ [act15]: gbpDgbpDaberrant F-actin organization | increased cell-substrate adhesion | increased lateral pseudopod formation | decreased chemotaxis rate | abolished aggregation
DG1120gbqA-gbqAaberrant fruiting body morphology
DBS0302679gca-/ sgcA-gcAaberrant streaming | aberrant chemotaxis to cAMP | increased lateral pseudopod formation | decreased chemotaxis rate | decreased aggregate size | decreased fruiting body size
DBS0302679gca-/ sgcA-sgcAaberrant streaming | aberrant chemotaxis to cAMP | increased lateral pseudopod formation | decreased chemotaxis rate | decreased aggregate size | decreased fruiting body size
DBS0236002gcsA-gcsAabolished gene expression | aberrant initiation of development | abolished growth | decreased gene expression | increased gene expression | development arrests at mound stage | cell cycle arrest | spores inviable
DBS0350387gcsA-/ [act15]: carAcarA-1aberrant initiation of development
DBS0350387gcsA-/ [act15]: carAcarA-2aberrant initiation of development
DBS0350387gcsA-/ [act15]: carAgcsAaberrant initiation of development
DBS0236003gcsA-/ [act15]: gcsAgcsAdecreased spore viability | development arrests at mound stage
DBS0236004gdt1-gdt1increased gene expression | decreased growth rate | precocious aggregation
DBS0237190gdt1-/ [act15]: pkaR(G135E/ G261A)gdt1increased gene expression | abolished aggregation
DBS0237190gdt1-/ [act15]: pkaR(G135E/ G261A)pkaRincreased gene expression | abolished aggregation
DBS0236095gdt1-/ gpaB-gdt1increased gene expression | abolished aggregation
DBS0236095gdt1-/ gpaB-gpaBincreased gene expression | abolished aggregation
DBS0236006gdt2-gdt2increased gene expression | precocious aggregation
RI19gefA-gefAdecreased chemoattractant-mediated F-actin polymerization | decreased cAMP-induced cGMP pulse | decreased positive regulation of GTPase activity | decreased gene expression | decreased chemotaxis rate | abolished activation of adenylate cyclase | abolished aggregation | decreased cAMP-induced cAMP pulse | increased protein kinase activation
JB10gefA-gefAabolished aggregation
DBS0350821gefA-gefAdecreased F-actin polymerization | decreased activation of GTPase activity | aberrant chemotaxis to cAMP | decreased protein kinase activation | abolished aggregation
DBS0236009gefB-gefBaberrant cytoskeleton organisation | abolished pinocytosis | increased basal F-actin level | abolished growth | delayed aggregation | decreased phagocytosis | decreased growth rate | decreased aggregate size | aberrant cell morphology | aberrant fruiting body morphology
DBS0350822gefH-gefHdecreased F-actin polymerization | decreased activation of GTPase activity | aberrant chemotaxis to cAMP | delayed development | decreased protein kinase activation
DBS0350823gefH-/ gefA-gefAdecreased F-actin polymerization | aberrant chemotaxis to cAMP | abolished activation of GTPase activity | decreased protein kinase activation | abolished aggregation
DBS0350823gefH-/ gefA-gefHdecreased F-actin polymerization | aberrant chemotaxis to cAMP | abolished activation of GTPase activity | decreased protein kinase activation | abolished aggregation
HSB61gefM-gefMincreased cAMP-induced cGMP pulse | aberrant activation of adenylate cyclase activity | development arrests at mound stage | decreased chemotaxis rate | decreased lateral pseudopod suppression | decreased cAMP-induced cAMP pulse
DBS0304968gefQ-gefQabolished Ras guanyl-nucleotide exchange factor activity | decreased positive regulation of GTPase activity | increased myosin II assembly | decreased growth rate | increased lateral pseudopod formation | abolished sorting to prestalk region | decreased fruiting body size | abolished phototaxis | multiple tips in mound
DBS0237700gflB-gflBdecreased culmination | aberrant signal transduction during aggregation | increased F-actin polymerization at the leading edge | delayed aggregation | aberrant CRAC localization to the plasma membrane | decreased aggregate size | decreased chemotaxis to cAMP | decreased myosin II assembly
DG1109ggtA-ggtAaberrant fruiting body morphology
DBS0266723glcS-/ DH1glcSaberrant stalk morphogenesis | decreased spore size | decreased intracellular glycogen level | decreased fruiting body size
DBS0236079gmsA-gmsAdecreased sexual fusion
DBS0236080gmsA-gmsAdecreased sexual fusion
DBS0238382gnt15-gnt15decreased gene expression | decreased growth rate | increased calcium-independent cell-cell adhesion | abolished aggregation | abolished culmination
DBS0238383gnt15-gnt15decreased gene expression | decreased growth rate | increased calcium-independent cell-cell adhesion | abolished aggregation | abolished culmination
DBS0236087gpaA-gpaAincreased stalk length | decreased stalk width
DBS0236092gpaA-/ [gpaA]: gpaA(G45V)gpaAdelayed development
DBS0236093gpaA-/ [gpaA]: gpaA(Q206L)gpaAincreased basal disc size
DBS0238605gpaA-/ rpkA-gpaAdelayed aggregation | abolished aggregation
DBS0238605gpaA-/ rpkA-rpkAdelayed aggregation | abolished aggregation
DBS0236575gpaB-gpaBdecreased cAMP-induced cGMP pulse | abolished activation of GTPase activity | decreased protein kinase activation | decreased cAMP-induced cAMP pulse
JH104gpaB-gpaBdecreased gene expression | abolished activation of adenylate cyclase | abolished aggregation
DBS0236096gpaB-/ [act15]: gpaBgpaBabolished aggregation
DBS0266942gpaB-/ [act15]: gpaBgpaBdelayed aggregation
DBS0266939gpaB-/ [act15]: gpaB(1-345): gpaD(337-345)gpaBabolished aggregation
DBS0266939gpaB-/ [act15]: gpaB(1-345): gpaD(337-345)gpaDabolished aggregation
DBS0237137gpaB-/ [act15]: gpaB(D154V)gpaBaberrant aggregation | decreased cAMP-induced cGMP pulse | decreased activation of adenylate cyclase | decreased chemotaxis rate | decreased cAMP-induced cAMP pulse
DBS0237138gpaB-/ [act15]: gpaB(E190G)gpaBaberrant aggregation | decreased cAMP-induced cGMP pulse | decreased activation of adenylate cyclase | decreased cAMP-induced cAMP pulse
DBS0237139gpaB-/ [act15]: gpaB(I104S)gpaBaberrant aggregation | decreased cAMP-induced cGMP pulse | decreased activation of adenylate cyclase | decreased chemotaxis rate | decreased cAMP-induced cAMP pulse
DBS0237140gpaB-/ [act15]: gpaB(L110S)gpaBaberrant aggregation | decreased cAMP-induced cGMP pulse | decreased activation of adenylate cyclase | decreased chemotaxis rate | decreased cAMP-induced cAMP pulse
DBS0237141gpaB-/ [act15]: gpaB(L76P)gpaBabolished aggregation
DBS0237142gpaB-/ [act15]: gpaB(N74D)gpaBdecreased cAMP-induced cGMP pulse | decreased activation of adenylate cyclase | decreased chemotaxis rate | abolished aggregation | decreased cAMP-induced cAMP pulse
DBS0237143gpaB-/ [act15]: gpaB(R64G)gpaBdecreased chemotaxis rate | abolished aggregation
DBS0237144gpaB-/ [act15]: gpaB(S155P)gpaBdecreased chemotaxis rate | abolished aggregation
DBS0236097gpaB-/ [gpaA]: gpaBgpaBabolished aggregation
DBS0350373gpaB-/ regA-gpaBdecreased number of aggregates
DBS0350373gpaB-/ regA-regAdecreased number of aggregates
DBS0235986gpaC-gpaCaberrant activation of adenylate cyclase activity | decreased gene expression | increased protein kinase activity | abolished aggregation
JH417gpaD-gpaDdecreased gene expression | abolished SDF production | decreased accumulation of cGMP | decreased chemotaxis to folate | decreased protein kinase activation | aberrant fruiting body morphology | decreased sporulation
DBS0266944gpaD-/ [act15]: gpaBgpaBdecreased accumulation of cGMP | decreased chemotaxis to folate | aberrant fruiting body morphology
DBS0266944gpaD-/ [act15]: gpaBgpaDdecreased accumulation of cGMP | decreased chemotaxis to folate | aberrant fruiting body morphology
DBS0266946gpaD-/ [act15]: gpaB(1-345): gpaD(337-345)gpaBdecreased accumulation of cGMP | aberrant fruiting body morphology
DBS0266946gpaD-/ [act15]: gpaB(1-345): gpaD(337-345)gpaDdecreased accumulation of cGMP | aberrant fruiting body morphology
DBS0350608gpaD-/ [act15]: gpaD(Q200L)gpaDdevelopment arrests at loose mound stage | decreased chemotaxis to folate | decreased protein kinase activation
DBS0350607gpaD-/ [act15]: gpaD(R107E,R108E)gpaDabolished culmination
DBS0266945gpaD-/ [act15]: gpaEgpaDdecreased accumulation of cGMP | decreased chemotaxis to folate | aberrant fruiting body morphology
DBS0266945gpaD-/ [act15]: gpaEgpaEdecreased accumulation of cGMP | decreased chemotaxis to folate | aberrant fruiting body morphology
DBS0266947gpaD-/ [act15]: gpaE(1-339): gpaD(337-345)gpaDdecreased accumulation of cGMP | decreased chemotaxis to folate | aberrant fruiting body morphology
DBS0266947gpaD-/ [act15]: gpaE(1-339): gpaD(337-345)gpaEdecreased accumulation of cGMP | decreased chemotaxis to folate | aberrant fruiting body morphology
DBS0350374gpaD-/ regA-gpaDaberrant aggregation | abolished slug migration | decreased sporulation
DBS0350374gpaD-/ regA-regAaberrant aggregation | abolished slug migration | decreased sporulation
DBS0350378gpaD-/ regA-/ [ecmB]: lacZgpaDincreased prestalk 0 cell differentiation
DBS0350378gpaD-/ regA-/ [ecmB]: lacZregAincreased prestalk 0 cell differentiation
JH257gpaE-gpaEincreased chemotaxis to folate | delayed tip formation | increased cell size | decreased sorting to prestalk region | delayed gene expression
DBS0266941gpaE-/ [act15]: gpaEgpaEprecocious tip formation
DBS0266948gpaE-/ [act15]: gpaE(1-339): gpaD(337-345)gpaDprecocious tip formation
DBS0266948gpaE-/ [act15]: gpaE(1-339): gpaD(337-345)gpaEprecocious tip formation
DBS0350678gpaE-/ [act15]: gpaE(K10E/ K11E)gpaEdelayed tip formation | delayed gene expression
DBS0350624gpaE-/ erkA-erkAwild type | decreased aggregate size | precocious development
DBS0350624gpaE-/ erkA-gpaEwild type | decreased aggregate size | precocious development
DBS0236107gpaH-gpaHwild type | increased cell death | decreased spore viability | abolished negative chemotaxis | increased growth rate
DBS0236109gpaI-gpaIaberrant cellular homeostasis | increased cell death | precocious aggregation | decreased aggregate size | increased number of aggregates | decreased fruiting body size | increased growth rate
LW5gpbA-gpbAincreased resistance to N-Phenylthiourea | abolished aggregation
LW6gpbA-gpbAdecreased CRAC localization to the plasma membrane | aberrant cellular homeostasis | decreased cAMP-induced cGMP pulse | decreased positive regulation of GTPase activity | increased cell death | decreased phagocytosis | decreased engulfment during phagocytosis | abolished F-actin polymerization | decreased chemotaxis to folate | decreased protein kinase activation | decreased chemotaxis to cAMP | increased growth rate | decreased cAMP-induced cAMP pulse | aberrant protein localization
DBS0350477gpr89-gpr89aberrant spore morphology | aberrant mitochondrion morphology | abolished growth | decreased gene expression | decreased cell motility | abolished sorting to prestalk region | decreased fruiting body size | precocious gene expression | aberrant slug formation | decreased phototaxis | delayed gene expression
DBS0304814grlA-grlAdecreased gene expression | abolished SDF production | delayed gene expression | decreased sporulation | delayed culmination
DBS0304815grlA-/ [act15]: grlA: GFPgrlAaberrant tip formation
DBS0350074grlB-grlBdecreased small molecule binding | delayed aggregation | delayed gene expression
DBS0350078grlB-/ grlE-grlBdecreased small molecule binding | delayed aggregation
DBS0350078grlB-/ grlE-grlEdecreased small molecule binding | delayed aggregation
DBS0236112grlE-grlEabolished SDF production | aberrant gamma-aminobutyric acid signaling pathway | decreased sporulation
DBS0236113grlE-grlEdelayed aggregation | aberrant gene expression | decreased chemotaxis to cAMP
DBS0350075grlE-grlEdecreased spore viability | delayed aggregation
DBS0238865grlJ-grlJaberrant spore morphology | decreased spore viability | increased slug size | precocious development | decreased fruiting body size | precocious gene expression
DBS0350283grlJ-grlJaberrant spore morphology | increased resistance to N-Phenylthiourea
DBS0238686grpA-grpAdecreased spore germination | abolished protein secretion
ARK200gskA-gskAincreased gene expression | decreased gene expression | aberrant CRAC localization to the plasma membrane | decreased chemotaxis to cAMP | abolished streaming | aberrant protein localization to plasma membrane | decreased sporulation
DBS0236114gskA-gskAaberrant aggregation | decreased slug migration | aberrant sorus morphology | abolished CRAC localization to the plasma membrane | decreased gene expression | aberrant cAMP signaling during aggregation | abolished protein phosphorylation | decreased chemotaxis to folate | decreased stalk length | abolished chemotaxis to cAMP
HM338gskA-gskAprecocious aggregation | aberrant spindle elongation | decreased prespore cell differentiation | aberrant fruiting body morphology | increased prestalk cell differentiation | decreased sporulation
DBS0349881gskA-/ [act15]: gskA(Y214F)gskAabolished streaming
DBS0350427gskA-/ gskA(K85R): GFPgskAaberrant aggregation
DBS0266891gtaC-gtaCabolished stalk cell differentiation in vitro | aberrant streaming | decreased aggregate size | aberrant prestalk B cell differentiation
DBS0350347gtaC-gtaCabolished gene expression | decreased fruiting body size | abolished aggregation
DBS0350357gtaC-/ [act15]: GFP: gtaC(C500,503,522,525S)gtaCaberrant gene expression | abolished aggregation | decreased fruiting body size
DBS0350361gtaC-/ [act15]: gtaC: (468-496): GFP: gtaCgtaCdevelopment arrests at mound stage | decreased aggregate size | precocious development
DBS0236120gxcA-gxcAdecreased chemoattractant-mediated F-actin polymerization | decreased positive regulation of GTPase activity | delayed development
DBS0236121gxcB-gxcBdecreased exocytosis | aberrant cytoskeleton organisation | delayed development
DBS0350256gxcC-gxcCdelayed development
DBS0238825gxcDD-gxcDDaberrant streaming | delayed development
LAS105gxcKK-gxcKKdecreased socially cooperative development
DBS0350268gxcT-gxcTdecreased cell polarity | aberrant cytokinesis | decreased growth rate | aberrant CRAC localization to the plasma membrane | delayed aggregation | increased lateral pseudopod formation | aberrant regulation of GTPase activity | decreased chemotaxis to cAMP | decreased fruiting body size
DBS0236131hbx2-/ warA-hbx2increased basal disc size | development arrests at mound stage | decreased prespore cell differentiation | increased prestalk 0 cell differentiation
DBS0236131hbx2-/ warA-warAincreased basal disc size | development arrests at mound stage | decreased prespore cell differentiation | increased prestalk 0 cell differentiation
DBS0350324hbx4-/ [ecmAO]: lacZhbx4increased prespore cell differentiation
DBS0350879hbx9-hbx9decreased cell-cell adhesion | decreased gene expression | delayed aggregation | decreased growth rate | decreased chemotaxis to cAMP
DBS0350880hbx9-/ [ecmA]: lacZhbx9increased prestalk A cell differentiation
DBS0305109hdaB-hdaBdecreased sporulation | decreased histone deacetylase activity
HM1012helC-helCdecreased gene expression | delayed development | aberrant fruiting body morphology
HM444helC-helCdecreased gene expression | delayed development | aberrant fruiting body morphology
DG1059helE-helEincreased slug migration
DBS0236163helF-helFincreased stalk cell differentiation | increased slug size | delayed development | increased post-transciptional gene silencing by RNA
DBS0350878hephA-hephAincreased response to cAMP | delayed aggregation | aberrant development | decreased intracellular cAMP level
DBS0350362hfnA-hfnAincreased phototaxis | decreased slug size | increased slug migration
DBS0350363hfnA-/ [ecmO]: lacZhfnAaberrant prestalk 0 cell differentiation | aberrant slug formation
DBS0350364hfnA-/ abpC-abpCwild type | aberrant prestalk 0 cell differentiation | decreased phototaxis
DBS0350364hfnA-/ abpC-hfnAwild type | aberrant prestalk 0 cell differentiation | decreased phototaxis
DBS0238583hipA-hipAaberrant spore morphology | decreased spore viability | aberrant spore coat morphology
DBS0305951hipA-/ epnA-epnAaberrant spore morphology | decreased spore viability
DBS0305951hipA-/ epnA-hipAaberrant spore morphology | decreased spore viability
DBS0349776htt-httdecreased growth rate in suspension | aberrant cell separation during cytokinesis | decreased chemotaxis rate | delayed development | delayed gene expression | decreased myosin II assembly
DBS0349788htt-httaberrant aggregation | development arrests at loose mound stage | aberrant cellular response to starvation | abolished potassium-dependent chemotaxis to cAMP | aberrant spore morphology | decreased spore viability | aberrant response to hypo-osmotic stress | aberrant F-actin organization | abolished chemotaxis to calcium | abolished streaming | aberrant development | abolished culmination | multiple tips in mound | decreased sporulation | aberrant prespore cell differentiation | abolished calcium-independent cell-cell adhesion | abolished protein level
DBS0349794ibrA-ibrAaberrant stalk formation
DBS0252699icmA-icmA-1abolished sporulation | aberrant signal transduction during aggregation | abolished growth | development arrests at mound stage | abolished cell polarity | abolished streaming | aberrant protein localization to nucleus | aberrant cAMP wave formation | delayed gene expression | aberrant fruiting body morphology | aberrant protein localization
DBS0252699icmA-icmA-2abolished sporulation | aberrant signal transduction during aggregation | abolished growth | development arrests at mound stage | abolished cell polarity | abolished streaming | aberrant protein localization to nucleus | aberrant cAMP wave formation | delayed gene expression | aberrant fruiting body morphology | aberrant protein localization
BS153ifkA-ifkAincreased aggregate size | precocious aggregation | decreased extracellular counting factor component(s) level | precocious gene expression
BS161ifkA-/ ifkB-ifkAincreased aggregate size | increased cell-cell adhesion | increased cell-substrate adhesion | aberrant fruiting body morphology | multiple tips in mound
BS161ifkA-/ ifkB-ifkBincreased aggregate size | increased cell-cell adhesion | increased cell-substrate adhesion | aberrant fruiting body morphology | multiple tips in mound
DBS0236425ino1-ino1decreased intracellular myo-inositol level | abolished growth | decreased phagocytosis | increased intracellular 2,3-bisphosphoglycerate level | multiple tips in mound
DBS0350801ino1-ino1aberrant cellular metabolic process | increased number of autophagosomes | decreased intracellular myo-inositol level | decreased cell-substrate adhesion | abolished growth | aberrant phosphatidylinositol metabolism | aberrant cytokinesis | aberrant fruiting body morphology
DBS0266326iplA-iplAabolished cellulose biosynthesis | abolished autophagic vacuole formation | abolished autophagic cell death
HM1038iplA-iplAabolished cAMP-induced Ca2+ influx | aberrant cell motility | precocious aggregation | delayed aggregation | aberrant chemotaxis | increased chemotaxis to arachidonic acid
DBS0252878iptA-iptAdecreased spore viability
DBS0350057keaA-keaAdecreased gene expression | delayed aggregation | decreased growth rate | aberrant cAMP signaling during aggregation | decreased intracellular cAMP level
DBS0238720krsA-krsAaberrant response to hyperosmotic stress | precocious culmination | abolished activation of adenylate cyclase | decreased aggregate size | decreased intracellular cAMP level | precocious gene expression | abolished streaming | decreased cell size
DBS0238722krsA-/ [act15]: GFP: krsA(K49R)krsAaberrant streaming
DBS0238723krsA-/ [act15]: GFP: krsA(T173A)krsAabolished streaming
DBS0238725krsA-/ [act15]: GFP: krsA(deltaC)krsAaberrant streaming
DBS0238724krsA-/ [act15]: GFP: krsA(deltaKinase)krsAabolished streaming
DBS0238726krsA-/ [act15]: GFP: krsA(deltaNS)krsAabolished streaming
DBS0350598krsB-krsBaberrant streaming | decreased cell motility | increased cell-substrate adhesion | delayed development | decreased chemotaxis to cAMP
DBS0350599krsB-/ [tet]: krsB(T176A): GFPkrsBaberrant streaming
DBS0350600krsB-/ krsA-krsAaberrant streaming | delayed development
DBS0350600krsB-/ krsA-krsBaberrant streaming | delayed development
DBS0236498lagD-tgrD1aberrant aggregation | aberrant cAMP signaling during aggregation | abolished streaming
DBS0236499limB-limBdecreased cell polarity | decreased cell-substrate adhesion | decreased gene expression | development arrests at mound stage | aberrant F-actin organization | aberrant cell-cell adhesion | decreased chemotaxis rate | abolished sorting to prestalk region | delayed gene expression
DBS0236502limB-/ [act15]: paxB: GFPlimBdevelopment arrests at mound stage
DBS0236502limB-/ [act15]: paxB: GFPpaxBdevelopment arrests at mound stage
DBS0236500limB-/ [cotC]: limBlimBdevelopment arrests at mound stage
DBS0236729limB-/ paxB-limBdevelopment arrests at mound stage
DBS0236729limB-/ paxB-paxBdevelopment arrests at mound stage
DBS0350563limC-limCdelayed aggregation | decreased growth rate | aberrant cytokinesis | aberrant response to osmotic stress
DBS0350564limD1-limD1decreased cell polarity | delayed aggregation | decreased growth rate | aberrant F-actin organization | aberrant cytokinesis | increased lateral pseudopod formation | aberrant response to osmotic stress | decreased chemotaxis to cAMP
DBS0350565limD1-/ limC-limCdecreased cell polarity | abolished growth | delayed aggregation | aberrant F-actin organization | aberrant cytokinesis | aberrant response to osmotic stress | decreased chemotaxis to cAMP
DBS0350565limD1-/ limC-limD1decreased cell polarity | abolished growth | delayed aggregation | aberrant F-actin organization | aberrant cytokinesis | aberrant response to osmotic stress | decreased chemotaxis to cAMP
DG1006lipA-lipAabolished culmination
DG1056lipB-captCaberrant fruiting body morphology
DBS0349950lmbd2B-lmbd2Bincreased pseudopod formation | aberrant chemotaxis | delayed development | aberrant cell morphology
DBS0350354lmpA-lmpAdecreased fruiting body size | decreased sporulation
DBS0236516lrrA-lrrAdecreased cell polarity | increased aggregate size | decreased cell-substrate adhesion | increased basal F-actin level | decreased spore viability | decreased gene expression | development arrests at mound stage | abolished positive chemotaxis | abolished aggregation | aberrant cell morphology | delayed gene expression
DBS0350407lrrB-lrrBaberrant thermotaxis | delayed slug formation | decreased gene expression | aberrant culminant morphology | aberrant gene expression | aberrant phototaxis | aberrant development
DBS0350478lrrB-/ [ecmB]: lacZlrrBaberrant prestalk B cell differentiation
DBS0350476lrrB-/ [ecmO]: lacZlrrBaberrant prestalk 0 cell differentiation
DBS0236517lst8-lst8decreased F-actin polymerization | aberrant activation of adenylate cyclase activity | decreased chemotaxis rate | abolished aggregation | decreased myosin II assembly
AD63lvsA-lvsAabolished cytokinesis | abolished cAMP-induced Ca2+ influx
DBS0349933macA-macAaberrant macrocyst differentiation | decreased sexual fusion
DBS0350211mef2A-mef2Aaberrant streaming | decreased growth rate | aberrant development | decreased sporulation
DBS0350212mef2A-mef2Aaberrant streaming | decreased growth rate | aberrant gene expression | aberrant development | decreased sporulation
DBS0350213mef2A-/ [ecmA]: lacZmef2Aaberrant prestalk A cell differentiation
DBS0350214mef2A-/ [ecmB]: lacZmef2Aaberrant prestalk B cell differentiation
DBS0350215mef2A-/ [pspA]: lacZmef2Adecreased prespore cell differentiation
DBS0236543mekA-mekAdecreased aggregate size | precocious development | abolished chemotaxis to cAMP
DBS0350036mekA-/ [act15]: mekA(299-360)mekAdecreased aggregate size
DBS0350035mekA-/ [act15]: mekA(K321A)mekAdecreased aggregate size
DBS0350032mekA-/ [act15]: mekA(S444A/ T448A)mekAdecreased aggregate size
DBS0350031mekA-/ [act15]: mekA(S444E/ T448E)mekAdevelopment arrests at mound stage
DBS0238098mekA-/ ppp4C-mekAdecreased aggregate size
DBS0238098mekA-/ ppp4C-ppp4cdecreased aggregate size
DBS0238109mekA-/ ppp4C-/ [act15]: FLAG: pppCppp4cdecreased aggregate size | precocious development
DBS0236542mekA-/ smkA-mekAdecreased aggregate size
DBS0236542mekA-/ smkA-smkAdecreased aggregate size
DBS0236544mfeA-mfeAdecreased protein level | development arrests at mound stage | aberrant cAMP signaling during aggregation
DBS0266843mgp1-mgp1aberrant contractile vacuole organization and biogenesis | increased phototaxis | increased filopodium formation | decreased cell motility | decreased fruiting body size | abolished streaming | decreased stalk width | decreased stalk length
DBS0266846mgp1-/ mgp2-mgp1aberrant contractile vacuole organization and biogenesis | increased filopodium formation | aberrant culmination | decreased cell motility | decreased phototaxis | decreased stalk length
DBS0266846mgp1-/ mgp2-mgp2aberrant contractile vacuole organization and biogenesis | increased filopodium formation | aberrant culmination | decreased cell motility | decreased phototaxis | decreased stalk length
DBS0266844mgp2-mgp2increased aggregate size | increased slug size
HS1mhcA-mhcAaberrant response to hypo-osmotic stress | development arrests at mound stage | aberrant cytokinesis | decreased growth rate | increased F-actin polymerization | aberrant regulation of GTPase activity | aberrant regulation of protein kinase activity
HS2207mhcA-mhcAabolished cytokinesis | development arrests at mound stage
DBS0350808mhcA-/ [act15]: mhcA(1-933: 1455-2116]mhcAwild type | aberrant cytokinesis | aberrant fruiting body morphology
DBS0238158mhcA-/ [act15]: mhcA(81-2116)mhcAdecreased growth rate | development arrests at tipped mound stage
DBS0236552mhcA-/ [mhcA]: mhcA(1-1224)mhcAaberrant cytokinesis | development arrests at mound stage
DBS0236557mhkA-/ [act15]: mhkAmhkAdecreased growth rate | development arrests at mound stage | aberrant cytokinesis | decreased myosin II assembly
DG1069mhkC-mhkCaberrant fruiting body morphology
DBS0236559midA-midAdecreased pinocytosis | aberrant spore morphology | decreased thermotaxis | increased autophagy | decreased mitochondrial fission | decreased growth rate | decreased phagocytosis | increased intracellular glutamate level | decreased intracellular glycogen level | increased extracellular ammonia level | increased slug migration | decreased cell size | decreased phototaxis
DG1020migA-migAabolished slug migration | decreased fruiting body size | aberrant fruiting body morphology
DBS0350025mip1-mip1-1increased aggregate size | decreased chemotaxis to cAMP
DBS0350025mip1-mip1-2increased aggregate size | decreased chemotaxis to cAMP
DBS0236561mkcA-/ tagB-mkcAdecreased sporulation
DBS0236561mkcA-/ tagB-tagBdecreased sporulation
DBS0236562mkcA-/ tagC-mkcAdecreased sporulation
DBS0236562mkcA-/ tagC-tagCdecreased sporulation
DG1101mkcB-mkcBdecreased fruiting body size
DBS0236564mkkA-mkkAprecocious culmination | decreased sorus size | increased stalk length
DG1121mkpA-mkpAabolished aggregation
DBS0236566mlcE-mlcEdecreased growth rate in suspension | aberrant cytokinesis | delayed aggregation | decreased cell motility | mislocalized gene expression | aberrant development
DBS0236567mlcR-mlcRaberrant myosin II organization | aberrant cytokinesis | development arrests at mound stage
DBS0349919mlkA-/ [act15]: GFP-mhcAmlkAaberrant stalk morphogenesis
DG1033modA-modAabolished catalytic activity | aberrant fruiting body morphology
DBS0266903mpl1-mpl1decreased cell motility | decreased chemotaxis to cAMP | abolished streaming | abolished aggregation
DBS0349986mrfA-mrfAaberrant slug migration | delayed development
DBS0350390mrfA-/ [act15]: myc: mrfA(S767A): FLAGmrfAaberrant protein modification | delayed development
DBS0349987mrfA-/ [emcA]: lacZmrfAdecreased prestalk A cell differentiation
DBS0349988mrfA-/ dimB-/ [emcA]: lacZdimBdecreased prestalk A cell differentiation
DBS0349988mrfA-/ dimB-/ [emcA]: lacZmrfAdecreased prestalk A cell differentiation
DBS0236569mrps4-mrps4delayed aggregation | aberrant fruiting body morphology
DBS0304881mrps4-mrps4delayed aggregation
DBS0304882mtDNA-DidioMp05abolished growth | abolished aggregation
DBS0304882mtDNA-DidioMp21abolished growth | abolished aggregation
DBS0304882mtDNA-DidioMp26abolished growth | abolished aggregation
DBS0304882mtDNA-DidioMp27abolished growth | abolished aggregation
DBS0304882mtDNA-DidioMp30abolished growth | abolished aggregation
DBS0304882mtDNA-DidioMp35abolished growth | abolished aggregation
DBS0304882mtDNA-DidioMp36abolished growth | abolished aggregation
DBS0304882mtDNA-ai2aabolished growth | abolished aggregation
DBS0304882mtDNA-ai2babolished growth | abolished aggregation
DBS0304882mtDNA-ai3abolished growth | abolished aggregation
DBS0304882mtDNA-ai4abolished growth | abolished aggregation
DBS0304882mtDNA-atp1abolished growth | abolished aggregation
DBS0304882mtDNA-atp4abolished growth | abolished aggregation
DBS0304882mtDNA-atp6abolished growth | abolished aggregation
DBS0304882mtDNA-atp8abolished growth | abolished aggregation
DBS0304882mtDNA-atp9abolished growth | abolished aggregation
DBS0304882mtDNA-cox1/ 2abolished growth | abolished aggregation
DBS0304882mtDNA-cox3abolished growth | abolished aggregation
DBS0304882mtDNA-cytBabolished growth | abolished aggregation
DBS0304882mtDNA-mrpl11abolished growth | abolished aggregation
DBS0304882mtDNA-mrpl14abolished growth | abolished aggregation
DBS0304882mtDNA-mrpl16abolished growth | abolished aggregation
DBS0304882mtDNA-mrpl2abolished growth | abolished aggregation
DBS0304882mtDNA-mrpl6abolished growth | abolished aggregation
DBS0304882mtDNA-mrps12abolished growth | abolished aggregation
DBS0304882mtDNA-mrps13abolished growth | abolished aggregation
DBS0304882mtDNA-mrps14abolished growth | abolished aggregation
DBS0304882mtDNA-mrps19abolished growth | abolished aggregation
DBS0304882mtDNA-mrps2abolished growth | abolished aggregation
DBS0304882mtDNA-mrps4abolished growth | abolished aggregation
DBS0304882mtDNA-mrps7abolished growth | abolished aggregation
DBS0304882mtDNA-mrps8abolished growth | abolished aggregation
DBS0304882mtDNA-nad1abolished growth | abolished aggregation
DBS0304882mtDNA-nad11abolished growth | abolished aggregation
DBS0304882mtDNA-nad2abolished growth | abolished aggregation
DBS0304882mtDNA-nad3abolished growth | abolished aggregation
DBS0304882mtDNA-nad4abolished growth | abolished aggregation
DBS0304882mtDNA-nad4Labolished growth | abolished aggregation
DBS0304882mtDNA-nad5abolished growth | abolished aggregation
DBS0304882mtDNA-nad6abolished growth | abolished aggregation
DBS0304882mtDNA-nad7abolished growth | abolished aggregation
DBS0304882mtDNA-nad9abolished growth | abolished aggregation
DBS0304882mtDNA-rnlAabolished growth | abolished aggregation
DBS0350868mtpn-mtpnaberrant streaming | decreased growth rate | decreased cell motility | decreased macropinocytosis | decreased basal F-actin level
DBS0236570mybB-mybBdecreased cAMP-induced cGMP pulse | decreased gene expression | decreased activation of adenylate cyclase | abolished aggregation | decreased cAMP-induced cAMP pulse
DBS0236571mybB-mybBabolished aggregation
HM388mybC-mybCdecreased SDF production | decreased gene expression | abolished culmination
DBS0236572mybE-mybEincreased gene expression | increased slug size | abolished outer basal disc formation
DBS0237709mybE-/ [mrrA]: lacZmrrAaberrant prestalk cell differentiation
DBS0237709mybE-/ [mrrA]: lacZmybEaberrant prestalk cell differentiation
DBS0236573mybE-/ mybE: GFPmybEwild type | aberrant prestalk cell differentiation
HDT1myoA-myoAdelayed aggregation | decreased cell motility | decreased chemotaxis rate | decreased lateral pseudopod suppression
HDT5myoA-/ myoBmyoAdecreased pinocytosis | decreased growth rate in suspension | aberrant cytoskeleton organisation | increased secretion of lysosomal enzyme | decreased cell motility | decreased fruiting body size
HDT5myoA-/ myoBmyoBdecreased pinocytosis | decreased growth rate in suspension | aberrant cytoskeleton organisation | increased secretion of lysosomal enzyme | decreased cell motility | decreased fruiting body size
DBS0236580myoB-myoBdecreased phagocytosis | delayed aggregation | decreased cell motility | decreased lateral pseudopod suppression
DBS0236583myoB-/ [AS]myoDmyoBdecreased pinocytosis | aberrant aggregation | decreased growth rate | decreased phagocytosis | decreased cell motility | decreased aggregate size
DBS0236583myoB-/ [AS]myoDmyoDdecreased pinocytosis | aberrant aggregation | decreased growth rate | decreased phagocytosis | decreased cell motility | decreased aggregate size
DBS0236584myoB-/ [AS]myoD/ [KD]myoCmyoBsmall pinosomes | decreased pinocytosis | aberrant aggregation | decreased growth rate | decreased phagocytosis | decreased cell motility | increased number of pinosomes | decreased aggregate size
DBS0236584myoB-/ [AS]myoD/ [KD]myoCmyoCsmall pinosomes | decreased pinocytosis | aberrant aggregation | decreased growth rate | decreased phagocytosis | decreased cell motility | increased number of pinosomes | decreased aggregate size
DBS0236584myoB-/ [AS]myoD/ [KD]myoCmyoDsmall pinosomes | decreased pinocytosis | aberrant aggregation | decreased growth rate | decreased phagocytosis | decreased cell motility | increased number of pinosomes | decreased aggregate size
HDT6myoB-/ myoC-myoBincreased secretion of lysosomal enzyme | decreased growth rate in suspension | aberrant cytoskeleton organisation | decreased fruiting body size
HDT6myoB-/ myoC-myoCincreased secretion of lysosomal enzyme | decreased growth rate in suspension | aberrant cytoskeleton organisation | decreased fruiting body size
DBS0350251myoG-myoGdecreased protein localization to plasma membrane | decreased F-actin polymerization | aberrant chemotaxis to cAMP | abolished cell polarity | abolished aggregation
DBS0236589myoI-myoIdecreased spore germination
DBS0349844myoK-myoKaberrant cortical actin cytoskeleton stabilization | delayed aggregation | decreased phagocytosis | aberrant engulfment during phagocytosis | decreased chemotaxis rate | aberrant cell morphology
HC476ncsA-ncsAincreased intracellular cAMP level | precocious gene expression | precocious development
HC477ncsA-ncsAincreased intracellular cAMP level | precocious gene expression | precocious development
DBS0350297ncstn-ncstnaberrant culmination | abolished catalytic activity | decreased prespore cell differentiation
DBS0350301ncstn-/ psenA-ncstnaberrant culmination | decreased prespore cell differentiation
DBS0350301ncstn-/ psenA-psenAaberrant culmination | decreased prespore cell differentiation
DBS0349947ndm-ndmaberrant chemotaxis | increased pinocytosis | decreased fruiting body size | aberrant pseudopod formation
DBS0350121ndufaf5-ndufaf5aberrant spore morphology | decreased growth rate | delayed development | aberrant phototaxis | spores inviable | decreased fruiting body size
DBS0304633nfaA-nfaAincreased pseudopod formation | increased chemoattractant-mediated F-actin polymerization | increased basal F-actin level | delayed aggregation | decreased cell motility | aberrant cAMP signaling during aggregation | aberrant regulation of GTPase activity | aberrant regulation of protein kinase activity | aberrant protein localization to plasma membrane | decreased chemotaxis to cAMP
DBS0236604nhe1-nhe1abolished potassium-dependent chemotaxis to cAMP | decreased intracellular pH level | decreased cell polarity | decreased F-actin polymerization | aberrant F-actin organization | abolished chemotaxis to calcium | decreased chemotaxis rate | delayed development | abolished cell polarity | abolished chemotaxis to cAMP
DBS0350006nhe1-/ [act15]: GFP: aip1(E125A, E167A, F181A, F193A)aip1abolished aggregation | abolished chemotaxis to cAMP
DBS0350006nhe1-/ [act15]: GFP: aip1(E125A, E167A, F181A, F193A)nhe1abolished aggregation | abolished chemotaxis to cAMP
DBS0350001nhe1-/ [act15]: aip1(168-597)aip1delayed development
DBS0350001nhe1-/ [act15]: aip1(168-597)nhe1delayed development
DBS0236606nosA null (15-S-12)nosAdevelopment arrests at mound stage
DBS0236607nosA null (2E4)nosAdevelopment arrests at mound stage
DBS0235950nosA-nosAdevelopment arrests at mound stage | aberrant protein modification
DBS0236608noxA-noxAabolished sporulation | aberrant development
DBS0236611noxA-/ [act15]: noxA: myc2noxAaberrant fruiting body morphology
DBS0236610noxA-/ noxBnoxAabolished sporulation | decreased superoxide production | aberrant development
DBS0236610noxA-/ noxBnoxBabolished sporulation | decreased superoxide production | aberrant development
DBS0236612noxB-noxBabolished sporulation | decreased superoxide production | aberrant development
DBS0236613noxC-noxCabolished sporulation | aberrant development
DBS0350092nrampB-nrampBdelayed aggregation | increased infection rate by Legionella pneumophila
DBS0350093nrampB-/ nramp1-nramp1delayed aggregation | increased infection rate by Legionella pneumophila | multiple tips
DBS0350093nrampB-/ nramp1-nrampBdelayed aggregation | increased infection rate by Legionella pneumophila | multiple tips
DBS0236955nxnA-nxnAdecreased culmination | decreased growth rate | delayed development | decreased chemotaxis to cAMP | decreased lysosomal enzyme activity
DBS0236702nxnA-/ [act15]: GFP: nxnB nxnAdevelopment arrests at mound stage
DBS0236702nxnA-/ [act15]: GFP: nxnB nxnBdevelopment arrests at mound stage
DBS0236704osbA-osbAincreased slug migration | precocious development
DBS0304465padA(1-276)padAaberrant streaming | aberrant aggregation | decreased cell-cell adhesion | decreased gene expression | development arrests at slug stage | delayed aggregation | aberrant stalk cell differentiation | aberrant chemotaxis to cAMP | delayed development | aberrant fruiting body morphology
DBS0236705pakA-pakAaberrant cytokinesis | delayed development | decreased myosin II assembly
DBS0349885pakA-pakAdelayed development | decreased chemotaxis to cAMP
DBS0350428pakB-/ [act15]: RFP: abpEabpE-1aberrant establishment and/ or maintenance of cell polarity | decreased chemotaxis to cAMP | abolished aggregation | aberrant protein localization
DBS0350428pakB-/ [act15]: RFP: abpEabpE-2aberrant establishment and/ or maintenance of cell polarity | decreased chemotaxis to cAMP | abolished aggregation | aberrant protein localization
DBS0350428pakB-/ [act15]: RFP: abpEpakBaberrant establishment and/ or maintenance of cell polarity | decreased chemotaxis to cAMP | abolished aggregation | aberrant protein localization
DBS0350281pakD-pakDaberrant cellular homeostasis | aberrant F-actin polymerization | aberrant filopodium formation | aberrant actin cytoskeleton organization | aberrant establishment and/ or maintenance of cell polarity | abolished negative regulation of vegetative growth | aberrant vegetative growth | abolished aggregation | decreased chemotaxis to cAMP | increased growth rate
DBS0350282pakD-/ [act15]: pakDpakDdevelopment arrests at mound stage
LAS45pats1-pats1decreased socially cooperative development
DBS0236728paxB-paxBdecreased exocytosis | decreased cell-substrate adhesion | decreased gene expression | abolished slug migration | increased chemotaxis to cAMP | development arrests at mound stage | decreased sorting to prestalk region | aberrant fruiting body morphology | increased phagocytosis
DBS0236730paxB-/ [ecmA]: paxB: GFPpaxBdecreased sorting to prestalk region
DBS0236732paxB-/ [pspA]: paxB: GFPpaxBdecreased sorting to prestalk region
DBS0236734pde4-pde4decreased culmination | multiple tips in culminant | delayed slug formation | delayed culmination
DBS0236736pdeD-pdeDdecreased cAMP-induced Ca2+ influx | delayed cAMP-induced Ca2+ influx | decreased Ca2+-induced Ca2+ influx
DBS0350517pdeD-pdeDdecreased 3',5'-cyclic-GMP phosphodiesterase activity | aberrant streaming | increased fruiting body size
DBS0350893pdeD-/ pdeE-/ [unk]: pdeEpdeDdelayed aggregation
DBS0350893pdeD-/ pdeE-/ [unk]: pdeEpdeEdelayed aggregation
DBS0350900pdeE-pdeEabolished 3',5'-cyclic-AMP phosphodiesterase activity | increased cAMP-induced cAMP pulse
DBS0350817pdkA-pdkAdecreased aggregate size | decreased protein kinase activation
DBS0350799pdkA-/ pdkB-pdkAdecreased cell polarity | aberrant chemotaxis to cAMP | development arrests at mound stage | decreased protein kinase activation
DBS0350799pdkA-/ pdkB-pdkBdecreased cell polarity | aberrant chemotaxis to cAMP | development arrests at mound stage | decreased protein kinase activation
DBS0350818pdkB-pdkBdecreased aggregate size
DBS0237029pdsA-pdsAaberrant streaming | aberrant chemotaxis to cAMP
UK7pdsA-pdsAdecreased 3',5'-cyclic-AMP phosphodiesterase activity | decreased gene expression | abolished aggregation | aberrant development
HPX235pdsA-pdsAabolished catalytic activity | abolished aggregation
DBS0236749pefB-/ noxC-noxCabolished sporulation | aberrant development
DBS0236749pefB-/ noxC-pefBabolished sporulation | aberrant development
DBS0305022pgtB-pgtBaberrant cellular metabolic process | aberrant response to hyperosmotic stress | aberrant spore coat morphology
DBS0305024pgtB-/ pgtC-pgtBaberrant cellular metabolic process | aberrant response to hyperosmotic stress | aberrant spore coat morphology
DBS0305024pgtB-/ pgtC-pgtCaberrant cellular metabolic process | aberrant response to hyperosmotic stress | aberrant spore coat morphology
DBS0236752phdA-phdAdecreased basal F-actin level | decreased aggregate size | decreased chemotaxis rate | decreased fruiting body size
DBS0236755phg1A-phg1Aincreased secretion of lysosomal enzyme | decreased protein level | decreased cell-substrate adhesion | abolished resistance to a bacterium | decreased gene expression | aberrant defense response to bacterium | aberrant cytokinesis | decreased phagocytosis | decreased growth rate | development arrests at slug stage | decreased protein localization to cell surface | aberrant phagocytosis | increased lysosomal pH | decreased protein stabilization | decreased lysosomal enzyme activity
DBS0304872phg1A-/ phg1B-phg1Aincreased secretion of lysosomal enzyme | decreased cell-substrate adhesion | decreased phagocytosis | decreased growth rate | development arrests at tipped mound stage | abolished culmination
DBS0304872phg1A-/ phg1B-phg1Bincreased secretion of lysosomal enzyme | decreased cell-substrate adhesion | decreased phagocytosis | decreased growth rate | development arrests at tipped mound stage | abolished culmination
DBS0304866phg1B-phg1Bincreased secretion of lysosomal enzyme | decreased protein level | decreased phagocytosis | decreased growth rate | abolished culmination
DBS0236758phg2-phg2decreased cell-substrate adhesion | decreased phagocytosis | aberrant cytokinesis | aberrant F-actin organization | decreased cell motility | aberrant response to nutrients | aberrant cell morphology | precocious development | precocious gene expression
DBS0236762phlp1-phlp1decreased cAMP-induced cGMP pulse | aberrant regulation of protein modification | decreased growth rate | abolished positive chemotaxis | abolished aggregation | decreased cAMP-induced cAMP pulse | aberrant protein localization
DBS0350824phr-phraberrant chemotaxis to cAMP | delayed development
HW288phyA-phyAabolished sporulation | decreased peptidyl-proline hydroxylation | abolished stalk formation | abolished culmination
DBS0266770phyA-/ [ecmA]: phyA(R276A): mycphyAabolished peptidyl-proline hydroxylation | abolished culmination
DBS0236767pia-piaAaberrant activation of adenylate cyclase activity
piaA(G917D)piaA
DBS0236769piaA(G917D)/ [act15]: piaApiaAdelayed aggregation
DBS0350882piaA(G917D)/ acrA-acrAabolished gene expression | abolished chemotaxis to cAMP during aggregation | abolished cell polarity
DBS0350882piaA(G917D)/ acrA-piaAabolished gene expression | abolished chemotaxis to cAMP during aggregation | abolished cell polarity
DBS0350877piaA(G917D)/ hephA-hephAincreased response to cAMP | wild type | abolished activation of adenylate cyclase | decreased intracellular cAMP level
DBS0350877piaA(G917D)/ hephA-piaAincreased response to cAMP | wild type | abolished activation of adenylate cyclase | decreased intracellular cAMP level
DBS0236771piaA-piaAabolished aggregation | decreased myosin II assembly | increased phagocytosis
DBS0236766pikA-/ pikB-pikAaberrant negative chemotaxis | abolished protein localization to plasma membrane | aberrant chemotaxis to cAMP | decreased cell motility | abolished protein kinase activation | abolished protein localization | decreased basal F-actin level | decreased chemotaxis to folate | decreased chemotaxis to cAMP | aberrant protein localization to cell cortex | decreased cAMP-induced cAMP pulse | decreased myosin II assembly
DBS0236766pikA-/ pikB-pikBaberrant negative chemotaxis | abolished protein localization to plasma membrane | aberrant chemotaxis to cAMP | decreased cell motility | abolished protein kinase activation | abolished protein localization | decreased basal F-actin level | decreased chemotaxis to folate | decreased chemotaxis to cAMP | aberrant protein localization to cell cortex | decreased cAMP-induced cAMP pulse | decreased myosin II assembly
DBS0236773pikA-/ pikB-pikAdecreased pinocytosis | aberrant aggregation | decreased exocytosis | abolished CRAC localization to the plasma membrane | increased intracellular cAMP level | aberrant adaptation of adenylate cyclase | abolished SDF production | abolished growth | aberrant macropinocytosis | delayed aggregation | aberrant F-actin organization | aberrant phagolysosome formation | aberrant phagosome maturation | multiple tips | decreased phosphatidylinositol biosynthesis | abolished streaming | aberrant cell morphology | decreased cAMP-induced cAMP pulse
DBS0236773pikA-/ pikB-pikBdecreased pinocytosis | aberrant aggregation | decreased exocytosis | abolished CRAC localization to the plasma membrane | increased intracellular cAMP level | aberrant adaptation of adenylate cyclase | abolished SDF production | abolished growth | aberrant macropinocytosis | delayed aggregation | aberrant F-actin organization | aberrant phagolysosome formation | aberrant phagosome maturation | multiple tips | decreased phosphatidylinositol biosynthesis | abolished streaming | aberrant cell morphology | decreased cAMP-induced cAMP pulse
HM1200pikA-/ pikB-/ pikC-/ pikF-/ pikG-pikAaberrant aggregation | decreased pinocytosis | decreased protein tyrosine phosphorylation | increased chemotaxis to folate | decreased growth rate | decreased cell motility | aberrant signal transduction
HM1200pikA-/ pikB-/ pikC-/ pikF-/ pikG-pikBaberrant aggregation | decreased pinocytosis | decreased protein tyrosine phosphorylation | increased chemotaxis to folate | decreased growth rate | decreased cell motility | aberrant signal transduction
HM1200pikA-/ pikB-/ pikC-/ pikF-/ pikG-pikCaberrant aggregation | decreased pinocytosis | decreased protein tyrosine phosphorylation | increased chemotaxis to folate | decreased growth rate | decreased cell motility | aberrant signal transduction
HM1200pikA-/ pikB-/ pikC-/ pikF-/ pikG-pikFaberrant aggregation | decreased pinocytosis | decreased protein tyrosine phosphorylation | increased chemotaxis to folate | decreased growth rate | decreased cell motility | aberrant signal transduction
HM1200pikA-/ pikB-/ pikC-/ pikF-/ pikG-pikGaberrant aggregation | decreased pinocytosis | decreased protein tyrosine phosphorylation | increased chemotaxis to folate | decreased growth rate | decreased cell motility | aberrant signal transduction
HM1295pikA-/ pikB-/ pikC-/ pikF-/ pikG-/ pten-pikAaberrant aggregation | decreased growth rate | decreased cell motility | increased resistance to N-Phenylthiourea | increased infection rate by Legionella pneumophila
HM1295pikA-/ pikB-/ pikC-/ pikF-/ pikG-/ pten-pikBaberrant aggregation | decreased growth rate | decreased cell motility | increased resistance to N-Phenylthiourea | increased infection rate by Legionella pneumophila
HM1295pikA-/ pikB-/ pikC-/ pikF-/ pikG-/ pten-pikCaberrant aggregation | decreased growth rate | decreased cell motility | increased resistance to N-Phenylthiourea | increased infection rate by Legionella pneumophila
HM1295pikA-/ pikB-/ pikC-/ pikF-/ pikG-/ pten-pikFaberrant aggregation | decreased growth rate | decreased cell motility | increased resistance to N-Phenylthiourea | increased infection rate by Legionella pneumophila
HM1295pikA-/ pikB-/ pikC-/ pikF-/ pikG-/ pten-pikGaberrant aggregation | decreased growth rate | decreased cell motility | increased resistance to N-Phenylthiourea | increased infection rate by Legionella pneumophila
HM1295pikA-/ pikB-/ pikC-/ pikF-/ pikG-/ pten-ptenaberrant aggregation | decreased growth rate | decreased cell motility | increased resistance to N-Phenylthiourea | increased infection rate by Legionella pneumophila
DBS0238073pikA-/ pikB-/ plaA-pikAdecreased chemoattractant-mediated F-actin polymerization | delayed aggregation | aberrant chemotaxis to cAMP | abolished positive chemotaxis
DBS0238073pikA-/ pikB-/ plaA-pikBdecreased chemoattractant-mediated F-actin polymerization | delayed aggregation | aberrant chemotaxis to cAMP | abolished positive chemotaxis
DBS0238073pikA-/ pikB-/ plaA-plaAdecreased chemoattractant-mediated F-actin polymerization | delayed aggregation | aberrant chemotaxis to cAMP | abolished positive chemotaxis
DBS0236777pikD1pikDabolished slug migration | delayed aggregation | decreased aggregate size | decreased sporulation | aberrant fruiting body morphology
LAS31pikG-pikGaberrant socially cooperative development
HM1513pikI-pikIdecreased chemoattractant-mediated F-actin polymerization | decreased catalytic activity | decreased cAMP-induced cGMP pulse | decreased cAMP-induced Ca2+ influx | decreased growth rate | aberrant chemotaxis to cAMP | decreased protein kinase activation | increased bleb formation | decreased cAMP-induced cAMP pulse
DBS0350828pinA-/ [ecmAO]: lacZpinAaberrant prestalk cell differentiation
DBS0350827pinA-/ [pspA]: lacZpinAaberrant prespore cell differentiation
DBS0349901pisA-pisAincreased gene expression | precocious development | decreased fruiting body size | aberrant prestalk cell differentiation
DBS0236783pkaC-pkaCabolished gene expression | increased protein phosphorylation | decreased protein level | decreased gene expression | aberrant myosin II organization | decreased activation of GTPase activity | aberrant cAMP signaling | abolished catalytic activity | aberrant F-actin organization | aberrant CRAC localization to the plasma membrane | decreased protein kinase activation | abolished aggregation | aberrant protein localization to cell cortex | abolished chemotaxis to cAMP | increased protein kinase activation | increased activation of GTPase activity
DBS0350694pkaC-/ [act15]: pkaCpkaCabolished culmination
DBS0350707pkaC-/ [act6]: pkaC(330-648)pkaCabolished aggregation
DBS0236782pkaC-/ gdt1-gdt1increased gene expression | abolished aggregation
DBS0236782pkaC-/ gdt1-pkaCincreased gene expression | abolished aggregation
HTY217pkaR(A31T)pkaRabolished protein kinase activation | precocious development
DBS0235411pkaR-pkaRdecreased spore germination | aberrant response to lithium | increased gene expression | precocious sporulation | aberrant chemotaxis to cAMP | aberrant response to valproic acid | decreased cell motility | increased lateral pseudopod formation | aberrant cAMP signaling during aggregation | decreased fruiting body size | aberrant cell morphology | abolished streaming
DBS0236785pkbA-/ pkgB-pkbAabolished growth | aberrant chemotaxis to cAMP | decreased chemotaxis rate | abolished protein phosphorylation | abolished aggregation | increased activation of GTPase activity
DBS0236785pkbA-/ pkgB-pkgBabolished growth | aberrant chemotaxis to cAMP | decreased chemotaxis rate | abolished protein phosphorylation | abolished aggregation | increased activation of GTPase activity
DBS0236786pkgB-pkgBdecreased protein phosphorylation | abolished SDF production | development arrests at mound stage
DBS0304638pkgB-pkgBdecreased cell-substrate adhesion | development arrests at mound stage | decreased chemotaxis rate | increased cell motility
DBS0236789pkgB-/ [act15]: pkgB(K182M)pkgBdevelopment arrests at mound stage
DBS0350319pks17-pks17decreased fatty acid level | aberrant gene expression | delayed development | decreased fruiting body size
LAS44pks2-pks2decreased socially cooperative development
LAS19pks26-pks26aberrant socially cooperative development
DBS0238068plaA-plaAaberrant chemotaxis to cAMP | abolished aggregation
DBS0238067plaA-plaAabolished aggregation
DBS0306196plaA-plaAaberrant chemotaxis to cAMP | decreased necrotic cell death
DG1067plbG-plbGdecreased stalk width | decreased stalk length
HAD236plc-plcdecreased CRAC localization to the plasma membrane | aberrant chemotaxis to cAMP | decreased protein localization to cytoplasm | decreased protein kinase activation | abolished aggregation
DBS0236796pldB-pldBdecreased catalytic activity | precocious aggregation
DBS0236797pldB-/ [act15]: pldB: GFPpldBabolished aggregation
DBS0350604pldB-/ [unk]: GFPpldBincreased sorting to prestalk region
DBS0350605pldB-/ [unk]: lacZpldBincreased sorting to prestalk region
DBS0236799plip-plipdelayed aggregation
DBS0350007png-pngdelayed aggregation | decreased aggregate size | aberrant fruiting body morphology
DBS0350492png-/ [ecmAO]: lacZpngaberrant prestalk cell differentiation
DBS0350491png-/ [ecmA]: lacZpngaberrant prestalk A cell differentiation
DBS0350493png-/ [pspA]: lacZpngdecreased prespore cell differentiation
DBS0236820ponA-ponAprecocious aggregation | decreased lateral pseudopod traction | decreased actin nucleation on plasma membranes | aberrant development
DBS0236821ponA-ponAprecocious aggregation | decreased lateral pseudopod traction | decreased actin nucleation on plasma membranes | aberrant development
DG1057potA-potAaberrant fruiting body morphology
DBS0236824ppk1-ppk1decreased growth rate | decreased phagocytosis | decreased fruiting body size | delayed culmination | decreased sporulation
ASH01ppk1-ppk1aberrant cellular homeostasis | decreased growth rate | aberrant spore germination | decreased intracellular ATP level | aberrant macromolecule biosynthesis | decreased fruiting body size | increased growth rate
DBS0238099ppp4C-ppp4cdevelopment arrests at mound stage | delayed development
DBS0238110ppp4C-/ [act15]: smkAppp4cdevelopment arrests at mound stage | delayed development
DBS0238110ppp4C-/ [act15]: smkAsmkAdevelopment arrests at mound stage | delayed development
DBS0266803psenA-psenAaberrant culmination | decreased prespore cell differentiation
DBS0350302psenA-psenAdecreased prespore cell differentiation | increased cytosolic Ca2+ response
DBS0350304psenA-/ psenB-psenAincreased intracellular cAMP level | abolished prespore cell differentiation | development arrests at mound stage | aberrant gene expression | increased cytosolic Ca2+ response | decreased stalk cell differentiation
DBS0350304psenA-/ psenB-psenBincreased intracellular cAMP level | abolished prespore cell differentiation | development arrests at mound stage | aberrant gene expression | increased cytosolic Ca2+ response | decreased stalk cell differentiation
DBS0350303psenB-psenBdecreased prespore cell differentiation | increased cytosolic Ca2+ response
DBS0350298psenB-/ psenA-psenAaberrant culmination | decreased phagocytosis | abolished catalytic activity | decreased prespore cell differentiation
DBS0350298psenB-/ psenA-psenBaberrant culmination | decreased phagocytosis | abolished catalytic activity | decreased prespore cell differentiation
HOK2psiA-psiAabolished prespore cell division
DBS0236828pslA-pslAabolished gene expression | abolished sporulation | abolished stalk cell differentiation in vitro | decreased sorus size | increased aggregate size | increased stalk length | mislocalized gene expression
DBS0236829psmC1-psmC1curly fingers | increased resistance to spectinomycin | abolished slug migration | increased cell size
HW70pspB-pspBaberrant spore coat morphology | precocious spore germination
DBS0302352psrA-psrAdecreased culmination | increased protein phosphorylation | decreased activation of GTPase activity | increased protein kinase B activation | decreased cell motility | delayed development | delayed gene expression | increased protein kinase activation
DBS0302357psrA-/ [act15]: gskA(K84M/ K85M)gskAdecreased culmination | decreased gene expression | delayed development | increased protein kinase activation
DBS0302357psrA-/ [act15]: gskA(K84M/ K85M)psrAdecreased culmination | decreased gene expression | delayed development | increased protein kinase activation
HM1289pten-ptenaberrant cell motility | decreased cell motility | abolished aggregation | decreased chemotaxis to cAMP | decreased lateral pseudopod suppression
DBS0236830pten-ptenabolished CRAC localization to the plasma membrane | decreased F-actin polymerization | increased pseudopod formation | decreased positive regulation of GTPase activity | decreased growth rate | increased F-actin polymerization | abolished protein localization to plasma membrane | decreased phagocytosis | increased lateral pseudopod formation | decreased cell motility | increased CRAC localization to the plasma membrane | decreased chemotaxis to cAMP | abolished aggregation | aberrant pseudopod formation | decreased lateral pseudopod suppression | aberrant signal transduction
DBS0236832ptpA1-ptpA1-1decreased prespore cell differentiation | increased prestalk 0 cell differentiation | precocious development
DBS0236832ptpA1-ptpA1-2decreased prespore cell differentiation | increased prestalk 0 cell differentiation | precocious development
DBS0236833ptpB-ptpBincreased slug size
DBS0350675ptpB-/ [act15]: 6xHis: erkAerkAaberrant streaming
DBS0350675ptpB-/ [act15]: 6xHis: erkAptpBaberrant streaming
DBS0236835pufA-pufAincreased protein kinase activity | increased protein level | precocious development | aberrant fruiting body morphology
DBS0304391pyk3-pyk3increased gene expression | decreased gene expression | increased prespore cell differentiation | delayed culmination
DBS0236836pykA-pykAdecreased growth rate | abolished aggregation
DBS0350017qdpr-qdprdecreased spore viability | abolished catalytic activity
DBS0236839qkgA-qkgA-1increased aggregate size | delayed aggregation | aberrant vegetative growth | aberrant nucleus organization | increased growth rate | abolished negative chemotaxis
DBS0236839qkgA-qkgA-2increased aggregate size | delayed aggregation | aberrant vegetative growth | aberrant nucleus organization | increased growth rate | abolished negative chemotaxis
DBS0236841racB-racBdecreased chemoattractant-mediated F-actin polymerization | delayed aggregation | decreased basal F-actin level | decreased chemotaxis rate | aberrant fruiting body morphology | decreased myosin II assembly
DBS0236842racC-racCdecreased protein localization to plasma membrane | aberrant streaming | decreased chemotaxis rate | aberrant cell morphology | aberrant protein localization
DBS0350271racE-racEdecreased cell polarity | aberrant CRAC localization to the plasma membrane | aberrant cytokinesis | delayed aggregation | decreased growth rate | increased lateral pseudopod formation | aberrant regulation of GTPase activity | decreased chemotaxis to cAMP
DBS0236843racF2-racF2increased aggregate size | increased cell-cell adhesion | decreased sexual fusion
DBS0350864rapgap3-/ AX2rapgap3delayed aggregation | decreased chemotaxis to cAMP | decreased fruiting body size
DBS0350863rapgap3-/ KAX3rapgap3aberrant sorting to prestalk region | increased calcium-dependent cell-cell adhesion | delayed tip formation | decreased cell motility | aberrant regulation of GTPase activity
DBS0350316rapgap9-rapgap9increased filopodium formation | increased basal F-actin level | aberrant cytokinesis | decreased spore size | increased cell-substrate adhesion | decreased chemotaxis to cAMP
DBS0350628rapgapB-rapgapBaberrant aggregation | aberrant F-actin organization | increased cell-substrate adhesion | aberrant regulation of GTPase activity
DBS0350631rapgapB-/ [ecmA]: lacZrapgapBaberrant sorting to prestalk region
DBS0350632rapgapB-/ [ecmO]: lacZrapgapBaberrant sorting to prestalk region
DBS0236853rasC-/ AX2rasCincreased rate of endocytosis | aberrant F-actin organization | increased cell size | decreased cell motility | decreased protein kinase activation | abolished aggregation | aberrant pseudopod formation
DBS0236854rasC-/ JH10rasCwild type | aberrant gene expression | decreased protein kinase activation | abolished aggregation | abolished chemotaxis to cAMP
DBS0350740rasC-/ [rasC]: rasGrasCabolished activation of adenylate cyclase | abolished aggregation
DBS0350740rasC-/ [rasC]: rasGrasGabolished activation of adenylate cyclase | abolished aggregation
DBS0350741rasC-/ [rasC]: rasG(D30A)rasCaberrant aggregation | decreased activation of adenylate cyclase
DBS0350741rasC-/ [rasC]: rasG(D30A)rasGaberrant aggregation | decreased activation of adenylate cyclase
DBS0236855rasC-/ dmpA-dmpAabolished streaming
DBS0236855rasC-/ dmpA-rasCabolished streaming
DBS0236856rasC-/ pikD1pikDincreased chemotaxis to cAMP | aberrant gene expression | decreased protein kinase activation | abolished aggregation | increased cell polarity | aberrant fruiting body morphology
DBS0236856rasC-/ pikD1rasCincreased chemotaxis to cAMP | aberrant gene expression | decreased protein kinase activation | abolished aggregation | increased cell polarity | aberrant fruiting body morphology
DBS0236857rasC-/ rasD-rasCabolished aggregation
DBS0236857rasC-/ rasD-rasDabolished aggregation
DBS0236858rasC-/ rasG-rasCaberrant cell separation during cytokinesis | wild type | decreased gene expression | abolished growth | abolished guanylyl cyclase activity | abolished chemotaxis to folate | decreased growth rate | aberrant chemotaxis to folate | abolished protein kinase activation | decreased activation of adenylate cyclase | decreased cell motility | increased protein level | abolished aggregation | delayed gene expression | abolished chemotaxis to cAMP
DBS0236858rasC-/ rasG-rasGaberrant cell separation during cytokinesis | wild type | decreased gene expression | abolished growth | abolished guanylyl cyclase activity | abolished chemotaxis to folate | decreased growth rate | aberrant chemotaxis to folate | abolished protein kinase activation | decreased activation of adenylate cyclase | decreased cell motility | increased protein level | abolished aggregation | delayed gene expression | abolished chemotaxis to cAMP
DBS0266697rasC-/ rasG-/ [act15]: carAcarA-1abolished growth | abolished activation of GTPase activity | decreased growth rate | decreased activation of adenylate cyclase | abolished protein kinase activation | abolished cAMP-induced cGMP pulse | abolished chemotaxis to cAMP
DBS0266697rasC-/ rasG-/ [act15]: carAcarA-2abolished growth | abolished activation of GTPase activity | decreased growth rate | decreased activation of adenylate cyclase | abolished protein kinase activation | abolished cAMP-induced cGMP pulse | abolished chemotaxis to cAMP
DBS0266697rasC-/ rasG-/ [act15]: carArasCabolished growth | abolished activation of GTPase activity | decreased growth rate | decreased activation of adenylate cyclase | abolished protein kinase activation | abolished cAMP-induced cGMP pulse | abolished chemotaxis to cAMP
DBS0266697rasC-/ rasG-/ [act15]: carArasGabolished growth | abolished activation of GTPase activity | decreased growth rate | decreased activation of adenylate cyclase | abolished protein kinase activation | abolished cAMP-induced cGMP pulse | abolished chemotaxis to cAMP
DBS0236859rasD(G12T)rasDdevelopment arrests at mound stage | development arrests at tipped mound stage
DBS0236862rasG-/ AX2rasGdecreased pinocytosis | decreased cAMP-induced cGMP pulse | decreased gene expression | delayed aggregation | decreased protein kinase activation | delayed gene expression
DBS0236863rasG-/ JH10rasGaberrant cell separation during cytokinesis | decreased cAMP-induced cGMP pulse | wild type | decreased gene expression | delayed aggregation | abolished activation of GTPase activity | aberrant chemotaxis to folate | decreased growth rate | decreased protein kinase activation | delayed gene expression
DBS0350261rbg3-rbg3precocious development | increased growth rate
DBS0236877rblA-rblAdecreased gene expression | increased gene expression | decreased spore viability | abolished negative regulation of vegetative growth | decreased growth rate | aberrant vegetative growth | increased sorting to prestalk region | precocious development | increased prestalk cell differentiation in response to DIF-1 | decreased cell size
DBS0349999rblA-/ [act15]: GFPrblAincreased sorting to prestalk region
DBS0349996rblA-/ [act15]: GFP/ [act15]: myc: btgbtgincreased sorting to prestalk region
DBS0349996rblA-/ [act15]: GFP/ [act15]: myc: btgrblAincreased sorting to prestalk region
DBS0236878rbrA-rbrAincreased gene expression | decreased gene expression | development arrests at slug stage | mislocalized gene expression | decreased sorting to prestalk region | decreased phototaxis | decreased sporulation
DBS0236880rckA-rckAdelayed slug formation | increased aggregate size | precocious aggregation | delayed gene expression | increased chemotaxis rate
DBS0236885rckA-/ [act15]: myc: rckArckAdelayed development | decreased chemotaxis rate
DBS0236881rckA-/ [act15]: myc: rckA(C551A)rckAdelayed slug formation | decreased chemotaxis rate
DBS0236883rckA-/ [act15]: myc: rckA(E510G/ N511A)rckAdelayed slug formation | decreased chemotaxis rate
DBS0236884rckA-/ [act15]: myc: rckA(K867A)rckAdevelopment arrests at mound stage | decreased chemotaxis rate
FR17rdeA-rdeAprecocious aggregation | decreased aggregate size | precocious development | precocious gene expression | aberrant fruiting body morphology
HH201rdeA-rdeAincreased intracellular cAMP level | aberrant chemotaxis to cAMP in response to DIF-2
WTC10rdeA-rdeAincreased intracellular cAMP level | aberrant chemotaxis to cAMP in response to DIF-2
FR17rdeA-rdeAprecocious aggregation | decreased aggregate size | precocious development | precocious gene expression | aberrant fruiting body morphology
DBS0350688rdeA-/ acaA-acaAincreased intracellular cAMP level | decreased number of spores
DBS0350688rdeA-/ acaA-rdeAincreased intracellular cAMP level | decreased number of spores
DBS0266664redA-redAdevelopment arrests at mound stage | aberrant mound color
DG1047redA-redAdevelopment arrests at mound stage | aberrant mound color
DBS0236889regA-regAincreased resistance to cisplatin | increased intracellular cAMP level | aberrant chemotaxis to cAMP | aberrant fruiting body morphology
DBS0236958regA-regAdecreased spore germination | precocious sporulation | abolished protein localization to cell cortex | aberrant chemotaxis to cAMP | increased lateral pseudopod formation
HR45regA-regAaberrant fruiting body morphology
HM1015regA-regAincreased intracellular cAMP level
DBS0350372regA-regAprecocious sporulation | increased sporulation
DBS0235706regA-/ [act15]: dhkK(D1125N)dhkKprecocious development | aberrant fruiting body morphology
DBS0235706regA-/ [act15]: dhkK(D1125N)regAprecocious development | aberrant fruiting body morphology
DBS0235708regA-/ [act15]: dhkK(H825Q)dhkKprecocious development | aberrant fruiting body morphology
DBS0235708regA-/ [act15]: dhkK(H825Q)regAprecocious development | aberrant fruiting body morphology
DBS0350670regA-/ [regA]: regA(D212N)regAprecocious sporulation
DBS0350380regA-/ dhkD-dhkDaberrant fruiting body morphology
DBS0350380regA-/ dhkD-regAaberrant fruiting body morphology
DBS0236891regA-/ tagB-regAdecreased sporulation
DBS0236891regA-/ tagB-tagBdecreased sporulation
DBS0236892regA-/ tagC-regAdecreased sporulation
DBS0236892regA-/ tagC-tagCdecreased sporulation
DBS0236893rgaA-rgaAaberrant cytokinesis | abolished sorting to prestalk region | abolished stalk cell differentiation | decreased protein kinase activation | abolished culmination | decreased sporulation
DBS0349935rgaA-rgaAaberrant stalk morphogenesis | aberrant cellular response to fluid shear stress | increased basal F-actin level | aberrant F-actin organization | multiple tips | increased growth rate | increased cell motility
DBS0349921rgaA-/ [act15]: GFP-mhcArgaAaberrant stalk morphogenesis | aberrant tip formation | aberrant protein localization
DBS0350020rgfA-/ [act15]: rgfArgfAdecreased chemotaxis to folate | delayed development
DBS0350192ric8-ric8abolished gene expression | abolished chemotaxis to folate | decreased chemotaxis to cAMP | abolished aggregation | aberrant signal transduction
DBS0236900ripA-ripAdecreased cell polarity | decreased guanylyl cyclase activity | abolished activation of adenylate cyclase | decreased chemotaxis rate | abolished aggregation | aberrant regulation of protein kinase activity | decreased myosin II assembly | increased phagocytosis
DBS0350096roco11-roco11increased stalk length
DBS0350095roco4-roco4delayed slug formation | aberrant stalk formation | delayed culmination
DBS0238225rpkA-rpkAdevelopment arrests at loose mound stage | aberrant response to conditioned medium factor | decreased cell polarity | aberrant cellular response to nitrogen starvation | decreased phagocytosis | decreased cell motility | increased infection rate by Legionella pneumophila | abolished aggregation
DBS0236875rtoA-rtoAdecreased rate of endocytosis | decreased infection rate by Legionella pneumophila | increased prestalk cell differentiation | delayed culmination
DBS0236911rtoA-rtoAdelayed development
DBS0236914rzpA-rzpAaberrant aggregation | decreased slug migration | increased aggregate size | increased gene expression | decreased gene expression | delayed development
DG1105scaA-scaAabolished aggregation
DBS0350825scaA-scaAdecreased F-actin polymerization | aberrant chemotaxis to cAMP | abolished activation of GTPase activity | decreased protein kinase activation | abolished aggregation
DBS0236924scrA-scrAdecreased exocytosis | decreased pinocytosis | decreased phagocytosis | decreased basal F-actin level | increased lateral pseudopod formation | abolished protein localization | multiple tips | decreased fruiting body size | precocious development | decreased cell size
DBS0350264sepA-sepAaberrant cytokinesis | delayed aggregation | decreased growth rate | decreased fruiting body size
DBS0236928set1-set1precocious aggregation | abolished histone H3-K4 methylation | precocious gene expression
DG1008sfbA-sfbAdecreased fruiting body size
DBS0350889sgcA-/ AX2sgcAaberrant aggregation | decreased guanylyl cyclase activity | aberrant chemotaxis to cAMP
DBS0350888sgcA-/ AX3sgcAaberrant aggregation | decreased guanylyl cyclase activity | aberrant chemotaxis to cAMP
SA555sglA-sglAaberrant cytoskeleton organisation | increased stalk width | increased resistance to cisplatin | increased aggregate size | decreased gene expression | abolished slug migration | decreased cell motility | decreased chemotaxis rate | decreased fruiting body size | decreased lateral pseudopod suppression | decreased sporulation
SA554sglA-sglAdelayed aggregation | decreased aggregate size
DBS0236934shkA-shkAaberrant aggregation | decreased cell polarity | aberrant F-actin organization | decreased phagocytosis | aberrant cytokinesis | decreased chemotaxis rate | decreased fruiting body size
DBS0350859sir2D-sir2Ddecreased gene expression | increased gene expression | delayed aggregation | decreased growth rate | decreased autophagy | decreased aggregate size | decreased stalk length | multiple tips in mound
DBS0350860sir2D-/ [ecmAO]: lacZsir2Ddecreased prestalk cell differentiation
DBS0350861sir2D-/ [pspA]: lacZsir2Daberrant prespore cell differentiation
DBS0236938smkA-smkAaberrant cytokinesis | delayed development | decreased chemotaxis rate | decreased myosin II assembly
HDB7YAsmlA-smlAdecreased secretion of lysosomal enzyme | decreased cell-cell adhesion | aberrant cellular metabolic process | decreased cAMP-induced cGMP pulse | decreased GTP-gamma-S-stimulated guanylyl cyclase activity | increased cAMP-induced cAMP pulse | increased resistance to cisplatin | decreased protein level | increased basal F-actin level | increased myosin II assembly | increased protein level | increased extracellular counting factor component(s) level | increased cell motility | decreased fruiting body size | increased intracellular counting factor component(s) level
DBS0302657smlA-/ cnrN-cnrNdecreased fruiting body size
DBS0302657smlA-/ cnrN-smlAdecreased fruiting body size
DBS0304496smlA-/ sslA1(CR11)smlAincreased fruiting body size
DBS0304496smlA-/ sslA1(CR11)sslA1increased fruiting body size
DBS0302524sodC-sodCdecreased chemoattractant-mediated F-actin polymerization | aberrant aggregation | decreased positive regulation of GTPase activity | increased basal F-actin level | increased protein localization to plasma membrane | decreased chemotaxis rate | aberrant protein localization to plasma membrane | aberrant cell morphology
HL351spiA-spiAdecreased spore viability
DBS0236943spkA-1-/ spkA-2-spkA-1decreased cell polarity | decreased cell-substrate adhesion | aberrant cytokinesis | decreased chemotaxis rate | decreased aggregate size | aberrant cell morphology | decreased fruiting body size
DBS0236943spkA-1-/ spkA-2-spkA-2decreased cell polarity | decreased cell-substrate adhesion | aberrant cytokinesis | decreased chemotaxis rate | decreased aggregate size | aberrant cell morphology | decreased fruiting body size
DBS0236944spkA-1-/ spkA-2-/ [act15]: spkA: FLAGspkA-1aberrant aggregation | decreased cell polarity | aberrant F-actin organization | decreased chemotaxis rate
DBS0236944spkA-1-/ spkA-2-/ [act15]: spkA: FLAGspkA-2aberrant aggregation | decreased cell polarity | aberrant F-actin organization | decreased chemotaxis rate
DBS0236945splA-splAaberrant spore morphology | increased sorus size | translucent sorus | spores inviable | decreased stalk length
DBS0236947spnA-spnAabolished prespore cell differentiation | development arrests at mound stage | abolished prestalk cell differentiation | aberrant development
DBS0236948spnA-/ arkA-arkAdecreased gene expression | increased sorus size | decreased stalk length | delayed gene expression
DBS0236948spnA-/ arkA-spnAdecreased gene expression | increased sorus size | decreased stalk length | delayed gene expression
DBS0236949sr-srdecreased intracellular pteridine level | decreased spore viability | decreased cytochrome C oxidase activity | decreased growth rate
DBS0236950srfA(1-8): lacZsrfAdecreased slug migration | aberrant fruiting body morphology | delayed culmination
DBS0236951srfA-srfAaberrant spore morphology | aberrant spore coat morphology | decreased spore viability | decreased gene expression
DBS0266691srfB-srfBprecocious aggregation | decreased growth rate | increased pinocytosis | aberrant cytokinesis | increased lateral pseudopod formation | aberrant cAMP signaling during aggregation | abolished streaming | precocious gene expression
DBS0304409srsA-srsAdecreased gene expression | increased gene expression | increased aggregate size | delayed aggregation
DBS0304497sslA1-/ sslA1(CR11)sslA1decreased cAMP-induced cGMP pulse | increased fruiting body size | decreased cAMP-induced cAMP pulse
DBS0236952stkA-stkAincreased gene expression | decreased gene expression | increased prestalk cell differentiation | aberrant fruiting body morphology | delayed gene expression
HM1157stlA-stlAaberrant cellular metabolic process | aberrant streaming | aberrant aggregation | abolished sporulation | wild type | increased gene expression | decreased gene expression | abolished MPBD production | translucent sorus | abolished SDF-1 production | decreased intracellular cAMP level | decreased chemotaxis to cAMP
DBS0350222stlA-/ [cotB]: lacZstlAdecreased sporulation | aberrant prespore cell differentiation
DBS0350224stlA-/ stlB-/ [ecmA]: lacZstlAdecreased prestalk cell differentiation
DBS0350224stlA-/ stlB-/ [ecmA]: lacZstlBdecreased prestalk cell differentiation
HM1154stlB-stlBabolished DIF production | abolished prestalk B cell differentiation | decreased prestalk 0 cell differentiation | abolished lower cup formation | abolished outer basal disc formation | decreased prestalk cell differentiation | aberrant fruiting body morphology
DBS0349941sunB-sunBaberrant cytokinesis | multiple tips
DBS0304547svkA-svkAdelayed cell separation during cytokinesis | aberrant cytokinesis | aberrant fruiting body morphology
AK1200tagA-tagAabolished SDF production | aberrant fruiting body morphology
AK859tagA-tagAdecreased spore viability | abolished SDF production | multiple tips in mound | increased prestalk A cell differentiation
AK1201tagA-/ [ecmA]: GFPtagAabolished sorting to prestalk region
AK228tagB-tagBabolished sporulation | development arrests at mound stage | abolished DIF production | aberrant prestalk A cell differentiation
DBS0350672tagB-/ pkaR-pkaRdecreased sporulation
DBS0350672tagB-/ pkaR-tagBdecreased sporulation
DBS0236974tagB-/ psmA1-psmA1abolished sporulation
DBS0236974tagB-/ psmA1-tagBabolished sporulation
DBS0236975tagC-tagCdevelopment arrests at mound stage | spores inviable
DBS0350698tagC-/ [pkaC]: pkaCpkaCdevelopment arrests at mound stage | abolished SDF-2 production
DBS0350698tagC-/ [pkaC]: pkaCtagCdevelopment arrests at mound stage | abolished SDF-2 production
DBS0304581talA-/ talB-talAdevelopment arrests at loose mound stage | abolished cell-substrate adhesion | aberrant cytokinesis | abolished cell motility
DBS0304581talA-/ talB-talBdevelopment arrests at loose mound stage | abolished cell-substrate adhesion | aberrant cytokinesis | abolished cell motility
HKT104talB-talBdecreased slug migration | decreased cell motility | development arrests at tipped mound stage | increased protein level
DBS0302472talB-talBabolished autophagic vacuole formation | abolished autophagic cell death
DBS0304586talB-/ [act15]: talA: GFPtalAaberrant fruiting body morphology
DBS0304586talB-/ [act15]: talA: GFPtalBaberrant fruiting body morphology
DBS0350712talB-/ [act15]: talB(K16A)talBdevelopment arrests at tipped mound stage
DBS0304820tgrB1-tgrB1development arrests at loose mound stage | delayed sporulation | decreased cell motility | decreased sporulation
AK1540tgrB1-/ tgrC1-tgrB1development arrests at loose mound stage | abolished cell-cell self recognition
AK1540tgrB1-/ tgrC1-tgrC1development arrests at loose mound stage | abolished cell-cell self recognition
AK1664tgrB1-/ tgrC1-/ alg9(-19ins)alg9decreased sporulation
AK1664tgrB1-/ tgrC1-/ alg9(-19ins)tgrB1decreased sporulation
AK1664tgrB1-/ tgrC1-/ alg9(-19ins)tgrC1decreased sporulation
AK127tgrC1-tgrC1development arrests at loose mound stage | aberrant aggregation | abolished gene expression | increased aggregate size | decreased gene expression
DBS0304821tgrC1-tgrC1abolished sporulation | development arrests at loose mound stage | decreased cell motility
AK1657tgrC1-/ QS38[tgrC1]: tgrC1/ alg9(-19ins)alg9delayed development | decreased fruiting body size | decreased sporulation
AK1657tgrC1-/ QS38[tgrC1]: tgrC1/ alg9(-19ins)tgrC1delayed development | decreased fruiting body size | decreased sporulation
AK1661tgrC1-/ alg9(-19ins)alg9delayed development | decreased fruiting body size | decreased sporulation
AK1661tgrC1-/ alg9(-19ins)tgrC1delayed development | decreased fruiting body size | decreased sporulation
DBS0350743tgrC1-/ alg9(-19ins)-REMIalg9decreased sporulation
DBS0350743tgrC1-/ alg9(-19ins)-REMItgrC1decreased sporulation
DBS0350625tgrC1-/ stcA-stcAdecreased aggregate size | delayed development | decreased sporulation
DBS0350625tgrC1-/ stcA-tgrC1decreased aggregate size | delayed development | decreased sporulation
DBS0350626tgrC1-/ stcB-stcBdelayed development | decreased aggregate size | decreased sporulation
DBS0350626tgrC1-/ stcB-tgrC1delayed development | decreased aggregate size | decreased sporulation
DBS0350627tgrC1-/ stcC-stcCaberrant streaming | delayed development | decreased fruiting body size | decreased sporulation
DBS0350627tgrC1-/ stcC-tgrC1aberrant streaming | delayed development | decreased fruiting body size | decreased sporulation
AK244tipA-tipAincreased aggregate size | decreased gene expression | development arrests at mound stage | multiple tips
JS64tipA-/ tipB-/ [act15]: lacZtipAincreased aggregate size | development arrests at mound stage | multiple tips in mound
JS64tipA-/ tipB-/ [act15]: lacZtipBincreased aggregate size | development arrests at mound stage | multiple tips in mound
JS98tipA-/ tipC-/ [ecmA]: lacZtipAdevelopment arrests at loose mound stage
JS98tipA-/ tipC-/ [ecmA]: lacZtipCdevelopment arrests at loose mound stage
JS128tipA-/ tipD-/ [ecmA]: lacZtipAdevelopment arrests at loose mound stage
JS128tipA-/ tipD-/ [ecmA]: lacZtipDdevelopment arrests at loose mound stage
JS56tipB-tipBincreased aggregate size | development arrests at mound stage | multiple tips | multiple tips in mound
JS99tipB-/ tipC-/ [ecmA]: lacZtipBdevelopment arrests at tipped mound stage | multiple tips in mound
JS99tipB-/ tipC-/ [ecmA]: lacZtipCdevelopment arrests at tipped mound stage | multiple tips in mound
JS129tipB-/ tipD-/ [ecmA]: lacZtipBdevelopment arrests at tipped mound stage | multiple tips in mound
JS129tipB-/ tipD-/ [ecmA]: lacZtipDdevelopment arrests at tipped mound stage | multiple tips in mound
JS55tipC-tipCincreased aggregate size | development arrests at mound stage | decreased number of autophagosomes | decreased autophagy | multiple tips
DBS0350729tipC-/ [unk]: tipC(2725-3848): GFPtipCdecreased fruiting body size
JS130tipC-/ tipD-/ [ecmA]: lacZtipCdevelopment arrests at loose mound stage
JS130tipC-/ tipD-/ [ecmA]: lacZtipDdevelopment arrests at loose mound stage
JS93tipD-tipDincreased aggregate size | development arrests at mound stage | aberrant vacuole organization and biogenesis | decreased autophagy | multiple tips
DBS0350730tipD-tipDdecreased pinocytosis | increased gene expression | aberrant phagosome maturation | aberrant fruiting body morphology | aberrant slug formation | multiple tips in mound
DBS0237017torA-torAdelayed aggregation | decreased growth rate | decreased cell motility | decreased chemotaxis rate
DBS0350504tpp1-tpp1decreased catalytic activity | aberrant response to chemical stimulus | aberrant autophagic cell death | aberrant cell morphology | precocious development
DBS0237924triA-triAdecreased cell-cell adhesion | aberrant streaming | increased stalk width | aberrant upper cup formation | aberrant cell motility | decreased spore viability | aberrant culminant morphology | decreased spore size | decreased cell fate determination | increased number of aggregates | decreased cell fate commitment
DBS0237996triA-triAaberrant culminant morphology
DBS0237997triA-triAaberrant culminant morphology
DBS0237998triA-/ [act15]: GFPtriAaberrant culminant morphology
DBS0237999triA-/ [ecmAO]: lacZ: [ecmAO]: gustriAincreased prestalk 0 cell differentiation
DBS0238001triA-/ [psA]: lacZ: [psA]: gustriAincreased prespore cell differentiation
DBS0237022tsg101-tsg101decreased fruiting body size
DBS0302370tsuA-tsuAincreased period of cAMP wave formation | aberrant chemotaxis to folate | aberrant chemotaxis to cAMP | delayed aggregation | decreased aggregate size | abolished cell polarity | decreased fruiting body size
DBS0302383tsuA-/ [unk]: tsuA(1-1774): YFPtsuAabolished localization to microtubules | decreased aggregate size | abolished localization to microtubule organizing center | decreased fruiting body size
DBS0302385tsuA-/ [unk]: tsuA(1-260): YFPtsuAabolished localization to microtubules | abolished localization to microtubule organizing center | decreased aggregate size | decreased fruiting body size
DBS0302384tsuA-/ [unk]: tsuA(1774-2247): YFPtsuAabolished localization to microtubules | abolished localization to microtubule organizing center | decreased aggregate size | decreased fruiting body size
DBS0302382tsuA-/ [unk]: tsuA(K34R): YFPtsuAdecreased aggregate size | decreased fruiting body size
DBS0237024ubcB-ubcBdevelopment arrests at mound stage | multiple tips
DBS0237025ubpA-ubpAdecreased gene expression | decreased chemotaxis rate | abolished aggregation | decreased cAMP-induced cAMP pulse
DBS0237026ubpB-ubpBaberrant sorus morphology | increased gene expression | decreased gene expression | precocious development
DBS0237028ugpB-/ DH1ugpBaberrant cell differentiation | decreased intracellular glycogen level | spores inviable | decreased fruiting body size | delayed culmination
DBS0266763ugpB-/ DH1ugpBdecreased stalk length
DBS0236058vmp1-vmp1aberrant aggregation | decreased exocytosis | increased cell death | aberrant response to hypo-osmotic stress | decreased gene expression | decreased growth rate | decreased macropinocytosis | aberrant vacuole organization and biogenesis | aberrant autophagic cell death | aberrant protein localization | aberrant signal transduction
DG1118vps46-vps46increased sorus size
DBS0237046vwkA-vwkAincreased myosin II assembly | aberrant response to hypo-osmotic stress | decreased growth rate | aberrant cytokinesis | aberrant contractile vacuole morphology | delayed development | increased protein level | decreased contractile vacuole discharge | aberrant fruiting body morphology
DBS0237048warA-warAdevelopment arrests at slug stage | increased basal disc size | decreased prespore cell differentiation | increased prestalk 0 cell differentiation
DBS0237049warA-warAdevelopment arrests at slug stage | increased basal disc size | decreased prespore cell differentiation | increased prestalk 0 cell differentiation
DBS0237050warA-/ hbx2-hbx2increased basal disc size | development arrests at mound stage | decreased prespore cell differentiation | increased prestalk 0 cell differentiation
DBS0237050warA-/ hbx2-warAincreased basal disc size | development arrests at mound stage | decreased prespore cell differentiation | increased prestalk 0 cell differentiation
DBS0237051wasA1-wasAaberrant F-actin organization | decreased cell motility | delayed development
DBS0237052wasA1-/ [tet]: YFP: wasA2wasAdecreased F-actin polymerization | aberrant F-actin organization | abolished positive chemotaxis | abolished aggregation
DG1053wimA-wimAaberrant fruiting body morphology
DG1064wimA-wimAaberrant fruiting body morphology
AK235yakA-yakAabolished aggregation
AK800yakA-yakAdecreased gene expression | aberrant cell cycle | aberrant gene expression | decreased protein kinase activation | abolished aggregation | decreased intracellular cAMP level | aberrant response to oxidative stress
AK804yakA-/ pufA-pufAincreased protein kinase activity | increased protein level | increased growth rate | precocious development | aberrant fruiting body morphology
AK804yakA-/ pufA-yakAincreased protein kinase activity | increased protein level | increased growth rate | precocious development | aberrant fruiting body morphology
DBS0350898yelA-/ AX2yelAprecocious prestalk gene expression | increased basal disc size
DG1014yelA-/ AX4yelAdecreased spore viability | precocious sporulation | development arrests at mound stage | aberrant mound color
DBS0349797zak2-zak2decreased gene expression | decreased protein kinase activation | decreased sporulation | aberrant fruiting body morphology
DBS0349883zak2-/ [act15]: GFPzak2decreased sporulation
ARK100-110zakA-zakAincreased gene expression | decreased gene expression | decreased protein kinase activity | abolished streaming | decreased chemotaxis to cAMP | delayed culmination | aberrant fruiting body morphology | decreased sporulation
DBS0238142zakA-zakAdevelopment arrests at tipped mound stage
DG1050zipA-zipAdecreased fruiting body size
DBS0350068zizB-zizBdelayed development | decreased chemotaxis to cAMP | aberrant fruiting body morphology

Last updated March 28, 2017

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