Dictyostelium Mutants

Phenotypes for Dictyostelium mutants

View other mutant types: All mutant strains - Null - Overexpression - Multiple - Other - Developmental

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Systematic Name Strain Descriptor Associated gene(s) Phenotypes
DBS0350059 mcln-mclnaberrant cellular response to fluid shear stress | aberrant post-lysosome organization and biogenesis | increased growth rate
DBS0350826 pinA-pinAdecreased growth rate | decreased aggregate size | decreased sporulation
DBS02354121C7gp130decreased cell-substrate adhesion | delayed development | increased growth rate
DBS02354142F5gp130decreased cell-substrate adhesion | delayed development | increased growth rate
DBS02386015NT-5NTmultiple tips in culminant | delayed tip formation | multiple tips in mound
DBS0235584CF45-1-cf45-1increased aggregate size | decreased cell motility | increased cell-cell adhesion | decreased aggregate size | increased intracellular glucose level
DBS0235585CF50-cf50-1increased aggregate size | increased gene expression | increased cell-cell adhesion | decreased extracellular counting factor component(s) level | increased protein level
DBS0235612CMFR1-cmfBdecreased gene expression | abolished aggregation
DBS0235596ChLim-ChLimincreased growth rate | increased phagocytosis
DBS0235659DD3-3-DD3-3decreased gene expression | precocious aggregation
DBS0236049DDB_G0268012-DDB_G0268012wild type
DBS0236046DDB_G0268158-DDB_G0268158wild type
DBS0236039DDB_G0268678-DDB_G0268678wild type
DG1007DDB_G0269232-DDB_G0269232abolished culmination
DBS0236025DDB_G0270366-DDB_G0270366wild type
DBS0236026DDB_G0270368-DDB_G0270368wild type
DBS0236036DDB_G0270744-DDB_G0270744wild type
LAS29DDB_G0273201-DDB_G0273201decreased socially cooperative development
LAS8DDB_G0273809-DDB_G0273091 | DDB_G0273809decreased socially cooperative development
LAS43DDB_G0274429-DDB_G0274429decreased socially cooperative development
DBS0236043DDB_G0276221-fam21wild type
DBS0236042DDB_G0276689-DDB_G0276689wild type
DBS0236041DDB_G0277179-DDB_G0277179wild type
LAS26DDB_G0277239-DDB_G0277239decreased socially cooperative development
DBS0236045DDB_G0277575-DDB_G0277575wild type
DBS0236044DDB_G0278315-DDB_G0278315wild type
LAS34DDB_G0278585-DDB_G0278585decreased socially cooperative development
DBS0236038DDB_G0279005-DDB_G0279005wild type
DBS0236032DDB_G0279163-DDB_G0279163wild type
DBS0236033DDB_G0279163-DDB_G0279163wild type
LAS70DDB_G0279405-DDB_G0279405decreased socially cooperative development
DBS0236028DDB_G0279609-DDB_G0279609wild type
DBS0236029DDB_G0279609-DDB_G0279609wild type
LAS103DDB_G0280089-DDB_G0280089decreased socially cooperative development
LAS54DDB_G0280299-DDB_G0280299decreased socially cooperative development
DBS0236035DDB_G0280481-DDB_G0280481wild type
DBS0350107DDB_G0280527-DDB_G0280527decreased phagocytosis
DBS0236019DDB_G0281735-DDB_G0281735wild type
DBS0236020DDB_G0281735-DDB_G0281735wild type
LAS92DDB_G0283373-DDB_G0283373decreased socially cooperative development
LAS106DDB_G0283595-DDB_G0283595decreased socially cooperative development
LAS3DDB_G0287153-DDB_G0287153decreased socially cooperative development
LAS10DDB_G0288547-DDB_G0288547decreased socially cooperative development
DBS0350239DDB_G0288569-DDB_G0288569abolished exocytosis | decreased growth rate | abolished F-actin polymerization | abolished phagosome re-neutralization
LAS9DDB_G0289789-DDB_G0289789decreased socially cooperative development
DBS0236027DDB_G0290225-DDB_G0290225wild type
LAS7DDB_G0290685-DDB_G0290685decreased socially cooperative development
DG1003DDB_G0291992-DDB_G0291992aberrant culminant morphology
LAS39DDB_G0292148-DDB_G0292148decreased socially cooperative development
DBS0236037DDB_G0292186-DDB_G0292186wild type
DBS0350073DDB_G0293074-DDB_G0293074decreased spore viability | delayed aggregation
DBS0236023DDB_G0293116-DDB_G0293116wild type
DBS0236024DDB_G0293116-DDB_G0293116wild type
DBS0350516DDB_G0293356-DDB_G0293356increased infection rate by a gram-negative pathogenic bacterium
DBS0236030DDB_G0293762-DDB_G0293762wild type
DG1039DG1039-DDB_G0284037aberrant fruiting body morphology
DG1040DG1040-DDB_G0276029aberrant fruiting body morphology
DG1041DG1041-DDB_G0269126aberrant fruiting body morphology
DG1054DG1054-DDB_G0277719aberrant fruiting body morphology
DG1060DG1060-DDB_G0281953aberrant fruiting body morphology
DG1062DG1062-DDB_G0286351aberrant fruiting body morphology
DG1074DG1074-DDB_G0272108aberrant fruiting body morphology
DG1080DG1080-DDB_G0281559aberrant fruiting body morphology
DG1091DG1091-DG1091decreased fruiting body size
DG1098DG1098-DG1098decreased fruiting body size
DG1104DG1104-DDB_G0283535abolished aggregation
DG1106DG1106-keaAabolished aggregation
DG1110DG1110-DDB_G0269128aberrant fruiting body morphology
DG1112DG1112-DG1112decreased stalk width
DG1113DG1113-DG1113increased stalk length
DG1122DG1122-DG1122aberrant fruiting body morphology
DG1124DG1124-DG1124development arrests at loose mound stage
DG2033DG2033-DG2033development arrests at mound stage
DG2044DG2044-DG2044development arrests at loose mound stage
DBS0266700Dd5P1-Dd5P1wild type
DBS0235660Dd5P2-Dd5P2wild type | increased basal F-actin level
DBS0266702Dd5P3-Dd5P3wild type
DBS0266692Dd5P4-Dd5P4decreased growth rate | decreased phagocytosis | decreased engulfment during phagocytosis | multiple tips in mound
DBS0266693Dd5P4-/ [act15]: Dd5P4Dd5P4wild type
DBS0266719Dd5P4-/ [act15]: Dd5P4: GFPDd5P4wild type
DBS0266695Dd5P4-/ [act15]: GAP5P4Dd5P4decreased growth rate | multiple tips in mound
DBS0266720Dd5P4-/ [act15]: Hs-OCRLDd5P4decreased phagocytosis
DBS0266721Dd5P4-/ [act15]: Hs-OCRL(D422A)Dd5P4decreased phagocytosis
DBS0266694Dd5P4-/ [act15]: cat5P4Dd5P4decreased growth rate | multiple tips in mound
DBS0235940EB1-eb1aberrant mitosis | aberrant cytokinesis | aberrant protein localization
DBS0236015GEG04K11 (tmcB- in KAX3)tmcBsmall macrocysts | increased number of peripheral cells during sexual reproduction | aberrant aggregation during macrocyst formation
DBS0236016GEG04V12 (tmcB- in V12)tmcBsmall macrocysts | increased number of peripheral cells during sexual reproduction | aberrant aggregation during macrocyst formation
DBS0236017GEG10K23 (tmcC- in KAX3)tmcCincreased number of peripheral cells during sexual reproduction | aberrant aggregation during macrocyst formation
DBS0236018GEG10V03 (tmcC- in V12)tmcCincreased number of peripheral cells during sexual reproduction | aberrant aggregation during macrocyst formation
DBS0302615GFP: phgA(1-274: 283-438)/ phgA-phgAaberrant response to hypo-osmotic stress
DBS0302614GFP: phgA/ phgA-phgAwild type
DBS0236085GP138C-cfrCwild type
AP1HSPC300-hspc300aberrant cytokinesis
AP2HSPC300-hspc300decreased basal F-actin level | decreased cell motility | decreased phototaxis | decreased pseudopod size | decreased cell size
HTY506HTY506pkaRaberrant spore morphology | decreased spore viability | decreased phosphorylation of actin | increased sporulation | precocious development | decreased intracellular cAMP level | aberrant fruiting body morphology
DBS0236426I6KA-I6KAaberrant cellular homeostasis | aberrant inositol phosphate metabolic process | increased growth rate
DBS0236716PAKc-pakCdecreased chemotaxis rate | decreased lateral pseudopod suppression
DBS0236779PIPkinA-pik6decreased gene expression | abolished aggregation
DBS0236840R7nosAdevelopment arrests at mound stage
DBS0304456[AS]alrA/ gcsA-alrA | gcsAdecreased growth rate in suspension | cell cycle arrest
DBS0236827[AS]proA/ proB-proA | proBdecreased secretion of lysosomal enzyme | decreased exocytosis | decreased pinocytosis | increased basal F-actin level | abolished growth | development arrests at slug stage | aberrant cytokinesis | decreased cell motility
DBS0238036[AS]proA/ proB-/ [act15]: proAproA | proBwild type
DBS0238037[AS]proA/ proB-/ [act15]: proBproA | proBwild type
DBS0302658[act15]: cnrN: myc/ smlA-cnrN | smlAdecreased fruiting body size
DBS0304457[act15]: sodA/ gcsA-gcsA | sodAwild type
DBS0304460[act]: alrA/ gcsA-alrA | gcsAwild type
DBS0235407[carA]: carA(1-317)carA-1 | carA-2delayed development
DBS0350696[pkaC]: pkaC/ srfA-pkaC | srfAaberrant spore coat morphology | aberrant gene expression
HAD186aarA-aarAaberrant stalk morphogenesis | aberrant tip formation | decreased gene expression | aberrant establishment and/ or maintenance of cell polarity | aberrant stalk formation | aberrant Golgi localization | aberrant centrosome localization | decreased sporulation
DBS0349920aarA-/ [act15]: GFP-mhcAaarAaberrant stalk morphogenesis | aberrant protein localization
DBS0266687abiA-abiAdecreased protein level | aberrant cytokinesis | decreased growth rate | decreased chemotaxis to folate | aberrant protein localization
DBS0266688abiA-abiAaberrant protein localization
DBS0350386abiA-/ abiA(45-136)abiAdecreased protein level | aberrant cytokinesis
DBS0350384abiA-/ abiA(45-332)abiAaberrant cytokinesis
DBS0305672abpB-abpBincreased filopodium formation
HG1264abpC-abpCaberrant actin cytoskeleton organization
DBS0350936abpC-abpCdecreased cell polarity | aberrant cortical actin cytoskeleton organization | decreased phagocytosis | decreased cell motility | decreased chemotaxis to cAMP | aberrant pseudopod formation
DBS0236077abpC-abpCaberrant thermotaxis | decreased cell polarity | decreased cell motility | aberrant phototaxis
DBS0237938abpC-/ [act15]: GFP: abpC(9-148)abpCaberrant phototaxis
DBS0235426abpC-/ [act15]: abpCabpCwild type
DBS0350938abpC-/ [act15]: abpCabpCwild type
DBS0237945abpC-/ [act15]: abpC(1-348: 449-857): GFPabpCaberrant F-actin organization | aberrant phototaxis
DBS0237946abpC-/ [act15]: abpC(1-556: 644-857): GFPabpCaberrant F-actin organization | aberrant phototaxis
DBS0237941abpC-/ [act15]: abpC(1-739): GFPabpCaberrant phototaxis
DBS0237949abpC-/ [cotB]: abpC: GFPabpCaberrant phototaxis
DBS0237948abpC-/ [ecmA]: abpC: GFPabpCwild type
DBS0235427abpD-abpDdecreased cell-cell adhesion | decreased spore viability | delayed development | aberrant development
DBS0235428abpE-abpE-1 | abpE-2increased lateral pseudopod formation
DBS0349851abpE-abpE-1 | abpE-2aberrant phagosome maturation | precocious phagosome acidification | increased phagocytosis
DBS0349852abpE-/ [act15]: abpEabpE-1 | abpE-2decreased phagocytosis
DBS0350529abpG-abpGincreased basal F-actin level | decreased chemotaxis to cAMP | decreased fruiting body size
DBS0235562acaA-acaAabolished gene expression | decreased gene expression | abolished aggregation | decreased adenylate cyclase activity | abolished cell polarity | abolished streaming | decreased intracellular cAMP level
GP6acaA-acaAaberrant F-actin organization | increased lateral pseudopod formation | decreased chemotaxis rate | aberrant cell morphology | increased protein kinase activation
DBS0235429acaA-acaAdecreased gene expression
DBS0350720acaA-/ [acaA-agg]: acaA: mycacaAwild type | decreased gene expression | decreased fruiting body size
DBS0350721acaA-/ [acaA-psp]: acaA: mycacaAdecreased gene expression | decreased aggregate size | decreased fruiting body size
DBS0350722acaA-/ [acaA-pst]: acaA: mycacaAwild type
DBS0350702acaA-/ [act15]: HA: pkaCacaA | pkaCwild type | delayed development | decreased intracellular cAMP level
DBS0350737acaA-/ [act15]: acaAacaAaberrant slug formation
DBS0350738acaA-/ [act15]: acaA(1-390;398-1407)acaAabolished aggregation
DBS0350739acaA-/ [act15]: acaA(L394T/ K482N)acaAwild type
DBS0350603acaA-/ [act15]: cap: GFPacaA | capdevelopment arrests at loose mound stage | increased calcium-dependent cell-cell adhesion | wild type
DBS0350735acaA-/ [act15]: pkaR(G135E/ G261A)acaA | pkaRincreased intracellular cAMP level
DBS0350736acaA-/ [unk]: acaA(F306L/ S498G,K504E,E593V,I649T)acaAabolished cAMP wave formation
DBS0350734acaA-/ [unk]: acaA(N333D,G633S)acaAabolished adenylate cyclase activity
DBS0350733acaA-/ [unk]: acaA(V427I,S642F)acaAabolished activation of adenylate cyclase
DBS0350711acaA-/ [unk]: acgAacaA | acgAaberrant development
DBS0306125acapA-acapAwild type
DBS0350051acapA-acapAaberrant streaming | aberrant exocytosis | aberrant lysosome organization and biogenesis | aberrant filopodium formation | decreased infection rate by a gram-negative pathogenic bacterium | aberrant endocytosis | aberrant cytokinesis | decreased cell motility | delayed development
DBS0350055acapA-/ [act15]: acapA(R633Q): GFPacapAaberrant filopodium formation | aberrant post-lysosome organization and biogenesis
DBS0350054acapA-/ [act15]: acapA: GFPacapAincreased filopodium formation
DBS0306127acapB-acapBwild type
TL177acbA-acbAincreased sensitivity to cisplatin | abolished SDF production | decreased spore viability | abolished sorting to prestalk region
DBS0350194acbA-/ [act15]: acbA(Y72A)acbAabolished SDF production
DBS0235440acgA-acgAabolished response to MPBD | abolished response to SDF-1 | decreased spore viability | precocious spore germination | abolished SDF-1 production
DBS0237788acgA-acgAdecreased gene expression | decreased prespore cell differentiation
DBS0237790acgA-/ [acrA]: lacZacgA | acrAmislocalized gene expression
DG1100acrA-acrAdecreased gene expression | increased stalk length | spores inviable | decreased sporulation
DBS0349939acrA-acrAaberrant spore coat morphology | decreased stalk width
DBS0350723acrA-/ [act15]: acaA(L394S)acaA | acrAwild type
DBS0237786acrA-/ [act15]: acgA(1-401)acgA | acrAdecreased gene expression | decreased prespore cell differentiation | decreased sporulation
DBS0349970acrA-/ [act15]: acrA(D1010A)acrAdecreased adenylate cyclase activity
DBS0349971acrA-/ [act15]: acrA(D1174A)acrAincreased adenylate cyclase activity
DBS0349969acrA-/ [act15]: acrA(N796D/ D854A/ G856A)acrAwild type
DBS0350724acrA-/ [pkaC]: pkaCacrA | pkaCdecreased spore viability | decreased fruiting body size | precocious development
DBS0350443adcB-adcBwild type
DBS0350444adcC-adcCwild type
DBS0350538adprt1A-adprt1Aincreased sensitivity to DNA-damaging agents | decreased double strand break repair | decreased DNA mediated transformation
DBS0264268adprt1B-adprt1Bincreased sensitivity to DNA-damaging agents | wild type | decreased single strand break repair | aberrant cAMP wave formation
DBS0350539adprt2-adprt2increased sensitivity to DNA-damaging agents | decreased double strand break repair | increased sensitivity to cisplatin | decreased single strand break repair
DBS0238203adrm1-adrm1-1aberrant response to nutrients | precocious gene expression | precocious development
DBS0235457ahhA-ahhAaberrant culminant morphology
DBS0252637aip1-aip1decreased pinocytosis | delayed cytokinesis | increased basal F-actin level | decreased growth rate | decreased phagocytosis | aberrant nucleus morphology | decreased cell motility
DBS0266759alp-alpwild type
DBS0235513alrA-alrAincreased aggregate size | decreased intracellular glucose level | decreased cell motility | decreased extracellular counting factor component(s) level
DBS0235473alrA-/ [act15]: alrAalrAwild type
DBS0235474alxA-alxAdevelopment arrests at loose mound stage | decreased growth rate | aberrant fruiting body morphology
DBS0235475alxA-alxAabolished sporulation | decreased gene expression | development arrests at mound stage | aberrant fruiting body morphology
DBS0235488alxA-/ [act15]: FLAG: alxAalxAdelayed development
DBS0235476alxA-/ [act15]: alxA(1-596): myc2alxAwild type
DBS0235477alxA-/ [act15]: alxA(1-697): myc2alxAwild type
DBS0235478alxA-/ [act15]: alxA(155-697): myc2alxAaberrant fruiting body morphology
DBS0235479alxA-/ [act15]: alxA(293-697): myc2alxAaberrant fruiting body morphology
DBS0235480alxA-/ [act15]: alxA(460-794): myc2alxAaberrant fruiting body morphology
DBS0235481alxA-/ [act15]: alxA(D310A/ N311A)alxAwild type
DBS0235482alxA-/ [act15]: alxA(Q181E/ Q183)alxAwild type
DBS0235483alxA-/ [act15]: alxA(S700A/ S704A/ S708A)alxAwild type
DBS0235484alxA-/ [act15]: alxA(S700D/ S704D/ S708D)alxAwild type
DBS0235485alxA-/ [act15]: alxA(Y315D)alxAwild type
DBS0235486alxA-/ [act15]: alxA(Y315F)alxAwild type
DBS0235487alxA-/ [act15]: alxA: myc2alxAwild type
DBS0235489alyA-alyAincreased phagocytosis
DG1114amdA-amdAdecreased spore viability | translucent sorus | increased prestalk A cell differentiation
HM1158amdA-amdAdecreased fruiting body size | decreased sporulation | increased aspidocyte differentiation
DBS0235490amiB-amiBabolished aggregation
DBS0235491amiB-amiBdecreased cAMP-induced cGMP pulse | abolished down-regulation of growth phase genes | decreased gene expression | abolished aggregation | decreased chemotaxis to cAMP | decreased cAMP-induced cAMP pulse
DBS0235493ampA-ampAdelayed tip formation | increased cell-cell adhesion | increased cell-substrate adhesion | mislocalized gene expression | delayed development | precocious gene expression | decreased prestalk cell differentiation | delayed gene expression
DBS0349962ampA-ampAdecreased F-actin polymerization | wild type | aberrant chemotaxis to folate | increased cell-substrate adhesion | decreased pseudopod formation
DBS0235496ampA-/ pspD: lacZampAmislocalized gene expression
DBS0349952ampA/ [ampA]: ampA/ lmbd2B-ampA | lmbd2Baberrant chemotaxis
BS155amtA-amtAdecreased slug migration | decreased aggregate size | decreased fruiting body size | increased growth rate | decreased extracellular ammonia level
DBS0267100amtA-amtAdecreased spore viability | decreased aggregate size | increased number of aggregates | decreased extracellular ammonia level | increased intracellular glucose level | decreased stalk length | increased intracellular ammonia level
DBS0267101amtA-/ [OE]: amtAamtAwild type
amtB-amtB
BS154amtC-amtCdecreased gene expression | development arrests at slug stage | mislocalized gene expression | decreased extracellular ammonia level | delayed culmination | aberrant protein localization | aberrant fruiting body morphology
DBS0235501amtC-/ [act15]: cudAamtC | cudAdelayed culmination
DBS0235502amtC-/ [ecmA]: cudAamtC | cudAdelayed culmination
DBS0235503amtC-/ [pspA]: cudAamtC | cudAdevelopment arrests at slug stage
DBS0350432aoxA-aoxAincreased sensitivity to hydrogen peroxide | aberrant cellular process | aberrant development
DBS0349869ap1b1-ap1b1aberrant aggregation | aberrant contractile vacuole organization and biogenesis | aberrant cell separation during cytokinesis | aberrant response to hypo-osmotic stress | decreased growth rate | decreased protein stabilization
DBS0305197ap2a1-ap2a1-1 | ap2a1-2aberrant cell separation during cytokinesis
DBS0350296aph1-aph1aberrant culmination | abolished catalytic activity | decreased prespore cell differentiation
DBS0350805apl-aplaberrant response to cisplatin
DBS0235505apm1-apm1aberrant contractile vacuole organization and biogenesis | decreased spore germination | aberrant response to hypo-osmotic stress | decreased growth rate | aberrant endosome morphology | delayed development | decreased stalk width
DBS0235506apm2-apm2aberrant cell separation during cytokinesis
DBS0305085apm2-/ [dscB]: GFP: vamp7Aapm2 | vamp7Aincreased protein localization to plasma membrane
DBS0235507apm3-apm3decreased pinocytosis | increased exocytosis | aberrant post-lysosome organization and biogenesis | aberrant endosome morphology
DBS0305083apm3-/ [dscB]: GFP: vamp7Aapm3 | vamp7Aincreased protein localization to plasma membrane
DBS0235508apm4-apm4wild type
DBS0235509aprA-aprAaberrant cellular homeostasis | increased cell death | increased aggregate size | decreased spore viability | aberrant cytokinesis | aberrant vegetative growth | increased growth rate | abolished chemorepellant activity | aberrant fruiting body morphology | decreased sporulation
DBS0235510aprA-/ [act15]: aprAaprAdecreased growth rate | aberrant fruiting body morphology
DBS0350009aprA-/ [act15]: bzpN: GFPaprA | bzpNabolished negative regulation of vegetative growth
DBS0238124aqpA-aqpAdecreased spore viability
DBS0350886areA-areAincreased autophagy
DBS0350887areB-areBincreased autophagy
DBS0235511arkA-arkAincreased gene expression | aberrant fruiting body morphology
DBS0350191arpin-arpinincreased cell motility
DBS0350206arpin-/ [act15]: GFP: arpinarpinwild type
DBS0350654ase1A-ase1Aaberrant cytokinesis | aberrant microtubule cytoskeleton organization | aberrant spindle organization
DBS0350655ase1B-ase1Baberrant cell morphology
DBS0235514aslA-aslA-1 | aslA-2wild type
DBS0236305atg1-atg1aberrant macroautophagy | abolished autophagic vacuole formation
DBS0236304atg1-atg1aberrant macroautophagy | abolished autophagic vacuole formation
DBS0350450atg1-atg1aberrant vacuolation | aberrant defense response to bacterium | abolished autophagic cell death | increased infection rate by a gram-negative pathogenic bacterium
DBS0350839atg1-atg1decreased catalytic activity | abolished protein localization
HR131atg1-atg1abolished sporulation | decreased growth rate in suspension | abolished macroautophagy | increased number of autophagosomes | aberrant autophagy | increased infection rate by a gram-positive pathogenic bacterium | aberrant cellular response to nitrogen starvation | abolished SDF production | increased infection rate by a gram-negative pathogenic bacterium | aberrant vacuole organization and biogenesis | abolished stalk cell differentiation | abolished aggregation | decreased growth rate on bacterial plates | aberrant defense response to yeast | aberrant protein localization
DBS0238085atg1-/ [act15]: atg1atg1wild type
DBS0238092atg1-/ [act15]: atg1(1-628)atg1aberrant cellular response to nitrogen starvation | abolished aggregation
DBS0238087atg1-/ [act15]: atg1(K36A)atg1aberrant cellular response to nitrogen starvation | abolished aggregation
DBS0238093atg1-/ [act15]: atg1(P138S)atg1abolished aggregation
DBS0350884atg101-atg101decreased autophagy | multiple tips
DBS0350883atg13-atg13aberrant autophagy | abolished aggregation
DBS0350885atg17-atg17wild type
HR75atg5-atg5aberrant macroautophagy | abolished sporulation | aberrant cellular response to nitrogen starvation | multiple tips | abolished aggregation | aberrant protein localization
HR174 atg6-atg6Aaberrant macroautophagy | aberrant cellular response to nitrogen starvation | abolished SDF production | increased infection rate by a gram-negative pathogenic bacterium | multiple tips | decreased fruiting body size | decreased stalk length | decreased sporulation | aberrant defense response to yeast
HR79atg7-atg7aberrant macroautophagy | abolished sporulation | aberrant cellular response to nitrogen starvation | abolished SDF production | increased infection rate by a gram-negative pathogenic bacterium | multiple tips | aberrant protein localization
HR141atg8-atg8aaberrant macroautophagy | aberrant spore morphology | increased infection rate by a gram-positive pathogenic bacterium | aberrant cellular response to nitrogen starvation | abolished SDF production | aberrant vacuole organization and biogenesis | multiple tips | decreased fruiting body size | decreased sporulation
DBS0305977atg9-atg9increased stalk width | decreased pinocytosis | aberrant sorus morphology | aberrant autophagy | decreased phagocytosis | decreased growth rate | abolished catalytic activity | aberrant slug migration | aberrant protein modification | aberrant phagosome maturation | aberrant fruiting body morphology | aberrant slug formation | multiple tips in mound | abolished phototaxis
DBS0350535atg9-/ [act15]: cdcD(R155C): RFPatg9 | cdcDwild type | decreased growth rate | decreased phototaxis
DBS0350534atg9-/ [act15]: cdcD: RFPatg9 | cdcDdecreased growth rate | aberrant fruiting body morphology | abolished phototaxis
HM1591axeB-axeBincreased macropinocytosis | increased phagocytosis
DBS0349965bzpN-bzpNaberrant cytokinesis | abolished negative regulation of vegetative growth | increased growth rate
DBS0350419bzpR-bzpRincreased stalk width | aberrant sorus morphology | decreased spore viability
TL97cadA-cadAdecreased calcium-dependent cell-cell adhesion | decreased protein level | increased gene expression | increased chemotaxis to cAMP | aberrant cytokinesis | multiple tips | aberrant development | decreased sporulation | delayed culmination | increased prestalk cell differentiation
JB4carA-carA-1 | carA-2abolished aggregation
JS14carA-carA-1 | carA-2abolished protein tyrosine phosphorylation | decreased cAMP-induced cGMP pulse | abolished protein localization to nucleus | increased cell-substrate adhesion | aberrant regulation of GTPase activity | abolished aggregation | aberrant regulation of protein kinase activity | decreased cAMP-induced cAMP pulse
DBS0350431carA-/ [unk]: carA(261-359;S299A,S302G,S303G,S304G,S308A,S324G,S325A,S331A)(369-392;S383A,S385A): eYFPcarA-1 | carA-2aberrant adaptation of signaling pathway | aberrant localization to plasma membrane
DBS0235570carB-carBdevelopment arrests at mound stage
DBS0350661carB-carBabolished tip formation | increased gene expression | decreased gene expression | development arrests at tight mound stage | abolished culmination
JB6carC-carCwild type
DBS0235568carD-carDdecreased slug migration | decreased slug size | increased gene expression | decreased gene expression | aberrant slug migration | aberrant fruiting body morphology | decreased stalk length | decreased prestalk cell differentiation
DBS0235573carmil-carmildecreased pinocytosis | decreased growth rate | decreased basal F-actin level | decreased aggregate size
IR40catA-catAabolished catalase activity
IR41catA-catAabolished catalase activity
IR29catA-catAincreased sensitivity to hydrogen peroxide
DBS0235574catB-catBaberrant gene expression | delayed development | increased spore sensitivity to hydrogen peroxide
DBS0350249cbhA-cbhAdelayed development
DBS0350250cbhA-/ [cbhA]: cbhAcbhAwild type
DBS0304455cblA-cblA-1 | cblA-2abolished basal disc formation | aberrant slug formation | aberrant signal transduction
DBS0235575cbpJ-cbpJwild type
DBS0350238ccdc53-ccdc53abolished exocytosis | decreased growth rate | abolished F-actin polymerization | abolished phagosome re-neutralization
DBS0235661cdk8-cdk8decreased gene expression | mislocalized gene expression | abolished aggregation
DBS0350435cdk8-cdk8decreased gene expression | decreased spore viability | aberrant gene expression | abolished aggregation
DBS0350436cdk8-/ [act15]: myc: cdk8cdk8wild type
DBS0350437cdk8-/ [act15]: myc: cdk8(D194A)cdk8decreased spore viability | abolished aggregation
DBS0235578cdk8-/ [cdk8]: cdk8cdk8wild type
DBS0306226cenB-cenBincreased number of centrosomes | aberrant cell separation during cytokinesis | aberrant nuclear envelope morphology | abolished protein localization to microtubule organizing center | aberrant nucleus morphology | aberrant cytokinesis | decreased microtubule nucleation | aberrant centrosome organization
DBS0306227cenB-/ [act15]: RFP: cenBcenBwild type
DBS0349926cepC-cepCabolished growth | decreased growth rate | aberrant Golgi localization | aberrant spindle organization | aberrant centrosome organization
DBS0350265cepK-cepKdecreased protein level | decreased protein localization to nuclear envelope | aberrant chemotaxis to cAMP | decreased growth rate | decreased aggregate size | decreased fruiting body size | decreased cell size
DBS0302444cfaD-cfaDaberrant cellular homeostasis | increased cell death | decreased spore viability | aberrant vegetative growth | aberrant cytokinesis | increased growth rate | aberrant fruiting body morphology | decreased sporulation
DBS0350010cfaD-/ [act15]: bzpN: GFPbzpN | cfaDabolished negative regulation of vegetative growth
DBS0302446cfaD-/ [act15]: cfaDcfaDwild type
HO101chcA-chcAdecreased pinocytosis | aberrant cytokinesis | decreased growth rate
HO103chcA-chcAabolished sporulation | abolished cytokinesis | abolished gene expression | abolished growth | delayed aggregation | aberrant fruiting body morphology
DBS0350090chcA-/ [act15]: GFP: ap2a1ap2a1-1 | ap2a1-2 | chcAaberrant protein localization
DBS0235588chcA-/ [act15]: GFP: mhcAchcA | mhcAdecreased positive regulation of GTPase activity
DBS0302455chcA-/ [act15]: epnA: GFPchcA | epnAaberrant protein localization to coated pits
DBS0350091chcA-/ [act15]: gppA: GFPchcA | gppAaberrant protein localization to plasma membrane
DBS0235589chcA-/ [cotB]: lacZchcAmislocalized gene expression
DBS0235590chcA-/ [ecmA]: lacZchcAmislocalized gene expression
DBS0235591chcA-/ [ecmB]: lacZchcAmislocalized gene expression
DBS0235592chcA-/ [pspA]: lacZchcAmislocalized gene expression
DBS0350524chdA-chdAaberrant culmination | aberrant gene expression | decreased chemotaxis to cAMP
DBS0350525chdB-chdBaberrant gene expression | delayed development
DBS0350526chdC-chdCdecreased growth rate | development arrests at mound stage | aberrant gene expression | decreased chemotaxis to cAMP
DBS0350528chdC-/ [ecmA]: lacZchdCdecreased prestalk cell differentiation
DBS0350527chdC-/ [pspA]: lacZchdCdecreased prespore cell differentiation
HM1522chlA-chlAabolished DIF production | aberrant slug formation | aberrant fruiting body morphology
LAS1chtB-chtBdecreased socially cooperative development | increased growth rate
LAS5chtC-chtCdecreased socially cooperative development
DBS0235601clc-clcabolished cytokinesis | decreased protein localization to plasma membrane | aberrant response to hypo-osmotic stress | abolished growth | aberrant fruiting body morphology
DBS0235604clc-/ [act15]: GFP-clc(146-194)clcabolished cytokinesis | wild type | aberrant fruiting body morphology
DBS0235605clc-/ [act15]: GFP-clc(85-124)clcabolished cytokinesis | wild type | aberrant fruiting body morphology
DBS0235607clc-/ [act15]GFP: clc(1-124)clcabolished cytokinesis | wild type | aberrant fruiting body morphology
DBS0350408cldA-cldAdecreased gene expression
DBS0235608clmA-clmAaberrant response to hypo-osmotic stress | aberrant contractile vacuole morphology
DBS0350473cln3-cln3aberrant aggregation | increased protein secretion | increased pinocytosis | delayed aggregation | aberrant cell adhesion | aberrant slug migration | precocious development | increased growth rate | decreased protein secretion
DBS0350474cln3-/ [act15]: GFP: cln3cln3wild type
DBS0235609cluA-cluAdecreased mitochondrial fusion | decreased mitochondrial fission | aberrant cytokinesis | aberrant intracellular distribution of mitochondria | aberrant mitochondrion organization
DBS0349875cluA-/ [act15]: cluAcluAwild type
DBS0235613cnrB-cnrBwild type
DBS0350308cnrF-cnrFaberrant contractile vacuole organization and biogenesis | abolished response to hypo-osmotic stress | decreased contractile vacuole size | aberrant regulation of GTPase activity
DBS0350311cnrF-/ cnrF(E623Q/ D659Q)cnrFaberrant contractile vacuole organization and biogenesis | abolished response to hypo-osmotic stress | decreased contractile vacuole size | aberrant regulation of GTPase activity
DBS0350310cnrF-/ cnrF(R270A)cnrFaberrant contractile vacuole organization and biogenesis | abolished response to hypo-osmotic stress | decreased contractile vacuole size | aberrant regulation of GTPase activity
DBS0302655cnrN-cnrNaberrant streaming | increased cAMP-induced cAMP pulse | decreased spore viability | increased F-actin polymerization | aberrant cytokinesis | increased number of aggregates | increased growth rate | abolished positive regulation of chemorepellant activity | decreased sporulation
DBS0302656cnrN-/ [act15]: cnrNcnrNwild type
HG1770cnxA-cnxAdecreased extracellular Ca2+ uptake | increased cytosolic Ca2+ response
DBS0235615cofB-cofBwild type
DBS0235616cofC-cofC-1wild type
DBS0350522comA-comAaberrant response to hyperosmotic stress | aberrant phagocytosis | aberrant defense response to a microorganism
DBS0235617comB-comBabolished culmination
DG1016comB-comBabolished culmination
DBS0235618comC-comCaberrant streaming | aberrant aggregation
DBS0235619comD-comDabolished culmination
DBS0235620comE-comEtranslucent sorus | aberrant fruiting body morphology
DBS0235621comF-comF-1 | comF-2abolished aggregation
DBS0235622comG-comGdevelopment arrests at mound stage | multiple tips
DBS0235623comH-comHdevelopment arrests at mound stage
HG1570corA-corAincreased myosin II assembly | aberrant cytokinesis | decreased growth rate | decreased cell motility | aberrant cell morphology
HG1571corA-corAincreased myosin II assembly | aberrant cytokinesis | decreased growth rate | decreased cell motility | aberrant cell morphology
HG1569corA-corAincreased infection rate by a gram-positive pathogenic bacterium | increased myosin II assembly | increased basal F-actin level | aberrant cytokinesis | decreased growth rate | decreased phagocytosis | decreased cell motility | aberrant cell morphology
DBS0350370corA-corAaberrant response to conditioned medium factor | decreased cell polarity | decreased gene expression | aberrant chemotaxis to cAMP | aberrant cAMP signaling during aggregation | abolished aggregation
DBS0350345corA-/ [act15]: GFP: mhkAcorA | mhkAwild type
DBS0350346corA-/ [act15]: GFP: mhkBcorA | mhkBwild type
DBS0350344corA-/ [act15]: GFP: mhkCcorA | mhkCdecreased catalytic activity | wild type
DBS0350343corA-/ [act15]: GFP: pakA(797-1197)corA | pakAwild type
DBS0350371corA-/ [act15]: corAcorAwild type
DBS0350341corA-/ [act15]: corA(I118A/ S119A/ P121A): GFPcorAwild type | aberrant binding | increased myosin II assembly
DBS0305825corB-corBaberrant phagocytosis | decreased growth rate | increased lateral pseudopod formation | increased cell-substrate adhesion
DBS0349942cosA-cosAincreased pseudopod formation | aberrant F-actin organization | decreased cell motility | decreased fruiting body size | decreased chemotaxis to cAMP
TL55cotA-cotAaberrant spore coat morphology | decreased spore viability | abolished cellulose binding
TL26cotB-cotBaberrant spore coat morphology | decreased spore viability | abolished cellulose binding
TL52cotC-cotCaberrant spore coat morphology
DBS0238297cpnA-cpnAdelayed response to hypo-osmotic stress | aberrant thermotaxis | increased aggregate size | decreased growth rate | aberrant cytokinesis | aberrant stalk cell differentiation | development arrests at slug stage | increased slug size | delayed development | aberrant fruiting body morphology | abolished phototaxis
DBS0238320cpnA-/ [act15]: GFP: cpnAcpnAdelayed response to hypo-osmotic stress | decreased culmination | delayed development
DBS0350869crlA-/ AX2crlAwild type
DBS0235627crlA-/ KAX3crlAabolished response to MPBD | increased aggregate size | decreased spore viability | delayed tip formation | decreased sorting to prestalk region | abolished SDF-1 production | increased growth rate
DBS0235628crlA-/ [crlA]: crlAcrlAincreased aggregate size
DBS0235629crlB-crlBwild type
DBS0235630crlC-crlCwild type
HG1768crtA-crtAdecreased extracellular Ca2+ uptake | increased cytosolic Ca2+ response
DBS0235633crtf-crtfabolished sporulation | decreased gene expression | abolished aggregation
AX2-T10csaA-csaAdecreased cell-cell adhesion | decreased culmination | delayed aggregation | increased cell-substrate adhesion | decreased sporulation | aberrant protein localization
WTC127cshA-cshAdevelopment arrests at loose mound stage | decreased phagocytosis | decreased growth rate | delayed aggregation
DBS0235624ctnA-ctnAaberrant cellular metabolic process | decreased protein level | increased cAMP-induced cGMP pulse | increased aggregate size | decreased basal F-actin level | increased cell-cell adhesion | increased GTP-gamma-S-stimulated guanylyl cyclase activity | increased protein level | increased cell motility | increased intracellular glucose level | decreased cAMP-induced cAMP pulse | decreased myosin II assembly
DBS0235636ctnB-ctnBdecreased gene expression | increased number of aggregates | decreased fruiting body size
DBS0304927ctnnA-ctnnAwild type
DG1071ctr9-ctr9aberrant fruiting body morphology
DG1058ctrA-ctrAdecreased fruiting body size
DBS0350915ctsD-ctsDaberrant protein modification
DBS0235598ctxA-ctxAaberrant cytokinesis | decreased cell motility | aberrant cell morphology
HS1151ctxA-ctxAaberrant streaming | aberrant cytokinesis | decreased growth rate | aberrant cellular response to stress
DBS0237568ctxA-/ [RNAi]enlActxA | enlAwild type
DBS0349922ctxA-/ [act15]: GFP-mhcActxAaberrant stalk morphogenesis | aberrant tip formation | aberrant protein localization
DBS0237536ctxA-/ [act15]: enlA(92-497)ctxA | enlAwild type
DBS0235600ctxB-ctxBaberrant streaming | aberrant cytokinesis | aberrant cell morphology
DBS0350404ctxC-ctxCaberrant streaming | increased pinocytosis | decreased period cAMP wave formation | decreased chemotaxis to cAMP | increased growth rate | increased phagocytosis
DBS0235639cudA-cudAabolished sporulation | decreased gene expression | development arrests at slug stage | abolished stalk cell differentiation
DBS0238017cudA-cudAabolished gene expression
DBS0235640culA-culAmultiple tips | development arrests at tipped mound stage
DBS0235641culA-/ [cotC]: culAculAincreased sorus size | decreased stalk length | decreased sporulation
DBS0235642culA-/ [ecmA]: culAculAincreased sorus size | decreased stalk length
DBS0235643culA-/ [pkaC]pkaCculA | pkaCwild type
DBS0266745culB-culBdecreased fruiting body size | precocious gene expression | aberrant slug formation | decreased sporulation | multiple tips in mound
DBS0266761culB-/ [act15]: pkaCculB | pkaCabolished gene expression | abolished sporulation | precocious gene expression | abolished aggregation
DBS0235651cybA-cybAabolished sporulation | aberrant development
DBS0350641cynA-cynAdecreased F-actin polymerization | aberrant cell motility | aberrant chemotaxis to cAMP | delayed aggregation | aberrant cell morphology
AK108dagA-dagAabolished gene expression | decreased gene expression | abolished activation of adenylate cyclase | abolished aggregation | decreased chemotaxis to cAMP
DBS0235652dagA-/ [act15]: dagAdagAwild type
DBS0235560dagA-/ acaA(L394S)acaA | dagAwild type
DBS0235653darA-darAdecreased cell polarity | decreased cell motility | decreased aggregate size | abolished aggregation
DBS0350531dclre1-dclre1increased sensitivity to DNA-damaging agents | aberrant double strand break repair | decreased DNA mediated transformation
DBS0236307dcsA-dcsAabolished cellulose biosynthesis
DG1099dcsA-dcsAabolished sporulation | aberrant spore coat morphology | abolished cellulose biosynthesis | abolished stalk formation | abolished stalk cell differentiation
DG1128dcsA-dcsAabolished sporulation | aberrant spore coat morphology | abolished cellulose biosynthesis | abolished stalk formation
TL127dcsA-dcsAabolished sporulation | aberrant spore coat morphology | abolished cellulose biosynthesis | aberrant stalk formation | abolished stalk formation | abolished stalk cell differentiation
TL128dcsA-/ [act15]: dcsAdcsAwild type
DBS0349967dcx-/ lis1(D327H)dcx | lis1abolished aggregation
DBS0349804detA-detAincreased aggregate size | decreased growth rate | delayed development
DBS0349813detA-/ [cotB]: GFPdetAdecreased prespore cell differentiation
DBS0349811detA-/ [ecm0]: lacZdetAaberrant prestalk 0 cell differentiation
DBS0349812detA-/ [ecmA0]: GFPdetAincreased prestalk cell differentiation
DBS0349808detA-/ [ecmA0]: lacZdetAincreased prestalk cell differentiation
DBS0349809detA-/ [ecmA]: lacZdetAincreased prestalk A cell differentiation
DBS0349810detA-/ [ecmB]: lacZdetAdelayed development
DBS0350392dgat1-dgat1aberrant cellular metabolic process
DBS0349911dgcA-dgcAdevelopment arrests at slug stage | abolished stalk cell differentiation
DBS0349917dgcA-/ [act15]: dgcA(1-124): YFPdgcAdevelopment arrests at slug stage
DBS0349918dgcA-/ [act15]: dgcA(1-273): YFPdgcAdevelopment arrests at slug stage
DBS0349914dgcA-/ [act15]: dgcA(125-521): YFPdgcAwild type
DBS0349915dgcA-/ [act15]: dgcA(274-521): YFPdgcAwild type
DBS0349916dgcA-/ [act15]: dgcA(350-521): YFPdgcAdevelopment arrests at slug stage
DBS0349913dgcA-/ [act15]: dgcA-Ppal: YFPdgcAwild type
DBS0349912dgcA-/ [act15]: dgcA: YFPdgcAwild type
DBS0235695dgkA-dgkAdecreased spore viability | increased myosin II assembly | decreased chemotaxis rate | aberrant development
AK299dhkA-dhkAaberrant stalk morphogenesis | increased gene expression | mislocalized gene expression | abolished response to SDF-2 | increased sporulation | decreased sporulation | aberrant fruiting body morphology
DBS0350665dhkA-/ [act15]: dhkA(D2076N)dhkAdecreased sporulation
DBS0350664dhkA-/ [act15]: dhkA(H1396Q)dhkAdecreased sporulation
DBS0350666dhkA-/ [act15]: dhkA(H2396Q)/ [act15]: dhkA(D2076N)dhkAwild type
DBS0235703dhkA-/ [pkaC]: pkaCdhkA | pkaCaberrant stalk morphogenesis
DBS0235704dhkB-dhkBprecocious spore germination | translucent sorus | decreased intracellular cAMP level
TL135dhkC-dhkCprecocious culmination | decreased spore germination | precocious aggregation | precocious development | precocious gene expression
DBS0350855dhkC-dhkCaberrant chemotaxis to cAMP in response to DIF-2
DBS0350379dhkD-dhkDaberrant culminant morphology | precocious gene expression | abolished streaming | aberrant development | aberrant slug formation
DBS0350381dhkD-/ [ecmAO]: lacZdhkDaberrant prestalk cell differentiation
DBS0350382dhkD-/ [ecmB]: lacZdhkDaberrant prestalk cell differentiation
DBS0350383dhkD-/ [pspA]: lacZdhkDaberrant prespore cell differentiation
LAS99dhkE-dhkEdecreased socially cooperative development
DBS0235710dhkK-dhkKaberrant slug migration | delayed culmination | delayed gene expression
DBS0235712dhkK-/ [act15]: dhkK(D1125N)dhkKaberrant fruiting body morphology
DBS0348046dhkM-dhkMabolished autophagic vacuole formation | aberrant autophagic cell death
DBS0348047dhkM-dhkMabolished cellulose biosynthesis | abolished autophagic vacuole formation | abolished autophagic cell death | abolished F-actin depolymerization
DBS0350173dhkM-dhkMdecreased autophagic vacuole formation | delayed development
DBS0235895dimA-dimAincreased standing slug length | thin standing slug | abolished prestalk cell differentiation | increased slug size | decreased prestalk 0 cell differentiation | increased prespore cell differentiation | aberrant fruiting body morphology
DBS0235901dimB-dimBdecreased prestalk B cell differentiation | increased gene expression | aberrant chemotaxis to cAMP | aberrant gene expression | abolished response to DIF
DBS0235903dimB-/ [act15]: dimA: GFPdimA | dimBabolished protein localization to nucleus
DBS0235904dimB-/ [act15]: dimB: GFPdimBwild type
DBS0235902dimB-/ [cotB]: lacZdimBincreased prespore cell differentiation
DBS0350573dimB-/ [dimB]: dimB(S590A)dimBwild type
DBS0235906dimB-/ [ecmAO]: lacZdimBdecreased prestalk 0 cell differentiation
DBS0349974dimB-/ [ecmB]: lacZdimBabolished gene expression
DBS0235907dimB-/ [ecmO]: lacZdimBaberrant prestalk cell differentiation
DBS0350495dio3-dio3decreased cell-cell adhesion | aberrant aggregation | decreased gene expression | decreased growth rate | decreased prespore cell differentiation | decreased chemotaxis to folate | decreased intracellular cAMP level | increased prestalk cell differentiation | decreased phototaxis
DBS0350496dio3-/ [act15]: GFP: dio3dio3wild type
DBS0304919dlpA-dlpAaberrant cell separation during cytokinesis | aberrant cytokinesis | aberrant F-actin organization | increased cell size | decreased growth rate | increased F-actin depolymerization | aberrant protein localization
DBS0304920dlpB-dlpBaberrant cell separation during cytokinesis | aberrant cytokinesis | increased cell size | decreased growth rate
DBS0304921dlpC-dlpCaberrant cytokinesis
DBS0235913dmpA-dmpAaberrant streaming | translucent sorus | delayed development | decreased stalk cell differentiation | decreased sporulation | aberrant fruiting body morphology
HM1030dmtA-dmtAthin standing slug | decreased outer basal disc size | wild type | abolished DIF production | abolished prestalk 0 cell differentiation | delayed tip formation | decreased prestalk 0 cell differentiation | decreased lower cup size | delayed development | aberrant fruiting body morphology | decreased prestalk cell differentiation
DBS0350410dmtA-/ [act15]: dmtAdmtAwild type
DBS0349975dmtA-/ [dimB]: dimBdimB | dmtAdecreased prestalk B cell differentiation
DBS0235914dnapkcs-dnapkcsincreased sensitivity to DNA-damaging agents | decreased double strand break repair | decreased DNA mediated transformation
DBS0266875dnapkcs-/ GFP: pcnadnapkcs | pcnaaberrant response to DNA damaging agents
DBS0235915dng1-dng1decreased growth rate | delayed aggregation
DBS0235917dnmA-dnmAdecreased cytosine methylation in genomic DNA
DBS0235916dnmA-dnmAaberrant culminant morphology | translucent sorus | decreased cytosine methylation in genomic DNA | decreased sporulation
DBS0350457docA-docAdecreased chemotaxis to cAMP
DG2015docA-docAdevelopment arrests at mound stage
LAS32docA-docAdecreased socially cooperative development
DBS0350458docD-docDdecreased cell motility | decreased chemotaxis to cAMP
DBS0235920dokA-dokAaberrant response to hyperosmotic stress | translucent sorus | decreased sporulation
DBS0349789dotA-dotAdecreased growth rate | increased sensitivity to UV light | decreased spore size | delayed development | abolished histone H3-K79 methylation
HAD172dpoA-dpoAaberrant development
HAD200dpoA-dpoAaberrant development
HAD201dpoA-dpoAaberrant development
HAD202dpoA-dpoAaberrant development
HAD203dpoA-dpoAaberrant development
HM1467drcA-drcAabolished catalytic activity
DBS0238474drkC-drkCdecreased phagocytosis | decreased phagolysosome formation
DBS0238511drkC-/ [act15]: drkC(1-497): YFPdrkCdecreased phagocytosis
DBS0238513drkC-/ [act15]: drkC(K518R): YFPdrkCdecreased phagocytosis
DBS0238475drkC-/ [act15]: drkC: YFPdrkCwild type
DBS0350218drnB-/ [act15]: pre-miRNAdrnBabolished microRNA processing
DBS0350210drnB-/ [act6]: lacZ/ [RNAi]lacZdrnBabolished production of siRNA involved in RNA interference | abolished transitive RNA interference
DBS0235924dscA-dscA-1 | dscA-2aberrant cell morphology
DBS0350775dscA-dcsAdecreased cell motility
DBS0302608dsgg(1-571: 581-733)/ dsgg-dsggaberrant contractile vacuole organization and biogenesis | aberrant cellular localization
DBS0302597dsgg-dsggaberrant contractile vacuole organization and biogenesis | aberrant response to hypo-osmotic stress
DBS0302603dsgg-/ GFP: dsggdsggwild type
DBS0302602dsgg-/ OE]: dsgg(Delta-Fbox)dsggwild type
DBS0302606dsgg-/ [OE]: GFP: lvsDdsgg | lvsDwild type
DBS0302599dsgg-/ [OE]: dsggdsggwild type
DBS0302601dsgg-/ [OE]: dsgg(Q551A)dsggaberrant contractile vacuole organization and biogenesis
DBS0302600dsgg-/ [OE]: dsggR515A)dsggaberrant contractile vacuole organization and biogenesis
DBS0302607dsgg-/ [OE]: lvsAdsgg | lvsAaberrant contractile vacuole organization and biogenesis
DBS0302611dsgg-/ [OE]: phgAdsgg | phgAaberrant contractile vacuole organization and biogenesis
DBS0302678dsgg-/ [OE]: rab8Adsgg | rab8Aaberrant contractile vacuole organization and biogenesis
DBS0302604dsgg-/ lvsA-dsgg | lvsAwild type
DBS0302605dsgg-/ lvsD-dsgg | lvsDaberrant contractile vacuole organization and biogenesis
DBS0235925dstA-dstAabolished gene expression | increased gene expression | decreased gene expression | delayed aggregation | mislocalized gene expression | decreased cell motility | abolished stalk cell differentiation | abolished sorting to prestalk region | aberrant fruiting body morphology
DBS0235926dstA-dstAdelayed aggregation | mislocalized gene expression | decreased cell motility | abolished stalk cell differentiation | abolished sorting to prestalk region | aberrant fruiting body morphology
DBS0238237dstA-/ GFP: dstA(237-707): ORF+dstAabolished culmination | decreased stalk length
DBS0238236dstA-/ GFP: dstA(237-707): ORF+/ [OE]dutA(751-1322)dstA | dutAdecreased stalk length
DBS0252824dstA-/ GFP: dstA(237-707): ORF+/ [act15]: 2C2C | dstAaberrant fruiting body morphology
DBS0252823dstA-/ GFP: dstA(237-707): ORF+/ [act15]: 7E7E | dstA | hssBwild type
DBS0252826dstA-/ GFP: dstA(237-707): ORF+/ [act15]: DDB_G0276165DDB_G0276165 | dstAaberrant fruiting body morphology
DBS0252825dstA-/ GFP: dstA(237-707): ORF+/ [act15]: DDB_G0282325DDB_G0282325 | dstAaberrant fruiting body morphology
DBS0252816dstA-/ GFP: dstA(237-707): ORF+/ [act15]: hssAdstA | hssAwild type
DBS0235928dstA-/ [act15]: dstAdstAwild type
DBS0235929dstA-/ [cprB]: dstAdstAwild type
DBS0235930dstA-/ [ecmAO]: dstAdstAwild type
DBS0235931dstB-dstBdecreased gene expression | increased gene expression | decreased growth rate
DBS0235933dstB-/ [act15]: dstBdstBwild type
DBS0235934dstB-/ [act15]: dstB(L1025R)dstBwild type
DBS0235935dstB-/ [act15]: dstB(Y1143F)dstBwild type
DBS0238125dstC-dstCabolished gene expression | aberrant response to cation stress | aberrant response to osmotic stress
DBS0350425dstC-dstCaberrant protein phosphorylation
DBS0235937dtfA-dtfAdecreased cell-cell adhesion | aberrant sorting to prestalk region | delayed tip formation | aberrant cytokinesis | aberrant fruiting body morphology
DBS0350500dupA-dupAdecreased infection rate by a gram-negative pathogenic bacterium | abolished aggregation
DBS0350502dupA-dupAdecreased infection rate by a gram-negative pathogenic bacterium
DBS0238234dutA-dutAwild type
DBS0235939dwwA-dwwAaberrant cytokinesis | aberrant F-actin organization | aberrant cell morphology
DBS0350411dydA-dydAincreased myosin II assembly | increased chemoattractant-mediated F-actin polymerization | increased CRAC localization to the plasma membrane | decreased chemotaxis to cAMP
DBS0350414dydA-/ dydA(1-278: 501-1211)dydAincreased myosin II assembly | increased chemoattractant-mediated F-actin polymerization | aberrant chemotaxis to cAMP | decreased localization to cell cortex
DBS0350415dydA-/ dydA(1-586: 703-1211)dydAdecreased chemotaxis to cAMP | decreased localization to cell cortex
DBS0350060dymA-dymAaberrant cell separation during cytokinesis | aberrant F-actin organization | increased cell size | decreased growth rate | aberrant protein localization
DBS0347874dymA-dymAdecreased pinocytosis | aberrant cell separation during cytokinesis | decreased cell polarity | aberrant mitochondrion morphology | decreased phagolysosome size | increased cell size | increased basal disc size | decreased growth rate | aberrant stalk formation | aberrant nucleus morphology | aberrant endosome morphology | aberrant phagosome maturation | delayed development | aberrant pseudopod formation | abolished phagosome acidification | increased phagocytosis | aberrant fruiting body morphology | aberrant intracellular distribution of mitochondria
DBS0349839dymA-/ [dymA]: dymAdymAwild type
DBS0347875dymB-dymBaberrant response to hypo-osmotic stress | aberrant F-actin organization | decreased growth rate | increased cell-cell adhesion | increased cell-substrate adhesion | decreased catalase activity | increased growth rate | increased phagocytosis | decreased cell size
HJW117ecmA-ecmAincreased standing slug length | weak slime trail | thin standing slug
HJW01ecmB-ecmBwild type
HJW03ecmB-ecmBwild type
DBS0235944ecmF-ecmFwild type
DBS0350904efbA-efbAaberrant cytokinesis | delayed development
DBS0235945egeA-egeAdecreased gene expression | decreased activation of adenylate cyclase | abolished aggregation
DBS0350520egeA-/ [unk]: YFP: carAcarA-1 | carA-2 | egeAdevelopment arrests at mound stage
DBS0350521egeA-/ [unk]: pkaCegeA | pkaCdecreased gene expression | abolished aggregation
DBS0235946egeB-egeBdevelopment arrests at mound stage
DBS0350802ehd-ehdaberrant endosome morphology | aberrant phagosome maturation | decreased phagosomal proteolysis
DBS0350804ehd-/ [act15]: dymA: GFPdymA | ehdaberrant phagosome maturation | decreased phagosomal proteolysis
DBS0302590elmoA-elmoAincreased protein localization to pseudopodium | decreased culmination | increased pseudopod formation | increased F-actin polymerization | decreased cell motility | delayed development | abolished cell polarity | increased phagocytosis
DBS0302591elmoA-/ [act15]: elmoA: GFPelmoAwild type
DBS0350065elmoE-elmoEdecreased culmination | decreased F-actin polymerization at the leading edge | decreased chemotaxis to cAMP
DBS0302448epnA-epnAaberrant spore morphology | decreased spore viability | aberrant cytokinesis | abolished protein phosphorylation | aberrant protein localization
DBS0302457epnA-/ [act15]: GFP: epnA(253-677)epnAaberrant spore morphology | abolished localization to coated pits | abolished localization to plasma membrane
DBS0302456epnA-/ [act15]: epnA(1-133): GFPepnAaberrant localization to coated pits
DBS0302474epnA-/ [act15]: epnA(R65A/ K78A): GFPepnAaberrant spore morphology | abolished localization to coated pits | abolished localization to plasma membrane | abolished phosphatidylinositol-4,5-bisphosphate binding
DBS0302475epnA-/ [act15]: epnA(T107A): GFPepnAaberrant spore morphology
DBS0302454epnA-/ [act15]: epnA: GFPepnAwild type
DBS0235947eppA-eppAdecreased growth rate | delayed development | decreased chemotaxis to folate | decreased chemotaxis to cAMP | decreased intracellular cAMP level
DBS0235948eppA-/ [act6]: myc: eppAeppAwild type
DBS0350028erkA-erkAdecreased aggregate size | decreased chemotaxis to cAMP
DBS0350622erkA-erkAaberrant streaming | aberrant tip formation
DBS0350623erkA-erkAdecreased aggregate size | precocious development
DBS0350681erkA-/ [act15]: gpaEerkA | gpaEwild type
DBS0350029erkA-/ [act15]: mekA: FLAGerkA | mekAincreased protein localization to cell cortex
HS174erkB-erkBabolished gene expression | decreased catalytic activity | decreased gene expression | aberrant phagocytosis | decreased cell motility | decreased chemotaxis to folate | abolished aggregation | decreased chemotaxis to cAMP | aberrant cell morphology | aberrant development | decreased cAMP-induced cAMP pulse | decreased sporulation
AK240erkB-erkBabolished aggregation | decreased cAMP-induced cAMP pulse | decreased sporulation
DBS0350606erkB-erkBdecreased prespore cell differentiation
DBS0350683erkB-/ [ecmA]: lacZerkBaberrant sorting to prestalk region
DBS0350682erkB-/ [unk]: erkB(P140S)erkBabolished sporulation
DBS0350530exo1-exo1increased sensitivity to DNA-damaging agents | decreased double strand break repair | abolished DNA mediated transformation
DBS0304864expl7-expl7wild type
DBS0235951fadA-fadAincreased resistance to heat shock
DBS0235952fadB-fadBwild type
DBS0350240fam21-fam21abolished exocytosis | aberrant post-lysosome organization and biogenesis | aberrant vegetative growth | aberrant autophagic cell death | aberrant phagosome maturation | decreased phagosomal proteolysis | decreased protein localization
DBS0236034fam45-fam45wild type
DBS0236040fam91-fam91wild type
DBS0350717far1-far1decreased F-actin polymerization | aberrant defense response to bacterium | decreased growth rate | decreased engulfment during phagocytosis | decreased chemotaxis to folate | decreased protein kinase activation | decreased folic acid binding
DBS0235953fbxA-fbxAdecreased sporulation
HR6fbxA-fbxAdecreased socially cooperative development
DBS0235954fbxA-/ [ecmA]: GFP(S65T)fbxAincreased prespore cell differentiation
DBS0235956fbxA1-fbxAdevelopment arrests at slug stage | increased slug migration | aberrant fruiting body morphology | delayed culmination
DBS0235957fbxA2-fbxAdevelopment arrests at slug stage | increased slug migration | aberrant fruiting body morphology | delayed culmination
DBS0235958fbxA3-fbxAdevelopment arrests at slug stage | increased slug migration | aberrant fruiting body morphology | delayed culmination
DG1148fcpA-fcpAaberrant fruiting body morphology
DBS0235960fcsA-fcsAdecreased fatty acid level
DBS0350128fcsB-fcsBdecreased catalytic activity | decreased phagocytosis
DBS0350336febA-febAwild type
DBS0350953fhbA-fhbAincreased cell size | aberrant cellular response to stress
DBS0350954fhbB-fhbBincreased cell size | aberrant cellular response to stress
DBS0235961fimA-fimAdecreased cell size
HM1253fncD2-fncD2increased sensitivity to cisplatin
HM1416fncE-fncEincreased sensitivity to cisplatin
HM1356fncI-fncIincreased sensitivity to cisplatin
HM1302fncL-fncLincreased sensitivity to cisplatin
HM1407fncM-fncMincreased sensitivity to cisplatin
DBS0235966forA-forAwild type
DBS0350667forA-forAaberrant cellular response to fluid shear stress | decreased cell motility | increased cell motility
DBS0350669forA-/ [act15]: GFP: mhcAforA | mhcAaberrant bleb formation
DBS0235968forB-forBwild type
DBS0235969forC-forCaberrant culmination | development arrests at tipped mound stage | aberrant fruiting body morphology
DBS0350280forC-forCabolished slug formation | delayed aggregation | aberrant development | decreased chemotaxis to cAMP | decreased sporulation | delayed gene expression
DBS0304905forC-/ [act15]: GFP: forCforCwild type
DBS0350287forF-forFdecreased fruiting body size | aberrant phototaxis | increased chemotaxis rate
DBS0350835forG-forGdecreased growth rate | decreased phagocytosis | aberrant F-actin organization | aberrant actin cytoskeleton organization | decreased macropinocytosis
DBS0235970forH-forHdecreased cell-substrate adhesion | decreased chemotaxis rate | increased cell motility | aberrant pseudopod formation | aberrant cell morphology | decreased filopodium formation
DBS0235971forH-/ [act15]: GFP: forHforHincreased filopodium formation | decreased cell motility | increased cell-substrate adhesion
DBS0302506frmA-frmAdelayed aggregation | decreased cell motility | increased cell-substrate adhesion | decreased aggregate size | aberrant cell morphology
DBS0304440frmA-/ [unk]: GFPfrmAdecreased gene expression | increased cell-cell adhesion | delayed development | aberrant development | abolished phototaxis
DBS0302507frmA-/ [unk]: frmA-HAfrmAwild type
DBS0350252fspA-fspAdecreased gene expression | aberrant chemotaxis to folate | aberrant vegetative growth
DBS0350253fspA-/ [unk]: fspA: FLAGfspAwild type
DBS0235976fszA- fszAdecreased number of mitochondria | increased number of tubular mitochondria
DBS0235980fszB- fszBdecreased number of mitochondria | increased number of tubular mitochondria | decreased growth rate
DG1066fut1-fut1aberrant fruiting body morphology
DBS0305025gabT-gabTprecocious development | decreased sporulation
DBS0305026gabT-[pkaC]: pkaCgabT | pkaCaberrant protein secretion
DG1094gacT-gacTaberrant fruiting body morphology
DBS0235989gadA-gadAabolished SDF production | decreased sporulation
DBS0350071gadA-gadAdecreased spore viability
DBS0350072gadB-gadBdelayed aggregation
DBS0350963gapA-gapAaberrant cell separation during cytokinesis
DBS0349924gapA-gapAaberrant cellular response to fluid shear stress
DBS0350399gapA-gapAincreased myosin II assembly | increased F-actin polymerization | increased lateral pseudopod formation | decreased protein localization | decreased chemotaxis to cAMP | aberrant cellular response to stress | aberrant spindle organization
TL198gbfA-gbfAabolished gene expression | development arrests at mound stage
DBS0305094gbfA-gbfAabolished autophagic cell death | abolished autophagic vacuole formation
DBS0235994gbpC-gbpCdecreased protein kinase activation | decreased fruiting body size
DBS0235995gbpC-gbpCdecreased cell polarity | aberrant myosin II organization | aberrant chemotaxis to cAMP | decreased chemotaxis rate | aberrant cyclic nucleotide binding | aberrant cell morphology | decreased fruiting body size
DBS0302680gbpC-gbpCabolished protein localization to nucleus | decreased aggregate size | abolished protein phosphorylation | abolished aggregation
DBS0350881gbpC-gbpCaberrant cyclic nucleotide binding
DBS0304912gbpC-/ [act15]: gbpCgbpCwild type
DBS0304917gbpC-/ [act15]: gbpC(1-1698: 2005-2631)gbpCdecreased chemotaxis to cAMP
DBS0349868gbpC-/ [act15]: gbpC(1-2331: 2470-2631): GFPgbpCaberrant streaming | decreased chemotaxis to cAMP
DBS0304918gbpC-/ [act15]: gbpC(311-2631)gbpCdecreased chemotaxis to cAMP
DBS0304916gbpC-/ [act15]: gbpC(F1892A)gbpCdecreased chemotaxis to cAMP
DBS0304915gbpC-/ [act15]: gbpC(F2082A/ E2084A/ F2564A/ E2566A)gbpCdecreased chemotaxis to cAMP
DBS0304913gbpC-/ [act15]: gbpC(K342N)gbpCdecreased chemotaxis to cAMP
DBS0304914gbpC-/ [act15]: gbpC(K905W)gbpCdecreased chemotaxis to cAMP
DBS0235997gbpD-gbpDdecreased lateral pseudopod formation | decreased cell-substrate adhesion | increased cell polarity | increased chemotaxis rate
DBS0235998gbpD-/ [act15]: gbpDgbpDaberrant F-actin organization | increased cell-substrate adhesion | increased lateral pseudopod formation | decreased chemotaxis rate | abolished aggregation
DG1120gbqA-gbqAaberrant fruiting body morphology
DBS0350119gcA-gcAdecreased guanylyl cyclase activity
DBS0236002gcsA-gcsAabolished gene expression | aberrant initiation of development | abolished growth | decreased gene expression | increased gene expression | development arrests at mound stage | cell cycle arrest | spores inviable
DBS0350387gcsA-/ [act15]: carAcarA-1 | carA-2 | gcsAaberrant initiation of development
DBS0236003gcsA-/ [act15]: gcsAgcsAdecreased spore viability | development arrests at mound stage
DBS0350388gcsA-/ [act15]: yakAgcsA | yakAwild type
DBS0236004gdt1-gdt1increased gene expression | decreased growth rate | precocious aggregation
DBS0237190gdt1-/ [act15]: pkaR(G135E/ G261A)gdt1 | pkaRincreased gene expression | abolished aggregation
DBS0236006gdt2-gdt2increased gene expression | precocious aggregation
RI19gefA-gefAdecreased chemoattractant-mediated F-actin polymerization | decreased cAMP-induced cGMP pulse | decreased positive regulation of GTPase activity | decreased gene expression | decreased chemotaxis rate | abolished activation of adenylate cyclase | abolished aggregation | decreased cAMP-induced cAMP pulse | increased protein kinase activation
JB10gefA-gefAabolished aggregation
DBS0350821gefA-gefAdecreased F-actin polymerization | decreased activation of GTPase activity | aberrant chemotaxis to cAMP | decreased protein kinase activation | abolished aggregation
DBS0350449gefA-/ dscB]: rasG(S17N)gefA | rasGdecreased chemoattractant-mediated F-actin polymerization | decreased positive regulation of GTPase activity | aberrant chemotaxis to cAMP | decreased protein kinase activation
DBS0236009gefB-gefBaberrant cytoskeleton organisation | abolished pinocytosis | increased basal F-actin level | abolished growth | delayed aggregation | decreased phagocytosis | decreased growth rate | decreased aggregate size | aberrant cell morphology | aberrant fruiting body morphology
DBS0236868gefC-gefCwild type
DBS0236869 (DBS0235543)gefD-gefDwild type
DBS0236870gefE-gefEaberrant thermotaxis | aberrant phototaxis
DBS0350569gefE-gefEdecreased positive regulation of GTPase activity | decreased response to DIF
DBS0236011gefG-gefGwild type
DBS0350822gefH-gefHdecreased F-actin polymerization | decreased activation of GTPase activity | aberrant chemotaxis to cAMP | delayed development | decreased protein kinase activation
DBS0236012gefK-gefKwild type
DBS0236871gefL-gefLaberrant thermotaxis | aberrant phototaxis
HSB61gefM-gefMincreased cAMP-induced cGMP pulse | aberrant activation of adenylate cyclase activity | development arrests at mound stage | decreased chemotaxis rate | decreased lateral pseudopod suppression | decreased cAMP-induced cAMP pulse
DBS0304968gefQ-gefQabolished Ras guanyl-nucleotide exchange factor activity | decreased positive regulation of GTPase activity | increased myosin II assembly | decreased growth rate | increased lateral pseudopod formation | abolished sorting to prestalk region | decreased fruiting body size | abolished phototaxis | multiple tips in mound
DBS0304985gefQ-/ [act15]: GFP: gefQ(172-654)gefQabolished Ras guanyl-nucleotide exchange factor activity | decreased phototaxis
DBS0304986gefQ-/ [act15]: GFP: gefQ(910-1298)gefQdecreased phototaxis
DBS0236014gefR-gefRwild type
DBS0349892gefS-gefSwild type
DBS0349904gemA-gemAdecreased growth rate | decreased intracellular ATP level
DBS0237700gflB-gflBdecreased culmination | aberrant signal transduction during aggregation | increased F-actin polymerization at the leading edge | delayed aggregation | aberrant CRAC localization to the plasma membrane | decreased aggregate size | decreased chemotaxis to cAMP | decreased myosin II assembly
DBS0350814gflB-/ [act15]: GFP: gflB(380-1601,T1180E)gflBdecreased chemotaxis to cAMP
DG1109ggtA-ggtAaberrant fruiting body morphology
DBS0266723glcS-/ DH1glcSaberrant stalk morphogenesis | decreased spore size | decreased intracellular glycogen level | decreased fruiting body size
DBS0266765glcS-/ HMXglcSabolished cellulose biosynthesis | decreased autophagic vacuole formation | aberrant cell morphology
DBS0350514glk-glkincreased infection rate by a gram-negative pathogenic bacterium
DBS0236078glpD-glpDaberrant glycogen metabolism | aberrant regulation of catalytic activity
DBS0236079gmsA-gmsAdecreased sexual fusion
DBS0236080gmsA-gmsAdecreased sexual fusion
DBS0238384gnt14-gnt14wild type
DBS0238382gnt15-gnt15decreased gene expression | decreased growth rate | increased calcium-independent cell-cell adhesion | abolished aggregation | abolished culmination
DBS0238383gnt15-gnt15decreased gene expression | decreased growth rate | increased calcium-independent cell-cell adhesion | abolished aggregation | abolished culmination
DBS0238390gnt15-/ [act15]: FLAG: gnt15gnt15wild type
DBS0238391gnt15-/ [act15]: FLAG: gnt15gnt15wild type
DBS0236081gnt2-gnt2abolished catalytic activity | abolished protein modification
DBS0236082gol-golincreased resistance to cisplatin
DBS0236087gpaA-gpaAincreased stalk length | decreased stalk width
JH131gpaA-gpaAaberrant cellular homeostasis | wild type | increased growth rate
DBS0236091gpaA-/ [ecmB]: lacZgpaAdecreased gene expression
DBS0236092gpaA-/ [gpaA]: gpaA(G45V)gpaAdelayed development
DBS0236093gpaA-/ [gpaA]: gpaA(Q206L)gpaAincreased basal disc size
DBS0236575gpaB-gpaBdecreased cAMP-induced cGMP pulse | abolished activation of GTPase activity | decreased protein kinase activation | decreased cAMP-induced cAMP pulse
JH104gpaB-gpaBdecreased gene expression | abolished activation of adenylate cyclase | abolished aggregation
DBS0236096gpaB-/ [act15]: gpaBgpaBabolished aggregation
DBS0266942gpaB-/ [act15]: gpaBgpaBdelayed aggregation
DBS0266939gpaB-/ [act15]: gpaB(1-345): gpaD(337-345)gpaB | gpaDabolished aggregation
DBS0237137gpaB-/ [act15]: gpaB(D154V)gpaBaberrant aggregation | decreased cAMP-induced cGMP pulse | decreased activation of adenylate cyclase | decreased chemotaxis rate | decreased cAMP-induced cAMP pulse
DBS0237138gpaB-/ [act15]: gpaB(E190G)gpaBaberrant aggregation | decreased cAMP-induced cGMP pulse | decreased activation of adenylate cyclase | decreased cAMP-induced cAMP pulse
DBS0237139gpaB-/ [act15]: gpaB(I104S)gpaBaberrant aggregation | decreased cAMP-induced cGMP pulse | decreased activation of adenylate cyclase | decreased chemotaxis rate | decreased cAMP-induced cAMP pulse
DBS0237140gpaB-/ [act15]: gpaB(L110S)gpaBaberrant aggregation | decreased cAMP-induced cGMP pulse | decreased activation of adenylate cyclase | decreased chemotaxis rate | decreased cAMP-induced cAMP pulse
DBS0237141gpaB-/ [act15]: gpaB(L76P)gpaBabolished aggregation
DBS0237142gpaB-/ [act15]: gpaB(N74D)gpaBdecreased cAMP-induced cGMP pulse | decreased activation of adenylate cyclase | decreased chemotaxis rate | abolished aggregation | decreased cAMP-induced cAMP pulse
DBS0237143gpaB-/ [act15]: gpaB(R64G)gpaBdecreased chemotaxis rate | abolished aggregation
DBS0237144gpaB-/ [act15]: gpaB(S155P)gpaBdecreased chemotaxis rate | abolished aggregation
DBS0236097gpaB-/ [gpaA]: gpaBgpaBabolished aggregation
DBS0236099gpaB-/ [gpaB]: gpaBgpaBwild type
DBS0236098gpaB-/ [gpaB]: gpaB(Q208L)gpaBaberrant protein localization
DBS0235986gpaC-gpaCaberrant activation of adenylate cyclase activity | decreased gene expression | increased protein kinase activity | abolished aggregation
JH417gpaD-gpaDdecreased gene expression | abolished SDF production | decreased accumulation of cGMP | decreased chemotaxis to folate | decreased protein kinase activation | aberrant fruiting body morphology | decreased sporulation
DBS0266944gpaD-/ [act15]: gpaBgpaB | gpaDdecreased accumulation of cGMP | decreased chemotaxis to folate | aberrant fruiting body morphology
DBS0266946gpaD-/ [act15]: gpaB(1-345): gpaD(337-345)gpaB | gpaDdecreased accumulation of cGMP | aberrant fruiting body morphology
DBS0266943gpaD-/ [act15]: gpaDgpaDwild type
DBS0350608gpaD-/ [act15]: gpaD(Q200L)gpaDdevelopment arrests at loose mound stage | decreased chemotaxis to folate | decreased protein kinase activation
DBS0350607gpaD-/ [act15]: gpaD(R107E,R108E)gpaDabolished culmination
DBS0266945gpaD-/ [act15]: gpaEgpaD | gpaEdecreased accumulation of cGMP | decreased chemotaxis to folate | aberrant fruiting body morphology
DBS0266947gpaD-/ [act15]: gpaE(1-339): gpaD(337-345)gpaD | gpaEdecreased accumulation of cGMP | decreased chemotaxis to folate | aberrant fruiting body morphology
JH257gpaE-gpaEincreased chemotaxis to folate | delayed tip formation | increased cell size | decreased sorting to prestalk region | delayed gene expression
DBS0266941gpaE-/ [act15]: gpaEgpaEprecocious tip formation
DBS0266948gpaE-/ [act15]: gpaE(1-339): gpaD(337-345)gpaD | gpaEprecocious tip formation
DBS0350678gpaE-/ [act15]: gpaE(K10E/ K11E)gpaEdelayed tip formation | delayed gene expression
LW1gpaG-gpaGwild type | aberrant gamma-aminobutyric acid signaling pathway | abolished SDF production
DBS0236107gpaH-gpaHwild type | increased cell death | decreased spore viability | abolished negative chemotaxis | increased growth rate
DBS0236108gpaH-gpaHwild type
DBS0350972gpaH-/ AX2gpaHincreased growth rate
DBS0350975gpaH-/ [ecmO]: lacZgpaHaberrant cell differentiation
DBS0236109gpaI-gpaIaberrant cellular homeostasis | increased cell death | precocious aggregation | decreased aggregate size | increased number of aggregates | decreased fruiting body size | increased growth rate
LW5gpbA-gpbAincreased resistance to N-Phenylthiourea | abolished aggregation
LW6gpbA-gpbAdecreased CRAC localization to the plasma membrane | aberrant cellular homeostasis | decreased cAMP-induced cGMP pulse | decreased positive regulation of GTPase activity | increased cell death | decreased phagocytosis | decreased engulfment during phagocytosis | abolished F-actin polymerization | decreased chemotaxis to folate | decreased protein kinase activation | decreased chemotaxis to cAMP | increased growth rate | decreased cAMP-induced cAMP pulse | aberrant protein localization
LW14gpbA-/ [OE]: carAcarA-1 | carA-2 | gpbAdecreased protein kinase activation
DBS0350470gpbA-/ [act15]: GFP: capcap | gpbAdecreased phagocytosis
HO547gpbA-/ [act6]: FRB: [act15]: RFP: gpbA/ [act15]: cnxA: CFP: FKBP/ [act15]: limE(1-145): GFPgpbAaberrant cortical actin cytoskeleton organization
HO543gpbA-/ [act6]: FRB: [act15]: RFP: gpbA/ [act15]: cnxA: YFP: FKBPgpbAabolished chemotaxis to folate | decreased electrotaxis
DBS0350832gpbA-/ [unk]: gpbA(Q208L)gpbAaberrant adaptation of signaling pathway
DBS0350477gpr89-gpr89aberrant spore morphology | aberrant mitochondrion morphology | abolished growth | decreased gene expression | decreased cell motility | abolished sorting to prestalk region | decreased fruiting body size | precocious gene expression | aberrant slug formation | decreased phototaxis | delayed gene expression
DBS0350479gpr89-/ [act15]: gpr89: GFPgpr89wild type
DBS0304814grlA-grlAdecreased gene expression | abolished SDF production | delayed gene expression | decreased sporulation | delayed culmination
DBS0304815grlA-/ [act15]: grlA: GFPgrlAaberrant tip formation
DBS0350074grlB-grlBdecreased small molecule binding | delayed aggregation | delayed gene expression
DBS0236112grlE-grlEabolished SDF production | aberrant gamma-aminobutyric acid signaling pathway | decreased sporulation
DBS0236113grlE-grlEdelayed aggregation | aberrant gene expression | decreased chemotaxis to cAMP
DBS0350075grlE-grlEdecreased spore viability | delayed aggregation
DBS0238865grlJ-grlJaberrant spore morphology | decreased spore viability | increased slug size | precocious development | decreased fruiting body size | precocious gene expression
DBS0350283grlJ-grlJaberrant spore morphology | increased resistance to N-Phenylthiourea
DBS0238866grlJ-/ [act15]: grlJ: GFPgrlJwild type
DBS0350284grlJ-/ [act15]: grlJ: GFPgrlJwild type
DBS0238686grpA-grpAdecreased spore germination | abolished protein secretion
DBS0238687grpA-/ [act15]: grpA-FLAGgrpAwild type
ARK200gskA-gskAincreased gene expression | decreased gene expression | aberrant CRAC localization to the plasma membrane | decreased chemotaxis to cAMP | abolished streaming | aberrant protein localization to plasma membrane | decreased sporulation
DBS0236114gskA-gskAaberrant aggregation | decreased slug migration | aberrant sorus morphology | abolished CRAC localization to the plasma membrane | decreased gene expression | aberrant cAMP signaling during aggregation | abolished protein phosphorylation | decreased chemotaxis to folate | decreased stalk length | abolished chemotaxis to cAMP
HM338gskA-gskAprecocious aggregation | aberrant spindle elongation | decreased prespore cell differentiation | aberrant fruiting body morphology | increased prestalk cell differentiation | decreased sporulation
DBS0349930gskA-/ [act15]: GFP: tacAgskA | tacAincreased protein localization to nucleus
DBS0349881gskA-/ [act15]: gskA(Y214F)gskAabolished streaming
DBS0349800gskA-/ [ecmA]: LacZgskAaberrant gene expression
DBS0349801gskA-/ [ecmB]: LacZgskAaberrant gene expression
DBS0350260gskA-/ [unk]: pikA(1-492(S7D/ S11D/ S109D/ S113D/ S177D/ S181D))gskA | pikAwild type
DBS0350427gskA-/ gskA(K85R): GFPgskAaberrant aggregation
DBS0350426gskA-/ gskA: GFPgskAwild type
DBS0266891gtaC-gtaCabolished stalk cell differentiation in vitro | aberrant streaming | decreased aggregate size | aberrant prestalk B cell differentiation
DBS0350347gtaC-gtaCabolished gene expression | decreased fruiting body size | abolished aggregation
DBS0350357gtaC-/ [act15]: GFP: gtaC(C500,503,522,525S)gtaCaberrant gene expression | abolished aggregation | decreased fruiting body size
DBS0350358gtaC-/ [act15]: GFP: gtaC(T376A/ S379,380A/ C500,503,522,525S)gtaCaberrant localization to nucleus
DBS0350361gtaC-/ [act15]: gtaC: (468-496): GFP: gtaCgtaCdevelopment arrests at mound stage | decreased aggregate size | precocious development
DBS0236120gxcA-gxcAdecreased chemoattractant-mediated F-actin polymerization | decreased positive regulation of GTPase activity | delayed development
DBS0236121gxcB-gxcBdecreased exocytosis | aberrant cytoskeleton organisation | delayed development
DBS0350256gxcC-gxcCdelayed development
DBS0350257gxcC-/ [act15]: GFP: gxcCgxcCwild type
DBS0238825gxcDD-gxcDDaberrant streaming | delayed development
LAS105gxcKK-gxcKKdecreased socially cooperative development
DBS0350268gxcT-gxcTdecreased cell polarity | aberrant cytokinesis | decreased growth rate | aberrant CRAC localization to the plasma membrane | delayed aggregation | increased lateral pseudopod formation | aberrant regulation of GTPase activity | decreased chemotaxis to cAMP | decreased fruiting body size
DBS0350269gxcT-/ [act15]: GFP: gxcTgxcTwild type
DBS0350656hatA-/ [hatB]: hatBhatA | hatBaberrant cellular response to stress
DBS0236129hbx2-hbx2wild type
DBS0236130hbx2-hbx2wild type
DBS0350324hbx4-/ [ecmAO]: lacZhbx4increased prespore cell differentiation
DBS0350879hbx9-hbx9decreased cell-cell adhesion | decreased gene expression | delayed aggregation | decreased growth rate | decreased chemotaxis to cAMP
DBS0350880hbx9-/ [ecmA]: lacZhbx9increased prestalk A cell differentiation
DBS0236153hcpA-hcpAdecreased growth rate
DBS0236157hcpB-hcpBwild type
DBS0305109hdaB-hdaBdecreased sporulation | decreased histone deacetylase activity
HM1012helC-helCdecreased gene expression | delayed development | aberrant fruiting body morphology
HM444helC-helCdecreased gene expression | delayed development | aberrant fruiting body morphology
DG1059helE-helEincreased slug migration
DBS0236163helF-helFincreased stalk cell differentiation | increased slug size | delayed development | increased post-transciptional gene silencing by RNA
DBS0350878hephA-hephAincreased response to cAMP | delayed aggregation | aberrant development | decreased intracellular cAMP level
DBS0350362hfnA-hfnAincreased phototaxis | decreased slug size | increased slug migration
DBS0350363hfnA-/ [ecmO]: lacZhfnAaberrant prestalk 0 cell differentiation | aberrant slug formation
DBS0238583hipA-hipAaberrant spore morphology | decreased spore viability | aberrant spore coat morphology
DBS0350289hspc300-/ [act15]: myc: hspc300hspc300wild type
DBS0252818hssA-hssAwild type
DBS0349776htt-httdecreased growth rate in suspension | aberrant cell separation during cytokinesis | decreased chemotaxis rate | delayed development | delayed gene expression | decreased myosin II assembly
DBS0349788htt-httaberrant aggregation | development arrests at loose mound stage | aberrant cellular response to starvation | abolished potassium-dependent chemotaxis to cAMP | aberrant spore morphology | decreased spore viability | aberrant response to hypo-osmotic stress | aberrant F-actin organization | abolished chemotaxis to calcium | abolished streaming | aberrant development | abolished culmination | multiple tips in mound | decreased sporulation | aberrant prespore cell differentiation | abolished calcium-independent cell-cell adhesion | abolished protein level
DBS0350438ibrA-ibrAaberrant contractile vacuole organization and biogenesis | aberrant substrate adhesion-dependent cell spreading | aberrant response to hypo-osmotic stress | decreased phagocytosis | decreased growth rate | aberrant cytokinesis | decreased contractile vacuole discharge
DBS0349794ibrA-ibrAaberrant stalk formation
DBS0252699icmA-icmA-1 | icmA-2abolished sporulation | aberrant signal transduction during aggregation | abolished growth | development arrests at mound stage | abolished cell polarity | abolished streaming | aberrant protein localization to nucleus | aberrant cAMP wave formation | delayed gene expression | aberrant fruiting body morphology | aberrant protein localization
DBS0252702icmA-/ [act15]: TAP: YFP: rasGicmA-1 | icmA-2 | rasGabolished C-terminal protein amino acid methylation
DBS0252701icmA-/ [act15]: hICMTicmA-1 | icmA-2wild type
DBS0252700icmA-/ [act15]: icmAicmA-1 | icmA-2wild type
DBS0236421icpA-icpAaberrant mitosis | aberrant cytokinesis | aberrant protein localization
DBS0238521icpA-/ [act15]: GFP: icpA(1-1013)icpAaberrant protein localization
BS153ifkA-ifkAincreased aggregate size | precocious aggregation | decreased extracellular counting factor component(s) level | precocious gene expression
BS160ifkB-ifkBincreased gene expression
DBS0236425ino1-ino1decreased intracellular myo-inositol level | abolished growth | decreased phagocytosis | increased intracellular 2,3-bisphosphoglycerate level | multiple tips in mound
DBS0350801ino1-ino1aberrant cellular metabolic process | increased number of autophagosomes | decreased intracellular myo-inositol level | decreased cell-substrate adhesion | abolished growth | aberrant phosphatidylinositol metabolism | aberrant cytokinesis | aberrant fruiting body morphology
DBS0266326iplA-iplAabolished cellulose biosynthesis | abolished autophagic vacuole formation | abolished autophagic cell death
HM1038iplA-iplAabolished cAMP-induced Ca2+ influx | aberrant cell motility | precocious aggregation | delayed aggregation | aberrant chemotaxis | increased chemotaxis to arachidonic acid
DBS0350439iplA-/ [act15]: GFP: iplAiplAwild type
DBS0252878iptA-iptAdecreased spore viability
DBS0350400iqgC-iqgCdecreased myosin II assembly
DBS0236031kctd9-kctd9wild type
DBS0350472kif1-kif1aberrant transport
DBS0350959kif10-/ [act15]: dhcA(1384-4725)dhcA | kif10wild type
DBS0350038kif11-kif11wild type
DBS0236489kif12-kif12aberrant myosin II organization | aberrant cytokinesis | cell cycle arrest | aberrant protein localization
DBS0236490kif12-/ [act15]: FLAG: kif12kif12wild type
DBS0302534kif13-kif13decreased spindle stabilization | precocious spindle elongation
DBS0350039kif4-kif4decreased growth rate
DBS0350042kif4-/ [act15]: dhcA(1384-4725)dhcA | kif4aberrant spindle organization
DBS0350021kif5-kif5wild type
DBS0350022kif5-/ [act15]: FLAG: kif5kif5aberrant cytokinesis | aberrant cell morphology
DBS0350023kif5-/ [act15]: FLAG: kif5(342-990)kif5aberrant cell morphology
DBS0350024kif5-/ [act15]: GFP: kif5(805-990)kif5aberrant cytokinesis
DBS0236494kif7-kif7decreased sorting to prestalk region
DBS0350947kif8-/ [act15]: dhcA(1384-4725)dhcA | kif8wild type
DBS0349964kif9-kif9aberrant mitosis | decreased growth rate | aberrant centrosome localization | aberrant centromere complex assembly | aberrant protein localization | aberrant centrosome organization | aberrant spindle organization
DBS0236491kil1-kil1abolished resistance to a pathogenic bacterium | aberrant defense response to yeast
DBS0350043kil2-kil2abolished resistance to a pathogenic bacterium | aberrant response to cation stress | aberrant defense response to bacterium | decreased phagosomal proteolysis | aberrant defense response to yeast
DBS0350874kil2-kil2aberrant defense response to bacterium | decreased growth rate
DBS0350044kil2-/ [act15]: kil1kil1 | kil2abolished resistance to a pathogenic bacterium
DBS0236492krsA-krsAdecreased chemotaxis to cAMP
DBS0238720krsA-krsAaberrant response to hyperosmotic stress | precocious culmination | abolished activation of adenylate cyclase | decreased aggregate size | decreased intracellular cAMP level | precocious gene expression | abolished streaming | decreased cell size
DBS0236493krsA-/ [act15]: GFP: krsAkrsAwild type
DBS0238721krsA-/ [act15]: GFP: krsAkrsAwild type
DBS0238722krsA-/ [act15]: GFP: krsA(K49R)krsAaberrant streaming
DBS0238723krsA-/ [act15]: GFP: krsA(T173A)krsAabolished streaming
DBS0238725krsA-/ [act15]: GFP: krsA(deltaC)krsAaberrant streaming
DBS0238724krsA-/ [act15]: GFP: krsA(deltaKinase)krsAabolished streaming
DBS0238726krsA-/ [act15]: GFP: krsA(deltaNS)krsAabolished streaming
DBS0350598krsB-krsBaberrant streaming | decreased cell motility | increased cell-substrate adhesion | delayed development | decreased chemotaxis to cAMP
DBS0350599krsB-/ [tet]: krsB(T176A): GFPkrsBaberrant streaming
DBS0236495ku80-ku80increased sensitivity to DNA-damaging agents | decreased double strand break repair | decreased DNA mediated transformation
DBS0350537ku80-/ myc: ku80(1-782)ku80decreased DNA mediated transformation
DBS0236498lagD-tgrD1aberrant aggregation | aberrant cAMP signaling during aggregation | abolished streaming
DBS0236499limB-limBdecreased cell polarity | decreased cell-substrate adhesion | decreased gene expression | development arrests at mound stage | aberrant F-actin organization | aberrant cell-cell adhesion | decreased chemotaxis rate | abolished sorting to prestalk region | delayed gene expression
DBS0236502limB-/ [act15]: paxB: GFPlimB | paxBdevelopment arrests at mound stage
DBS0236500limB-/ [cotC]: limBlimBdevelopment arrests at mound stage
DBS0236501limB-/ [ecmAO]: limBlimBwild type
DBS0350563limC-limCdelayed aggregation | decreased growth rate | aberrant cytokinesis | aberrant response to osmotic stress
DBS0350564limD1-limD1decreased cell polarity | delayed aggregation | decreased growth rate | aberrant F-actin organization | aberrant cytokinesis | increased lateral pseudopod formation | aberrant response to osmotic stress | decreased chemotaxis to cAMP
DBS0236503limE-limEaberrant cytokinesis
DBS0236506limF-limFdecreased phagocytosis
DBS0236511lipA-lipAwild type
DBS0236512lipA-lipAwild type
DG1006lipA-lipAabolished culmination
DG1056lipB-captCaberrant fruiting body morphology
DBS0349950lmbd2B-lmbd2Bincreased pseudopod formation | aberrant chemotaxis | delayed development | aberrant cell morphology
DBS0349982lmnB-lmnBaberrant chromatin assembly | aberrant centrosome localization
DBS0350354lmpA-lmpAdecreased fruiting body size | decreased sporulation
DBS0350452lpten-lptenaberrant cell motility | decreased lateral pseudopod suppression
DBS0350453lpten-/ [act15]: lpten: RFPlptenwild type
DBS0236516lrrA-lrrAdecreased cell polarity | increased aggregate size | decreased cell-substrate adhesion | increased basal F-actin level | decreased spore viability | decreased gene expression | development arrests at mound stage | abolished positive chemotaxis | abolished aggregation | aberrant cell morphology | delayed gene expression
DBS0350407lrrB-lrrBaberrant thermotaxis | delayed slug formation | decreased gene expression | aberrant culminant morphology | aberrant gene expression | aberrant phototaxis | aberrant development
DBS0350478lrrB-/ [ecmB]: lacZlrrBaberrant prestalk B cell differentiation
DBS0350476lrrB-/ [ecmO]: lacZlrrBaberrant prestalk 0 cell differentiation
DBS0236517lst8-lst8decreased F-actin polymerization | aberrant activation of adenylate cyclase activity | decreased chemotaxis rate | abolished aggregation | decreased myosin II assembly
DBS0350106lst8-lst8increased phagocytosis
DBS0350114lst8-/ [act15]: GFP: rheb(Q64L)lst8 | rhebincreased phagocytosis
AD60lvsA-lvsAaberrant contractile vacuole organization and biogenesis | abolished cytokinesis | decreased pinocytosis | aberrant response to hypo-osmotic stress | decreased phagocytosis | increased cell-substrate adhesion
AD63lvsA-lvsAabolished cytokinesis | abolished contractile vacuole dissociation from plasma membrane | abolished cAMP-induced Ca2+ influx
DBS0236521lvsB-lvsBincreased secretion of lysosomal enzyme | increased lysosome size | increased exocytosis | aberrant post-lysosome organization and biogenesis | increased pinocytosis | aberrant protein localization
DBS0350567lvsB-/ [act15]: FLAG: Rab14(N121I)lvsB | rab14wild type
DBS0236522lvsC-lvsCwild type
DBS0236523lvsD-lvsDwild type
DBS0236524lvsE-lvsEwild type
DBS0236525lvsF-lvsFwild type
DBS0349933macA-macAaberrant macrocyst differentiation | decreased sexual fusion
DBS0236536malA-malAwild type
DBS0350211mef2A-mef2Aaberrant streaming | decreased growth rate | aberrant development | decreased sporulation
DBS0350212mef2A-mef2Aaberrant streaming | decreased growth rate | aberrant gene expression | aberrant development | decreased sporulation
DBS0350213mef2A-/ [ecmA]: lacZmef2Aaberrant prestalk A cell differentiation
DBS0350214mef2A-/ [ecmB]: lacZmef2Aaberrant prestalk B cell differentiation
DBS0350215mef2A-/ [pspA]: lacZmef2Adecreased prespore cell differentiation
DBS0236543mekA-mekAdecreased aggregate size | precocious development | abolished chemotaxis to cAMP
DBS0350030mekA-/ [act15]: Myc: erkAerkA | mekAabolished protein localization to cell cortex
DBS0350036mekA-/ [act15]: mekA(299-360)mekAdecreased aggregate size
DBS0350035mekA-/ [act15]: mekA(K321A)mekAdecreased aggregate size
DBS0350032mekA-/ [act15]: mekA(S444A/ T448A)mekAdecreased aggregate size
DBS0350031mekA-/ [act15]: mekA(S444E/ T448E)mekAdevelopment arrests at mound stage
DBS0236544mfeA-mfeAaberrant cellular metabolic process | decreased protein level | development arrests at mound stage | aberrant cAMP signaling during aggregation
DBS0266843mgp1-mgp1aberrant contractile vacuole organization and biogenesis | increased phototaxis | increased filopodium formation | decreased cell motility | decreased fruiting body size | abolished streaming | decreased stalk width | decreased stalk length
DBS0266846mgp1-/ mgp2-mgp1 | mgp2aberrant contractile vacuole organization and biogenesis | increased filopodium formation | aberrant culmination | decreased cell motility | decreased phototaxis | decreased stalk length
DBS0266844mgp2-mgp2increased aggregate size | increased slug size
HS1mhcA-mhcAaberrant response to hypo-osmotic stress | development arrests at mound stage | aberrant cytokinesis | decreased growth rate | increased F-actin polymerization | aberrant regulation of GTPase activity | aberrant regulation of protein kinase activity | aberrant cellular response to stress
HS2205mhcA-mhcAabolished cell motility | decreased cell motility
HS2207mhcA-mhcAabolished cytokinesis | development arrests at mound stage
DBS0350064mhcA-mhcAdecreased cell polarity | decreased cell motility
HS2206mhcA-mhcAabolished bleb formation
HK321mhcA-mhcAaberrant cell morphology
HK323mhcA-mhcAdecreased cell motility
DBS0266674mhcA-/ [act15]: GFP: abpC(9-148)abpC | mhcAdecreased uropod retraction | decreased pseudopod retraction
DBS0237564mhcA-/ [act15]: GFP: ctxA/ [RNAi]enlActxA | enlA | mhcAaberrant cytokinesis, contractile ring contraction
DBS0266675mhcA-/ [act15]: GFP: mhcA(E476K)mhcAdecreased pseudopod retraction
DBS0350489mhcA-/ [act15]: GFP: mhcA/ [RNAi]rmd1mhcA | rmd1aberrant protein localization
DBS0236548mhcA-/ [act15]: GFP: pats1(2087-2351)mhcA | pats1aberrant cytokinesis
DBS0350291mhcA-/ [act15]: gppA: GFPgppA | mhcAaberrant contractile vacuole morphology | decreased contractile vacuole discharge
DBS0236549mhcA-/ [act15]: limE(1-145): GFPlimE | mhcAincreased F-actin polymerization
DBS0350808mhcA-/ [act15]: mhcA(1-933: 1455-2116]mhcAwild type | aberrant cytokinesis | aberrant fruiting body morphology
DBS0238158mhcA-/ [act15]: mhcA(81-2116)mhcAdecreased growth rate | development arrests at tipped mound stage
CW0401mhcA-/ [act15]: mhcA(T1823A/ T1833A/ T2029A)mhcAdecreased growth rate in suspension | increased myosin II assembly | aberrant chemotaxis
DBS0236550mhcA-/ [act15]: mhcA(T1823A/ T1833A/ T2029A)mhcAdecreased filopodium formation
DBS0236551mhcA-/ [act15]: mhcA(T1823D/ T1833D/ T2029D)mhcAincreased filopodium formation
DBS0238399mhcA-/ [act15]: rapA(G12V)mhcA | rapAincreased basal F-actin level | aberrant myosin II organization | increased cell polarity
DBS0236552mhcA-/ [mhcA]: mhcA(1-1224)mhcAaberrant cytokinesis | development arrests at mound stage
DBS0350948mhcA-/ [mhcA]: mhcA(1-1224)/ [act15]: mhcA(E683K)mhcAaberrant catalytic activity
DBS0350949mhcA-/ [mhcA]: mhcA(1-1224)/ [act15]: mhcA(R686C)mhcAaberrant catalytic activity
DBS0238157mhcA-/ [mhcA]: mhcA(1-1224)/ [act15]: mhcA(R689H)mhcAdecreased actin filament sliding
DBS0236547mhcA-/ [unk]: GFP: icpAicpA | mhcAaberrant protein localization
CW0371mhkA-mhkAincreased myosin II assembly | aberrant chemotaxis | decreased cell motility | aberrant protein localization to pseudopodium
DBS0236557mhkA-/ [act15]: mhkAmhkAdecreased growth rate | development arrests at mound stage | aberrant cytokinesis | decreased myosin II assembly
CW0166mhkB-mhkBincreased myosin II assembly | decreased cell motility
CW0403mhkC-mhkCincreased myosin II assembly | aberrant cytokinesis | aberrant chemotaxis
DG1069mhkC-mhkCaberrant fruiting body morphology
CW0435mhkD-mhkDincreased myosin II assembly | decreased cell motility
DBS0236559midA-midAdecreased pinocytosis | aberrant spore morphology | decreased thermotaxis | increased autophagy | decreased mitochondrial fission | decreased growth rate | decreased phagocytosis | increased intracellular glutamate level | decreased intracellular glycogen level | increased extracellular ammonia level | increased slug migration | decreased cell size | decreased phototaxis
DBS0350123midA-/ [act15]: GFP: atg18atg18 | midAincreased number of autophagosomes
DBS0350136midA-/ [act15]: GFP: tktmidA | tkt-1 | tkt-2increased autophagy
DG1020migA-migAabolished slug migration | decreased aggregate size | decreased fruiting body size | aberrant fruiting body morphology
DBS0350958migA-migAdecreased gene expression | aberrant chemotaxis to cAMP
DBS0350025mip1-mip1-1 | mip1-2increased aggregate size | decreased chemotaxis to cAMP
DBS0350027mip1-/ [act15]: mekA: FLAGmekA | mip1-1 | mip1-2aberrant protein localization to cytoplasm
DBS0266620mipp1-mipp1aberrant inositol phosphate metabolic process | increased response to lithium
DBS0236560mkcA-mkcAdecreased gene expression
DG1101mkcB-mkcBdecreased fruiting body size
DBS0236564mkkA-mkkAprecocious culmination | decreased sorus size | increased stalk length
DG1121mkpA-mkpAabolished aggregation
DBS0236566mlcE-mlcEdecreased growth rate in suspension | aberrant cytokinesis | delayed aggregation | decreased cell motility | mislocalized gene expression | aberrant development
DBS0238058mlcE-/ [act15]: myc: mlcEmlcEwild type
DBS0236567mlcR-mlcRaberrant myosin II organization | aberrant cytokinesis | development arrests at mound stage
HS183mlkA-mlkAaberrant cytokinesis
DBS0349919mlkA-/ [act15]: GFP-mhcAmlkAaberrant stalk morphogenesis
DG1033modA-modAabolished catalytic activity | aberrant fruiting body morphology
DBS0266903mpl1-mpl1decreased cell motility | decreased chemotaxis to cAMP | abolished streaming | abolished aggregation
DBS0266904mpl1-/ [act15]: flag: mpl1mpl1wild type
DBS0349986mrfA-mrfAaberrant slug migration | delayed development
DBS0350391mrfA-/ [act15]: myc: mrfA(K772A): FLAGmrfAaberrant protein modification
DBS0350390mrfA-/ [act15]: myc: mrfA(S767A): FLAGmrfAaberrant protein modification | delayed development
DBS0350389mrfA-/ [act15]: myc: mrfA: FLAGmrfAwild type
DBS0349987mrfA-/ [emcA]: lacZmrfAdecreased prestalk A cell differentiation
DBS0350960mroh1-mroh1aberrant exocytosis | aberrant post-lysosome organization and biogenesis
DBS0236569mrps4-mrps4delayed aggregation | aberrant fruiting body morphology
DBS0350868mtpn-mtpnaberrant streaming | decreased growth rate | decreased cell motility | decreased macropinocytosis | decreased basal F-actin level
HM1464mus81-mus81wild type
DBS0350866mvpA-mvpAaberrant cell morphology
DBS0236570mybB-mybBdecreased cAMP-induced cGMP pulse | decreased gene expression | decreased activation of adenylate cyclase | abolished aggregation | decreased cAMP-induced cAMP pulse
DBS0236571mybB-mybBabolished aggregation
HM388mybC-mybCdecreased SDF production | decreased gene expression | abolished culmination
DBS0236572mybE-mybEincreased gene expression | increased slug size | abolished outer basal disc formation
DBS0237709mybE-/ [mrrA]: lacZmrrA | mybEaberrant prestalk cell differentiation
DBS0236573mybE-/ mybE: GFPmybEwild type | aberrant prestalk cell differentiation
HDT1myoA-myoAdelayed aggregation | decreased cell motility | decreased chemotaxis rate | decreased lateral pseudopod suppression
HDT2myoA-myoAincreased secretion of lysosomal enzyme
DBS0236579myoB-myoBincreased secretion of lysosomal enzyme
DBS0236580myoB-myoBdecreased phagocytosis | delayed aggregation | decreased cell motility | decreased lateral pseudopod suppression
DBS0349853myoB-myoBdecreased phagolysosome size | aberrant phagosome maturation | delayed phagosome re-neutralization
DBS0236583myoB-/ [AS]myoDmyoB | myoDdecreased pinocytosis | aberrant aggregation | decreased growth rate | decreased phagocytosis | decreased cell motility | decreased aggregate size
DBS0236584myoB-/ [AS]myoD/ [KD]myoCmyoB | myoC | myoDsmall pinosomes | decreased pinocytosis | aberrant aggregation | decreased growth rate | decreased phagocytosis | decreased cell motility | increased number of pinosomes | decreased aggregate size
DBS0236585myoC-myoCdecreased phagocytosis
DBS0236587myoD-myoDwild type
HDT8myoF-myoFwild type
DBS0350251myoG-myoGdecreased protein localization to plasma membrane | decreased F-actin polymerization | aberrant chemotaxis to cAMP | abolished cell polarity | abolished aggregation
DBS0236589myoI-myoIdecreased spore germination
DBS0236592myoI-myoIdecreased cell-substrate adhesion | aberrant cytokinesis | decreased phagocytosis | aberrant cell morphology
HDT15myoI-myoIdecreased phagocytosis
HDT17myoI-myoIdecreased cell-cell adhesion | decreased protein level | decreased cell-substrate adhesion | decreased phagocytosis | decreased filopodium formation
DBS0266889myoI-/ [act15]: GFP: myoImyoIwild type
DBS0266890myoI-/ [act15]: GFP: myoI(809-1154)myoIdecreased phagocytosis
DBS0237617myoI-/ [act15]: gbpDgbpD | myoIincreased pseudopod formation | increased cell-substrate adhesion | aberrant cell morphology
HTD7myoJ-myoJwild type
DBS0350931myoJ-myoJdecreased response to hypo-osmotic stress | aberrant contractile vacuole discharge | aberrant establishment of contractile vacuole localization
DBS0349844myoK-myoKaberrant cortical actin cytoskeleton stabilization | delayed aggregation | decreased phagocytosis | aberrant engulfment during phagocytosis | decreased chemotaxis rate | aberrant cell morphology
DBS0349846myoK-/ [act15]: YFP: myoK(1-121: 262-858)myoKdecreased phagocytosis
DBS0349850myoK-/ [act15]: myoKmyoKincreased phagocytosis
DBS0349854myoK-/ [act15]: pakB(1-337: 563-852)myoK | pakBwild type
DBS0236595myoM-myoMwild type
SB12napA-napAdecreased cell-cell adhesion | decreased cell polarity | decreased cell-substrate adhesion | decreased cell motility | decreased basal F-actin level | decreased cell size | decreased phototaxis
HC476ncsA-ncsAincreased intracellular cAMP level | precocious gene expression | precocious development
HC477ncsA-ncsAincreased intracellular cAMP level | precocious gene expression | precocious development
DBS0350297ncstn-ncstnaberrant culmination | abolished catalytic activity | decreased prespore cell differentiation
DBS0350307ncstn-ncstnwild type
DBS0349947ndm-ndmaberrant chemotaxis | increased pinocytosis | decreased fruiting body size | aberrant pseudopod formation
DBS0349895ndrA-ndrAdecreased engulfment during phagocytosis
DBS0349896ndrA-/ [unk]: GFP: ndrAndrAwild type
DBS0350446ndrC-ndrCincreased positive regulation of GTPase activity | increased number of centrosomes | aberrant cell separation during cytokinesis
DBS0350121ndufaf5-ndufaf5aberrant spore morphology | decreased growth rate | delayed development | aberrant phototaxis | spores inviable | decreased fruiting body size
DBS0350125ndufaf5--/ [act15]: ndufaf5(G86V): GFP: TAPndufaf5decreased growth rate
DBS0350126ndufaf5--/ [act15]: ndufaf5(L165F): GFP: TAPndufaf5decreased growth rate
DBS0350127ndufaf5--/ [act15]: ndufaf5(L235P): GFP: TAPndufaf5decreased growth rate
DBS0350124ndufaf5--/ [act15]: ndufaf5: GFP: TAPndufaf5wild type
DBS0350122ndufaf5-/ [act15]: GFP: atg18atg18 | ndufaf5increased number of autophagosomes
DBS0350134ndufaf5-/ [act15]: GFP: tktndufaf5 | tkt-1 | tkt-2increased autophagy
DBS0350137ndufaf5-/ [act15]: [AS]snfAndufaf5 | snfAaberrant phototaxis
DBS0304633nfaA-nfaAincreased pseudopod formation | increased chemoattractant-mediated F-actin polymerization | increased basal F-actin level | delayed aggregation | decreased cell motility | aberrant cAMP signaling during aggregation | aberrant regulation of GTPase activity | aberrant regulation of protein kinase activity | aberrant protein localization to plasma membrane | decreased chemotaxis to cAMP
DBS0236604nhe1-nhe1abolished potassium-dependent chemotaxis to cAMP | decreased intracellular pH level | decreased cell polarity | decreased F-actin polymerization | aberrant F-actin organization | abolished chemotaxis to calcium | decreased chemotaxis rate | delayed development | abolished cell polarity | abolished chemotaxis to cAMP
DBS0350003nhe1-/ [act15]: GFP: aip1aip1 | nhe1decreased cell polarity | decreased chemotaxis to cAMP
DBS0350006nhe1-/ [act15]: GFP: aip1(E125A, E167A, F181A, F193A)aip1 | nhe1abolished aggregation | abolished chemotaxis to cAMP
DBS0350001nhe1-/ [act15]: aip1(168-597)aip1 | nhe1delayed development
DBS0350002nhe1-/ [act15]: aip1(383-597): FLAGaip1 | nhe1decreased F-actin polymerization | abolished cell polarity | abolished chemotaxis to cAMP
DBS0349841nhe1-/ [act15]: mhcA: GFPmhcA | nhe1aberrant protein localization
DBS0236605nhe1-/ [act15]: nhe1: HAnhe1wild type
DBS0350508nlp-nlpwild type
DBS0236606nosA null (15-S-12)nosAdevelopment arrests at mound stage
DBS0236607nosA null (2E4)nosAdevelopment arrests at mound stage
DBS0235950nosA-nosAdevelopment arrests at mound stage | aberrant protein modification
DBS0236608noxA-noxAabolished sporulation | aberrant development
DBS0236611noxA-/ [act15]: noxA: myc2noxAaberrant fruiting body morphology
DBS0236612noxB-noxBabolished sporulation | decreased superoxide production | aberrant development
DBS0236613noxC-noxCabolished sporulation | aberrant development
DBS0238849npcA-npcAwild type
HSB60nramp1-nramp1increased infection rate by a gram-positive pathogenic bacterium | increased infection rate by a gram-negative pathogenic bacterium | abolished iron ion transport
DBS0236696nramp1-/ [act15]: nramp1: GFPnramp1decreased infection rate by a gram-negative pathogenic bacterium
DBS0236697nramp1-/ [act15]: nramp1: GFPnramp1decreased infection rate by a gram-negative pathogenic bacterium
DBS0350092nrampB-nrampBdelayed aggregation | increased infection rate by a gram-negative pathogenic bacterium
DBS0236955nxnA-nxnAdecreased culmination | decreased growth rate | delayed development | decreased chemotaxis to cAMP | decreased lysosomal enzyme activity
DBS0236702nxnA-/ [act15]: GFP: nxnB nxnA | nxnBdevelopment arrests at mound stage
DBS0350857odc-odcabolished growth | aberrant cell cycle
DBS0236704osbA-osbAincreased slug migration | precocious development
DBS0238357p2xA-p2xAaberrant response to hypo-osmotic stress
DBS0304487p2xA-p2xAwild type
DBS0350312p2xA-p2xAaberrant contractile vacuole organization and biogenesis | abolished response to hypo-osmotic stress | decreased contractile vacuole size | aberrant regulation of GTPase activity
DBS0350484p2xA-/ AX2p2xAwild type | aberrant contractile vacuole discharge
DBS0350485p2xA-/ AX4p2xAaberrant contractile vacuole discharge | aberrant response to hypo-osmotic stress
DBS0238362p2xA-/ [act15]: p2xA: GFPp2xAwild type
DBS0350315p2xA-/ p2xA(K67A/ K289A)p2xAabolished response to hypo-osmotic stress
DBS0350314p2xA-/ p2xA(R285K)p2xAdecreased response to hypo-osmotic stress
DBS0350313p2xA-/ p2xA(R63A)p2xAprecocious response to hypo-osmotic stress
DBS0306166p2xB-p2xBwild type
DBS0306167p2xC-p2xCwild type
DBS0306168p2xD-p2xDwild type
DBS0304486p2xE-p2xEwild type
DBS0350013pah-pahabolished growth | abolished catalytic activity
DBS0350014pah-/ [act15]: 6xHis: pahpahwild type
DBS0350016pah-/ [act15]: 6xHis: pah(92-415)pahabolished growth
DBS0350015pah-/ [act15]: 6xHis: pah(92-441)pahwild type
DBS0236705pakA-pakAaberrant cytokinesis | delayed development | decreased myosin II assembly
DBS0236706pakA-pakAwild type
DBS0349885pakA-pakAdelayed development | decreased chemotaxis to cAMP
DBS0236707pakA-/ [act15]: pakApakAwild type
DBS0350810pakA-/ [act15]: pakA(T579A)pakAdecreased chemotaxis to cAMP
DBS0236709pakB-pakBdecreased growth rate
DBS0236712pakB-/ [act15]: GFP-pak(1-600)pakBabolished cytokinesis
DBS0236710pakB-/ [act15]: GFP-pakB(1-337: 563-851)pakBabolished cytokinesis | increased pinocytosis | increased phagocytosis
DBS0350428pakB-/ [act15]: RFP: abpEabpE-1 | abpE-2 | pakBaberrant establishment and/ or maintenance of cell polarity | decreased chemotaxis to cAMP | abolished aggregation | aberrant protein localization
DBS0350430pakB-/ [act15]: RFP: abpE/ [act15]: GFP: pak(1-180)abpE-1 | abpE-2 | pakBwild type
DBS0350281pakD-pakDaberrant cellular homeostasis | aberrant F-actin polymerization | aberrant filopodium formation | aberrant actin cytoskeleton organization | aberrant establishment and/ or maintenance of cell polarity | abolished negative regulation of vegetative growth | aberrant vegetative growth | abolished aggregation | decreased chemotaxis to cAMP | increased growth rate
DBS0350282pakD-/ [act15]: pakDpakDdevelopment arrests at mound stage
DBS0350395pakD-/ [act15]: pakD: GFPpakDwild type
HC392patB-patBabolished growth
DBS0236726pats1-pats1aberrant cytokinesis
DBS0350097pats1-pats1aberrant cytokinesis
LAS45pats1-pats1decreased socially cooperative development
DBS0236727pats1-/ [act15]: GFP: pats1(2087-2351)pats1aberrant cytokinesis
DBS0236728paxB-paxBdecreased exocytosis | decreased cell-substrate adhesion | decreased gene expression | abolished slug migration | increased chemotaxis to cAMP | development arrests at mound stage | decreased sorting to prestalk region | aberrant fruiting body morphology | increased phagocytosis
DBS0304926paxB-paxBaberrant cell separation during cytokinesis | decreased cell-substrate adhesion | aberrant cytokinesis | decreased cell motility
DBS0304930paxB-/ [act15]: GFP: paxBpaxBwild type
DBS0350973paxB-/ [act15]: gpaHgpaH | paxBaberrant cytokinesis
DBS0350094paxB-/ [act15]: pldBpaxB | pldBwild type | increased phagocytosis
DBS0236730paxB-/ [ecmA]: paxB: GFPpaxBdecreased sorting to prestalk region
DBS0236732paxB-/ [pspA]: paxB: GFPpaxBdecreased sorting to prestalk region
DBS0236733pcp-pcpwild type | aberrant response to hypo-osmotic stress
DBS0236734pde4-pde4decreased culmination | multiple tips in culminant | delayed slug formation | delayed culmination
DBS0236735pde4-/ [act15]: pde4: GFPpde4wild type
DBS0235991pdeD-pdeDdecreased 3',5'-cyclic-GMP phosphodiesterase activity
DBS0236736pdeD-pdeDdecreased cAMP-induced Ca2+ influx | delayed cAMP-induced Ca2+ influx | decreased Ca2+-induced Ca2+ influx
DBS0350517pdeD-pdeDdecreased 3',5'-cyclic-GMP phosphodiesterase activity | aberrant streaming | increased fruiting body size
DBS0350518pdeD-/ [act15]: pdeD: YFPpdeDwild type
DBS0350900pdeE-pdeEabolished 3',5'-cyclic-AMP phosphodiesterase activity | increased cAMP-induced cAMP pulse
DBS0235993pdeE-pdeEdecreased 3',5'-cyclic-AMP phosphodiesterase activity | aberrant chemotaxis to cAMP
DBS0350797pdkA-pdkAdecreased protein kinase activation
DBS0350817pdkA-pdkAdecreased aggregate size | decreased protein kinase activation
DBS0350818pdkB-pdkBdecreased aggregate size
DBS0237029pdsA-pdsAaberrant streaming | aberrant chemotaxis to cAMP
UK7pdsA-pdsAdecreased 3',5'-cyclic-AMP phosphodiesterase activity | decreased gene expression | abolished aggregation | aberrant development
DBS0236741pefA-pefAwild type
DBS0236744pefB-pefBwild type
HW260pgtA-pgtAincreased cell size
DBS0305022pgtB-pgtBaberrant cellular metabolic process | aberrant response to hyperosmotic stress | aberrant spore coat morphology
DBS0305023pgtC-pgtCaberrant cellular metabolic process | aberrant response to hyperosmotic stress
DBS0236752phdA-phdAdecreased basal F-actin level | decreased aggregate size | decreased chemotaxis rate | decreased fruiting body size
DBS0236753phdA-/ [act15]: phdAphdAwild type
DBS0236754phdA-/ [act15]: phdA: GFPphdAwild type
DBS0350865phdG-phdGdecreased chemotaxis to cAMP
DBS0236755phg1A-phg1Aabolished resistance to a pathogenic bacterium | increased secretion of lysosomal enzyme | decreased protein level | decreased cell-substrate adhesion | decreased gene expression | aberrant defense response to bacterium | aberrant cytokinesis | decreased phagocytosis | decreased growth rate | development arrests at slug stage | decreased protein localization to cell surface | aberrant phagocytosis | increased lysosomal pH | decreased protein stabilization | decreased lysosomal enzyme activity
DBS0236757phg1A-/ [act15]: kil1kil1 | phg1Aincreased secretion of lysosomal enzyme | wild type | increased lysosomal pH | decreased protein stabilization | decreased lysosomal enzyme activity
DBS0304869phg1A-/ [act15]: phg1A(1-276): phg1B221-587)phg1A | phg1Bdecreased phagocytosis
DBS0304868phg1A-/ [act15]: phg1Bphg1A | phg1Bincreased secretion of lysosomal enzyme | wild type | decreased cell-substrate adhesion | aberrant protein level | decreased phagocytosis
DBS0304870phg1A-/ [act15]: phg1B(1-220): phg1a(277-642)phg1A | phg1Bdecreased phagocytosis
DBS0304866phg1B-phg1Bincreased secretion of lysosomal enzyme | decreased protein level | decreased phagocytosis | decreased growth rate | abolished culmination
DBS0236758phg2-phg2decreased cell-substrate adhesion | decreased phagocytosis | aberrant cytokinesis | aberrant F-actin organization | decreased cell motility | aberrant response to nutrients | aberrant cell morphology | precocious development | precocious gene expression
DBS0238400phg2-phg2increased filopodium formation | increased basal F-actin level | increased cell-substrate adhesion | decreased chemotaxis to cAMP | aberrant cell morphology | increased phagocytosis
DBS0350578phg2-phg2abolished gene expression | decreased protein phosphorylation | aberrant protein localization to nucleus
DBS0236760phg2-/ [act15]: GFP: phg2(199-1389)phg2decreased phagocytosis
DBS0237615phg2-/ [act15]: gbpDgbpD | phg2increased pseudopod formation | aberrant cell morphology | abolished chemotaxis to cAMP
DBS0350580phg2-/ [act15]: myc: ptpCphg2 | ptpCabolished protein phosphorylation
HG1648phgA-phgAaberrant contractile vacuole organization and biogenesis | increased contractile vacuole size | aberrant response to hypo-osmotic stress | aberrant pore formation during contractile vacuole discharge
DBS0302610phgA-/ [OE]: dsggdsgg | phgAaberrant contractile vacuole organization and biogenesis
DBS0236761phgA-/ lvsA-/ [act6]: GFP: lvsAlvsA | phgAaberrant protein localization
DBS0236762phlp1-phlp1decreased cAMP-induced cGMP pulse | aberrant regulation of protein modification | decreased growth rate | abolished positive chemotaxis | abolished aggregation | decreased cAMP-induced cAMP pulse | aberrant protein localization
DBS0236763phlp1-/ [OE]: phpl1phlp1wild type
DBS0236764phlp3-phlp3wild type
DBS0350824phr-phraberrant chemotaxis to cAMP | delayed development
HW288phyA-phyAabolished sporulation | decreased peptidyl-proline hydroxylation | abolished stalk formation | abolished culmination
DBS0266771phyA-/ [ecmA]: phyA(D132N): mycphyAdecreased peptidyl-proline hydroxylation
DBS0266770phyA-/ [ecmA]: phyA(R276A): mycphyAabolished peptidyl-proline hydroxylation | abolished culmination
DBS0236767pia-piaAaberrant activation of adenylate cyclase activity
DBS0236770piaA-piaAaberrant cytokinesis
DBS0236771piaA-piaAabolished aggregation | decreased myosin II assembly | increased phagocytosis
DBS0304637piaA-piaAdecreased cell polarity | decreased cell motility | decreased chemotaxis rate | aberrant protein tyrosine phosphorylation
DBS0349879piaA-piaAdecreased protein phosphorylation | decreased protein kinase activity | abolished protein phosphorylation | decreased chemotaxis to cAMP | aberrant protein localization to plasma membrane | increased activation of GTPase activity
DBS0236772pikA-pikAwild type
DBS0236774pikB-pikBwild type
DBS0236776pikC-pikCwild type
DBS0236777pikD1pikDabolished slug migration | delayed aggregation | decreased aggregate size | decreased sporulation | aberrant fruiting body morphology
DBS0236778pikE-pikEwild type
HM1241pikF-pikFdecreased pinocytosis | decreased growth rate | aberrant pinosome maturation
LAS31pikG-pikGaberrant socially cooperative development
HM1513pikI-pikIdecreased chemoattractant-mediated F-actin polymerization | decreased catalytic activity | decreased cAMP-induced cGMP pulse | decreased cAMP-induced Ca2+ influx | decreased growth rate | aberrant chemotaxis to cAMP | decreased protein kinase activation | increased bleb formation | decreased cAMP-induced cAMP pulse
DBS0350828pinA-/ [ecmAO]: lacZpinAaberrant prestalk cell differentiation
DBS0350827pinA-/ [pspA]: lacZpinAaberrant prespore cell differentiation
SB16pirA-pirAincreased cell motility | decreased cell size
SB3pirA-pirAincreased pseudopod formation | increased basal F-actin level | increased cell size | decreased cell motility
DBS0349901pisA-pisAincreased gene expression | precocious development | decreased fruiting body size | aberrant prestalk cell differentiation
DBS0236783pkaC-pkaCabolished gene expression | increased protein phosphorylation | decreased protein level | decreased gene expression | aberrant myosin II organization | decreased activation of GTPase activity | aberrant cAMP signaling | abolished catalytic activity | aberrant F-actin organization | aberrant CRAC localization to the plasma membrane | decreased protein kinase activation | abolished aggregation | aberrant protein localization to cell cortex | abolished chemotaxis to cAMP | increased protein kinase activation | increased activation of GTPase activity
DBS0350694pkaC-/ [act15]: pkaCpkaCabolished culmination
DBS0350708pkaC-/ [act6]: pkaC(303-648)pkaCwild type
DBS0350707pkaC-/ [act6]: pkaC(330-648)pkaCabolished aggregation
DBS0350710pkaC-/ [dscC]: LUCpkaCdecreased gene expression
DBS0235411pkaR-pkaRdecreased spore germination | aberrant response to lithium | increased gene expression | precocious sporulation | aberrant chemotaxis to cAMP | aberrant response to valproic acid | decreased cell motility | increased lateral pseudopod formation | aberrant cAMP signaling during aggregation | decreased fruiting body size | aberrant cell morphology | abolished streaming
DBS0236784pkbA-pkbAdecreased pinocytosis | decreased protein phosphorylation | aberrant macropinocytosis | abolished protein kinase activation | abolished protein localization | aberrant phagosome maturation | aberrant protein localization to cell cortex | increased phagocytosis | decreased myosin II assembly
DBS0350113pkbA-/ [act15]: GFP: rheb(Q64L)pkbA | rhebdecreased phagocytosis
DBS0350916pkcA-pkcAdecreased cell-cell adhesion | decreased protein level | increased chemotaxis to cAMP | decreased gene expression | increased F-actin polymerization | decreased fruiting body size | aberrant cAMP wave formation | multiple tips in mound
DBS0350918pkcA-pkcAaberrant aggregation | decreased catalytic activity | aberrant cytokinesis | aberrant development
DBS0350919pkcA-/ [act15]: pldBpkcA | pldBaberrant aggregation | decreased sporulation
DBS0350917pkcA-/ [ecmA]: GFPpkcAmislocalized gene expression
DBS0350475pkd2-pkd2increased resistance to naringenin | decreased growth rate
DBS0350367pkd2-pkd2aberrant cellular response to fluid shear stress | aberrant exocytosis
DBS0236786pkgB-pkgBdecreased protein phosphorylation | abolished SDF production | development arrests at mound stage
DBS0350328pkgB-pkgBaberrant development
DBS0304638pkgB-pkgBdecreased cell-substrate adhesion | development arrests at mound stage | decreased chemotaxis rate | increased cell motility
DBS0236787pkgB-/ [act15]: pkbApkbA | pkgBwild type
DBS0236789pkgB-/ [act15]: pkgB(K182M)pkgBdevelopment arrests at mound stage
DBS0350329pkgB-/ [emcB]: lacZpkgBabolished gene expression
DBS0236790pkgB-/ [gbfA]: pkbApkbA | pkgBwild type
DBS0236791pkgB-/ [gbfA]: pkgBpkgBwild type
DBS0350319pks17-pks17decreased fatty acid level | aberrant gene expression | delayed development | decreased fruiting body size
LAS44pks2-pks2decreased socially cooperative development
LAS19pks26-pks26aberrant socially cooperative development
DBS0238068plaA-plaAaberrant chemotaxis to cAMP | abolished aggregation
DBS0238067plaA-plaAabolished aggregation
DG1067plbG-plbGdecreased stalk width | decreased stalk length
HAD236plc-plcdecreased CRAC localization to the plasma membrane | aberrant chemotaxis to cAMP | decreased protein localization to cytoplasm | decreased protein kinase activation | abolished aggregation
HD1.19plc-plcaberrant negative chemotaxis
HD10plc-plcwild type
DBS0267125plc-/ [OE]: dagA(PH): GFP/ [OE]: plcdagA | plcincreased CRAC localization to the plasma membrane | decreased chemotaxis to cAMP | aberrant protein localization
DBS0350047plc-/ [act15]: pten: GFPplc | ptenwild type | aberrant protein localization to cytoplasm
DBS0236796pldB-pldBdecreased catalytic activity | precocious aggregation
DBS0236797pldB-/ [act15]: pldB: GFPpldBabolished aggregation
DBS0350604pldB-/ [unk]: GFPpldBincreased sorting to prestalk region
DBS0350605pldB-/ [unk]: lacZpldBincreased sorting to prestalk region
DBS0236799plip-plipdelayed aggregation
DBS0350007png-pngdelayed aggregation | decreased aggregate size | aberrant fruiting body morphology
DBS0350492png-/ [ecmAO]: lacZpngaberrant prestalk cell differentiation
DBS0350491png-/ [ecmA]: lacZpngaberrant prestalk A cell differentiation
DBS0350493png-/ [pspA]: lacZpngdecreased prespore cell differentiation
DBS0236820ponA-ponAprecocious aggregation | decreased lateral pseudopod traction | decreased actin nucleation on plasma membranes | aberrant development
DBS0236821ponA-ponAprecocious aggregation | decreased lateral pseudopod traction | decreased actin nucleation on plasma membranes | aberrant development
DG1057potA-potAaberrant fruiting body morphology
DBS0236824ppk1-ppk1decreased growth rate | decreased phagocytosis | decreased fruiting body size | delayed culmination | decreased sporulation
ASH01ppk1-ppk1aberrant cellular homeostasis | decreased growth rate | aberrant spore germination | decreased intracellular ATP level | aberrant macromolecule biosynthesis | decreased fruiting body size | increased growth rate
DBS0236825ppk1-/ [act15]: ppk1ppk1wild type
DBS0238099ppp4C-ppp4cdevelopment arrests at mound stage | delayed development
DBS0238110ppp4C-/ [act15]: smkAppp4c | smkAdevelopment arrests at mound stage | delayed development
DBS0238033proC-proCdecreased cell polarity | increased lateral pseudopod formation | decreased chemotaxis rate
DBS0238034proC-/ [unk]: FLAG: proCproCwild type
DBS0266716pscA-pscAwild type
DBS0266803psenA-psenAaberrant culmination | decreased prespore cell differentiation
DBS0350302psenA-psenAdecreased prespore cell differentiation | increased cytosolic Ca2+ response
DBS0350295psenB-psenBdecreased phagocytosis | abolished catalytic activity
DBS0350303psenB-psenBdecreased prespore cell differentiation | increased cytosolic Ca2+ response
HOK2psiA-psiAabolished prespore cell division
DBS0236021psiM-psiMwild type
DBS0236022psiM-psiMwild type
DBS0236828pslA-pslAabolished gene expression | abolished sporulation | abolished stalk cell differentiation in vitro | decreased sorus size | increased aggregate size | increased stalk length | mislocalized gene expression
DBS0236829psmC1-psmC1curly fingers | increased resistance to spectinomycin | abolished slug migration | increased cell size
HW70pspB-pspBaberrant spore coat morphology | precocious spore germination
DBS0302352psrA-psrAdecreased culmination | increased protein phosphorylation | decreased activation of GTPase activity | increased protein kinase B activation | decreased cell motility | delayed development | delayed gene expression | increased protein kinase activation
DBS0302356psrA-/ [act15]: FLAG: gskAgskA | psrAincreased protein kinase activation
DBS0302353psrA-/ [act15]: ecmA: lacZpsrAaberrant gene expression
DBS0302354psrA-/ [act15]: ecmB: lacZpsrAaberrant gene expression
DBS0302357psrA-/ [act15]: gskA(K84M/ K85M)gskA | psrAdecreased culmination | decreased gene expression | delayed development | increased protein kinase activation
DBS0302355psrA-/ [act15]: psrApsrAwild type
DBS0350829psrA-/ [unk]: FLAG: rasD(G12T)psrA | rasDincreased protein kinase activation
HM1289pten-ptenaberrant cell motility | decreased cell motility | abolished aggregation | decreased chemotaxis to cAMP | decreased lateral pseudopod suppression
DBS0236830pten-ptenabolished CRAC localization to the plasma membrane | decreased F-actin polymerization | increased pseudopod formation | decreased positive regulation of GTPase activity | decreased growth rate | increased F-actin polymerization | abolished protein localization to plasma membrane | decreased phagocytosis | increased lateral pseudopod formation | decreased cell motility | increased CRAC localization to the plasma membrane | decreased chemotaxis to cAMP | abolished aggregation | aberrant pseudopod formation | decreased lateral pseudopod suppression | aberrant signal transduction
DBS0349884pten-ptendecreased cell polarity | aberrant cytokinesis | increased protein kinase activity | decreased chemotaxis to cAMP
DBS0350660pten-ptendecreased uropod retraction | decreased growth rate | aberrant cytokinesis | decreased protein localization
DBS0350454pten-/ [act15]: lpten: RFPlpten | ptenwild type
DBS0349890pten-/ [act15]: pakA: GFPpakA | ptenaberrant cytokinesis
DBS0350754pten-/ [act15]: pten(186-515): GFPptendecreased chemotaxis to cAMP | aberrant development
DBS0350755pten-/ [act15]: pten(C124S): GFPptendecreased chemotaxis to cAMP | aberrant development
DBS0236831pten-/ [act15]: pten: GFPptenwild type
DBS0349900pten-/ pakA-/ [act15]: pakA(T585E): GFPpakA | ptenaberrant cytokinesis | decreased chemotaxis to cAMP
DBS0349899pten-/ pakA-/ [act15]: pakA: GFPpakA | ptenaberrant cytokinesis
DBS0236832ptpA1-ptpA1-1 | ptpA1-2decreased prespore cell differentiation | increased prestalk 0 cell differentiation | precocious development
DBS0236833ptpB-ptpBincreased slug size
DBS0350675ptpB-/ [act15]: 6xHis: erkAerkA | ptpBaberrant streaming
DBS0236835pufA-pufAincreased protein kinase activity | increased protein level | precocious development | aberrant fruiting body morphology
DBS0304391pyk3-pyk3increased gene expression | decreased gene expression | increased prespore cell differentiation | delayed culmination
DBS0350577pyk3-pyk3decreased protein phosphorylation | decreased gene expression | aberrant protein localization to nucleus
DBS0350581pyk3-pyk3decreased protein phosphorylation | decreased gene expression
DBS0304393pyk3-/ [act15]: T7: pyk3pyk3wild type
DBS0236837pyr56-pyr56increased resistance to 5-Fluoroorotic acid (5-FOA) | uracil auxotroph
DBS0236838pyr56-pyr56increased resistance to 5-Fluoroorotic acid (5-FOA) | uracil auxotroph
DBS0350017qdpr-qdprdecreased spore viability | abolished catalytic activity
DBS0350018qdpr-/ [act15]: pahpah | qdprdecreased growth rate
DBS0236839qkgA-qkgA-1 | qkgA-2increased aggregate size | delayed aggregation | aberrant vegetative growth | aberrant nucleus organization | increased growth rate | abolished negative chemotaxis
DBS0350011qkgA-/ [act15]: bzpN: GFPbzpN | qkgA-1 | qkgA-2abolished negative regulation of vegetative growth
DBS0350263rab7A-rab7Adecreased growth rate
DBS0236841racB-racBdecreased chemoattractant-mediated F-actin polymerization | delayed aggregation | decreased basal F-actin level | decreased chemotaxis rate | aberrant fruiting body morphology | decreased myosin II assembly
DBS0236842racC-racCdecreased protein localization to plasma membrane | aberrant streaming | decreased chemotaxis rate | aberrant cell morphology | aberrant protein localization
DBS0350272racC-racCaberrant cytokinesis | decreased growth rate
DBS0237191racC-/ [act15]: CFP: racCracCincreased chemoattractant-mediated F-actin polymerization
DBS0235413racE-racEabolished cytokinesis
DBS0350271racE-racEdecreased cell polarity | aberrant CRAC localization to the plasma membrane | aberrant cytokinesis | delayed aggregation | decreased growth rate | increased lateral pseudopod formation | aberrant regulation of GTPase activity | decreased chemotaxis to cAMP
DBS0349949racE-/ [act15]: fttBfttB | racEdecreased growth rate
DBS0349946racE-/ [act15]: fttB: GFPfttB | racEabolished protein localization to cell cortex
DBS0350956racE-/ [act15]racE(G20V)racEwild type
DBS0350957racE-/ [act15]racE(T25N)racEabolished cytokinesis
DBS0236843racF2-racF2increased aggregate size | increased cell-cell adhesion | decreased sexual fusion
DBS0236849racG-racGdecreased cell motility
DBS0236850racH-racHdecreased exocytosis | increased infection rate by a gram-negative pathogenic bacterium | aberrant protein localization
DBS0266936rapgap1-rapgap1decreased positive regulation of GTPase activity | increased basal F-actin level | increased cell-substrate adhesion | decreased cell motility | decreased myosin II assembly | increased protein kinase activation
DBS0266937rapgap1-/ [act15]: GFP: rapgap1rapgap1increased positive regulation of GTPase activity | decreased cell-substrate adhesion | increased myosin II assembly | increased basal F-actin level | increased lateral pseudopod formation | increased cell motility
DBS0350864rapgap3-/ AX2rapgap3delayed aggregation | decreased chemotaxis to cAMP | decreased fruiting body size
DBS0350863rapgap3-/ KAX3rapgap3aberrant sorting to prestalk region | increased calcium-dependent cell-cell adhesion | delayed tip formation | decreased cell motility | aberrant regulation of GTPase activity
DBS0350316rapgap9-rapgap9increased filopodium formation | increased basal F-actin level | aberrant cytokinesis | decreased spore size | increased cell-substrate adhesion | decreased chemotaxis to cAMP
DBS0350317rapgap9-/ [act15]: GFP: rapgap9rapgap9wild type
DBS0350628rapgapB-rapgapBaberrant aggregation | aberrant F-actin organization | increased cell-substrate adhesion | aberrant regulation of GTPase activity
DBS0350630rapgapB-/ [ecmAO]: RFPecmA | rapgapBaberrant cell-cell adhesion
DBS0350631rapgapB-/ [ecmA]: lacZrapgapBaberrant sorting to prestalk region
DBS0350632rapgapB-/ [ecmO]: lacZrapgapBaberrant sorting to prestalk region
DBS0350629rapgapB-/ [pspA]: RFPpspA | rapgapBaberrant cell-cell adhesion
DBS0236852rasB-rasBdecreased growth rate
DBS0350836rasB-rasBdecreased phagocytosis | aberrant F-actin organization
DBS0236853rasC-/ AX2rasCincreased rate of endocytosis | aberrant F-actin organization | increased cell size | decreased cell motility | decreased protein kinase activation | abolished aggregation | aberrant pseudopod formation
DBS0236854rasC-/ JH10rasCwild type | aberrant gene expression | decreased protein kinase activation | abolished aggregation | abolished chemotaxis to cAMP
DBS0237614rasC-/ [act15]: gbpDgbpD | rasCincreased cell-substrate adhesion | aberrant cell morphology
DBS0350740rasC-/ [rasC]: rasGrasC | rasGabolished activation of adenylate cyclase | abolished aggregation
DBS0350742rasC-/ [rasC]: rasG(1-77(D30A)): rasC(79-189)rasC | rasGwild type
DBS0350741rasC-/ [rasC]: rasG(D30A)rasC | rasGaberrant aggregation | decreased activation of adenylate cyclase
DBS0236860rasD-rasDaberrant thermotaxis | aberrant phototaxis
DBS0236862rasG-/ AX2rasGdecreased pinocytosis | decreased cAMP-induced cGMP pulse | decreased gene expression | delayed aggregation | decreased protein kinase activation | delayed gene expression
IR15rasG-/ AX2rasGdecreased chemoattractant-mediated F-actin polymerization | decreased cell polarity | increased cell size | decreased growth rate | decreased protein kinase activation
IR17rasG-/ AX3rasGaberrant cytokinesis | increased cell size | decreased cell motility
DBS0236863rasG-/ JH10rasGaberrant cell separation during cytokinesis | decreased cAMP-induced cGMP pulse | wild type | decreased gene expression | delayed aggregation | abolished activation of GTPase activity | aberrant chemotaxis to folate | decreased growth rate | decreased protein kinase activation | delayed gene expression
DBS0236864rasG-/ [OE]: rasBrasB | rasGdecreased growth rate
DBS0350572rasG-/ [act15]: FLAG: rasG(K169R,K173R,K176R,K178R)rasGaberrant cytokinesis
DBS0350571rasG-/ [act15]: FLAG: rasG(K169R,K173R,K176R,K178R,K179R,K180R,K184R)rasGdecreased protein modification
DBS0350448rasG-/ [dscB]: rasG(S17N)rasGdecreased chemoattractant-mediated F-actin polymerization | decreased positive regulation of GTPase activity | decreased protein kinase activation | decreased chemotaxis to cAMP
DBS0236872rasS-rasSdecreased pinocytosis | decreased cell polarity | aberrant pinosome maturation
DBS0236873rasS-rasSaberrant cytoskeleton organisation | decreased rate of endocytosis | increased basal F-actin level | abolished growth | decreased growth rate | increased cell motility
DBS0236874rasZ-rasZwild type
DBS0350261rbg3-rbg3precocious development | increased growth rate
DBS0236877rblA-rblAdecreased gene expression | increased gene expression | decreased spore viability | abolished negative regulation of vegetative growth | decreased growth rate | aberrant vegetative growth | increased sorting to prestalk region | precocious development | increased prestalk cell differentiation in response to DIF-1 | decreased cell size
DBS0349999rblA-/ [act15]: GFPrblAincreased sorting to prestalk region
DBS0349996rblA-/ [act15]: GFP/ [act15]: myc: btgbtg | rblAincreased sorting to prestalk region
DBS0236878rbrA-rbrAincreased gene expression | decreased gene expression | development arrests at slug stage | mislocalized gene expression | decreased sorting to prestalk region | decreased phototaxis | decreased sporulation
DBS0236879rbrA-/ [unk]: rbrArbrAwild type
DBS0236880rckA-rckAdelayed slug formation | increased aggregate size | precocious aggregation | delayed gene expression | increased chemotaxis rate
DBS0236885rckA-/ [act15]: myc: rckArckAdelayed development | decreased chemotaxis rate
DBS0236881rckA-/ [act15]: myc: rckA(C551A)rckAdelayed slug formation | decreased chemotaxis rate
DBS0236882rckA-/ [act15]: myc: rckA(E510G)rckAwild type | decreased chemotaxis rate
DBS0236883rckA-/ [act15]: myc: rckA(E510G/ N511A)rckAdelayed slug formation | decreased chemotaxis rate
DBS0236884rckA-/ [act15]: myc: rckA(K867A)rckAdevelopment arrests at mound stage | decreased chemotaxis rate
FR17rdeA-rdeAprecocious aggregation | decreased aggregate size | precocious development | precocious gene expression | aberrant fruiting body morphology
WTC10rdeA-rdeAincreased intracellular cAMP level | aberrant chemotaxis to cAMP in response to DIF-2
FR17rdeA-rdeAprecocious aggregation | decreased aggregate size | precocious development | precocious gene expression | aberrant fruiting body morphology
DBS0236886rdeA-/ [act15]: rdeArdeAwild type
DBS0350468rdiA-rdiAdecreased pinocytosis | decreased protein localization to cell cortex | decreased F-actin polymerization | decreased protein level | aberrant contractile vacuole morphology | decreased growth rate | aberrant cytokinesis
DBS0236887recA-recAincreased sensitivity to hydrogen peroxide | increased sensitivity to mitomycin C (MMC) | increased sensitivity to UV light
DBS0266664redA-redAdevelopment arrests at mound stage | aberrant mound color
DBS0350511redA-redAincreased infection rate by a gram-negative pathogenic bacterium
DG1047redA-redAdevelopment arrests at mound stage | aberrant mound color
DBS0236889regA-regAincreased resistance to cisplatin | increased intracellular cAMP level | aberrant chemotaxis to cAMP | aberrant fruiting body morphology
DBS0236958regA-regAdecreased spore germination | precocious sporulation | abolished protein localization to cell cortex | aberrant chemotaxis to cAMP | increased lateral pseudopod formation
HM332regA-regAdecreased lateral pseudopod suppression
HR45regA-regAaberrant fruiting body morphology
HM1015regA-regAincreased intracellular cAMP level
DBS0350372regA-regAprecocious sporulation | increased sporulation
DBS0235706regA-/ [act15]: dhkK(D1125N)dhkK | regAprecocious development | aberrant fruiting body morphology
DBS0235708regA-/ [act15]: dhkK(H825Q)dhkK | regAprecocious development | aberrant fruiting body morphology
DBS0350689regA-/ [regA]: regAregAwild type
DBS0350670regA-/ [regA]: regA(D212N)regAprecocious sporulation
HM1351rev3-rev3increased sensitivity to cisplatin
HM1451rev3-/ xpf-rev3 | xpfincreased sensitivity to cisplatin
DBS0236893rgaA-rgaAaberrant cytokinesis | abolished sorting to prestalk region | abolished stalk cell differentiation | decreased protein kinase activation | abolished culmination | decreased sporulation
DBS0349935rgaA-rgaAaberrant stalk morphogenesis | aberrant cellular response to fluid shear stress | increased basal F-actin level | aberrant F-actin organization | multiple tips | increased growth rate | increased cell motility
DBS0350398rgaA-rgaAincreased lateral pseudopod formation | decreased myosin II assembly | increased chemotaxis rate
DBS0349921rgaA-/ [act15]: GFP-mhcArgaAaberrant stalk morphogenesis | aberrant tip formation | aberrant protein localization
DBS0350019rgfA-rgfAwild type
DBS0350020rgfA-/ [act15]: rgfArgfAdecreased chemotaxis to folate | delayed development
DBS0350108rheb-rhebincreased phagocytosis
DBS0236894rhgA-rhgAwild type
DBS0350192ric8-ric8abolished gene expression | abolished chemotaxis to folate | decreased chemotaxis to cAMP | abolished aggregation | aberrant signal transduction
DBS0350193ric8-/ [act15]: GFP: ric8ric8wild type
DBS0236900ripA-ripAdecreased cell polarity | decreased guanylyl cyclase activity | abolished activation of adenylate cyclase | decreased chemotaxis rate | abolished aggregation | aberrant regulation of protein kinase activity | decreased myosin II assembly | increased phagocytosis
DBS0350115ripA-/ [act15]: GFP: rheb(Q64L)rheb | ripAincreased phagocytosis
DBS0236902ripA-/ [unk]: ripA(K680E/ R681E)ripAdecreased chemotaxis rate | aberrant development
DBS0236901ripA-/ [unk]ripAripAwild type
DBS0350770ripA-[act15]: GFP: rapA(G12V)rapA | ripAdecreased protein kinase activation
DBS0236903rnpA-rnpAincreased gene expression
DBS0350096roco11-roco11increased stalk length
DBS0350095roco4-roco4delayed slug formation | aberrant stalk formation | delayed culmination
DBS0350100roco4-/ [unk]: roco4(1018-1292(G1179S))roco4increased catalytic activity
DBS0350098roco4-/ [unk]: roco4(1018-1292(S1187A))roco4abolished catalytic activity
DBS0350099roco4-/ [unk]: roco4(1018-1292(S1189A))roco4decreased catalytic activity
DBS0238225rpkA-rpkAdevelopment arrests at loose mound stage | aberrant response to conditioned medium factor | decreased cell polarity | aberrant cellular response to nitrogen starvation | decreased phagocytosis | decreased cell motility | increased infection rate by a gram-negative pathogenic bacterium | abolished aggregation
DBS0236906rrpA-rrpAabolished post-transciptional gene silencing by RNA
DBS0350209rrpC-rrpCdecreased gene expression | increased gene expression
DBS0350219rrpC-/ [act15]: pre-miRNArrpCincreased microRNA processing
DBS0350216rrpC-/ [act6]: LacZ/ [RNAi]lacZrrpCabolished transitive RNA interference
DBS0350217rrpC-/ [act6]: lacZ/ [AS]lacZrrpCaberrant production of siRNA involved in RNA interference
DBS0236875rtoA-rtoAdecreased rate of endocytosis | decreased infection rate by a gram-negative pathogenic bacterium | increased prestalk cell differentiation | delayed culmination
DBS0236911rtoA-rtoAdelayed development
DBS0236914rzpA-rzpAaberrant aggregation | decreased slug migration | increased aggregate size | increased gene expression | decreased gene expression | delayed development
sadAsadA-sadAabolished protein localization to cell surface | decreased phagocytosis | decreased protein stabilization
DBS0236921sadA-sadAabolished cell-substrate adhesion | decreased phagocytosis | aberrant cytokinesis | aberrant F-actin organization | increased growth rate | aberrant cell morphology
DBS0350974sadA-/ [act15]: gpaHgpaH | sadAaberrant cytokinesis
DBS0349790sadA-/ [act15]: sadA(1-923): GFPsadAdecreased cell-substrate adhesion
DBS0349792sadA-/ [act15]: sadA(S924A/ S925A): GFPsadAwild type
DBS0349791sadA-/ [act15]: sadA(S924E/ S925E): GFPsadAdecreased cell-substrate adhesion
DBS0236922sadA-/ [act15]: sadA: GFPsadAwild type
DG1105scaA-scaAabolished aggregation
DBS0350825scaA-scaAdecreased F-actin polymerization | aberrant chemotaxis to cAMP | abolished activation of GTPase activity | decreased protein kinase activation | abolished aggregation
DBS0236924scrA-scrAdecreased exocytosis | decreased pinocytosis | decreased phagocytosis | decreased basal F-actin level | increased lateral pseudopod formation | abolished protein localization | multiple tips | decreased fruiting body size | precocious development | decreased cell size
IR46scrA-scrAaberrant cytokinesis | decreased cell motility | aberrant spindle stabilization | decreased cell size
IR48scrA-scrAdecreased growth rate | aberrant cytokinesis | decreased phototaxis
DBS0236925scrA-scrAincreased filopodium formation | aberrant F-actin organization
DBS0349927scrA-/ [act15]: wasA: GFP/ [ act8]: RFP: arcDscrAdecreased cell polarity | decreased pseudopod formation
DBS0350063scrA-/ [tet]: scrA/ mhcA-mhcA | scrAaberrant cytokinesis
DBS0237774scrA-/ [unk]: scrA(97-443): GFPscrAaberrant cytoskeleton organisation | increased cell size | aberrant cytokinesis | decreased chemotaxis to cAMP
DBS0237779scrA-/ [unk]: scrA: GFPscrAwild type
HM1163sec1-/ sec1(M213K/ E258G/ M427V/ K527I/ T541N/ F558S/ N581D)sec1abolished cell motility
HM1325sec1-/ sec1(M250L/ A296V/ M427L/ S435R/ K505N/ V552D/ H570Q)sec1aberrant response to hypo-osmotic stress | aberrant plasma membrane organization and biogenesis | abolished cell motility | aberrant cell morphology
DBS0350286sec1-/ sec1(M250L/ A296V/ M427L/ S435R/ K505N/ V552D/ H570Q)/ gppA: GFPgppA | sec1abolished contractile vacuole discharge
DBS0350101sec7-sec7aberrant cell motility | decreased phagocytosis | decreased growth rate | aberrant phototaxis | decreased protein secretion
DBS0306234secG-secGdecreased cell-substrate adhesion | decreased chemotaxis rate
DBS0350264sepA-sepAaberrant cytokinesis | delayed aggregation | decreased growth rate | decreased fruiting body size
DBS0236928set1-set1precocious aggregation | abolished histone H3-K4 methylation | precocious gene expression
DG1008sfbA-sfbAdecreased fruiting body size
DBS0350889sgcA-/ AX2sgcAaberrant aggregation | decreased guanylyl cyclase activity | aberrant chemotaxis to cAMP
DBS0350888sgcA-/ AX3sgcAaberrant aggregation | decreased guanylyl cyclase activity | aberrant chemotaxis to cAMP
SA576sgkA-sgkAincreased sensitivity to cisplatin | increased sensitivity to carboplatin | decreased growth rate
HM1091sgkB-sgkBincreased sensitivity to cisplatin | increased sensitivity to carboplatin | decreased growth rate
SA555sglA-sglAaberrant cytoskeleton organisation | increased stalk width | increased resistance to cisplatin | increased aggregate size | decreased gene expression | abolished slug migration | decreased cell motility | decreased chemotaxis rate | decreased fruiting body size | decreased lateral pseudopod suppression | decreased sporulation
SA554sglA-sglAdelayed aggregation | decreased aggregate size
DBS0236934shkA-shkAaberrant aggregation | decreased cell polarity | aberrant F-actin organization | decreased phagocytosis | aberrant cytokinesis | decreased chemotaxis rate | decreased fruiting body size
DBS0236935sibA-sibAdecreased cell-substrate adhesion | decreased phagocytosis
DBS0302653sibC-sibCdecreased phagocytosis
DBS0236936sigB-sigBwild type
DBS0236937sigD-sigDwild type
DBS0350859sir2D-sir2Ddecreased gene expression | increased gene expression | delayed aggregation | decreased growth rate | decreased autophagy | decreased aggregate size | decreased stalk length | multiple tips in mound
DBS0350860sir2D-/ [ecmAO]: lacZsir2Ddecreased prestalk cell differentiation
DBS0350861sir2D-/ [pspA]: lacZsir2Daberrant prespore cell differentiation
DBS0349958sma-smaincreased chemotaxis to folate | decreased gene expression | increased cell-substrate adhesion | increased cell-cell adhesion | decreased cell size
DBS0349957sma-/ ampA/ [ampA]: ampAampA | smadecreased chemotaxis to folate
DBS0350327smdA-/ [pspA]: lacZsmdAmislocalized gene expression
DBS0236938smkA-smkAaberrant cytokinesis | delayed development | decreased chemotaxis rate | decreased myosin II assembly
HDB7YAsmlA-smlAdecreased secretion of lysosomal enzyme | decreased cell-cell adhesion | aberrant cellular metabolic process | decreased cAMP-induced cGMP pulse | decreased GTP-gamma-S-stimulated guanylyl cyclase activity | increased cAMP-induced cAMP pulse | increased resistance to cisplatin | decreased protein level | increased basal F-actin level | increased myosin II assembly | increased protein level | increased extracellular counting factor component(s) level | increased cell motility | decreased fruiting body size | increased intracellular counting factor component(s) level
DBS0304496smlA-/ sslA1(CR11)smlA | sslA1increased fruiting body size
DBS0350977snfA-snfAdecreased spore viability | decreased prespore cell differentiation | aberrant gene expression | aberrant development | increased growth rate | aberrant prestalk cell differentiation
DBS0302523sodC-sodCaberrant cytokinesis
DBS0302524sodC-sodCdecreased chemoattractant-mediated F-actin polymerization | aberrant aggregation | decreased positive regulation of GTPase activity | increased basal F-actin level | increased protein localization to plasma membrane | decreased chemotaxis rate | aberrant protein localization to plasma membrane | aberrant cell morphology
DBS0350894sodD-sodDincreased sensitivity to UV light
DBS0350891spdA-spdAdecreased substrate adhesion-dependent cell spreading | decreased phagocytosis
HL351spiA-spiAdecreased spore viability
DBS0236945splA-splAaberrant spore morphology | increased sorus size | translucent sorus | spores inviable | decreased stalk length
DBS0350131splB-splBabolished protein tyrosine phosphorylation | abolished protein localization to nucleus | decreased gene expression | abolished response to DIF
DBS0236947spnA-spnAabolished prespore cell differentiation | development arrests at mound stage | abolished prestalk cell differentiation | aberrant development
DBS0350914spsA-spsAdecreased stalk length
DBS0236949sr-srdecreased intracellular pteridine level | decreased spore viability | decreased cytochrome C oxidase activity | decreased growth rate
DBS0236950srfA(1-8): lacZsrfAdecreased slug migration | aberrant fruiting body morphology | delayed culmination
DBS0236951srfA-srfAaberrant spore morphology | aberrant spore coat morphology | decreased spore viability | decreased gene expression
DBS0266691srfB-srfBprecocious aggregation | decreased growth rate | increased pinocytosis | aberrant cytokinesis | increased lateral pseudopod formation | aberrant cAMP signaling during aggregation | abolished streaming | precocious gene expression
DBS0304409srsA-srsAdecreased gene expression | increased gene expression | increased aggregate size | delayed aggregation
DBS0236952stkA-stkAincreased gene expression | decreased gene expression | increased prestalk cell differentiation | aberrant fruiting body morphology | delayed gene expression
HM1157stlA-stlAaberrant cellular metabolic process | aberrant streaming | aberrant aggregation | abolished sporulation | wild type | increased gene expression | decreased gene expression | abolished MPBD production | translucent sorus | abolished SDF-1 production | decreased intracellular cAMP level | decreased chemotaxis to cAMP
DBS0350222stlA-/ [cotB]: lacZstlAdecreased sporulation | aberrant prespore cell differentiation
HM1154stlB-stlBabolished DIF production | abolished prestalk B cell differentiation | decreased prestalk 0 cell differentiation | abolished lower cup formation | abolished outer basal disc formation | decreased prestalk cell differentiation | aberrant fruiting body morphology
DBS0350409stlB-/ [act15]: stlBstlBwild type
DBS0304547svkA-svkAdelayed cell separation during cytokinesis | aberrant cytokinesis | aberrant fruiting body morphology
DBS0236055swip-swipaberrant protein localization to cytoplasm | abolished exocytosis | abolished F-actin polymerization | abolished phagosome re-neutralization | aberrant protein localization
AK1200tagA-tagAabolished SDF production | aberrant fruiting body morphology
AK859tagA-tagAdecreased spore viability | abolished SDF production | multiple tips in mound | increased prestalk A cell differentiation
AK1201tagA-/ [ecmA]: GFPtagAabolished sorting to prestalk region
AK228tagB-tagBabolished sporulation | development arrests at mound stage | abolished DIF production | aberrant prestalk A cell differentiation
DBS0350637tagB-/ [pkaC]: pkaCpkaC | tagBabolished SDF-1 production | aberrant response to SDF-1
DBS0236975tagC-tagCdevelopment arrests at mound stage | spores inviable
DBS0350698tagC-/ [pkaC]: pkaCpkaC | tagCdevelopment arrests at mound stage | abolished SDF-2 production
DBS0236976talA-talAdecreased protein level | decreased cell-substrate adhesion | aberrant cytokinesis | decreased phagocytosis | aberrant cell morphology
HG1666talA-talAdecreased cell-cell adhesion | decreased cell-substrate adhesion | aberrant cytokinesis | decreased growth rate | decreased phagocytosis | increased cell-substrate adhesion
HG1663talA-talAdecreased cell-substrate adhesion
HG1664talA-talAdecreased uropod retraction | decreased growth rate | decreased phagocytosis | aberrant cytokinesis, contractile ring contraction
HG1665talA-talAdecreased cell-cell adhesion | aberrant cytokinesis
DBS0304585talA-/ [act15]: FLAG: talBtalA | talBdecreased cell-substrate adhesion
DBS0237616talA-/ [act15]: gbpDgbpD | talAincreased pseudopod formation | increased cell-substrate adhesion | aberrant cell morphology
DBS0238395talA-/ [act15]: rapA(G12V)rapA | talAincreased cell-substrate adhesion
DBS0304582talA-/ talB-/ [act15]: FLAG: talBtalA | talBwild type
HKT104talB-talBdecreased slug migration | decreased cell motility | development arrests at tipped mound stage | increased protein level
DBS0302472talB-talBabolished autophagic vacuole formation | abolished autophagic cell death
DBS0304586talB-/ [act15]: talA: GFPtalA | talBaberrant fruiting body morphology
DBS0350712talB-/ [act15]: talB(K16A)talBdevelopment arrests at tipped mound stage
DBS0304820tgrB1-tgrB1development arrests at loose mound stage | delayed sporulation | decreased cell motility | decreased sporulation
AK127tgrC1-tgrC1development arrests at loose mound stage | aberrant aggregation | abolished gene expression | increased aggregate size | decreased gene expression
DBS0304821tgrC1-tgrC1abolished sporulation | development arrests at loose mound stage | decreased cell motility
AK1657tgrC1-/ QS38[tgrC1]: tgrC1/ alg9(-19ins)alg9 | tgrC1delayed development | decreased fruiting body size | decreased sporulation
AK1661tgrC1-/ alg9(-19ins)alg9 | tgrC1delayed development | decreased fruiting body size | decreased sporulation
DBS0350743tgrC1-/ alg9(-19ins)-REMIalg9 | tgrC1decreased sporulation
DBS0350625tgrC1-/ stcA-stcA | tgrC1decreased aggregate size | delayed development | decreased sporulation
DBS0350626tgrC1-/ stcB-stcB | tgrC1delayed development | decreased aggregate size | decreased sporulation
DBS0350627tgrC1-/ stcC-stcC | tgrC1aberrant streaming | delayed development | decreased fruiting body size | decreased sporulation
AK244tipA-tipAincreased aggregate size | decreased gene expression | development arrests at mound stage | multiple tips
JS56tipB-tipBincreased aggregate size | development arrests at mound stage | multiple tips | multiple tips in mound
JS55tipC-tipCincreased aggregate size | development arrests at mound stage | decreased number of autophagosomes | decreased autophagy | multiple tips
DBS0350729tipC-/ [unk]: tipC(2725-3848): GFPtipCdecreased fruiting body size
JS93tipD-tipDincreased aggregate size | development arrests at mound stage | aberrant vacuole organization and biogenesis | decreased autophagy | multiple tips
DBS0350730tipD-tipDdecreased pinocytosis | increased gene expression | aberrant phagosome maturation | aberrant fruiting body morphology | aberrant slug formation | multiple tips in mound
DBS0304519tirA-tirAaberrant defense response to bacterium | decreased growth rate | aberrant phagocytosis | increased infection rate by a gram-negative pathogenic bacterium
YLD31Atlp2-tlp2decreased growth rate
DBS0350285tom1-tom1decreased rate of endocytosis
DBS0237017torA-torAdelayed aggregation | decreased growth rate | decreased cell motility | decreased chemotaxis rate
DBS0237018torA-/ [act15]: torA: GFPtorAabolished growth
DBS0350506tpp1-tpp1aberrant response to chemical stimulus
DBS0350504tpp1-tpp1decreased catalytic activity | aberrant response to chemical stimulus | aberrant autophagic cell death | aberrant cell morphology | precocious development
DBS0350505tpp1-/ [cotB]: tpp1tpp1wild type
DBS0237924triA-triAdecreased cell-cell adhesion | aberrant streaming | increased stalk width | aberrant upper cup formation | aberrant cell motility | decreased spore viability | aberrant culminant morphology | decreased spore size | decreased cell fate determination | increased number of aggregates | decreased cell fate commitment
DBS0237996triA-triAaberrant culminant morphology
DBS0237997triA-triAaberrant culminant morphology
DBS0237998triA-/ [act15]: GFPtriAaberrant culminant morphology
DBS0237999triA-/ [ecmAO]: lacZ: [ecmAO]: gustriAincreased prestalk 0 cell differentiation
DBS0238001triA-/ [psA]: lacZ: [psA]: gustriAincreased prespore cell differentiation
DBS0237022tsg101-tsg101decreased fruiting body size
DBS0350816tspC-tspCaberrant response to osmotic stress
HM1725tstD-tstDdecreased growth rate | decreased membrane organization during endocytosis | increased growth rate
DBS0302370tsuA-tsuAincreased period of cAMP wave formation | aberrant chemotaxis to folate | aberrant chemotaxis to cAMP | delayed aggregation | decreased aggregate size | abolished cell polarity | decreased fruiting body size
DBS0302383tsuA-/ [unk]: tsuA(1-1774): YFPtsuAabolished localization to microtubules | decreased aggregate size | abolished localization to microtubule organizing center | decreased fruiting body size
DBS0302385tsuA-/ [unk]: tsuA(1-260): YFPtsuAabolished localization to microtubules | abolished localization to microtubule organizing center | decreased aggregate size | decreased fruiting body size
DBS0302384tsuA-/ [unk]: tsuA(1774-2247): YFPtsuAabolished localization to microtubules | abolished localization to microtubule organizing center | decreased aggregate size | decreased fruiting body size
DBS0302382tsuA-/ [unk]: tsuA(K34R): YFPtsuAdecreased aggregate size | decreased fruiting body size
DBS0302381tsuA-/ [unk]: tsuA: YFPtsuAwild type
DBS0237024ubcB-ubcBdevelopment arrests at mound stage | multiple tips
DBS0306165ube2t-ube2tincreased sensitivity to cisplatin
DBS0237025ubpA-ubpAdecreased gene expression | decreased chemotaxis rate | abolished aggregation | decreased cAMP-induced cAMP pulse
DBS0237026ubpB-ubpBaberrant sorus morphology | increased gene expression | decreased gene expression | precocious development
DBS0237027ufc1-ufc1wild type
DBS0237028ugpB-/ DH1ugpBaberrant cell differentiation | decreased intracellular glycogen level | spores inviable | decreased fruiting body size | delayed culmination
DBS0266763ugpB-/ DH1ugpBdecreased stalk length
DBS0266764ugpB-/ HMXugpBabolished cellulose biosynthesis | decreased autophagic vacuole formation | aberrant cell morphology
DBS0350591uppA-uppAdecreased catalytic activity
DBS0237031vacA-vacAwild type
DBS0237032vacB-vacBdecreased exocytosis
DBS0237034vasP-vasPabolished filopodium formation
DBS0237035vasP-vasPdecreased cell-substrate adhesion | aberrant F-actin organization | decreased chemotaxis rate | decreased lateral pseudopod suppression | decreased cell size | abolished filopodium formation | decreased filopodium formation
DBS0237033vasP-/ [act15]: GFP: vasP(1-264/ 285-380)vasPabolished filopodium formation
DBS0237836vasP-/ [act15]: YFP: wipAvasP | wipAdecreased filopodium formation
DBS0237842vasP-/ [act15]: YFP: wipA/ [act15]: vasP: FLAGvasP | wipAincreased filopodium formation
DBS0237036vasP-/ [act15]: myr: vasPvasPincreased filopodium formation | increased basal F-actin level | aberrant cytokinesis
DBS0237040vasP-/ [act15]: vasPvasPdecreased filopodium formation
DBS0237840vasP-/ [act15]: vasPvasPincreased filopodium formation | increased basal F-actin level
DBS0237037vasP-/ [act15]: vasP(1-110: 231-380)vasPincreased basal F-actin level | aberrant cytokinesis | decreased filopodium formation
DBS0237038vasP-/ [act15]: vasP(1-228)vasPdecreased filopodium formation
DBS0237039vasP-/ [act15]: vasP(111-380)vasPincreased filopodium formation | increased basal F-actin level
DBS0350466vasP-/ [unk]: vasP(1-197: 221-380)vasPwild type
DBS0350467vasP-/ [unk]: vasP(1-261: 285-380)vasPdecreased cell motility | abolished filopodium formation
DBS0350602vilA-vilAdecreased chemotaxis to cAMP | decreased phototaxis
DBS0236058vmp1-vmp1aberrant aggregation | decreased exocytosis | increased cell death | aberrant response to hypo-osmotic stress | decreased gene expression | decreased growth rate | decreased macropinocytosis | aberrant vacuole organization and biogenesis | aberrant autophagic cell death | aberrant protein localization | aberrant signal transduction
DBS0350873vps13F-vps13Faberrant defense response to bacterium | decreased growth rate
DG1118vps46-vps46increased sorus size
DBS0237046vwkA-vwkAincreased myosin II assembly | aberrant response to hypo-osmotic stress | decreased growth rate | aberrant cytokinesis | aberrant contractile vacuole morphology | delayed development | increased protein level | decreased contractile vacuole discharge | aberrant fruiting body morphology
DBS0350290vwkA-/ [act15]: GFP: mhcAmhcA | vwkAaberrant myosin II organization
TL61wacA-wacAwild type
TL99wacA-wacAwild type
DBS0237048warA-warAdevelopment arrests at slug stage | increased basal disc size | decreased prespore cell differentiation | increased prestalk 0 cell differentiation
DBS0237049warA-warAdevelopment arrests at slug stage | increased basal disc size | decreased prespore cell differentiation | increased prestalk 0 cell differentiation
DBS0350254wasB-wasBaberrant chemotaxis to cAMP | increased F-actin polymerization | increased protein level | aberrant pseudopod formation | aberrant protein localization
DBS0350255wasB-/ [act15]: YFP: wasBwasBwild type
DG1053wimA-wimAaberrant fruiting body morphology
DG1064wimA-wimAaberrant fruiting body morphology
DBS0349863wshA-wshAdecreased secretion of lysosomal enzyme | aberrant lysosome organization and biogenesis | increased protein localization | abolished exocytosis | decreased macroautophagy | abolished endocytic recycling | aberrant vegetative growth | decreased phagocytosis | aberrant phagosome maturation | decreased infection rate by a gram-positive pathogenic bacterium | decreased phagosomal proteolysis | abolished phagosome re-neutralization | aberrant protein localization
DBS0350943xacA-xacAdecreased response to hypo-osmotic stress | aberrant F-actin organization | aberrant contractile vacuole morphology
DBS0350950xacA-xacAaberrant F-actin organization | increased lateral pseudopod formation | decreased chemotaxis to cAMP
DBS0350944xacA-/ [act15]: xacA(1-320)xacAdecreased growth rate | aberrant cytokinesis
DBS0350945xacA-/ [act15]: xacA(779-1335)xacAdecreased response to hypo-osmotic stress | aberrant contractile vacuole morphology
HM1456xpc-xpcwild type
HM1403xpf-xpfincreased sensitivity to cisplatin
AK235yakA-yakAabolished aggregation
AK800yakA-yakAdecreased gene expression | aberrant cell cycle | aberrant gene expression | decreased protein kinase activation | abolished aggregation | decreased intracellular cAMP level | aberrant response to oxidative stress
DBS0237091yakA-/ [crlA]: crlAcrlA | yakAabolished growth
DBS0350058yakA-/ keaA-keaA | yakAwild type
DBS0350898yelA-/ AX2yelAprecocious prestalk gene expression | increased basal disc size
DG1014yelA-/ AX4yelAdecreased spore viability | precocious sporulation | development arrests at mound stage | aberrant mound color
DBS0349797zak2-zak2decreased gene expression | decreased protein kinase activation | decreased sporulation | aberrant fruiting body morphology
DBS0349883zak2-/ [act15]: GFPzak2decreased sporulation
DBS0349798zak2-/ [ecmA]: LacZzak2aberrant gene expression
DBS0349882zak2-/ [ecmA]: zakAzak2 | zakAaberrant gene expression
ARK100-110zakA-zakAincreased gene expression | decreased gene expression | decreased protein kinase activity | abolished streaming | decreased chemotaxis to cAMP | delayed culmination | aberrant fruiting body morphology | decreased sporulation
DBS0238142zakA-zakAdevelopment arrests at tipped mound stage
DBS0349803zakA-/ [ecmB]: LacZzakAaberrant gene expression
DG1050zipA-zipAdecreased fruiting body size
DBS0350068zizB-zizBdelayed development | decreased chemotaxis to cAMP | aberrant fruiting body morphology

Last updated August 28, 2017

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