Dictyostelium Mutants

Phenotypes for Dictyostelium mutants

View other mutant types: All mutant strains - Null - Overexpression - Multiple - Other - Developmental

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Systematic Name Strain Descriptor Associated gene(s) Phenotypes
DBS0266705Dd5P1-/ Dd5P2-Dd5P1 | Dd5P2wild type
DBS0266704Dd5P1-/ Dd5P3-Dd5P1 | Dd5P3wild type
DBS0266703Dd5P2-/ Dd5P3-Dd5P2 | Dd5P3wild type
DBS0302615GFP: phgA(1-274: 283-438)/ phgA-phgAaberrant response to hypo-osmotic stress
DBS0236084GP138A-/ GP138B-/ GP138C-/ GP138D-cfrA | cfrB | cfrC | cfrDdecreased gene expression
DBS0237228[AS]GP138A/ [AS]GP138BcfrA | cfrBdecreased sexual fusion
DBS0350570[AS]PARPDDB_G0286613 | DDB_G0289141 | adprt1A | adprt1B | adprt2 | adprt3 | adprt4 | pARTf | pARTgdecreased non-apoptotic programmed cell death | aberrant positive regulation of mitochondrial membrane potential
DBS0236827[AS]proA/ proB-proA | proBdecreased secretion of lysosomal enzyme | decreased exocytosis | decreased pinocytosis | increased basal F-actin level | abolished growth | development arrests at slug stage | aberrant cytokinesis | decreased cell motility
DBS0238036[AS]proA/ proB-/ [act15]: proAproA | proBwild type
DBS0238037[AS]proA/ proB-/ [act15]: proBproA | proBwild type
DBS0238035[AS]proA/ proB-/ [unk]: FLAG: proCproA | proB | proCwild type
DBS0350355[AS]proA/ proB-/ lmpA-lmpA | proA | proBwild type | decreased spore viability
DBS0350334[AS]proA/ proB-/ scrA-proA | proB | scrAdecreased secretion of lysosomal enzyme | decreased exocytosis | decreased pinocytosis
DBS0302685[OE]: sgcA(1-2000)(N1106A): GFP/ gca-/ sgcA-gcA | sgcAdecreased chemotaxis rate
DBS0302683[OE]: sgcA(878-2843)(N1106A): GFP/ gca-/ sgcA-gcA | sgcAdecreased chemotaxis rate
DBS0302681[OE]: sgcA(878-2843): GFP/ sgcA-gcA | sgcAaberrant chemotaxis to cAMP | decreased chemotaxis rate
DBS0302682[OE]: sgcA(N1106A): GFP/ gca-/ sgcA-gcA | sgcAaberrant streaming | aberrant chemotaxis to cAMP | increased lateral pseudopod formation | decreased chemotaxis rate
DBS0302684[OE]: sgcA: GFP/ gca-/ sgcA-gcA | sgcAincreased lateral pseudopod formation | decreased chemotaxis rate
DBS0350322[act15]: FLAG: hbx4/ [act15]: cadAcadA | hbx4wild type
DBS0350441[act15]: GFP: talA/ mhcA-/ talA-mhcA | talAaberrant protein localization
DBS0350397[act15]: ifkA(881-1514(K1258G,F1320L))ifkAdecreased growth rate | increased protein level
DBS0350050[act15]: myc: cdk8/ [act15]: FLAG: cycCcdk8 | cycCprecocious tip formation
DBS0350498[act6]: GFP: rab2A(N118I)rab2Aaberrant response to hypo-osmotic stress | aberrant cell-cell adhesion | increased growth rate | precocious development
DBS0350499[act6]: GFP: rab2A(Q64L)rab2Adecreased autophagic cell death | aberrant response to hypo-osmotic stress | aberrant cell-cell adhesion | increased growth rate | increased phagocytosis
DBS0350706[cotC]: pkaC/ [spiA]: lacZpkaC | spiAprecocious gene expression
DBS0350700[ecmA]: pkaR(G135E/ G261A)/ [ecmB-frag]: lacZpkaRabolished stalk cell differentiation
DBS0350696[pkaC]: pkaC/ srfA-pkaC | srfAaberrant spore coat morphology | aberrant gene expression
DBS0350494[tgrB1]: [RNAi]abcB3/ [tgrC1]: GFPabcB3decreased extracellular cAMP level | delayed development
DBS0350837[unk]: rasD(G12T)/ [rasD]: rapArapA | rasDaberrant culmination | decreased prespore cell differentiation | aberrant gene expression | decreased stalk cell differentiation | multiple tips in mound
DBS0236539abcG2-/ abcG18-abcG18 | abcG2decreased rate of endocytosis | abolished growth | decreased growth rate
DBS0236540abcG2-/ abcG18-/ rtoA-abcG18 | abcG2 | rtoAabolished growth | decreased growth rate
DBS0266689abiA-/ scrA-abiA | scrAdecreased cell motility | decreased cell size
DBS0235456abpA-/ abpC-abpA | abpCaberrant response to hyperosmotic stress | decreased phagocytosis | decreased growth rate | decreased cell motility | aberrant development
DBS0235425abpB-/ fimA-abpB | fimAdecreased fruiting body size | decreased sporulation | decreased cell size
DBS0350720acaA-/ [acaA-agg]: acaA: mycacaAwild type | decreased gene expression | decreased fruiting body size
DBS0350721acaA-/ [acaA-psp]: acaA: mycacaAdecreased gene expression | decreased aggregate size | decreased fruiting body size
DBS0350722acaA-/ [acaA-pst]: acaA: mycacaAwild type
DBS0350702acaA-/ [act15]: HA: pkaCacaA | pkaCwild type | delayed development | decreased intracellular cAMP level
DBS0350725acaA-/ [act15]: HA: pkaC/ acrA-acaA | acrA | pkaCdecreased gene expression | abolished adenylate cyclase activity | development arrests at tipped mound stage
DBS0350737acaA-/ [act15]: acaAacaAaberrant slug formation
DBS0350738acaA-/ [act15]: acaA(1-390;398-1407)acaAabolished aggregation
DBS0350739acaA-/ [act15]: acaA(L394T/ K482N)acaAwild type
DBS0350603acaA-/ [act15]: cap: GFPacaA | capdevelopment arrests at loose mound stage | increased calcium-dependent cell-cell adhesion | wild type
DBS0350735acaA-/ [act15]: pkaR(G135E/ G261A)acaA | pkaRincreased intracellular cAMP level
DBS0350736acaA-/ [unk]: acaA(F306L/ S498G,K504E,E593V,I649T)acaAabolished cAMP wave formation
DBS0350711acaA-/ [unk]: acgAacaA | acgAaberrant development
DBS0306126acapA-/ acapB-acapA | acapBdecreased sporulation
DBS0350194acbA-/ [act15]: acbA(Y72A)acbAabolished SDF production
AK1211acbA-/ tagA-acbA | tagAincreased prestalk B cell differentiation
DBS0350724acrA-/ [pkaC]: pkaCacrA | pkaCdecreased spore viability | decreased fruiting body size | precocious development
DBS0350445adcC-/ adcB-adcB | adcCaberrant endocytosis | delayed aggregation | decreased period cAMP wave formation | aberrant regulation of protein kinase activity
DBS0350541adprt1A-/ adprt2-adprt1A | adprt2increased sensitivity to DNA-damaging agents | decreased double strand break repair | decreased DNA mediated transformation | increased sensitivity to cisplatin
DBS0349951ampA-/ lmbd2B-ampA | lmbd2Baberrant chemotaxis
DBS0349963ampA-/ sma-ampA | smaincreased chemotaxis to folate | increased cell-substrate adhesion
BS165amtA-/ amtC-amtA | amtCdecreased protein localization to nucleus | aberrant slug migration | decreased extracellular ammonia level | delayed gene expression
BS169amtB-/ amtA-amtA | amtBdecreased extracellular ammonia level
BS168amtB-/ amtC-amtB | amtCdecreased extracellular ammonia level
BS163amtC-/ dhkC-amtC | dhkCmislocalized gene expression
DBS0236890amtC-/ regA-amtC | regAprecocious sporulation
DBS0350299aph1-/ ncstn-aph1 | ncstndecreased phagocytosis | decreased prespore cell differentiation
DBS0350300aph1-/ psenA-aph1 | psenAaberrant culmination | abolished catalytic activity | decreased prespore cell differentiation
DBS0350000arpB+/ aprB-/ [act15]: myc: arpB(T235A/ T236A)arpBwild type
DBS0349998arpB+/ aprB-/ [act15]: myc: arpB(Y200F/ T235A/ T236A)arpBdecreased chemoattractant-mediated F-actin polymerization | decreased cell polarity | delayed aggregation | decreased fruiting body size | decreased chemotaxis to cAMP | delayed gene expression
DBS0350206arpin-/ [act15]: GFP: arpinarpinwild type
DBS0266655atg1-/ iplA-atg1 | iplAdecreased necrotic cell death
DBS0252632atg1-/ pcp-atg1 | pcpabolished autophagic vacuole formation
DBS0350838atg1-/ vmp1-atg1 | vmp1wild type | abolished protein localization
DBS0350535atg9-/ [act15]: cdcD(R155C): RFPatg9 | cdcDwild type | decreased growth rate | decreased phototaxis
DBS0350534atg9-/ [act15]: cdcD: RFPatg9 | cdcDdecreased growth rate | aberrant fruiting body morphology | abolished phototaxis
DBS0350731atg9-/ tipD-atg9 | tipDdecreased pinocytosis | aberrant phagosome maturation | development arrests at tipped mound stage
DBS0350431carA-/ [unk]: carA(261-359;S299A,S302G,S303G,S304G,S308A,S324G,S325A,S331A)(369-392;S383A,S385A): eYFPcarA-1 | carA-2aberrant adaptation of signaling pathway | aberrant localization to plasma membrane
RI9carA-/ carC-carA-1 | carA-2 | carCdecreased gene expression | abolished protein localization to plasma membrane
RI4carA-/ carC-carA-1 | carA-2 | carCdecreased chemoattractant-mediated F-actin polymerization | abolished activation of GTPase activity | abolished aggregation | abolished cAMP-induced cGMP pulse | abolished cAMP-induced cAMP pulse
DBS0350568carA-/ carC-/ [act15]: carA(261-359;S299A,S302G,S303G,S304G,S308A,S324G,S325A,S331A)(369-392;S383A,S385A)carA-1 | carA-2 | carCaberrant F-actin polymerization | aberrant adaptation of adenylate cyclase | aberrant chemotaxis to cAMP | abolished streaming | aberrant cAMP wave formation
DBS0235570carB-carBdevelopment arrests at mound stage
DBS0350528chdC-/ [ecmA]: lacZchdCdecreased prestalk cell differentiation
DBS0350527chdC-/ [pspA]: lacZchdCdecreased prespore cell differentiation
DBS0350851corA-/ aip1-aip1 | corAaberrant endocytosis | increased basal F-actin level | aberrant cytokinesis | increased cell size | development arrests at mound stage | decreased growth rate | aberrant nucleus morphology | increased protein level | decreased chemotaxis to cAMP
TL53cotA-/ cotB-cotA | cotBaberrant spore coat morphology
TL56cotA-/ cotB-/ cotC-cotA | cotB | cotCaberrant spore coat morphology | decreased spore viability | abolished cellulose binding
TL57cotA-/ cotB-/ cotC-cotA | cotB | cotCaberrant spore coat morphology
TL54cotB-/ cotC-cotB | cotCaberrant spore coat morphology
HG1772crtA-/ cnxA-cnxA | crtAdecreased growth rate | delayed response to cAMP | decreased extracellular Ca2+ uptake | decreased phagocytosis | increased cytosolic Ca2+ response
TL73csaA-/ csbA-/ csbC-/ csbC-csaA | csbA | csbB | csbCaberrant culminant morphology
TL72csbA-/ csbB-/ csbC-csbA | csbB | csbCincreased resistance to cisplatin | aberrant culminant morphology
DBS0304928ctnnA-/ mhcA-ctnnA | mhcAaberrant cytokinesis
DBS0237568ctxA-/ [RNAi]enlActxA | enlAwild type
DBS0235599ctxA-/ ctxB-ctxA | ctxBaberrant cellular response to fluid shear stress | abolished adenylate cyclase activity | aberrant cytokinesis | aberrant chemotaxis to cAMP | increased lateral pseudopod formation | decreased cell motility | aberrant regulation of GTPase activity | aberrant cell morphology | abolished culmination | abolished streaming | abolished aggregation | aberrant regulation of protein kinase activity
DBS0350293ctxA-/ ctxB-/ [act15]: GFP: arcAarcA | ctxA | ctxBaberrant protein localization to cell cortex
DBS0349972ctxA-/ ctxB-/ [act15]: acaA: YFPacaA | ctxA | ctxBaberrant fruiting body morphology
DBS0349973ctxA-/ ctxB-/ [act15]: carA: YFPcarA-1 | carA-2 | ctxA | ctxBabolished adenylate cyclase activity | abolished culmination | abolished streaming
DBS0266760culB-/ pkaR-culB | pkaRabolished gene expression | abolished sporulation | precocious gene expression | abolished aggregation
DBS0349807detA-/ [act6]: GFP: detAdetAwild type
DBS0349816detA-/ [act6]: GFP: detA/ [act6]: 3xHA: culDculD | detAincreased gene expression
DBS0349817detA-/ [act6]: GFP: detA/ [act6]: 3xHA: repEdetA | repEincreased gene expression
DBS0350393dgat1-/ dgat2-dgat1 | dgat2decreased growth rate
DBS0349917dgcA-/ [act15]: dgcA(1-124): YFPdgcAdevelopment arrests at slug stage
DBS0349918dgcA-/ [act15]: dgcA(1-273): YFPdgcAdevelopment arrests at slug stage
DBS0349916dgcA-/ [act15]: dgcA(350-521): YFPdgcAdevelopment arrests at slug stage
DBS0350665dhkA-/ [act15]: dhkA(D2076N)dhkAdecreased sporulation
DBS0350664dhkA-/ [act15]: dhkA(H1396Q)dhkAdecreased sporulation
DBS0350666dhkA-/ [act15]: dhkA(H2396Q)/ [act15]: dhkA(D2076N)dhkAwild type
TL134dhkA-/ dhkB-dhkA | dhkBabolished sporulation | increased stalk length | decreased stalk width
HR49dhkA-/ fbxA-dhkA | fbxAdecreased intracellular cAMP level | aberrant fruiting body morphology | decreased sporulation
HR51dhkA-/ fbxA-dhkA | fbxAaberrant fruiting body morphology | decreased sporulation
HR50dhkA-/ fbxA-dhkA | fbxAabolished culmination | decreased sporulation
DBS0350663dhkA-/ pkaR-dhkA | pkaRdecreased sporulation
DBS0350662dhkA-/ regA-dhkA | regAdecreased sporulation
DBS0235714dhkK-/ regA-dhkK | regAprecocious development
DBS0235899dimA-/ dimB-dimA | dimBincreased standing slug length | thin standing slug | increased slug size | aberrant chemotaxis to cAMP
DBS0302608disgorgin(1-571: 581-733)/ disgorgin-DDB_G0280955aberrant contractile vacuole organization and biogenesis | aberrant cellular localization
DBS0302606disgorgin-/ [OE]: GFP: lvsDDDB_G0280955 | lvsDwild type
DBS0302607disgorgin-/ [OE]: lvsADDB_G0280955 | lvsAaberrant contractile vacuole organization and biogenesis
DBS0302611disgorgin-/ [OE]: phgADDB_G0280955 | phgAaberrant contractile vacuole organization and biogenesis
DBS0302604disgorgin-/ lvsA-DDB_G0280955 | lvsAwild type
DBS0302605disgorgin-/ lvsD-DDB_G0280955 | lvsDaberrant contractile vacuole organization and biogenesis
HM1196dmtA-/ stlA-dmtA | stlBdecreased outer basal disc size | decreased prestalk 0 cell differentiation
DBS0350561dnapkcs-/ adprt2-adprt2 | dnapkcsincreased sensitivity to DNA-damaging agents | increased sensitivity to cisplatin
DBS0350459docD-/ docA-docA | docDdelayed development | decreased chemotaxis to cAMP | aberrant fruiting body morphology
HAD205dpoA-/ gskA-dpoA | gskAaberrant development
DBS0235927dstA-/ dstB-dstA | dstBwild type
DBS0235932dstB-/ dstC-dstB | dstCwild type
DBS0350414dydA-/ dydA(1-278: 501-1211)dydAincreased myosin II assembly | increased chemoattractant-mediated F-actin polymerization | aberrant chemotaxis to cAMP | decreased localization to cell cortex
DBS0350415dydA-/ dydA(1-586: 703-1211)dydAdecreased chemotaxis to cAMP | decreased localization to cell cortex
DBS0350803dymA-/ ehd-dymA | ehdaberrant phagosome maturation | decreased phagosomal proteolysis
DBS0350521egeA-/ [unk]: pkaCegeA | pkaCdecreased gene expression | abolished aggregation
DBS0350804ehd-/ [act15]: dymA: GFPdymA | ehdaberrant phagosome maturation | decreased phagosomal proteolysis
DBS0302598elmoA-/ [act15]: elmoA(1-903/ 959-977): GFPelmoAdecreased cell motility | increased phagocytosis
DBS0302474epnA-/ [act15]: epnA(R65A/ K78A): GFPepnAaberrant spore morphology | abolished localization to coated pits | abolished localization to plasma membrane | abolished phosphatidylinositol-4,5-bisphosphate binding
DBS0302475epnA-/ [act15]: epnA(T107A): GFPepnAaberrant spore morphology
DBS0350681erkA-/ [act15]: gpaEerkA | gpaEwild type
DBS0350029erkA-/ [act15]: mekA: FLAGerkA | mekAincreased protein localization to cell cortex
DBS0350682erkB-/ [unk]: erkB(P140S)erkBabolished sporulation
DBS0235949erkB-/ regA-erkB | regAincreased cAMP-induced cAMP pulse | abolished aggregation
HR46fbxA-/ regA-fbxA | regAaberrant fruiting body morphology | decreased sporulation
HR48fbxA-/ regA-fbxA | regAaberrant fruiting body morphology | decreased sporulation
DBS0350129fcsB-/ fcsA-fcsA | fcsBdecreased catalytic activity | decreased growth rate | delayed development
HM1351 fncD2-/ rev3-fncD2 | rev3increased sensitivity to cisplatin
HM1405fncD2-/ xpf-fncD2 | xpfincreased sensitivity to cisplatin
DBS0235967forA-/ forB-forA | forBwild type
DBS0235978fszA-/ fszB- fszA | fszBincreased number of tubular mitochondria
DBS0350077gadA-/ gadB-gadA | gadBdelayed aggregation
DBS0350403gapA-/ iqgC-gapA | iqgCdecreased protein kinase activation | decreased chemotaxis to cAMP
DBS0235992gbpA-/ gbpB-pdeD | pdeEincreased protein kinase activation
DBS0349868gbpC-/ [act15]: gbpC(1-2331: 2470-2631): GFPgbpCaberrant streaming | decreased chemotaxis to cAMP
DBS0235996gbpC-/ gbpD-gbpC | gbpDdecreased cell polarity | decreased chemotaxis rate
DBS0236000gca-/ sgcA-gcA | sgcAdecreased protein kinase activation
DBS0302679gca-/ sgcA-gcA | sgcAaberrant streaming | aberrant chemotaxis to cAMP | increased lateral pseudopod formation | decreased chemotaxis rate | decreased aggregate size | decreased fruiting body size
DBS0236095gdt1-/ gpaB-gdt1 | gpaBincreased gene expression | abolished aggregation
DBS0236010gefB-/ rasS-gefB | rasSdecreased phagocytosis | increased cell motility
DBS0350823gefH-/ gefA-gefA | gefHdecreased F-actin polymerization | aberrant chemotaxis to cAMP | abolished activation of GTPase activity | decreased protein kinase activation | abolished aggregation
DBS0350814gflB-/ [act15]: GFP: gflB(380-1601,T1180E)gflBdecreased chemotaxis to cAMP
DBS0238605gpaA-/ rpkA-gpaA | rpkAdelayed aggregation | abolished aggregation
DBS0350373gpaB-/ regA-gpaB | regAdecreased number of aggregates
DBS0350608gpaD-/ [act15]: gpaD(Q200L)gpaDdevelopment arrests at loose mound stage | decreased chemotaxis to folate | decreased protein kinase activation
DBS0350607gpaD-/ [act15]: gpaD(R107E,R108E)gpaDabolished culmination
DBS0350374gpaD-/ regA-gpaD | regAaberrant aggregation | abolished slug migration | decreased sporulation
DBS0350378gpaD-/ regA-/ [ecmB]: lacZgpaD | regAincreased prestalk 0 cell differentiation
DBS0350678gpaE-/ [act15]: gpaE(K10E/ K11E)gpaEdelayed tip formation | delayed gene expression
DBS0350624gpaE-/ erkA-erkA | gpaEwild type | decreased aggregate size | precocious development
HO547gpbA-/ [act6]: FRB: [act15]: RFP: gpbA/ [act15]: cnxA: CFP: FKBP/ [act15]: limE(1-145): GFPgpbAaberrant cortical actin cytoskeleton organization
DBS0350078grlB-/ grlE-grlB | grlEdecreased small molecule binding | delayed aggregation
DBS0350284grlJ-/ [act15]: grlJ: GFPgrlJwild type
DBS0349881gskA-/ [act15]: gskA(Y214F)gskAabolished streaming
DBS0350260gskA-/ [unk]: pikA(1-492(S7D/ S11D/ S109D/ S113D/ S177D/ S181D))gskA | pikAwild type
DBS0350269gxcT-/ [act15]: GFP: gxcTgxcTwild type
DBS0350656hatA-/ [hatB]: hatBhatA | hatBaberrant cellular response to stress
DBS0236131hbx2-/ warA-hbx2 | warAincreased basal disc size | development arrests at mound stage | decreased prespore cell differentiation | increased prestalk 0 cell differentiation
DBS0350880hbx9-/ [ecmA]: lacZhbx9increased prestalk A cell differentiation
DBS0350364hfnA-/ abpC-abpC | hfnAwild type | aberrant prestalk 0 cell differentiation | decreased phototaxis
DBS0305951hipA-/ epnA-epnA | hipAaberrant spore morphology | decreased spore viability
BS161ifkA-/ ifkB-ifkA | ifkBincreased aggregate size | increased cell-cell adhesion | increased cell-substrate adhesion | aberrant fruiting body morphology | multiple tips in mound
DBS0350042kif4-/ [act15]: dhcA(1384-4725)dhcA | kif4aberrant spindle organization
DBS0350044kil2-/ [act15]: kil1kil1 | kil2abolished resistance to a bacterium
DBS0350875kil2-/ vps13F-kil2 | vps13Faberrant defense response to bacterium | decreased growth rate
DBS0350600krsB-/ krsA-krsA | krsBaberrant streaming | delayed development
DBS0350536ku80-/ dclre1-dclre1 | ku80wild type
DBS0236729limB-/ paxB-limB | paxBdevelopment arrests at mound stage
DBS0350565limD1-/ limC-limC | limD1decreased cell polarity | abolished growth | delayed aggregation | aberrant F-actin organization | aberrant cytokinesis | aberrant response to osmotic stress | decreased chemotaxis to cAMP
DBS0350453lpten-/ [act15]: lpten: RFPlptenwild type
DBS0350114lst8-/ [act15]: GFP: rheb(Q64L)lst8 | rhebincreased phagocytosis
DBS0350030mekA-/ [act15]: Myc: erkAerkA | mekAabolished protein localization to cell cortex
DBS0238098mekA-/ ppp4C-mekA | ppp4cdecreased aggregate size
DBS0238109mekA-/ ppp4C-/ [act15]: FLAG: pppCppp4cdecreased aggregate size | precocious development
DBS0236542mekA-/ smkA-mekA | smkAdecreased aggregate size
DBS0237564mhcA-/ [act15]: GFP: ctxA/ [RNAi]enlActxA | enlA | mhcAaberrant cytokinesis, contractile ring contraction
DBS0350489mhcA-/ [act15]: GFP: mhcA/ [RNAi]rmd1mhcA | rmd1aberrant protein localization
DBS0350808mhcA-/ [act15]: mhcA(1-933: 1455-2116]mhcAwild type | aberrant cytokinesis | aberrant fruiting body morphology
DBS0350668mhcA-/ forA-forA | mhcAabolished cell motility | decreased cell motility
CW0431mhkA-/ mhkB-/ mhkC-mhkA | mhkB | mhkCdecreased growth rate in suspension | increased myosin II assembly | aberrant cytokinesis | aberrant chemotaxis | decreased cell motility
DBS0236556mhkA-/ mhkC-mhkA | mhkCincreased myosin II assembly | decreased growth rate | aberrant cytokinesis
CW0394mhkA/ mhkBmhkA | mhkBdecreased growth rate in suspension | increased myosin II assembly | aberrant cytokinesis
DBS0350123midA-/ [act15]: GFP: atg18atg18 | midAincreased number of autophagosomes
DBS0350136midA-/ [act15]: GFP: tktmidA | tkt-1 | tkt-2increased autophagy
DBS0350027mip1-/ [act15]: mekA: FLAGmekA | mip1-1 | mip1-2aberrant protein localization to cytoplasm
DBS0309109mipp1-/ dpoA-dpoA | mipp1aberrant inositol phosphate metabolic process | increased response to lithium
DBS0236561mkcA-/ tagB-mkcA | tagBdecreased sporulation
DBS0236562mkcA-/ tagC-mkcA | tagCdecreased sporulation
DBS0349988mrfA-/ dimB-/ [emcA]: lacZdimB | mrfAdecreased prestalk A cell differentiation
DBS0304881mrps4-mrps4delayed aggregation
DBS0304882mtDNA-DidioMp05 | DidioMp21 | DidioMp26 | DidioMp27 | DidioMp30 | DidioMp35 | DidioMp36 | ai2a | ai2b | ai3 | ai4 | atp1 | atp4 | atp6 | atp8 | atp9 | cox1/ 2 | cox3 | cytB | mrpl11 | mrpl14 | mrpl16 | mrpl2 | mrpl6 | mrps12 | mrps13 | mrps14 | mrps19 | mrps2 | mrps4 | mrps7 | mrps8 | nad1 | nad11 | nad2 | nad3 | nad4 | nad4L | nad5 | nad6 | nad7 | nad9 | rnlAabolished growth | abolished aggregation
HDT5myoA-/ myoBmyoA | myoBdecreased pinocytosis | decreased growth rate in suspension | aberrant cytoskeleton organisation | increased secretion of lysosomal enzyme | decreased cell motility | decreased fruiting body size
HDT6myoB-/ myoC-myoB | myoCincreased secretion of lysosomal enzyme | decreased growth rate in suspension | aberrant cytoskeleton organisation | decreased fruiting body size
SB14napA-/ pirA-napA | pirAdecreased basal F-actin level
DBS0350301ncstn-/ psenA-ncstn | psenAaberrant culmination | decreased prespore cell differentiation
DBS0350125ndufaf5--/ [act15]: ndufaf5(G86V): GFP: TAPndufaf5decreased growth rate
DBS0350126ndufaf5--/ [act15]: ndufaf5(L165F): GFP: TAPndufaf5decreased growth rate
DBS0350127ndufaf5--/ [act15]: ndufaf5(L235P): GFP: TAPndufaf5decreased growth rate
DBS0350122ndufaf5-/ [act15]: GFP: atg18atg18 | ndufaf5increased number of autophagosomes
DBS0350134ndufaf5-/ [act15]: GFP: tktndufaf5 | tkt-1 | tkt-2increased autophagy
DBS0304634nfaA-/ rasG-nfaA | rasGdecreased cell polarity
DBS0350003nhe1-/ [act15]: GFP: aip1aip1 | nhe1decreased cell polarity | decreased chemotaxis to cAMP
DBS0350006nhe1-/ [act15]: GFP: aip1(E125A, E167A, F181A, F193A)aip1 | nhe1abolished aggregation | abolished chemotaxis to cAMP
DBS0350001nhe1-/ [act15]: aip1(168-597)aip1 | nhe1delayed development
DBS0350002nhe1-/ [act15]: aip1(383-597): FLAGaip1 | nhe1decreased F-actin polymerization | abolished cell polarity | abolished chemotaxis to cAMP
DBS0350509nlp-/ slp-nlp | slpdecreased F-actin polymerization | aberrant organelle organization and biogenesis | abolished protein localization | decreased chemotaxis to cAMP
DBS0236610noxA-/ noxBnoxA | noxBabolished sporulation | decreased superoxide production | aberrant development
DBS0350768noxA-/ noxB-/ noxC-noxA | noxB | noxCaberrant defense response to bacterium
DBS0350093nrampB-/ nramp1-nramp1 | nrampBdelayed aggregation | increased infection rate by Legionella pneumophila | multiple tips
DBS0350196nsfA(A1854T, T1984A, C2131A, A2398T, T2574A)nsfA | pkaCabolished SDF production
DBS0306169p2xA-/ p2xB-/ p2xC-/ p2xD-/ p2xE-p2xA | p2xB | p2xC | p2xD | p2xEdelayed response to hypo-osmotic stress | decreased growth rate
DBS0350430pakB-/ [act15]: RFP: abpE/ [act15]: GFP: pak(1-180)abpE-1 | abpE-2 | pakBwild type
DBS0236715pakB-/ pakC-pakB | pakCdecreased chemotaxis rate
DBS0304929paxB-/ mhcA-mhcA | paxBaberrant cytokinesis
DBS0350799pdkA-/ pdkB-pdkA | pdkBdecreased cell polarity | aberrant chemotaxis to cAMP | development arrests at mound stage | decreased protein kinase activation
DBS0350819pdkA-/ pdkB-pdkA | pdkBaberrant development
DBS0236742pefA-/ pefB-pefA | pefBwild type
DBS0236745pefB-/ cybA-cybA | pefBwild type
DBS0236746pefB-/ noxA-noxA | pefBwild type
DBS0236747pefB-/ noxA-/ [act15]: pefBnoxA | pefBaberrant development
DBS0236748pefB-/ noxB-noxB | pefBwild type
DBS0236749pefB-/ noxC-noxC | pefBabolished sporulation | aberrant development
DBS0305024pgtB-/ pgtC-pgtB | pgtCaberrant cellular metabolic process | aberrant response to hyperosmotic stress | aberrant spore coat morphology
DBS0304869phg1A-/ [act15]: phg1A(1-276): phg1B221-587)phg1A | phg1Bdecreased phagocytosis
DBS0304868phg1A-/ [act15]: phg1Bphg1A | phg1Bincreased secretion of lysosomal enzyme | wild type | decreased cell-substrate adhesion | aberrant protein level | decreased phagocytosis
DBS0304870phg1A-/ [act15]: phg1B(1-220): phg1a(277-642)phg1A | phg1Bdecreased phagocytosis
DBS0304872phg1A-/ phg1B-phg1A | phg1Bincreased secretion of lysosomal enzyme | decreased cell-substrate adhesion | decreased phagocytosis | decreased growth rate | development arrests at tipped mound stage | abolished culmination
DBS0302610phgA-/ [OE]: disgorginDDB_G0280955 | phgAaberrant contractile vacuole organization and biogenesis
DBS0350882piaA(G917D)/ acrA-acrA | piaAabolished gene expression | abolished chemotaxis to cAMP during aggregation | abolished cell polarity
DBS0350877piaA(G917D)/ hephA-hephA | piaAincreased response to cAMP | wild type | abolished activation of adenylate cyclase | decreased intracellular cAMP level
DBS0236766pikA-/ pikB-pikA | pikBaberrant negative chemotaxis | abolished protein localization to plasma membrane | aberrant chemotaxis to cAMP | decreased cell motility | abolished protein kinase activation | abolished protein localization | decreased basal F-actin level | decreased chemotaxis to folate | decreased chemotaxis to cAMP | aberrant protein localization to cell cortex | decreased cAMP-induced cAMP pulse | decreased myosin II assembly
DBS0236773pikA-/ pikB-pikA | pikBdecreased pinocytosis | aberrant aggregation | decreased exocytosis | abolished CRAC localization to the plasma membrane | increased intracellular cAMP level | aberrant adaptation of adenylate cyclase | abolished SDF production | abolished growth | aberrant macropinocytosis | delayed aggregation | aberrant F-actin organization | aberrant phagolysosome formation | aberrant phagosome maturation | multiple tips | decreased phosphatidylinositol biosynthesis | abolished streaming | aberrant cell morphology | decreased cAMP-induced cAMP pulse
HM1141pikA-/ pikB-pikA | pikBdecreased pinocytosis | decreased growth rate | decreased cell motility
DBS0350471pikA-/ pikB-/ [act15]: GFP: capcap | pikA | pikBwild type
DBS0252703pikA-/ pikB-/ pikC-pikA | pikB | pikCdecreased protein localization | increased cell motility
HM1200pikA-/ pikB-/ pikC-/ pikF-/ pikG-pikA | pikB | pikC | pikF | pikGaberrant aggregation | decreased pinocytosis | decreased protein tyrosine phosphorylation | increased chemotaxis to folate | decreased growth rate | decreased cell motility | aberrant signal transduction
HM1284pikA-/ pikB-/ pikC-/ pikF-/ pikG-/ pikH-pikA | pikB | pikC | pikF | pikG | pikHdecreased cell motility | increased infection rate by Legionella pneumophila
HM1295pikA-/ pikB-/ pikC-/ pikF-/ pikG-/ pten-pikA | pikB | pikC | pikF | pikG | ptenaberrant aggregation | decreased growth rate | decreased cell motility | increased resistance to N-Phenylthiourea | increased infection rate by Legionella pneumophila
DBS0238073pikA-/ pikB-/ plaA-pikA | pikB | plaAdecreased chemoattractant-mediated F-actin polymerization | delayed aggregation | aberrant chemotaxis to cAMP | abolished positive chemotaxis
DBS0350828pinA-/ [ecmAO]: lacZpinAaberrant prestalk cell differentiation
DBS0350827pinA-/ [pspA]: lacZpinAaberrant prespore cell differentiation
DBS0350708pkaC-/ [act6]: pkaC(303-648)pkaCwild type
DBS0350707pkaC-/ [act6]: pkaC(330-648)pkaCabolished aggregation
DBS0350710pkaC-/ [dscC]: LUCpkaCdecreased gene expression
DBS0236782pkaC-/ gdt1-gdt1 | pkaCincreased gene expression | abolished aggregation
DBS0350113pkbA-/ [act15]: GFP: rheb(Q64L)pkbA | rhebdecreased phagocytosis
DBS0236785pkbA-/ pkgB-pkbA | pkgBabolished growth | aberrant chemotaxis to cAMP | decreased chemotaxis rate | abolished protein phosphorylation | abolished aggregation | increased activation of GTPase activity
DBS0304640pkbA-/ pkgB-pkbA | pkgBabolished growth
DBS0350831plaA-/ piaA-piaA | plaAaberrant F-actin organization | decreased chemotaxis to cAMP
DBS0350486plaA-/ sgcA-plaA | sgcAaberrant chemotaxis to cAMP
DBS0350487plaA-/ sgcA-/ pkgB-pkgB | plaA | sgcAaberrant chemotaxis to cAMP
DBS0350304psenA-/ psenB-psenA | psenBincreased intracellular cAMP level | abolished prespore cell differentiation | development arrests at mound stage | aberrant gene expression | increased cytosolic Ca2+ response | decreased stalk cell differentiation
DBS0350305psenA-/ psenB-/ [act15]: GFP: psenBpsenA | psenBwild type
DBS0350306psenA-/ psenB-/ [act15]: psenB(D348A/ D394A)psenA | psenBwild type
DBS0350298psenB-/ psenA-psenA | psenBaberrant culmination | decreased phagocytosis | abolished catalytic activity | decreased prespore cell differentiation
DBS0350829psrA-/ [unk]: FLAG: rasD(G12T)psrA | rasDincreased protein kinase activation
DBS0350454pten-/ [act15]: lpten: RFPlpten | ptenwild type
DBS0350754pten-/ [act15]: pten(186-515): GFPptendecreased chemotaxis to cAMP | aberrant development
DBS0350755pten-/ [act15]: pten(C124S): GFPptendecreased chemotaxis to cAMP | aberrant development
DBS0349888pten-/ gefS-gefS | ptenaberrant cytokinesis | decreased chemotaxis to cAMP
DBS0349891pten-/ pakA-pakA | ptendecreased chemotaxis to cAMP
DBS0349893pten-/ pakA-/ [act15]: pakA(T585A): GFPpakA | ptendecreased chemotaxis to cAMP
DBS0349900pten-/ pakA-/ [act15]: pakA(T585E): GFPpakA | ptenaberrant cytokinesis | decreased chemotaxis to cAMP
DBS0349899pten-/ pakA-/ [act15]: pakA: GFPpakA | ptenaberrant cytokinesis
DBS0349887pten-/ piaA-piaA | ptendecreased protein kinase activity | decreased chemotaxis to cAMP
DBS0349880pten-/ pkbA-pkbA | ptendecreased chemotaxis to cAMP
DBS0349886pten-/ pkgB-pkgB | ptenaberrant cytokinesis | increased protein kinase activation
DBS0350675ptpB-/ [act15]: 6xHis: erkAerkA | ptpBaberrant streaming
DBS0350579pyk3-/ phg2-phg2 | pyk3abolished gene expression | decreased protein phosphorylation | aberrant protein localization to nucleus
DBS0349949racE-/ [act15]: fttBfttB | racEdecreased growth rate
DBS0349946racE-/ [act15]: fttB: GFPfttB | racEabolished protein localization to cell cortex
DBS0350631rapgapB-/ [ecmA]: lacZrapgapBaberrant sorting to prestalk region
DBS0350632rapgapB-/ [ecmO]: lacZrapgapBaberrant sorting to prestalk region
DBS0350740rasC-/ [rasC]: rasGrasC | rasGabolished activation of adenylate cyclase | abolished aggregation
DBS0350742rasC-/ [rasC]: rasG(1-77(D30A)): rasC(79-189)rasC | rasGwild type
DBS0350741rasC-/ [rasC]: rasG(D30A)rasC | rasGaberrant aggregation | decreased activation of adenylate cyclase
DBS0236855rasC-/ dmpA-dmpA | rasCabolished streaming
DBS0236857rasC-/ rasD-rasC | rasDabolished aggregation
DBS0236858rasC-/ rasG-rasC | rasGaberrant cell separation during cytokinesis | wild type | decreased gene expression | abolished growth | abolished guanylyl cyclase activity | abolished chemotaxis to folate | decreased growth rate | aberrant chemotaxis to folate | abolished protein kinase activation | decreased activation of adenylate cyclase | decreased cell motility | increased protein level | abolished aggregation | delayed gene expression | abolished chemotaxis to cAMP
DBS0266697rasC-/ rasG-/ [act15]: carAcarA-1 | carA-2 | rasC | rasGabolished growth | abolished activation of GTPase activity | decreased growth rate | decreased activation of adenylate cyclase | abolished protein kinase activation | abolished cAMP-induced cGMP pulse | abolished chemotaxis to cAMP
DBS0350480rasC-/ rasG-/ [rasG]: rasDrasC | rasD | rasGdecreased chemotaxis to folate
DBS0350482rasC-/ rasG-/ [rasG]: rasD(1-104): rasG(103-189)rasC | rasD | rasGdecreased chemotaxis to folate
DBS0350481rasC-/ rasG-/ [rasG]: rasGrasC | rasGwild type
DBS0350483rasC-/ rasG-/ [rasG]: rasG(1-104): rasD(103-187)rasC | rasD | rasGwild type
DBS0236864rasG-/ [OE]: rasBrasB | rasGdecreased growth rate
DBS0350688rdeA-/ acaA-acaA | rdeAincreased intracellular cAMP level | decreased number of spores
DBS0350670regA-/ [regA]: regA(D212N)regAprecocious sporulation
DBS0350380regA-/ dhkD-dhkD | regAaberrant fruiting body morphology
DBS0236891regA-/ tagB-regA | tagBdecreased sporulation
DBS0236892regA-/ tagC-regA | tagCdecreased sporulation
HM1451rev3-/ xpf-rev3 | xpfincreased sensitivity to cisplatin
DBS0349937rgaA-/ ctxA-ctxA | rgaAaberrant cytokinesis | abolished protein localization
DBS0349936rgaA-/ gapA-gapA | rgaAaberrant cellular response to fluid shear stress | aberrant cytokinesis | abolished protein localization | increased cell motility
DBS0350401rgaA-/ gapA-gapA | rgaAincreased myosin II assembly | increased F-actin polymerization | decreased chemotaxis to cAMP | increased protein kinase activation
DBS0350406rgaA-/ gapA-/ [unk]: myc: gapA(R308E/ K317E)gapA | rgaAincreased protein kinase activation
DBS0350402rgaA-/ iqgC-iqgC | rgaAdecreased myosin II assembly | increased protein kinase activation
DBS0350115ripA-/ [act15]: GFP: rheb(Q64L)rheb | ripAincreased phagocytosis
DBS0350770ripA-[act15]: GFP: rapA(G12V)rapA | ripAdecreased protein kinase activation
DBS0350100roco4-/ [unk]: roco4(1018-1292(G1179S))roco4increased catalytic activity
DBS0350098roco4-/ [unk]: roco4(1018-1292(S1187A))roco4abolished catalytic activity
DBS0350099roco4-/ [unk]: roco4(1018-1292(S1189A))roco4decreased catalytic activity
DBS0350178rrpA-/ rrpB-/ rrpC-rrpA | rrpB | rrpCincreased gene expression | decreased gene expression
DBS0350189rrpA-/ rrpB-/ rrpC-/ [act6]: lacZ/ [RNAi]lacZrrpA | rrpB | rrpCabolished transitive RNA interference
DBS0350176rrpA-/ rrpC-rrpA | rrpCincreased gene expression | decreased gene expression
DBS0350187rrpA-/ rrpC-/ [act6]: lacZ/ [AS]lacZrrpA | rrpCaberrant production of siRNA involved in RNA interference
DBS0350182rrpA-/ rrpC-/ [act6]: lacZ/ [RNAi]lacZrrpA | rrpCabolished transitive RNA interference
DBS0350177rrpB-/ rrpC-rrpB | rrpCincreased gene expression | decreased gene expression
DBS0350185rrpB-/ rrpC-/ [act6]: lacZ/ [AS]lacZrrpB | rrpCaberrant production of siRNA involved in RNA interference
DBS0350184rrpB-/ rrpC-/ [act6]: lacZ/ [RNAi]lacZrrpB | rrpCabolished transitive RNA interference
DBS0349790sadA-/ [act15]: sadA(1-923): GFPsadAdecreased cell-substrate adhesion
DBS0349792sadA-/ [act15]: sadA(S924A/ S925A): GFPsadAwild type
DBS0349791sadA-/ [act15]: sadA(S924E/ S925E): GFPsadAdecreased cell-substrate adhesion
DBS0350063scrA-/ [tet]: scrA/ mhcA-mhcA | scrAaberrant cytokinesis
SB18scrA-/ napA-napA | scrAdecreased cell motility | decreased basal F-actin level
SB7scrA-/ pirA-pirA | scrAdecreased cell size
DBS0350286sec1-/ sec1(M250L/ A296V/ M427L/ S435R/ K505N/ V552D/ H570Q)/ gppA: GFPgppA | sec1abolished contractile vacuole discharge
HM1093sgkA-/ sgkB-sgkA | sgkBincreased sensitivity to cisplatin | increased sensitivity to carboplatin | decreased growth rate
DBS0266513sigN(group1)-sigN1 | sigN105-1 | sigN2 | sigN25 | sigN3 | sigN4 | sigN5wild type
DBS0266514sigN(group2)-DDB_G0271820 | sigN10 | sigN11 | sigN12 | sigN14 | sigN6 | sigN7 | sigN8 | sigN9wild type
DBS0350860sir2D-/ [ecmAO]: lacZsir2Ddecreased prestalk cell differentiation
DBS0350861sir2D-/ [pspA]: lacZsir2Daberrant prespore cell differentiation
DBS0302657smlA-/ cnrN-cnrN | smlAdecreased fruiting body size
DBS0236940smlA-/ ctnA-ctnA | smlAincreased cell-cell adhesion
DBS0304496smlA-/ sslA1(CR11)smlA | sslA1increased fruiting body size
DBS0236943spkA-1-/ spkA-2-spkA-1 | spkA-2decreased cell polarity | decreased cell-substrate adhesion | aberrant cytokinesis | decreased chemotaxis rate | decreased aggregate size | aberrant cell morphology | decreased fruiting body size
DBS0236944spkA-1-/ spkA-2-/ [act15]: spkA: FLAGspkA-1 | spkA-2aberrant aggregation | decreased cell polarity | aberrant F-actin organization | decreased chemotaxis rate
DBS0350582splB-/ pyk3-pyk3 | splBabolished gene expression | abolished protein localization to nucleus | abolished protein phosphorylation | aberrant development
DBS0236948spnA-/ arkA-arkA | spnAdecreased gene expression | increased sorus size | decreased stalk length | delayed gene expression
DBS0350224stlA-/ stlB-/ [ecmA]: lacZstlA | stlBdecreased prestalk cell differentiation
DBS0350637tagB-/ [pkaC]: pkaCpkaC | tagBabolished SDF-1 production | aberrant response to SDF-1
DBS0350672tagB-/ pkaR-pkaR | tagBdecreased sporulation
DBS0236974tagB-/ psmA1-psmA1 | tagBabolished sporulation
DBS0350442talA-/ sibA-sibA | talAwild type
DBS0304581talA-/ talB-talA | talBdevelopment arrests at loose mound stage | abolished cell-substrate adhesion | aberrant cytokinesis | abolished cell motility
DBS0350713talA-/ talB-/ [act15]: talB(K16A)talA | talBdecreased cell-substrate adhesion
DBS0350712talB-/ [act15]: talB(K16A)talBdevelopment arrests at tipped mound stage
AK1540tgrB1-/ tgrC1-tgrB1 | tgrC1development arrests at loose mound stage | abolished cell-cell self recognition
AK1664tgrB1-/ tgrC1-/ alg9(-19ins)alg9 | tgrB1 | tgrC1decreased sporulation
AK1657tgrC1-/ QS38[tgrC1]: tgrC1/ alg9(-19ins)alg9 | tgrC1delayed development | decreased fruiting body size | decreased sporulation
JS64tipA-/ tipB-/ [act15]: lacZtipA | tipBincreased aggregate size | development arrests at mound stage | multiple tips in mound
JS98tipA-/ tipC-/ [ecmA]: lacZtipA | tipCdevelopment arrests at loose mound stage
JS128tipA-/ tipD-/ [ecmA]: lacZtipA | tipDdevelopment arrests at loose mound stage
JS99tipB-/ tipC-/ [ecmA]: lacZtipB | tipCdevelopment arrests at tipped mound stage | multiple tips in mound
JS129tipB-/ tipD-/ [ecmA]: lacZtipB | tipDdevelopment arrests at tipped mound stage | multiple tips in mound
DBS0350729tipC-/ [unk]: tipC(2725-3848): GFPtipCdecreased fruiting body size
JS130tipC-/ tipD-/ [ecmA]: lacZtipC | tipDdevelopment arrests at loose mound stage
DBS0350507tpp1-/ stpA-stpA | tpp1wild type
DBS0350466vasP-/ [unk]: vasP(1-197: 221-380)vasPwild type
DBS0350467vasP-/ [unk]: vasP(1-261: 285-380)vasPdecreased cell motility | abolished filopodium formation
DBS0237050warA-/ hbx2-hbx2 | warAincreased basal disc size | development arrests at mound stage | decreased prespore cell differentiation | increased prestalk 0 cell differentiation
DBS0350872wshA-/ [act15]: GFP: wshA/ [act15]: vatB: RFPvatB | wshAabolished endocytic recycling
DBS0350451wshA-/ atg1-atg1 | wshAwild type
DBS0350247wshA-/ fam21-/ [act15]: GFP: wshAfam21 | wshAaberrant post-lysosome organization and biogenesis
DBS0350058yakA-/ keaA-keaA | yakAwild type
AK804yakA-/ pufA-pufA | yakAincreased protein kinase activity | increased protein level | increased growth rate | precocious development | aberrant fruiting body morphology

Last updated February 28, 2017

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