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Phenotypes for Dictyostelium mutants

View other mutant types: All mutant strains - Null - Overexpression - Multiple - Other - Developmental

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To view more details, including parent strains and references, click on the corresponding dictyBase ID.

Strain ID Strain Descriptor Associated gene(s) Phenotypes
DBS0266721Dd5P4-/ [act15]: Hs-OCRL(D422A)Dd5P4decreased phagocytosis
DBS0237041VatMprvatMaberrant intracellular pH level, decreased growth rate, decreased phagocytosis, increased localization of protein to the cytoplasm
DBS0237236[AS]: [tet]: trrAtrrAabolished aggregation, decreased growth rate, delayed development
DBS0237228[AS]GP138A/ [AS]GP138BcfrA, cfrBdecreased sexual fusion
DBS0304456[AS]alrA/ gcsA-alrA, gcsAcell cycle arrest, decreased growth rate in suspension
DBS0237273[AS]calAcalAabolished cytokinesis
DBS0237224[AS]cmfAcmfAabolished aggregation
DBS0237225[AS]cupBcupBabolished aggregation
DBS0237226[AS]dia1dia1decreased gene expression, precocious aggregation
DBS0238235[AS]dutAdutAwild type
DBS0237229[AS]gpaAgpaAwild type
HPF414[AS]hspAhspAaberrant fruiting body morphology, decreased growth rate
DBS0238749[AS]hspA/ snfAhspA, snfAwild type
DBS0252819[AS]hssAhssAwild type
DBS0237230[AS]ino1ino1abolished growth
DBS0236725[AS]patApatAdecreased growth rate under Ca2+ stress
DBS0237504[AS]pikEpikEaberrant stalk morphogenesis, decreased growth rate
DBS0237232[AS]proAproAwild type
DBS0236827[AS]proA/ proB-proA, proBaberrant cytokinesis, abolished growth, decreased cell motility, development arrests at slug stage, increased basal F-actin level
DBS0238036[AS]proA/ proB-/ [act15]: proAproA, proBwild type
DBS0238037[AS]proA/ proB-/ [act15]: proBproA, proBwild type
DBS0236851[AS]rapArapAaberrant osmosensory signaling pathway, aberrant response to hyperosmotic stress, decreased phagocytosis, decreased pinocytosis, increased basal phosphorylated actin level, inviable
DBS0236904[AS]rps4mrps4aberrant fruiting body morphology, delayed aggregation
DBS0238748[AS]snfAsnfAaberrant mitochondrion organization and biogenesis, decreased fruiting body size, decreased intracellular ATP level, decreased number of mitochondria, increased growth rate
DBS0304498[AS]sslA1sslA1decreased fruiting body size
DBS0237235[AS]tcp1tcp1aberrant fruiting body morphology, decreased growth rate, development arrests at mound stage
DBS0266892[KD]gtaCgtaCabolished stalk cell differentiation
DBS0266893[KD]gtaC/ [act15]: GFP: gtaCgtaCwild type
DBS0302601[OE]: disgorgin(Q551A)/ disgorgin-DDB_G0280955aberrant contractile vacuole organization and biogenesis
DBS0302600[OE]: disgorgin(R515A)/ disgorgin-DDB_G0280955aberrant contractile vacuole organization and biogenesis
DBS0235409[RNAi]cnbAcnbAaberrant stalk cell differentiation, decreased gene expression, decreased stalk length, multiple tips in culminant
DBS0237295[RNAi]fimAfimAwild type
DBS0252820[RNAi]hssAhssAwild type
DBS0237310[RNAi]lipAlipAwild type
DBS0237296[RNAi]pks16pks16wild type
DBS0237311[RNAi]racF2racF2abolished growth in suspension
DBS0238734[RNAi]sdhAsdhAabolished aggregation, decreased phototaxis
DBS0304564[RNAi]sun1sun1aberrant nucleus morphology, increased cell size
DBS0237818[RNAi]wipAwipAdecreased F-actin polymerization at the leading edge, decreased chemotaxis to cAMP, decreased filopodium formation, delayed pseudopod formation
DBS0238108[act15]: FLAG: ppp4C(H113Q)ppp4cdelayed development, development arrests at mound stage
DBS0237132[act15]: GFP: racH(T18N)racHaberrant cell morphology, aberrant cytokinesis
DBS0238393[act15]: GFP: rapA(G12V)rapAincreased cell-substrate adhesion
DBS0238394[act15]: GFP: rapA(S17N)rapAdecreased cell-substrate adhesion
DBS0304563[act15]: GFP: sun1(283-905)sun1aberrant centrosome localization, aberrant nucleus morphology, aberrant perinuclear space, aberrant sister chromosome segregation, decreased localization of a protein to the nuclear envelope, increased cell size, increased number of centrosomes
DBS0237227[act15]: [AS]dia2dia2aberrant cAMP signaling during aggregation, abolished aggregation, decreased extracellular cAMP level
DBS0238088[act15]: atg1(K36A)atg1aberrant cellular response to nitrogen starvation, abolished aggregation, abolished macroautophagy, increased number of autophagosomes
DBS0252740[act15]: carA(I104D)carA-1, carA-2aberrant cAMP wave formation, decreased MAP kinase activation, delayed aggregation, increased cAMP binding
DBS0252744[act15]: carA(I104E)carA-1, carA-2aberrant cAMP wave formation, delayed aggregation, increased cAMP binding
DBS0252747[act15]: carA(I104H)carA-1, carA-2abolished cAMP wave formation, decreased MAP kinase activation, development arrests at loose aggregate stage, increased cAMP binding
DBS0252749[act15]: carA(I104K)carA-1, carA-2abolished aggregation, abolished cAMP wave formation, decreased MAP kinase activation, increased cAMP binding
DBS0252746[act15]: carA(I104N)carA-1, carA-2abolished cAMP wave formation, decreased MAP kinase activation, development arrests at loose aggregate stage, increased cAMP binding
DBS0252745[act15]: carA(I104Q)carA-1, carA-2abolished cAMP wave formation, decreased MAP kinase activation, development arrests at loose aggregate stage, increased cAMP binding
DBS0252750[act15]: carA(I104R)carA-1, carA-2abolished cAMP wave formation, decreased MAP kinase activation, development arrests at loose aggregate stage, increased cAMP binding
DBS0252748[act15]: carA(I104Y)carA-1, carA-2aberrant cAMP wave formation, decreased MAP kinase activation, development arrests at loose aggregate stage, increased cAMP binding
DBS0237098[act15]: cdk5(D144N)cdk5decreased extracellular counting factor component(s) level, decreased growth rate, decreased phagocytosis, decreased pinocytosis, decreased sporulation, delayed aggregation, increased aggregate size, increased extracellular counting factor component(s) level, increased intracellular counting factor component(s) level
DBS0266839[act15]: myc: ptpΔ(3C649S)ptpCaberrant localization of protein to the nucleus, increased protein tyrosine phosphorylation
DBS0266838[act15]: myc: ptpC(C649S)ptpCaberrant localization of protein to the nucleus, increased protein tyrosine phosphorylation
DBS0238396[act15]: myc: rapA(G12V)rapAdecreased cell motility, delayed aggregation, increased cell-substrate adhesion
DBS0238397[act15]: myc: rapA(S17N)rapAdecreased cell-substrate adhesion
DBS0237183[act15]: pakA(K394A)pakAdelayed development, development arrests at mound stage
DBS0237184[act15]: pakA[CA]pakAabolished aggregation
DBS0237219[act6]: ptpC(C649S)ptpCdecreased growth rate, increased aggregate size
DBS0237252[gpaA]: gpaA(G45V)gpaAdelayed development
DBS0237253[gpaA]: gpaA(Q206L)gpaAincreased basal disc size
DBS0238351[tet]: [RNAi]cinCcinCdecreased growth rate, decreased translation, precocious aggregation
DBS0237318[tet]: ptenptendecreased cell motility
DBS0237622[tet]: rapA(S17N)/ [act15]: gbpDgbpD, rapAaberrant cell morphology, increased cell polarity, increased cell-substrate adhesion
DBS0304911[tre]: paxBpaxBaberrant chemotaxis to folate, aberrant endocytosis, abolished sporulation, decreased cell motility, decreased cell-substrate adhesion, development arrests at mound stage, increased cell-cell adhesion
DBS0237786acrA-/ [act15]: acgA(1-401)acgA, acrAdecreased gene expression, decreased prespore cell differentiation, decreased sporulation
DBS0238093atg1-/ [act15]: atg1(P138S)atg1abolished aggregation
DBS0235570carB-carBdevelopment arrests at mound stage
DBS0237568ctxA-/ [RNAi]enlActxA, enlAwild type
DBS0304913gbpC-/ [act15]: gbpC(K342N)gbpCdecreased chemotaxis to cAMP
DBS0304914gbpC-/ [act15]: gbpC(K905W)gbpCdecreased chemotaxis to cAMP
DBS0237190gdt1-/ [act15]: pkaR(G135E/ G261A)gdt1, pkaRabolished aggregation, increased gene expression
DBS0236092gpaA-/ [gpaA]: gpaA(G45V)gpaAdelayed development
DBS0236093gpaA-/ [gpaA]: gpaA(Q206L)gpaAincreased basal disc size
DBS0237564mhcA-/ [act15]: GFP: ctxA/ [RNAi]enlActxA, enlA, mhcAaberrant cytokinesis, contractile ring contraction
DBS0238399mhcA-/ [act15]: rapA(G12V)mhcA, rapAaberrant myosin II organization, increased basal F-actin level, increased cell polarity
DBS0304881mrps4-mrps4delayed aggregation
DBS0304882mtDNA-DidioMp05, DidioMp21, DidioMp26, DidioMp27, DidioMp30, DidioMp35, DidioMp36, ai2a, ai2b, ai3, ai4, atp1, atp6, atp9, cox1/ 2, cox3, cytB, mrpl11, mrpl14, mrpl16, mrpl2, mrpl6, mrps12, mrps13, mrps14, mrps19, mrps2, mrps4, mrps7, mrps8, nad1, nad11, nad2, nad3, nad4, nad4L, nad5, nad6, nad7, nad9, rnlAabolished aggregation, abolished growth
DBS0236583myoB-/ [AS]myoDmyoB, myoDaberrant aggregation, decreased aggregate size, decreased cell motility, decreased growth rate, decreased phagocytosis, decreased pinocytosis
DBS0236584myoB-/ [AS]myoD/ [KD]myoCmyoB, myoC, myoDaberrant aggregation, decreased aggregate size, decreased cell motility, decreased growth rate, decreased phagocytosis, decreased pinocytosis, increased number of pinosomes, small pinosomes
HM1060nsfA(A1847G, A1939T, T1977C, T2005G, A2025T, A2366T)nsfAabolished cell motility, decreased F-actin polymerization at the leading edge, decreased phagocytosis, decreased rate of endocytosis
HM1067nsfA(A1854T, T1984A, C2131A, A2398T, T2574A)nsfAabolished cell motility, decreased F-actin polymerization at the leading edge, decreased cell motility, decreased rate of endocytosis, increased phagocytosis
DBS0236789pkgB-/ [act15]: pkgB(K182M)pkgBdevelopment arrests at mound stage
DBS0302357psrA-/ [act15]: gskA(K84M/ K85M)gskA, psrAdecreased culmination, decreased gene expression, delayed development
DBS0236884rckA-/ [act15]: myc: rckA(K867A)rckAdecreased chemotaxis rate, development arrests at mound stage
HM1163sec1(M213K, E258G, M427V, K527I, T541N, F558S, N581D)sec1abolished cell motility
DBS0238395talA-/ [act15]: rapA(G12V)rapA, talAincreased cell-substrate adhesion
DBS0302382tsuA-/ [unk]: tsuA(K34R): YFPtsuAdecreased aggregate size, decreased fruiting body size
DBS0237051wasA1-wasAaberrant F-actin organization, decreased cell motility, delayed development
DBS0237052wasA1-/ [tet]: YFP: wasA2wasAaberrant F-actin organization, abolished aggregation, abolished chemotaxis, decreased F-actin polymerization
DBS0237811wasA1-/ [tet]: YFP: wasA2/ [act15]: wasA(Y33A/ W39A/ F90A/ F91A)wasAdecreased F-actin polymerization, decreased F-actin polymerization at the leading edge
DBS0237820wasA1-/ [tet]: YFP: wasA2/ [act15]: wipAwasA, wipAabolished chemotaxis

Last updated February 28, 2010

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